Cited by 1,435Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

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Banting Lecture 2001

McGarry, J. Denis·2002·Diabetes

DOI 10.2337/diabetes.51.1.7

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Abstract

Readers of this journal do not need to be reminded of the explosive increase in obesity/type 2 diabetes syndromes and their attendant staggering public health costs that are currently afflicting developed countries. Because of this alarming development and what it portends for the future if left unchecked, the American Diabetes Association, together with its counterparts around the world, as well as the World Health Organization, are faced with the daunting challenge of finding answers to two huge questions. First, what is the pathophysiological basis for these disorders? Second, why is their rate of appearance accelerating so rapidly at this particular juncture of human history, and what, if anything, can we do to intervene? The primary focus of this lecture will be on the first of these issues. I want to emphasize at the outset that I do not plan to dwell exclusively on our own studies in this area. Instead, I shall try to incorporate recent developments from a variety of other laboratories working in the field. Although these will of necessity have to be highly selective, I hope that collectively they will illustrate how we have come to a relatively new and exciting way of thinking about the etiology of type 2 diabetes. It has been said in literary circles that James Joyce’s Ulysses is probably the most frequently opened and least read book that has ever been published. In a similar vein, I sometimes think that the question of what causes type 2 diabetes might be one of the most frequently asked and least satisfactorily answered in the history of diabetes research. This is not meant to be an arrogant statement, nor indeed does it imply that I have a magical solution to the question at hand. Rather, it simply reflects the fact that at the dawn of …

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Authors: McGarry, J. D.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: McGarry, J. Denis
ORCID: McGarry, J. Denis
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-01-01
Volume: 51
Issue: 1
Pages: 7-18
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.1.7
OpenAlex: W2430143578
Cited by: 1,435
References: 96
Citations by year: 2026: 10 · 2025: 15 · 2024: 27 · 2023: 30 · 2022: 39 · 2021: 30 · 2020: 38 · 2019: 24 · 2018: 26 · 2017: 35 · 2016: 52 · 2015: 61 · 2014: 60 · 2013: 84 · 2012: 86
FWCI: 93.35
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, obesity, pathophysiology, disease acceleration, diabetes prevention
MeSH terms: Insulin Secretion, Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glucose, Homeostasis, Humans, Insulin, Islets of Langerhans, Models, Biological, Obesity, Triglycerides

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