The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels
Open accessAbstract
Orexins are novel appetite-stimulating peptides expressed in the lateral hypothalamic area (LHA), and their expression is stimulated by hypoglycemia in fasted rats. We investigated activation of orexin and other neurons during insulin-induced hypoglycemia using the immediate early gene product Fos. Insulin (50 U/kg) lowered plasma glucose by >50% after 5 h and stimulated feeding sixfold compared with saline-injected controls. Hypoglycemic rats allowed to feed and normoglycemic controls both showed sparse Fos-positive (Fos+) neurons in the LHA and the paraventricular nucleus (PVN) and arcuate nucleus (ARC) and showed none in the nucleus of the solitary tract (NTS), which relays visceral feeding signals to the LHA. In the LHA, total numbers of Fos+ neurons were comparable in fed hypoglycemic and control groups (60 ± 6 vs. 52 ± 4 cells/mm2, P > 0.05), as were Fos+ neurons immunoreactive for orexin (1.4 ± 0.4 vs. 0.6 ± 0.4 cells/mm2, P > 0.05). By contrast, hypoglycemic rats that were fasted showed significantly more Fos+ nuclei in the LHA (96 ± 10 cells/mm2, P < 0.05, vs. both other groups) and Fos+ orexin neurons (8.4 ± 3.3 cells/mm2, P < 0.001, vs. both other groups). They also showed two- to threefold more Fos+ nuclei (P < 0.001) in the PVN and ARC than both fed hypoglycemic rats and controls and showed strikingly abundant Fos+ neurons in the NTS and dorsal motor nucleus of the vagus. In parallel studies, whole hypothalamic orexin-A levels were not changed in hypoglycemic rats, whether fasted or freely fed, whereas orexin-B levels were 10-fold higher in hypoglycemic fasted rats than in control and hypoglycemic fed groups. These data support our hypothesis that orexin neurons are stimulated by falling glucose levels but are readily inhibited by signals related to nutrient ingestion and suggest that they may functionally link with neuronal activity in the NTS. Orexin-A and -B may play specific roles in behavioral or neuroendocrine responses to hypoglycemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Orexin neurons can integrate various metabolic state signals such as leptin, insulin, and glucose”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Self-citationThe hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Ricardo, J. A., & Koh, E. T. (1978) · Brain Research · doi:10.1016/0006-8993(78)91125-3 · Cited by 1,362
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234
Self-citationMice lacking melanin-concentrating hormone are hypophagic and lean
Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., & Maratos–Flier, E. (1998) · Nature · doi:10.1038/25341 · Cited by 1,152
Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050
Research works printed but not linked: 1
- Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK: Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402: 442-459, 1998 · DOI
Cited by
Sorted by citations
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276
The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X., Harrold, J. A., King, P., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 573
Self-citationThe selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn808 · Cited by 416
Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis
Sakurai, T. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.07.007 · Cited by 286
Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275
Functions of the orexinergic/hypocretinergic system
Kukkonen, J. P., Holmqvist, T., Ammoun, S., & Åkerman, K. E. O. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00055.2002 · Cited by 275
Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness
Ohno, K., & Sakurai, T. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.001 · Cited by 277
Berthoud, H.-R., & Münzberg, H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.051 · Cited by 260
Hypothalamic control of energy balance: different peptides, different functions
LEIBOWITZ, S. F., & Wortley, K. E. (2004) · Peptides · doi:10.1016/j.peptides.2004.02.006 · Cited by 241
Sakurai, T., & Mieda, M. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.03.007 · Cited by 228
Weight Management in Type 2 Diabetes: Current and Emerging Approaches to Treatment
Van Gaal, L., & Scheen, A. (2015) · Diabetes Care · doi:10.2337/dc14-1630 · Cited by 221
Homeostasis Meets Motivation in the Battle to Control Food Intake
Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 227
Serotonin, food intake, and obesity
van Galen, K. A., ter Horst, K. W., & Serlie, M. J. M. (2021) · Obesity Reviews · doi:10.1111/obr.13210 · Cited by 220
Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis
Spinazzi, R., Andreis, P. G., Rossi, G. P., & Nussdorfer, G. G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.4 · Cited by 195
Kirchgessner, A. L. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0454 · Cited by 190
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
Saper, C. B. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53014-6 · Cited by 178
