The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD
Abstract
OBJECTIVES: Treatment investigations with methylphenidate in adults with ADHD focus preferentially on the classical psychopathology: inattention, hyperactivity and impulsivity. ADHD-associated emotional symptoms, which are frequently present at least in ADHD subpopulations, were studied rarely. The vast majority of the placebo-controlled trials had observation periods between 4 and 8 weeks. To assess the medium- to long-term effects of extended release methylphenidate (MPH-ER) on emotional symptoms and other psychopathology frequently seen in ADHD patients, we conducted a large-scale, multicenter treatment study. METHODS: We performed a randomised, 24-week, double-blind, placebo-controlled study in adults with ADHD. The diagnosis was made on the basis of the DSM-IV criteria, which were confirmed by clinical history and a structured psychopathological interview and the use of rating instruments. 363 patients were randomized to MPH-ER or placebo at a ratio of 2:1. The duration of the titration period was 5 weeks followed by a maintainance phase of 19 weeks. The efficacy measures were the observer rated 10-item Emotional Dysregulation Scale (EDS) derived from the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) and a self-report, six-item Emotional Lability Scale (ELS) extracted from the long version of the Conners Adult ADHD Self Report Scale (CAARS:S:L). In addition we used the SCL-90-R for the assessment of ADHD associated and comorbid psychopathology. RESULTS: MPH-ER was statistically superior to placebo in reducing emotional symptoms as assessed by the EDS and the ELS. Obsessive-compulsive symptoms and those of problems with self-concept declined until the end of the observation period. The decline was more pronounced in MPH-ER treated individuals. The effects remained robust during the entire maintenance period until week 24. Symptoms of anxiety, depression, anger and hostility, phobia, paranoid ideations and psychoticism were not improved. CONCLUSIONS: MPH-ER appears to be an efficacious treatment for emotional symptoms with ADHD. Also obsessive-compulsive symptoms and problems with self-concept were affected positively.
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“Psychiatric and behavioral comorbidities, such as depression, anxiety disorder, bipolar disorder, substance use, and personality disorders, often co-occur with ADHD and result in increased difficulties for appropriate diagnoses and treatments (Barkley and Brown, 2008; Rosler et al., 2010; Mao and Findling, 2014; Katzman et al., 2017).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Rosler et al., 2010
In the citing paper
“The effect size ranged from 0.28 to 0.4, which is lower than stimulants’ effect size on diagnostic ADHD symptoms (meta-analyses suggest a range of 0.6–0.8 [36, 37]), but it is still clinically significant.”
From Using Stimulants to Treat ADHD-Related Emotional Lability (2014) · cites this paper as [34]
In the citing paper
“Following 24 weeks of treatment with extended release methylphenidate (MPH-ER), there was a significant reduction in emotional lability, as assessed by the emotional dysregulation items on the Wender-Reimherr Adult ADHD Scale [35].”
From Using Stimulants to Treat ADHD-Related Emotional Lability (2014) · cites this paper as [34]
Citations
Cites
(1998) · Cited by 2,026
Biederman, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.816 · Cited by 1,498
Mannuzza, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820190067007 · Cited by 1,368
Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder
Fayyad, J., De Graaf, R., Kessler, R., Alonso, J., Angermeyer, M., Demyttenaere, K., De Girolamo, G., Haro, J. M., Karam, E. G., Lara, C., et al. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.034389 · Cited by 1,321
Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle
SPENCER, T., BIEDERMAN, J., WILENS, T., HARDING, M., O'DONNELL, D., & GRIFFIN, S. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199604000-00008 · Cited by 830
Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies
Michelson, D., Adler, L., Spencer, T., Reimherr, F. W., West, S. A., Allen, A. J., Kelsey, D., Wernicke, J., Dietrich, A., & Milton, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01671-2 · Cited by 790
Wïttchen, H., Wunderlich, U., Gruschwitz, S., & Zaudig, M. (1997) · Max Planck Institute for Plasma Physics · Cited by 769
WEISS, G., HECHTMAN, L., MILROY, T., & PERLMAN, T. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60450-7 · Cited by 753
ATTENTION-DEFICIT HYPERACTIVITY DISORDER IN ADULTS
Wender, P. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70039-3 · Cited by 728
Prevalence, Clinical Correlates, and Longitudinal Course of Severe Mood Dysregulation in Children
Brotman, M. A., Schmajuk, M., Rich, B. A., Dickstein, D. P., Guyer, A. E., Costello, E. J., EGGER, H. L., Angold, A. C., Pine, D. S., & Leibenluft, E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.042 · Cited by 491
Faraone, S. V., Spencer, T., Aleardi, M., Pagano, C., & Biederman, J. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000108984.11879.95 · Cited by 404
Diagnostic Controversies in Adult Attention Deficit Hyperactivity Disorder
McGough, J. J., & Barkley, R. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1948 · Cited by 388
Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.043 · Cited by 385 · cited 2×
“Our fi ndings are in line with earlier research demonstrating no specifi c treatment effects on depression and anxiety by MPH (Spencer et al. 2005; Biederman et al. 2006; Jain et al. 2007).”
BackgroundResultBanaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P., Buitelaar, J., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., et al. (2006) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-006-0549-0 · Cited by 375
Walcott, C. M., & Landau, S. (2004) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3304_12 · Cited by 298
ADHD Rating Scale-IV: School Checklist
DuPaul, G. J., Power, T. J., Anastopoulos, A. D., & Reid, R. (2018) · PsycTESTS Dataset · doi:10.1037/t00680-000 · Cited by 297
Impact of comorbidity in adults with attention-deficit/hyperactivity disorder.
Biederman, J. (2004) · PubMed · Cited by 279
Retz-Junginger, P., Retz, W., Blocher, D., Weijers, H., Trott, G., Wender, P. H., & Rössler, M. (2002) · Der Nervenarzt · doi:10.1007/s00115-001-1215-x · Cited by 276
Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Harpold, T., Dunkel, S., Dougherty, M., Aleardi, M., & Spencer, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.011 · Cited by 267
Nutt, D. J., Fone, K., Asherson, P., Bramble, D., Hill, P., Matthews, K., Morris, K. A., Santosh, P., Sonuga-Barke, E., Taylor, E., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073219 · Cited by 259
Emotional Dysregulation in Adult ADHD and Response to Atomoxetine
Reimherr, F. W., Marchant, B. K., Strong, R. E., Hedges, D. W., Adler, L., Spencer, T. J., West, S. A., & Soni, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.040 · Cited by 258
Spencer, T., Biederman, J., Wilens, T., Faraone, S., Prince, J., Gerard, K., Doyle, R., Parekh, A., Kagan, J., & Bearman, S. K. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.8.775 · Cited by 250 · cited 1×
“…psychiatry, have shown signifi cant improvement of ADHD psychopathology with high effect sizes by far exceeding those of antidepressant or neuroleptic medications (Spencer et al. 1996, 2001, 2005, 2007, 2008; Faraone et al. 2004; Biederman et al. 2005, 2006; Jain et al. 2007; Reimherr et al. 2007).”
BackgroundRetz-Junginger, P., Retz, W., Blocher, D., Stieglitz, R.-D., Georg, T., Supprian, T., Wender, P. H., & Rösler, M. (2003) · Der Nervenarzt · doi:10.1007/s00115-002-1447-4 · Cited by 233
Self-citationRösler, M., Retz, W., Retz-Junginger, P., Thome, J., Supprian, T., Nissen, T., Stieglitz, R.-D., Blocher, D., Hengesch, G., & Trott, G. (2004) · Der Nervenarzt · doi:10.1007/s00115-003-1622-2 · Cited by 230
Philipsen, A., Limberger, M. F., Lieb, K., Feige, B., Kleindienst, N., Ebner-Priemer, U., Barth, J., Schmahl, C., & Bohus, M. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.035782 · Cited by 220
Reimherr, F. W., Williams, E. D., Strong, R. E., Mestas, R., Soni, P., & Marchant, B. K. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0113 · Cited by 180
Rösler, M., Retz, W., Thome, J., Schneider, M., Stieglitz, R., & Falkai, P. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-1001-7 · Cited by 164
Adler, L. A., Spencer, T. J., Milton, D. R., Moore, R. J., & Michelson, D. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0304 · Cited by 157
on behalf of the study group, Rösler, M., Fischer, R., Ammer, R., Ose, C., & Retz, W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0845-4 · Cited by 155
Spencer, T. J., Adler, L. A., McGough, J. J., Muniz, R., Jiang, H., & Pestreich, L. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.032 · Cited by 155
Faraone, S. V. (2005) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-005-0429-z · Cited by 150
Adler, L., Spencer, T., Brown, T. E., Holdnack, J., Saylor, K. E., Schuh, K., Trzepacz, P., Williams, D., & Kelsey, D. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318192e4a0 · Cited by 150
Koesters, M., Becker, T., Kilian, R., Fegert, J., & Weinmann, S. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108092338 · Cited by 142
A guide to the treatment of adults with ADHD.
