Microbiota-gut-brain axis and the central nervous system
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// Xiqun Zhu 1, * , Yong Han 2, * , Jing Du 3, * , Renzhong Liu 1 , Ketao Jin 4 and Wei Yi 1 1 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China 2 Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China 3 Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China 4 Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, P.R. China * These authors contributed equally to this work Correspondence to: Wei Yi, email: weiyi.renmin@whu.edu.cn Ketao Jin, email: jinketao2001@zju.edu.cn Keywords: gut microorganism, microbiota-gut-brain axis, central nervous system, disorders Received: April 19, 2017 Accepted: April 26, 2017 Published: May 10, 2017 ABSTRACT The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis. In this paper, we will review the latest advances of studies on the correlation between gut microorganisms and CNS functions & diseases.
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L. reuteri reverses social behavior deficits, restores hypothalamus oxytocin immunoreactive neurons to control levels, and corrects deficits in synaptic plasticity.
“One further study found that L. reuteri, could reverse observed social behavior deficits and restore hypothalamus oxytocin immunoreactive neurons to control levels as well as correct deficits in synaptic plasticity (Zhu et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Zhu et al., 2017
The ‘Microbiota-gut-brain axis and CNS disorders’ section says Lactobacillus reuteri could reverse changes in social behavior, oxytocin cells, and synaptic plasticity in mice. It does not specify hypothalamic oxytocin-immunoreactive neurons or say they were restored to control levels. (LLM, conf=0.85)
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- Authors
- Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Shaoxing People's Hospital (CN)
- Corresponding author
- Zhu, Xiqun
- Han, Yong
- Du, Jing
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2017-05-10
- Volume
- 8
- Issue
- 32
- Pages
- 53829-53838
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC5581153
- OpenAlex
- W2612857033
- Cited by
- 308
- References
- 77
- Citations by year
- 2026: 18 · 2025: 45 · 2024: 38 · 2023: 25 · 2022: 42 · 2021: 34 · 2020: 42 · 2019: 35 · 2018: 20 · 2017: 7
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30973073, 81172402, 81374014)
- Zhejiang Traditional Chinese Medicine Administration (2016ZB018)
- Medical Science and Technology Project of Zhejiang Province (2017C33213)
- Natural Science Foundation of Zhejiang Province (81374014, LY17H160065)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, central nervous system, enteric nervous system, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, schizophrenia, multiple sclerosis
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