Harrold, J. A., Dovey, T. M., Blundell, J. E., & Halford, J. C. G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.007 · Cited by 209
The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
Ferguson, A. V., & Samson, W. K. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(03)00028-1 · Cited by 172
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids
Karnani, M., Apergis‐Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L. H., & Burdakov, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.027 · Cited by 171
Hypothalamic glucose sensing: making ends meet
Routh, V. H., Hao, L., Santiago, A. M., Sheng, Z., & Zhou, C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00236 · Cited by 177
Orexins and appetite regulation
Rodgers, R. J., Ishii, Y., Halford, J. C. G., & Blundell, J. E. (2002) · Neuropeptides · doi:10.1016/s0143-4179(02)00085-9 · Cited by 163
Orexin stimulates breathing via medullary and spinal pathways
Young, J. K., Wu, M., Manaye, K. F., Kc, P., Allard, J. S., Mack, S. O., & Haxhiu, M. A. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00914.2004 · Cited by 156
Riediger, T., Zünd, D., Becskei, C., & Lutz, T. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00333.2003 · Cited by 155
Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y., & Kuwaki, T. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00679.2006 · Cited by 155
Brain Glucose-Sensing Mechanism and Energy Homeostasis
López-Gambero, A. J., Martínez, F., Salazar, K., Cifuentes, M., & Nualart, F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1099-4 · Cited by 158
A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats
Yi, C., Serlie, M. J. M., Ackermans, M. T., Foppen, E., Buijs, R. M., Sauerwein, H. P., Fliers, E., & Kalsbeek, A. (2009) · Diabetes · doi:10.2337/db09-0385 · Cited by 155
Hypocretin/orexin, sleep and narcolepsy
Hungs, M., & Mignot, E. J.-M. (2001) · BioEssays · doi:10.1002/bies.1058 · Cited by 151
Haynes, A. C., Chapman, H., Taylor, C., Moore, G. B. T., Cawthorne, M. A., Tadayyon, M., Clapham, J. C., & Arch, J. R. S. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00358-5 · Cited by 142
Self-citationOrexin modulates behavioral fear expression through the locus coeruleus
Soya, S., Takahashi, T. M., McHugh, T. J., Maejima, T., Herlitze, S., Abe, M., Sakimura, K., & Sakurai, T. (2017) · Nature Communications · doi:10.1038/s41467-017-01782-z · Cited by 149
Holland, P. R., Akerman, S., & Goadsby, P. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05168.x · Cited by 141
Zheng, H., Patterson, L. M., & Berthoud, H. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20515 · Cited by 137
Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R., & Berthoud, H.-R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00781.2002 · Cited by 135
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012
Kukkonen, J. P. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00227.2012 · Cited by 138
Parsons, M. P., & Hirasawa, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5741-09.2010 · Cited by 138
Regulation by Orexin of Feeding Behaviour and Locomotor Activity in the Goldfish
Nakamachi, T., Matsuda, K., Maruyama, K., Miura, T., Uchiyama, M., Funahashi, H., Sakurai, T., & Shioda, S. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01415.x · Cited by 134
Baldo, B. A., Gual‐Bonilla, L., Sijapati, K. S., Daniel, R. A., Landry, C. F., & Kelley, A. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03093.x · Cited by 130
Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors
Mieda, M. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00331-8 · Cited by 122
Deng, B.-S., Nakamura, A., Zhang, W., Yanagisawa, M., Fukuda, Y., & Kuwaki, T. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2007 · Cited by 121
Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas
Ouedraogo, R., Näslund, E. B., & Kirchgessner, A. L. (2003) · Diabetes · doi:10.2337/diabetes.52.1.111 · Cited by 121
Caloric restriction and physical activity in zebrafish (Danio rerio)
Novak, C. M., Jiang, X., Wang, C., Teske, J. A., Kotz, C. M., & Levine, J. A. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.03.048 · Cited by 118
Orexin gene expression is increased during states of hypertriglyceridemia
Wortley, K. E., Chang, G., Davydova, Z., & LEIBOWITZ, S. F. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00286.2002 · Cited by 117
Nixon, J. P., & Smale, L. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-28 · Cited by 116
Integration of feeding and spontaneous physical activity: Role for orexin
Kotz, C. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.031 · Cited by 111
Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control
Burdakov, D., Karnani, M., & Gonzalez, A. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.023 · Cited by 112
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Zhang, S., Zeitzer, J. M., Sakurai, T., Nishino, S., & Mignot, E. J.-M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129510 · Cited by 105
Multiple hypothalamic circuits sense and regulate glucose levels
