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Cited by 688

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Association between C-reactive protein and features of the metabolic syndrome: a population-based study.

Open access
Fröhlich, M, Imhof, A, Berg, G, Hutchinson, W L, Pepys, M B, Boeing, H, Muche, R, Brenner, H, Koenig, W·2000·Diabetes Care
DOI 10.2337/diacare.23.12.1835
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Abstract

OBJECTIVE: To assess the association of circulating levels of C-reactive protein, a sensitive systemic marker of inflammation, with different components of the metabolic syndrome. RESEARCH DESIGN AND METHODS: Total cholesterol (TC), HDL cholesterol, triglycerides, uric acid, BMI , and prevalence of diabetes and hypertension were assessed in 747 men and 956 women aged 18-89 years who were participating in the population-based National Health and Nutrition Survey, which was carried out in former West Germany in 1987-1988. RESULTS: There was a statistically significant positive crude correlation between C-reactive protein and TC (R = 0.19), TG (R = 0.29), BMI (R = 0.32), glucose (R = 0.11), and uric acid (R = 0.14) (all P < 0.0001). A negative correlation was found between C-reactive protein and HDL cholesterol (R = 0.13, P < 0.0001). The age-adjusted geometric means of C-reactive protein concentrations in subjects grouped according to the presence of 0-1, 2-3, and > or =4 features of the metabolic syndrome were 1.11, 1.27, and 2.16 mg/l, respectively, with a statistically highly significant trend (P < 0.0001). CONCLUSIONS: The data suggest that a variety of features of the metabolic syndrome are associated with a systemic inflammatory response.

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Metadata

Authors
Fröhlich, M., Imhof, A., Berg, G., Hutchinson, W. L., Pepys, M. B., Boeing, H., Muche, R., Brenner, H., & Koenig, W.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2000-12-01
Volume
23
Issue
12
Pages
1835-1839
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.23.12.1835
OpenAlex
W2048529677
Cited by
688
References
10
FWCI
19.58
Type
journal article
Language
en
Open access
bronze

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