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Cited by 321Diabetes Management and ResearchPhysical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Impact of physical activity on glycemic control and prevalence of cardiovascular risk factors in adults with type 1 diabetes: a cross-sectional multicenter study of 18,028 patients

Bohn, Barbara, Herbst, Antje, Pfeifer, Martin, Krakow, Dietmar, Zimny, Stefan, Kopp, Florian, Melmer, Andreas, Steinacker, Jürgen M. +1 more·2015·Diabetes Care
DOI 10.2337/dc15-0030
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Abstract

OBJECTIVE: Physical activity (PA) can improve cardiovascular risk in the general population and in patients with type 2 diabetes. Studies also indicate an HbA(1c)-lowering effect in patients with type 2 diabetes. Since reports in patients with type 1 diabetes are scarce, this analysis aimed to investigate whether there is an association between PA and glycemic control or cardiovascular risk in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 18,028 adults (≥18 to <80 years of age) from Germany and Austria with type 1 diabetes from the Diabetes-Patienten-Verlaufsdokumentation (DPV) database were included. Patients were stratified according to their self-reported frequency of PA (PA0, inactive; PA1, one to two times per week; PA2, more than two times per week). Multivariable regression models were applied for glycemic control, diabetes-related comorbidities, and cardiovascular risk factors. Data were adjusted for sex, age, and diabetes duration. P values for trend were given. SAS 9.4 was used for statistical analysis. RESULTS: An inverse association between PA and HbA(1c), diabetic ketoacidosis, BMI, dyslipidemia (all P < 0.0001), and hypertension (P = 0.0150), as well as between PA and retinopathy or microalbuminuria (both P < 0.0001), was present. Severe hypoglycemia (assistance required) did not differ in PA groups (P = 0.8989), whereas severe hypoglycemia with coma was inversely associated with PA (P < 0.0001). CONCLUSIONS: PA seemed to be beneficial with respect to glycemic control, diabetes-related comorbidities, and cardiovascular risk factors without an increase of adverse events. Hence, our data underscore the recommendation for subjects with type 1 diabetes to perform regular PA.

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  • Exercise is associated with improved fitness, increased insulin sensitivity, leading to reduced insulin requirement, improved cardiovascular health with better lipid profile and endothelial function, and decreased mortality.

    “People with type 1 diabetes should be encouraged to engage in a combination of aerobic and resistance exercise on most days because exercise is associated with improved fitness, increased insulin sensitivity, leading to reduced insulin requirement, improved cardiovascular health with better lipid profile and endothelial function, and decreased mortality (144-147).”

    From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [145]

  • A study in adults with type 1 diabetes found a dose-response inverse relationship between self-reported bouts of physical activity per week and A1C, BMI, hypertension, dyslipidemia, and diabetes-related complications such as hypoglycemia, diabetic ketoacidosis, retinopathy, and microalbuminuria.

    “A study in adults with type 1 diabetes found a doseresponse inverse relationship between self-reported bouts of physical activity per week and A1C, BMI, hypertension, dyslipidemia, and diabetes-related complications such as hypoglycemia, diabetic ketoacidosis, retinopathy, and microalbuminuria (260).”

    From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [260]

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Authors
Bohn, B., Herbst, A., Pfeifer, M., Krakow, D., Zimny, S., Kopp, F., Melmer, A., Steinacker, J. M., & Holl, R. W.
Affiliations
  • Universität Ulm (DE)
  • Klinikum Leverkusen (DE)
  • Diabetes Center, Clinic Tettnang, Tettnang, Germany
  • DZFO, Diabetes Centre Forchheim, Forchheim, Germany
  • Helios Hospital Schwerin (DE)
  • University Hospital Augsburg (DE)
  • Innsbruck Medical University (AT)
Corresponding author
Bohn, Barbara
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2015-05-26
Volume
38
Issue
8
Pages
1536-1543
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc15-0030
OpenAlex
W2135944584
Cited by
321
References
40
Citations by year
2026: 16 · 2025: 25 · 2024: 36 · 2023: 40 · 2022: 33 · 2021: 40 · 2020: 40 · 2019: 36 · 2018: 21 · 2017: 20 · 2016: 11 · 2015: 1
FWCI
15.33
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesministerium für Bildung und Forschung (FKZ 01GI1106)
  • European Foundation for the Study of Diabetes
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
physical activity, type 1 diabetes, glycemic control, HbA1c, cardiovascular risk factors, diabetic ketoacidosis, severe hypoglycemia, retinopathy, microalbuminuria, dyslipidemia, hypertension, body mass index
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Austria, Blood Glucose, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Female, Germany, Glycated Hemoglobin, Humans, Hypertension, Hypoglycemia, Male, Middle Aged, Motor Activity, Exercise, Databases, Factual, Diabetic Ketoacidosis, Dyslipidemias, Young Adult

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