Karnani, M., & Burdakov, D. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00527.2010 · Cited by 107
Ishibashi, M., Takano, S., Yanagida, H., Takatsuna, M., Nakajima, K., Oomura, Y., Wayner, M. J., & Sasaki, K. (2004) · Peptides · doi:10.1016/j.peptides.2004.10.014 · Cited by 96
Perry, R. J., Resch, J. M., Douglass, A. M., Madara, J. C., Rabin-Court, A., Kucukdereli, H., Wu, C., Song, J. D., Lowell, B. B., & Shulman, G. I. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901795116 · Cited by 95
Estradiol signaling in the regulation of reproduction and energy balance
Sinchak, K., & Wagner, E. J. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.004 · Cited by 94
Respiratory and cardiovascular actions of orexin-A in mice
Zhang, W., Fukuda, Y., & Kuwaki, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.032 · Cited by 92
Diet and nutrition in polycystic ovary syndrome (PCOS): Pointers for nutritional management
Farshchi, H., Rane, A., Love, A., & Kennedy, R. L. (2007) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610701667338 · Cited by 87
Neural and metabolic regulation of macronutrient intake and selection
Berthoud, H.-R., Münzberg, H., Richards, B. K., & Morrison, C. D. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000559 · Cited by 87
Peripheral tissue–brain interactions in the regulation of food intake
López, M., Tovar, S. A., Vazquez, M. J., Williams, L. M., & Diéguez, C. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005368 · Cited by 87
Interaction of central and peripheral clocks in physiological regulation
Barclay, J. L., Tsang, A. H. K., & Oster, H. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00030-7 · Cited by 91
Orexinergic modulation of breathing across vigilance states
Kuwaki, T. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.03.011 · Cited by 85
Rodent models of insomnia: A review of experimental procedures that induce sleep disturbances
Revel, F. G., Gottowik, J., Gatti, S., Wettstein, J. G., & Moreau, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.002 · Cited by 90
Modulation of Hunger by Plasma Glucose and Metformin
Schultes, B., Oltmanns, K. M., Kern, W., Fehm, H. L., Jan Born, A., & Peters, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021450 · Cited by 82
Levin, B. E. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00763-1 · Cited by 79
Kajiyama, S., Kawamoto, M., Shiraishi, S., Gaus, S., Matsunaga, A., Suyama, H., & Yuge, O. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.007 · Cited by 78
Regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation
Thorpe, A. J., Mullett, M. A., Wang, C., & Kotz, C. M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00344.2002 · Cited by 77
Neurophysiology of hunger and satiety
Smith, P., & Ferguson, A. V. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.13 · Cited by 82
Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP
Zheng, H., Corkern, M. M., Crousillac, S. M., Patterson, L. M., Phifer, C. B., & Berthoud, H. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00019.2002 · Cited by 74
Amylin and glucose co-activate area postrema neurons of the rat
Riediger, T., SCHMID, H. A., Lutz, T. A., & Simon, E. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00482-2 · Cited by 70
Williams, G. H., Cai, X., Elliott, J. C., & Harrold, J. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.005 · Cited by 75
Self-citationIshii, Y., Blundell, J. E., Halford, J. C. G., Upton, N., Porter, R. A., Johns, A., & Rodgers, R. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.009 · Cited by 68
Orexins, feeding, and energy balance
Girault, E. M., Yi, C., Fliers, E., & Kalsbeek, A. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00005-7 · Cited by 66
Role of Orexin-A in Hypertension and Obesity
Imperatore, R., Palomba, L., & Cristino, L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0729-y · Cited by 65
Orexin/Hypocretin System: Role in Food and Drug Overconsumption
Barson, J. R., & LEIBOWITZ, S. F. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.06.006 · Cited by 67
Grabauskas, G., & Moises, H. C. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029546 · Cited by 63
Food for thought: The role of appetitive peptides in age-related cognitive decline
Fadel, J. R., Jolivalt, C. G., & Reagan, L. P. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.009 · Cited by 63
Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Milbank, E., & López, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00830 · Cited by 63
Becskei, C., Riediger, T., Hernádfalvy, N., Arsenijevic, D., Lutz, T. A., & Langhans, W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.06.002 · Cited by 62
Insights into the role of neuronal glucokinase
Backer, I. D., Hussain, S., Bloom, S. R., & Gardiner, J. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00034.2016 · Cited by 61
Apelbaum, A. F., Perrut, A., & Chaput, M. A. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.01.003 · Cited by 59
Physiological functions of glucose‐inhibited neurones
Burdakov, D., & González, J. A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01922.x · Cited by 61
Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
de Lecea, L., Sutcliffe, G., & Fabre, V. (2002) · Neuropeptides · doi:10.1054/npep.2002.0892 · Cited by 56
Ahmadi‐Soleimani, S. M., Azizi, H., Gompf, H. S., & Semnanian, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.024 · Cited by 54
Liu, X., Morris, R., Spiller, D. G., White, M., & Williams, G. H. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2431 · Cited by 54
Self-citationPuškaš, N., Papp, R. S., Gallatz, K., & Palkovits, M. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.020 · Cited by 53
Orexin neurons as arousal-associated modulators of central cardiorespiratory regulation
Kuwaki, T., & Zhang, W. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.04.018 · Cited by 53
Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior
Barson, J. R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.08.018 · Cited by 53
Wu, X., Gao, J., Yan, J., Owyang, C., & Li, Y. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00791.2003 · Cited by 53
RetractedStratford, T. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.002 · Cited by 51
Orexins and the treatment of obesity
Smart, D., Haynes, A. C., Williams, G. H., & Arch, J. R. S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01429-2 · Cited by 51
Self-citationFunction and Dysfunction of Hypocretin/Orexin: An Energetics Point of View
Gao, X., & Horváth, T. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-013855 · Cited by 50
Elliott, J. C., Harrold, J. A., Brodin, P., Enquist, K., Bäckman, A., Byström, M., Lindgren, K., King, P., & Williams, G. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.010 · Cited by 50
Self-citationOrexin and Central Modulation of Cardiovascular and Respiratory Function
Carrive, P., & Kuwaki, T. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_46 · Cited by 48
The effect of orexin-A and -B on the histamine release in the anterior hypothalamus in rats
Ishizuka, T., Yamamoto, Y., & Yamatodani, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02552-6 · Cited by 48
Elevated sleep quality and orexin receptor mRNA in obesity-resistant rats
Mavanji, V., Teske, J. A., Billington, C. J., & Kotz, C. M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.93 · Cited by 48
β-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?
Harrold, J. A., Widdowson, P. S., & Williams, G. (2003) · Peptides · doi:10.1016/s0196-9781(03)00054-8 · Cited by 46
Self-citationPredictive models of glucose control: roles for glucose‐sensing neurones
Kosse, C., González, J. A., & Burdakov, D. (2014) · Acta Physiologica · doi:10.1111/apha.12360 · Cited by 49
Thermoregulation energy balance regulatory peptides recent developments
Székely, M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s116 · Cited by 45
Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats
Li, A., Wang, Q., Elsarelli, M. M., Brown, R. L., & Ritter, S. (2015) · Endocrinology · doi:10.1210/en.2015-1138 · Cited by 43
Yuan, P., & Yang, H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00538.2001 · Cited by 41
Miller, A. R., & Etgen, G. J. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.9.1489 · Cited by 41
Role of orexin in central regulation of gastrointestinal functions
Okumura, T., & Takakusaki, K. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2218-1 · Cited by 40
Korim, W. S., Llewellyn‐Smith, I. J., & Verberne, A. J. M. (2015) · Endocrinology · doi:10.1210/en.2015-1712 · Cited by 39
Orexins and adipoinsular axis function in the rat
Świtońska, M. M., Kaczmarek, P., Malendowicz, L. K., & Nowak, K. W. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00350-0 · Cited by 38
Metadata
- Authors
- Cai, X. J., Evans, M. L., Lister, C. A., Leslie, R. A., Arch, J. R. S., Wilson, S., & Williams, G.
- Affiliations
- From the Diabetes and Endocrinology Research Group (X.J.C., G.W.), University of Liverpool, Liverpool; and the Divisions of Neuroscience (M.L.E., R.A.L.) and Vascular Biology (C.A.L., J.R.S.A., S.W.), SmithKline Beecham Pharmaceuticals, Harlow, U.K.
- University of Liverpool (GB)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2001-01-01
- Volume
- 50
- Issue
- 1
- Pages
- 105-112
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2155164261
- Cited by
- 206
- References
- 48
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- orexin, orexin-A, orexin B, lateral hypothalamus, insulin-induced hypoglycemia, Fos expression, paraventricular nucleus, arcuate nucleus, nucleus tractus solitarius, dorsal motor nucleus of the vagus, feeding behavior, fasting, glucose detection, appetite regulation, hypothalamic neurons, vagal afferents
- MeSH terms
- Orexins, Animals, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Eating, Hyperphagia, Hypoglycemia, Hypothalamic Area, Lateral, Hypothalamus, Male, Neurons, Neuropeptides, Osmolar Concentration, Paraventricular Hypothalamic Nucleus, Vagus Nerve, Proto-Oncogene Proteins c-fos, Rats, Wistar, Solitary Nucleus, Fourth Ventricle, Intracellular Signaling Peptides and Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
