Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, Xinmei, Yeung, Dennis C.Y., Karpisek, Michal, Stejskal, David, Zhou, Zhi-Guang, Liu, Feng, Wong, Rachel L.C., Chow, Wing-Sun, Tso, Annette W.K., Lam, Karen S.L., Xu, Aimin·2008·Diabetes

DOI 10.2337/db07-1476

Cited by (907)

Items 201–300 of 907

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Stressed Liver and Muscle Call on Adipocytes with FGF21
Yongde Luo, Wallace L. McKeehan · 2013 · Frontiers in Endocrinology
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Plasma FGF21 displays a circadian rhythm during a 72‐h fast in healthy female volunteers
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Berti, Lucia, Irmler, Martin, Zdichavsky, Marty, Meile, Tobias, Böhm, Anja, Stefan, Norbert, Fritsche, Andreas, Beckers, Johannes, Königsrainer, Alfred, Häring, Hans-Ulrich et al. · 2015 · Molecular Metabolism
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Xingbo Cheng, Bei Lei Zhu, Fusong Jiang, Huaying Fan · 2011 · Endocrine Research
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Dongyu Wang, Wenjing Zhu, LI Jie-ming, Chongyou An, Zilian Wang · 2013 · PLoS ONE
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?
Pascal M. Mutie, Giuseppe Nicola Giordano, Paul W. Franks · 2017 · BMC Medicine
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
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Jung, Tae Woo, Yoo, Hye Jin, Choi, Kyung Mook · 2016 · BBA Clinical
White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice
Haizhao Song, Zihuan Zheng, Jianan Wu, Jia Lai, Qiang Chu, Xiaodong Zheng · 2016 · PLoS ONE
The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model
Redin A. Spann, Christopher D. Morrison, Laura J. den Hartigh · 2022 · Frontiers in Endocrinology
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
Andrew L. Coppage, Kathryn R. Heard, Matthew T. DiMare, Yuxin Liu, Wengen Wu, Jack Hung-Sen Lai, William W. Bachovchin · 2016 · PLoS ONE
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Zhanwei Zhuang, Shaoyun Li, Rongrong Ding, Ming Yang, Enqin Zheng, Huaqiang Yang, Ting Gu, Zheng Xu, Gengyuan Cai, Zhenfang Wu et al. · 2019 · PLoS ONE
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Richard D. Semba, Kai Sun, Josephine Mary Egan, Candace Crasto, Olga D. Carlson, Luigi Ferrucci · 2012 · The Journal of Clinical Endocrinology & Metabolism
Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders
Jun Zhang, Yang Li · 2015 · Frontiers in Endocrinology
Relationship Between 12 Adipocytokines and Distinct Components of the Metabolic Syndrome
Thomas Ebert, Claudia Gebhardt, Markus R. Scholz, Tobias Wohland, Dorit Schleinitz, Mathias Faßhauer, Matthias Blüher, Michael Stümvoll, Peter Louis Kovacs, Anke Tönjes · 2018 · The Journal of Clinical Endocrinology & Metabolism
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Ngoc Lieu Le · 2021 · International Journal of Food Science & Technology
Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta)
Else Nygaard, Cathrine Laustrup Møller, Paul Kievit, Kevin L. Grove, B Andersen · 2013 · International Journal of Obesity
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
Huating Li, Jing Zhang, Weiping Jia · 2013 · Frontiers of Medicine
Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques
So-Yeon An, Min Suk Lee, Sang‐A Yi, Eun Suk Ha, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee · 2012 · Diabetes Research and Clinical Practice
Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes
Rikke Kruse, Sara G. Vienberg, Birgitte F. Vind, Birgitte Andersen, Kurt Højlund · 2017 · Diabetologia
Homeostatic sensing of dietary protein restriction: a case for FGF21
Hill, Cristal M., Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D. · 2018 · Frontiers in Neuroendocrinology
The role of FGF21 in the pathogenesis of cardiovascular disease
Ying Zhang, Dan Liu, Xiao-Xue Long, Qi-Chen Fang, Wei-Ping Jia, Hua-Ting Li · 2021 · Chinese Medical Journal
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis
James Cantley · 2014 · Mammalian Genome
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
Kathleen R. Markan, Meghan C. Naber, Sarah M. Small, Lila Peltekian, Rachel L. Kessler, Matthew J. Potthoff · 2017 · Molecular Metabolism
Current status and future perspectives of FGF21 analogues in clinical trials
Zara Siu Wa Chui, Qing Shen, Aimin Xu · 2024 · Trends in Endocrinology and Metabolism
Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)
Hai Thi, Timofey V. Tselykh, Johanna Mäkelä, Tho Huu Ho, Vesa M. Olkkonen, Beat C. Bornhauser, Laura Korhonen, Noam Zelcer, Dan Lindholm · 2012 · Journal of Biological Chemistry
The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism
Daniel Cuevas Ramos, Paloma Almeda‐Valdés, Carlos Alberto Aguilar-Salinas, Gabriel Cuevas-Ramos, Andres Cuevas-Sosa, Francisco Javier Gomez-Perez · 2009 · Current Diabetes Reviews
Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
Peng Cheng, Fangfang Zhang, Lechu Yu, Xiufei Lin, Luqing He, Xiaokun Li, Xuemian Lu, Xiaoqing Yan, Yi Tan, Chi Zhang · 2016 · Journal of Diabetes Research
Protein appetite as an integrator in the obesity system: the protein leverage hypothesis
David Raubenheimer, Stephen James Simpson · 2023 · Philosophical Transactions of the Royal Society B Biological Sciences
Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease
Marina Kohara, Takahiro Masuda, Kazuhiro Shiizaki, Tetsu Akimoto, Yuko Watanabe, Sumiko Honma, Chuji Sekiguchi, Yasuharu Miyazawa, Eiji Kusano, Yoshinobu Kanda et al. · 2017 · PLoS ONE
FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans
Samms, Ricardo J, Lewis, Jo E, Norton, Luke, Stephens, Francis B, Gaffney, Christopher J, Butterfield, Tony, Smith, Dennis P, Cheng, Christine C, Perfield, James W, Adams, Andrew C et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Serum fibroblast growth factor–21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis
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Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lössner, Peter Louis Kovacs, Thomas Ebert, Matthias Blüher, Michael Stümvoll, Mathias Faßhauer · 2012 · Journal of Endocrinology
Increased FGF21 plasma levels in humans with sepsis and SIRS
Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin, François R. Jornayvaz · 2013 · Endocrine Connections
Diagnostic value of serum biomarkers FGF21 and GDF15 compared to muscle sample in mitochondrial disease
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Eleftheria Maratos–Flier · 2017 · Experimental Cell Research
Metformin Stimulates FGF21 Expression in Primary Hepatocytes
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Christian Faul · 2016 · Bone
Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues
Xiaolong Lin, Yuan Bo Liu, Huijun Hu · 2017 · Biomedical Reports
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Jane Rhyu, Run Yu · 2021 · World Journal of Hepatology
Nrf2 induces fibroblast growth factor 21 in diabetic mice
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Sophia Harlid, Robin Myte, Bethany R. Van Guelpen · 2017 · Mediators of Inflammation
FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
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