The relationship between neuropsychiatric symptoms and default-mode network connectivity in Alzheimer's disease
Open accessAbstract
OBJECTIVE: Neuropsychiatric symptoms of dementia are prevalent and extremely burdening for the patient and caregivers, but the underlying mechanism of these symptoms has not been investigated. This study aimed to investigate the relationship between neuropsychiatric symptoms and default-mode functional connectivity in Alzheimer's disease. METHODS: Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory. Functional magnetic resonance imaging was conducted on seventy patients with Alzheimer's disease during rest. We conducted a seed-based functional connectivity analysis to identify anterior and posterior default-mode networks (DMN). Seeds were the medial prefrontal cortex (Montreal Neurological Institute 12, 51, 36; seed radius=3 mm) for the anterior DMN and the precuneus (Montreal Neurological Institute -6, -63, 27; seed radius=3 mm) for the posterior DMN We then correlated the scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective, and psychosis syndrome) with maps of connectivity in the default-mode network. RESULTS: There was a significant correlation between decreased connectivity in the medial prefrontal cortex of the anterior defaultmode network and hyperactivity (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) syndrome (p<0.05, family wise error cluster-level corrected). CONCLUSION: Our study demonstrated that hyperactivity syndrome is related to hypoconnected default-mode network in Alzheimer's disease. This finding suggests that specific network alterations are associated with certain neuropsychiatric syndromes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The presence of psychiatric symptoms in patients with Alzheimer's disease is associated with alterations of brain circuitry.
“A number of studies has shown that the presence of psychiatric symptoms in patients with AD is associated with alterations of brain circuitry (37–39).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168 · see citing works
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002) · JAMA · doi:10.1001/jama.288.12.1475 · Cited by 2,049 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease
Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., Cedarbaum, J., Brashear, R., & Miller, D. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2410 · Cited by 1,139 · see citing works
Lyketsos, C. G., Steinberg, M. I., Tschanz, J. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.708 · Cited by 1,125 · see citing works
Palaniyappan, L., & Liddle, P. F. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100176 · Cited by 548 · see citing works
Functional connectivity tracks clinical deterioration in Alzheimer's disease
Damoiseaux, J. S., Prater, K. E., Miller, B. L., & Greicius, M. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.024 · Cited by 504 · see citing works
Peters, M. E., Schwartz, S., Han, D., Rabins, P. V., Steinberg, M., Tschanz, J. T., & Lyketsos, C. G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14040480 · Cited by 400 · see citing works
Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms
Lanctôt, K. L., Amatniek, J., Ancoli‐Israel, S., Arnold, S. E., Ballard, C., Cohen‐Mansfield, J., Ismail, Z., Lyketsos, C., Miller, D. S., Musiek, E., et al. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.07.001 · Cited by 395 · see citing works
Neuropsychiatric Syndromes in Dementia
Aalten, P., Verhey, F. R. J., Boziki, M. K., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., Elina, K., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000110738 · Cited by 388 · see citing works
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374 · see citing works
Age-related changes in the default mode network are more advanced in Alzheimer disease
Jones, D. T., Machulda, M. M., Vemuri, P., McDade, E. M., Zeng, G., Senjem, M. L., Gunter, J. L., Przybelski, S. A., Avula, R. T., Knopman, D. S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318233b33d · Cited by 370 · see citing works
Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
Gurol, M. E., Irizarry, M. C., Smith, E. E., Raju, S., Diaz-Arrastia, R., Bottiglieri, T., Rosand, J., Growdon, J. H., & Greenberg, S. M. (2006) · Neurology · doi:10.1212/01.wnl.0000191403.95453.6a · Cited by 339 · see citing works
Positron emission tomography metabolic correlates of apathy in Alzheimer disease.
Marshall, G., Monserratt, L., Harwood, D., Mandelkern, M., Cummings, J., & Sultzer, D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.1015 · Cited by 209 · see citing works
Balthazar, M. L. F., Pereira, F., Lopes, T. M., da Silva, E. L., Coan, A. C., de Campos, B. M., Duncan, N. W., Stella, F., Northoff, G., Damasceno, B. P., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22248 · Cited by 200 · see citing works
Choi, S. H., Na, D. L., Kwon, H., Yoon, S. J., Jeong, J. H., & Ha, C. K. (2000) · Journal of Korean Medical Science · doi:10.3346/jkms.2000.15.6.609 · Cited by 158 · see citing works
Does Cognitive Impairment Influence Burden in Caregivers of Patients with Alzheimer's Disease?
