Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
Abstract
Objective We evaluated microRNAs (miRNAs) as potential biomarkers for Alzheimer disease (AD) by analyzing the expression level of miRNAs in CSF of patients with AD dementia and nonaffected control subjects. Methods Using quantitative PCR, we profiled the expression level of 728 miRNAs in CSF of nonaffected control subjects and patients with clinically ascertained AD dementia, and we further compared the expression level of candidate miRNAs in 37 control subjects and 35 patients with AD dementia. Results The level of hsa-miR-27a-3p in CSF is reduced in patients with dementia due to AD in 2 different cohorts of subjects (cohort 1: p = 0.008; cohort 2: p = 0.015; 2-tailed unpaired Welch t test). Moreover, low levels of hsa-miR-27a-3p were accompanied by high CSF tau levels and low CSF β-amyloid levels. Conclusions Our pilot study highlights hsa-miR-27a-3p as a candidate biomarker for AD and provides the groundwork for further confirmation studies in larger cohorts and in other hospitals.
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More miRNAs can be detected in postmortem CSF because CSF can be contaminated by miRNAs released from degenerated brain tissues.
“It has been reported that more miRNAs can be detected in postmortem CSF, because CSF can be contaminated by miRNAs released from degenerated brain tissues19,37.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [19]
We detected a relatively smaller number of miRNAs in CSF compared to other miRNA profiling studies.
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [19]
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- Authors
- Sala Frigerio, C., Lau, P., Salta, E., Tournoy, J., Bossers, K., Vandenberghe, R., Wallin, A., Bjerke, M., Zetterberg, H., Blennow, K., & De Strooper, B.
- Affiliations
- From the VIB Center for the Biology of Disease (C.S.F., P.L., E.S., B.D.S.), Leuven; Center for Human Genetics and LIND (C.S.F., P.L., E.S., B.D.S.), and Alzheimer Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease (R.V.), University of Leuven; Geriatric Medicine (J.T.), and Neurology Department (R.V.), University Hospitals Leuven; Department of Clinical and Experimental Medicine and LIND (J.T.), Laboratory for Cognitive Neurology, Department of Neurosciences (R.V.), KU Leuven,...
- Netherlands Institute for Neuroscience (NL)
- ORCID
- Venue
- Neurology
- Published
- 2013-12-10
- Volume
- 81
- Issue
- 24
- Pages
- 2103-2106
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1975366875
- Cited by
- 156
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 17 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 17 · 2014: 9
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, microRNA, cerebrospinal fluid, biomarkers, CSF tau
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pilot Projects, Cohort Studies, Biomarkers, MicroRNAs
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