Evaluation of body fat distribution in pcos and its association with carotid atherosclerosis and insulin resistance

Karabulut, Aysun; Yaylali, Güzin Fidan; Demirlenk, Semra; Sevket, Osman; Acun, Ayhan

doi:10.3109/09513590.2011.589929

Cited by 61Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Evaluation of body fat distribution in pcos and its association with carotid atherosclerosis and insulin resistance

Karabulut, Aysun, Yaylali, Güzin Fidan, Demirlenk, Semra, Sevket, Osman, Acun, Ayhan·2012·Gynecological Endocrinology

DOI 10.3109/09513590.2011.589929

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Abstract

OBJECTIVE: The aim of this study was to compare body fat distribution in PCOS with healthy controls and to investigate the factors associated with carotid artery intima media thickness (IMT) and insulin resistance. SUBJECTS AND METHODS: A case control study was conducted in 46 women with PCOS and 43 age matched controls. Anthropometrical measurements, hormonal levels, lipid and glucose profile were evaluated. Body fat thickness in four regions and carotid IMT were measured. Body fat distribution was compared between groups. Correlation of these parameters with carotid artery IMT and insulin resistance was investigated. RESULT(S): Visceral and subcutaneous fat thickness and the mean carotid artery IMT were significantly higher in PCOS subjects (p < 0.01). In correlation analysis, age, body mass index (BMI) and waist hip ratio (WHR) showed correlation with carotid artery IMT (r = 0,55, p < 0,001; r = 0.41, p < 0.008 and r = 0.34 p = 0.03, respectively), whereas visceral fat thickness presented a correlation with HOMA-IR index as a sign of insulin resistance. CONCLUSION(S): Fat accumulation is more prominent in visceral and subcutaneous regions in PCOS. Increased BMI and abdominal type of obesity are closely related to the increased carotid artery IMT and insulin resistance. Weight control and regional weight loss are important part of the treatment for the future health of women with PCOS.

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Central adiposity likely plays a key role in cardiometabolic risk in PCOS.
“The level of central adiposity likely plays a key role in cardiometabolic risk, as insulin resistance has been associated with higher levels of central adiposity in the PCOS population [32,34,35,36].”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [36]
Insulin resistance is positively correlated with visceral fat thickness.
“Additionally, insulin resistance, which is positively correlated with visceral fat thickness (Karabulut et al., 2012), affects 75% of lean women and 95% of overweight women with PCOS (Stepto et al., 2013).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Karabulut et al., 2012

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Authors: Karabulut, A., Yaylali, G. F., Demirlenk, S., Sevket, O., & Acun, A.
Affiliations: Denizli Devlet Hastanesi (TR)
Denizli State Hospital, Department of Endocrinology, Denizli, Turkey
Denizli State Hospital, Department of Obstetrics and Gynecology, Denizli, Turkey
Corresponding author: Karabulut, Aysun
Venue: Gynecological Endocrinology
Publisher: Informa UK Limited
Published: 2011-07-20
Volume: 28
Issue: 2
Pages: 111-114
ISSN: 0951-3590 (ISSN-L)
1473-0766
DOI: 10.3109/09513590.2011.589929
OpenAlex: W2066323486
Cited by: 61
References: 34
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 5
FWCI: 5.00
Type: journal article
Language: en
Open access: closed
Locations: Gynecological Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, body fat distribution, visceral fat, subcutaneous adipose tissue, carotid intima-media thickness, carotid atherosclerosis, insulin resistance, abdominal obesity, waist-to-hip ratio, body mass index, HOMA-IR
MeSH terms: Adult, Carotid Artery Diseases, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Ultrasonography, Case-Control Studies, Tunica Intima, Tunica Media, Intra-Abdominal Fat, Body Fat Distribution, Young Adult

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Evaluation of body fat distribution in pcos and its association with carotid atherosclerosis and insulin resistance

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