Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance
Open accessAbstract
OBJECTIVE: Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of these metabolic abnormalities. We examined whether aging per se (in subjects with normal glucose tolerance [NGT]) impairs mitochondrial function and how this relates to ROS generation, whether older subjects with IGT have a further worsening of mitochondrial function (lower ATP production and elevated ROS generation), and whether exercise reverses age-related changes in mitochondrial function. RESEARCH DESIGN AND METHODS: Mitochondrial ATP and ROS production were measured in muscle from younger individuals with NGT, older individuals with NGT, and older individuals with IGT. Measurements were performed before and after 16 weeks of aerobic exercise. RESULTS: ATP synthesis was lower in older subjects with NGT and older subjects with IGT versus younger subjects. Notably, mitochondria from older subjects (with NGT and IGT) displayed reduced ROS production versus the younger group. ATP and ROS production were similar between older groups. Exercise increased ATP synthesis in the three groups. Mitochondrial ROS production also increased after training. Proteomic analysis revealed downregulation of several electron transport chain proteins with aging, and this was reversed by exercise. CONCLUSIONS: Old mitochondria from subjects with NGT and IGT display mitochondrial dysfunction as manifested by reduced ATP production but not with respect to increased ROS production. When adjusted to age, the development of IGT in elderly individuals does not involve changes in mitochondrial ATP and ROS production. Lastly, exercise reverses the mitochondrial phenotype (proteome and function) of old mitochondria.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maximal mitochondrial ATP production rates in response to a supply of complex I substrates are lower in older than in younger adults.
“These findings are consistent with recent data indicating that maximal mitochondrial ATP production rates in response to a supply of complex I substrates are lower in older than in younger adults (35, 39).”
From Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age (2015) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Self-citationDiagnosis and classification of diabetes mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s062 · Cited by 5,491 · see citing works
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
Self-citationDecline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139 · see citing works
Self-citationHandschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
Mitochondrial role in cell aging
Miquel, J., Economos, A. C., Fleming, J., & Johnson, J. E. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90010-8 · Cited by 937 · see citing works
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887 · see citing works
Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971–1993
Gu, K., Cowie, C. C., & Harris, M. I. (1998) · Diabetes Care · doi:10.2337/diacare.21.7.1138 · Cited by 881 · cited 4× · see citing works
“Succinate (5 mmol/L) was added to drive respiration through complex II, III, and IV.”
BackgroundInfluentialRossetti, L., Smith, D. J., Shulman, G. I., Papachristou, D. N., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112981 · Cited by 808 · see citing works
Self-citationMitochondrial disease in mouse results in increased oxidative stress
Esposito, L., Melov, S., Panov, A. V., Cottrell, B. A., & Wallace, D. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4820 · Cited by 637 · see citing works
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631 · see citing works
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
DeFronzo, R. A. (1979) · Diabetes · doi:10.2337/diab.28.12.1095 · Cited by 595 · see citing works
Self-citationEndurance Exercise as a Countermeasure for Aging
Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582 · see citing works
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works
Effect of age on <i>in vivo</i> rates of mitochondrial protein synthesis in human skeletal muscle
Rooyackers, O. E., Adey, D. B., Ades, P. A., & Nair, K. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15364 · Cited by 564 · see citing works
Mechanisms of Insulin Resistance in Aging
Fink, R. I., Kolterman, O., Griffin, J., & Olefsky, J. M. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110908 · Cited by 555 · see citing works
Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro
Reid, M. B., Haack, K. E., Franchek, K. M., Valberg, P. A., Kobzik, L., & West, M.-Y. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1797 · Cited by 492 · see citing works
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.
Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kanety, H., & Bashan, N. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1562 · Cited by 483 · see citing works
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.b71 · Cited by 456 · see citing works
Davidson, M. B. (1979) · Metabolism · doi:10.1016/0026-0495(79)90024-6 · Cited by 411 · see citing works
Effects of exercise on mitochondrial content and function in aging human skeletal muscle
Menshikova, E. V., Ritov, V. B., Fairfull, L., Ferrell, R. E., Kelley, D. E., & Goodpaster, B. H. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.6.534 · Cited by 398 · see citing works
Barazzoni, R., Short, K. R., & Nair, K. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3343 · Cited by 367 · see citing works
Skeletal Muscle Adaptation to Exercise Training
Röckl, K. S. C., Hirshman, M. F., Brandauer, J., FUJII, N. L., Witters, L. A., & Goodyear, L. J. (2007) · Diabetes · doi:10.2337/db07-0255 · Cited by 304 · see citing works
Melov, S., Shoffner, J. M., Kaufman, A. E., & Wallace, D. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.20.4122 · Cited by 271 · see citing works
Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., De Filippis, E. A., Roberts, C., Smoke, C. C., Meyer, C., Højlund, K., Yi, Z., et al. (2010) · Diabetes · doi:10.2337/db09-0214 · Cited by 255 · see citing works
Self-citationAndres, R. (1971) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)32479-8 · Cited by 232 · see citing works
Mansouri, A., Muller, F. L., Liu, Y., Ng, R., Faulkner, J., Hamilton, M., Richardson, A., Huang, T.-T., Epstein, C. J., & Van Remmen, H. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.004 · Cited by 227 · see citing works
Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218 · see citing works
Role of reactive oxygen species in contraction‐mediated glucose transport in mouse skeletal muscle
Sandström, M., Zhang, S., Bruton, J. D., Silva, J., Reid, M. B., Westerblad, H., & Katz, A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110601 · Cited by 209 · see citing works
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 201 · see citing works
Self-citationKahn, B. B., Shulman, G. I., DeFronzo, R. A., Cushman, S. W., & Rossetti, L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115031 · Cited by 171 · see citing works
Self-citationFree radical theory of aging: dietary implications
Harman, D. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.8.839 · Cited by 154 · see citing works
Age and sex differences in human skeletal muscle: Role of reactive oxygen species
Pansarasa, O., Castagna, L., Colombi, B., Vecchiet, J., Felzani, G., & Marzatico, F. (2000) · Free Radical Research · doi:10.1080/10715760000301451 · Cited by 135 · see citing works
Højlund, K., Yi, Z., Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., Langlais, P. R., Weintraub, S. T., & Mandarino, L. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700304-mcp200 · Cited by 119 · see citing works
Self-citationHigh-abundance mRNAs in human muscle: comparison between young and old
Welle, S. L., Bhatt, K. S., & Thornton, C. A. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.297 · Cited by 112 · see citing works
Lack of antioxidant adaptation to short-term aerobic training in human muscle
Tiidus, P. M., Pushkarenko, J., & Houston, M. E. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.4.r832 · Cited by 96 · see citing works
Superoxide dismutase gene expression in skeletal muscle: fiber-specific effect of age
Hollander, J. M., Bejma, J., Ookawara, T., et al. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00130-5 · Cited by 95 · see citing works
Reduced amount of mitochondrial DNA in aged human muscle
Welle, S., Bhatt, K., Shah, B., Needler, N., Delehanty, J. M., & Thornton, C. A. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01061.2002 · Cited by 86 · see citing works
Exercise-Induced Changes in Insulin Action and Glycogen Metabolism in Elderly Adults
Coker, R. H., Hays, N. P., Williams, R. H., Brown, A. D., Freeling, S. A., KORTEBEIN, P. M., Sullivan, D. H., Starling, R. D., & Evans, W. J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000191417.48710.11 · Cited by 81 · see citing works
Age-Associated Alterations of the Mitochondrial Genome
Lee, C. M., Weindruch, R. H., & Aiken, J. M. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00546-1 · Cited by 79 · see citing works
Lustgarten, M. S., Jang, Y. C., Liu, Y., Müller, F. L., Qi, W., Steinhelper, M. E., Brooks, S. V., Larkin, L. M., Shimizu, T., Shirasawa, T., et al. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00372.2009 · Cited by 78 · see citing works
Self-citationEffect of Age on Glucose Tolerance and Glucose Uptake in Healthy Individuals
Reaven, G. M., Chen, N.-G., Hollenbeck, C. B., & Chen, Y. I. (1989) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1989.tb02235.x · Cited by 76 · see citing works
Deterioration of Glucose Tolerance with Age: The Role of Insulin Resistance
Broughton, D., & Taylor, R. (1991) · Age and Ageing · doi:10.1093/ageing/20.3.221 · Cited by 73 · see citing works
Mitochondrial damage by the “pro-oxidant” peroxisomal proliferator clofibrate
Qu, B., Li, Q., Wong, K. P., Ong, C. N., & Halliwell, B. B. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00143-4 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
Chistiakov, D. A., Sobenin, I. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V. (2014) · BioMed Research International · doi:10.1155/2014/238463 · Cited by 497 · see citing works
Mitochondrial quality control and muscle mass maintenance.