Germain, S., the ICTUS-EADC Network, Adam, S., Olivier, C., Cash, H., Ousset, P., Andrieu, S., Vellas, B. J., Meulemans, T., Reynish, E. L., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1016 · Cited by 118 · see citing works
Donovan, N. J., Wadsworth, L. P., Lorius, N., Locascio, J. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2014) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.03.006 · Cited by 106 · see citing works
Robert, P. H., Darcourt, G., Koulibaly, M. P., Clairet, S., Benoit, M., Garcia, R., Dechaux, O., & Darcourt, J. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01088.x · Cited by 98 · see citing works
Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics
Peters, K. R., Rockwood, K. J., Black, S. E., Bouchard, R. W., Gauthier, S. G., Hogan, D. B., Kertesz, A., Loy-English, I., Beattie, B. L., Sadovnick, A. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000198255.84842.06 · Cited by 63 · see citing works
Guercio, B. J., Donovan, N. J., Ward, A., Schultz, A., Lorius, N., Amariglio, R. E., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2015) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.13060141 · Cited by 61 · see citing works
Jonsson, M., Edman, Å., Lind, K., Rolstad, S., Sjögren, M., & Wallin, A. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2379 · Cited by 56 · see citing works
A SPECT study of wandering behavior in Alzheimer's disease
Rolland, Y., Payoux, P., Lauwers‐Cancès, V., Voisin, T., Esquerré, J. P., & Vellas, B. J. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1362 · Cited by 46 · see citing works
White Matter Microstructure and Apathy Level in Amnestic Mild Cognitive Impairment
Cacciari, C., Moraschi, M., Paola, M. D., Cherubini, A., Orfei, M. D., Giove, F., Maraviglia, B., Caltagirone, C., & Spalletta, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1384 · Cited by 40 · see citing works
Hsu, J., Lee, W., Liao, Y., Lirng, J.-F., Wang, S., & Fuh, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137121 · Cited by 32 · see citing works
Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease
Hayata, T., Bergo, F. P. G., de Rezende, T. J. R., Damasceno, A., Damasceno, B. P., Cendes, F., Stella, F., & Balthazar, M. L. F. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20150068 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Manca, R., De Marco, M., & Venneri, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585540 · Cited by 227 · see citing works
Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Ismail, Z., Creese, B., Aarsland, D., Kales, H. C., Lyketsos, C. G., Sweet, R. A., & Ballard, C. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00597-3 · Cited by 189 · see citing works
Temporal irreversibility of large-scale brain dynamics in Alzheimer's disease
Cruzat, J., Herzog, R., Prado, P., Sanz-Perl, Y., Gonzalez-Gomez, R., Moguilner, S., Kringelbach, M. L., Deco, G., Tagliazucchi, E., & Ibañez, A. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.1312-22.2022 · Cited by 57 · see citing works
- Authors
- Lee, J. S., Kim, J. H., & Lee, S.-K.
- Affiliations
- National Health Insurance Service Ilsan Hospital (KR)
- Bundang Jesaeng Hospital (KR)
- Corresponding author
- Lee, Jung Suk
- Venue
- Psychiatry Investigation
- Publisher
- Korean Neuropsychiatric Association
- Published
- 2020-07-15
- Volume
- 17
- Issue
- 7
- Pages
- 662-666
- ISSN
- 1738-3684 (ISSN-L)
- 1976-3026
- PMC
- PMC7385213
- OpenAlex
- W3035765546
- Cited by
- 25
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 1 · 2020: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Psychiatry Investigation (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Health Insurance Service Ilsan Hospital (2016-03-041)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- neuropsychiatric symptoms, Alzheimer's disease, default mode network, functional connectivity, hyperactivity syndrome, agitation, medial prefrontal cortex, precuneus, posterior default mode network
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
