Regional Norepinephrine Turnover in Human Hypertension
Abstract
Overall and regional rates of norepinephrine overflow to plasma were measured in 55 untreated patients with primary hypertension and in 40 healthy subjects, to study sympathetic nervous pathophysiology in human hypertension. Total norepinephrine spillover was increased in primary hypertension, particularly in patients aged less than 40 years, largely due to higher rates of renal and cardiac norepinephrine overflow. Renal renin release, and arterial plasma renin activity, were highest in these younger patients with increased renal sympathetic nervous activity. In older patients sympathetic activity and norepinephrine release was typically normal. A selective increase in the sympathetic nervous outflow to the heart and kidneys is commonly present in young patients with primary hypertension, and probably contributes materially to the early pathogenesis of the hypertension.
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Studies of elderly hypertensives have not always documented an increase in renal norepinephrine spillover, in contrast to the finding of increased sympathetic nerve traffic to skeletal muscle circulation.
“Interestingly, studies of elderly hypertensives have not always documented an increase in renal norepinephrine spillover in contrast to the finding of increased sympathetic nerve traffic to the skeletal muscle circulation22,28,39,47.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [47]
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- Authors
- Esler, M., Lambert, G., & Jennings, G.
- Venue
- Clinical and Experimental Hypertension. Part A: Theory and Practice
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 11
- Issue
- sup1
- Pages
- 75-89
- ISSN
- 0148-3927 (ISSN-L)
- 0730-0077
- OpenAlex
- W2225494317
- Cited by
- 161
- References
- 22
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 21 · 2013: 17 · 2012: 8
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- norepinephrine spillover, essential hypertension, renal sympathetic nerve activity, cardiac sympathetic activity, renin secretion, plasma renin activity, age differences, hypertension pathogenesis
- MeSH terms
- Female, Heart Conduction System, Humans, Hypertension, Kidney, Male, Middle Aged, Norepinephrine, Sympathetic Nervous System, Tissue Distribution
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