Romanello, V., & Sandri, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00422 · Cited by 434 · see citing works
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works
Immune aging, dysmetabolism, and inflammation in neurological diseases
Deleidi, M., Jäggle, M., & Rubino, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00172 · Cited by 260 · see citing works
Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
Halter, J. B., Musi, N., McFarland Horne, F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., et al. (2014) · Diabetes · doi:10.2337/db14-0020 · Cited by 255 · see citing works
Self-citationMitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
Onyango, I. G., Dennis, J., & Khan, S. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.1007 · Cited by 260 · see citing works
Skeletal muscle aging and the mitochondrion
Johnson, M. L., Robinson, M. M., & Nair, K. S. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.12.003 · Cited by 233 · see citing works
Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves‐Smith, F., Norris, B., Pion, C. H., Barbat‐Artigas, S., Lemieux, F., Taivassalo, T., Morais, J. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-242750 · Cited by 217 · see citing works
Mitochondria, Muscle Health, and Exercise with Advancing Age
Carter, H. N., Chen, C. C. W., & Hood, D. A. (2015) · Physiology · doi:10.1152/physiol.00039.2014 · Cited by 191 · see citing works
Konopka, A. R., Suer, M. K., Wolff, C. A., & Harber, M. P. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glt107 · Cited by 187 · see citing works
Unravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works
Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging
Ghosh, S., Lertwattanarak, R., Garduno, J. D. J., Galeana, J. J., Li, J., Zamarripa, F., Lancaster, J. L., Mohan, S., Hussey, S., & Musi, N. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu067 · Cited by 150 · see citing works
Self-citationCombined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age
Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M., & Nair, K. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3081 · Cited by 139 · see citing works
Olesen, J., Gliemann, L., Biensø, R., Schmidt, J., Hellsten, Y., & Pilegaard, H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270256 · Cited by 119 · see citing works
Konopka, A. R., Asante, A., Lanza, I. R., Robinson, M. M., Johnson, M. L., Dalla Man, C., Cobelli, C., Amols, M. H., Irving, B. A., & Nair, K. S. (2015) · Diabetes · doi:10.2337/db14-1701 · Cited by 112 · see citing works
Sczelecki, S., Besse-Patin, A., Abboud, A., Kleiner, S., Laznik-Bogoslavski, D., Wrann, C. D., Ruas, J. L., Haibe-Kains, B., & Estall, J. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00578.2013 · Cited by 108 · see citing works
Autophagy as a Potential Target for Sarcopenia: AUTOPHAGY REGULATION IN SARCOPENIA
Fan, J., Kou, X., Jia, S., Yang, X., Yang, Y., & Chen, N. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25260 · Cited by 101 · see citing works
Balan, E., Schwalm, C., Naslain, D., Nielens, H., Francaux, M., & Deldicque, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01088 · Cited by 104 · see citing works
Role of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review
Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77 · see citing works
Gill, J. F., Santos, G., Schnyder, S., & Handschin, C. (2018) · Aging Cell · doi:10.1111/acel.12697 · Cited by 72 · see citing works
Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes
Fealy, C. E., Mulya, A., Axelrod, C. L., & Kirwan, J. P. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.011 · Cited by 63 · see citing works
Liu, Y., Guo, C., Liu, S., Zhang, S., Mao, Y., & Fang, L. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s308893 · Cited by 32 · see citing works
Minet, A. D., & Gaster, M. (2012) · Biogerontology · doi:10.1007/s10522-012-9372-9 · Cited by 25 · see citing works
Espinoza, S. E., Wang, C.-P., Tripathy, D., Clement, S. C., Schwenke, D. C., Banerji, M. A., Bray, G. A., Buchanan, T. A., Henry, R. R., Kitabchi, A. E., et al. (2016) · AGE · doi:10.1007/s11357-016-9946-6 · Cited by 14 · see citing works
Self-citation
- Authors
- Ghosh, S., Lertwattanarak, R., Lefort, N., Molina-Carrion, M., Joya-Galeana, J., Bowen, B. P., Garduno-Garcia, J. D. J., Abdul-Ghani, M., Richardson, A., DeFronzo, R. A., Mandarino, L., Van Remmen, H., & Musi, N.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Arizona State University (US)
- Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas
- Lawrence Berkeley National Laboratory (US)
- Audie L. Murphy Memorial VA Hospital (US)
- Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas
- Corresponding author
- Musi, Nicolas
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2011-07-18
- Volume
- 60
- Issue
- 8
- Pages
- 2051-2060
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3142073
- OpenAlex
- W2101232589
- Cited by
- 128
- References
- 51
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 12 · 2015: 17 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- American Diabetes Association
- U.S. Department of Veterans Affairs (I01 BX000517)
- National Institutes of Health
- National Institute on Aging (AG-030979, K23AG030979, P01AG020591, AG-019316, P01AG019316)
- National Heart, Lung, and Blood Institute (T32-HL-04776)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK024092, DK80157, R01DK080157, DK 24092, R01DK024092)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- reactive oxygen species, mitochondrial dysfunction, aging, impaired glucose tolerance, type 2 diabetes, skeletal muscle mitochondria, ATP production, aerobic exercise training, mitochondrial proteome, glucose tolerance
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adenosine Triphosphate, Adolescent, Adult, Aged, Aging, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Mitochondria, Transcription Factors, Lipid Peroxidation, Exercise, Reactive Oxygen Species, Glucose Intolerance, Gene Expression Profiling, Mitochondrial Proteins, Proteomics, Nuclear Respiratory Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