Weiss, M. D., & Weiss, J. (2004) · PubMed · Cited by 138
Gibbins, C., & Weiss, M. D. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0055-1 · Cited by 82
Rösler, M., Retz, W., Retz‐Junginger, P., Stieglitz, R., Kessler, H., Reimherr, F. W., & Wender, P. H. (2008) · Der Nervenarzt · doi:10.1007/s00115-007-2375-0 · Cited by 81
Long-Term Safety and Effectiveness of Mixed Amphetamine Salts Extended Release in Adults With ADHD
Biederman, J., Spencer, T., Wilens, T., Weisler, R., Read, S. C., & Tulloch, S. (2005) · CNS Spectrums · doi:10.1017/s1092852900002406 · Cited by 79
Aripiprazole in the Treatment of Pediatric Bipolar Disorder: A Systematic Chart Review
Biederman, J., McDonnell, M. A., Wozniak, J. R., Spencer, T. J., Aleardi, M., Falzone, R., & Mick, E. O. (2005) · CNS Spectrums · doi:10.1017/s1092852900019489 · Cited by 75
The Validity of the DSM-IV Subtypes of Attention-Deficit/Hyperactivity Disorder
Woo, B. S. C., & Rey, J. M. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01580.x · Cited by 74
Jain, U., Hechtman, L. T., Weiss, M. D., Ahmed, T. S., Reiz, J. L., Donnelly, G. A. E., Harsanyi, Z., & Darke, A. C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0213 · Cited by 56
Adult Attention Deficit Hyperactivity Disorder: Moving Beyond DSM-IV
McGough, J. J., & McCracken, J. T. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1673 · Cited by 39
Moll, G. H., Eysenbach, K., Woerner, W., Banaschewski, T., Schmidt, M. H., & Rothenberger, A. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101005389.x · Cited by 37
Research works printed but not linked: 2
- Biederman J, 2004, J Clin Psychiatry, 65, 3
- Weiss MD, 2004, J Clin Psychiatry, 65, 27
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Adult ADHD and comorbid disorders: clinical implications of a dimensional approach
Katzman, M. A., Bilkey, T. S., Chokka, P. R., Fallu, A., & Klassen, L. J. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1463-3 · Cited by 732
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Luo, Y., Weibman, D., Halperin, J. M., & Li, X. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00042 · Cited by 394
Faraone, S. V., Rostain, A. L., Blader, J., Busch, B., Childress, A. C., Connor, D. F., & Newcorn, J. H. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12899 · Cited by 400
Maternal emotion and cognitive control capacities and parenting: A conceptual framework
Crandall, A., Deater-Deckard, K. D., & Riley, A. W. (2015) · Developmental Review · doi:10.1016/j.dr.2015.01.004 · Cited by 417
Metadata
- Authors
- Rösler, M., Retz, W., Fischer, R., Ose, C., Alm, B., Deckert, J., Philipsen, A., Herpertz, S., & Ammer, R.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- Medice (Germany) (DE)
- Institut für Medizinische Informatik, Biometrie und Epidemiologie (DE)
- Central Institute of Mental Health (DE)
- University of Würzburg (DE)
- University of Freiburg (DE)
- University of Rostock (DE)
- Corresponding author
- Rösler, Michael
- ORCID
- Venue
- The World Journal of Biological Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2010-03-30
- Volume
- 11
- Issue
- 5
- Pages
- 709-718
- ISSN
- 1562-2975 (ISSN-L)
- 1814-1412
- OpenAlex
- W1985528539
- Cited by
- 131
- References
- 43
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 11 · 2014: 20 · 2013: 7 · 2012: 9
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The World Journal of Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adult ADHD, extended-release methylphenidate, emotional symptoms, emotional dysregulation, emotional lability, obsessive-compulsive symptoms, self-concept, long-term treatment efficacy, comorbid psychopathology
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Delayed-Action Preparations, Double-Blind Method, Emotions, Female, Follow-Up Studies, Humans, Long-Term Care, Male, Methylphenidate, Middle Aged, Obsessive-Compulsive Disorder, Personality Assessment, Psychometrics, Treatment Outcome, Young Adult
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