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Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exercise
Abstract
Neuroinflammation, aging, and neurodegenerative disorders are associated with excessive accumulation of neutral lipids in lipid droplets (LDs) in microglia. Type 2 diabetes mellitus (T2DM) may cause neuroinflammation and is a risk factor for neurodegenerative disorders. Here, we show that hippocampal pyramidal neurons contain smaller, more abundant LDs than their neighboring microglia. The density of LDs varied between pyramidal cells in adjacent subregions, with CA3 neurons containing more LDs than CA1 neurons. Within the CA3 region, a gradual increase in the LD content along the pyramidal layer from the hilus toward CA2 was observed. Interestingly, the high neuronal LD content correlated with less ramified microglial morphotypes. Using the db/db model of T2DM, we demonstrated that diabetes increased the number of LDs per microglial cell without affecting the neuronal LD density. High-intensity interval exercise induced smaller changes in the number of LDs in microglia but was not sufficient to counteract the diabetes-induced changes in LD accumulation. The changes observed in response to T2DM may contribute to the cerebral effects of T2DM and provide a mechanistic link between T2DM and neurodegenerative disorders.
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CA3 (and the adjacent DG) experiences greater lipid accumulation under hyperglycemia conditions than CA1.
“Notably, CA3 (and the adjacent DG) experiences greater lipid accumulation under hyperglycemia conditions than CA183, which could exacerbate astrocytic SCAP accumulation and NF-κB activation, leading to higher C3 production in those cells.”
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Cited by
Sorted by citations
Niu, T., Wang, S., Zhang, H., Zhu, W., Liu, K., Zhou, X., Sun, R., Niu, D., & Yuan, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01534-w · Cited by 7
Metadata
- Authors
- Seferi, G., Mjønes, H. S., Havik, M., Reiersen, H., Dalen, K. T., Nordengen, K., & Morland, C.
- Affiliations
- Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo
- Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo
- Department of Neurology, Oslo University Hospital, Oslo, Norway
- Venue
- Life Science Alliance
- Publisher
- Life Science Alliance, LLC
- Published
- 2024-08-08
- Volume
- 7
- Issue
- 10
- Pages
- e202302239
- ISSN
- 2575-1077
- PMC
- PMC11310565
- Cited by
- 9
- References
- 20
- Language
- en
- Funders
- Universitetet i Oslo
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