The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
In the citing paper
“Although the level of miR-9-5p was downregulated in AD brains and EVs from CSF [47,48,49]”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Similar to miR-146a-5p, miR-132-3p was reported to be downregulated in AD in five independent studies [48,72,80,84] but up-regulated in AD in only one independent study [81].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Among these miRNAs, miR-146a-5p [50,70,73,74,83] and miR-132-3p [48,72,80,81,84] were reported to be dysregulated in six independent AD studies, respectively.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“miR-125b-5p was upregulated in brains [36,48,50] and EVs from CSF of AD patients compared to HC [49,66].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Substantial recent evidence has demonstrated that microRNAs (miRNAs) are dysregulated already early on in AD pathology [2–7].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [4]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Both miRNAs are expressed in the human brain and are deregulated in AD [41–43, 54].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
Citations
Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
RAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 945
Blood-Based Biomarkers of Alzheimers Disease: Diagnostic Algorithms and New Technologies
Carmona, P., Molina, M., & Tolédano, A. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666151116130301 · Cited by 21
Mohammadi, H., & Amine, A. (2017) · Analytical Letters · doi:10.1080/00032719.2017.1302460 · Cited by 21
Llorens, F., Thüne, K., Andrés‐Benito, P., Tahir, W., Ansoleaga, B., Hernández‐Ortega, K., Martı́, E., Zerr, I., & Ferrer, I. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0971-4 · Cited by 20
Maternal immune activation alters brain microRNA expression in mouse offspring
Sunwoo, J., Jeon, D., Lee, S., Moon, J., Yu, J., Park, D.-K., Bae, J., Lee, D. Y., Kim, S. W., Jung, K., et al. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.652 · Cited by 20
Preliminary study of hsa-miR-626 change in the cerebrospinal fluid of Parkinson’s disease patients
Qin, L., Tan, J., Zhang, H., Tang, J., Jiang, B., Shen, X., Tang, B., & Wang, C. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.08.082 · Cited by 21
Circulating miRNAs: A New Opportunity in Bone Fragility
Donati, S., Ciuffi, S., Palmini, G., & Brandi, M. L. (2020) · Biomolecules · doi:10.3390/biom10060927 · Cited by 21
Mitochondrial microRNAs: Key Drivers in Unraveling Neurodegenerative Diseases
Yashooa, R. K., Duranti, E., Conconi, D., Lavitrano, M., Mustafa, S. A., & Villa, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020626 · Cited by 21
Solly, E. L., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718679 · Cited by 20
miRNA-126a-3p participates in hippocampal memory via alzheimer’s disease-related proteins
Xue, B., Qu, Y., Zhang, X., & Xu, X. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab515 · Cited by 20
Merighi, S., Nigro, M., Travagli, A., Pasquini, S., Borea, P. A., Varani, K., Vincenzi, F., & Gessi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095056 · Cited by 23
Hide and seek: tell-tale signs of breast cancer lurking in the blood
Guttery, D. S., Blighe, K., Page, K., Marchese, S. D., Hills, A., Coombes, R. C., Stebbing, J., & Shaw, J. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9414-4 · Cited by 20
Noncoding RNAs in Neurodegenerative Diseases
Rege, S. D., Geetha, T., Pondugula, S. R., Zizza, C. A., Wernette, C. M., & Babu, J. R. (2013) · ISRN Neurology · doi:10.1155/2013/375852 · Cited by 21
Wang, W., Fardo, D. W., Jicha, G. A., & Nelson, P. T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0316-2 · Cited by 20
MicroRNAs in Prion Diseases—From Molecular Mechanisms to Insights in Translational Medicine
Contiliani, D. F., Ribeiro, Y. D. A., de Moraes, V. N., & Pereira, T. C. (2021) · Cells · doi:10.3390/cells10071620 · Cited by 21
Blood cell microRNAs: what are they and what future do they hold?
Ryan, P., & Atreya, C. (2011) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2011.01.005 · Cited by 21
Emerging electrochemical nanoscale architectures for point-of-care detection of miRNA biomarkers
Dastidar, M. G., Schümann, U., Nisbet, D. R., Natoli, R., Murugappan, K., & Tricoli, A. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160903 · Cited by 19
Keighron, C. N., Avazzadeh, S., Goljanek‐Whysall, K., McDonagh, B., Howard, L., Ritter, T., & Quinlan, L. R. (2023) · Biomedicines · doi:10.3390/biomedicines11030728 · Cited by 22
Li, W., Chen, L., Wan, L., Qu, X., He, W., He, Y., Feng, C., Xu, J., Zhou, Y., Lv, J., et al. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-55 · Cited by 19
microRNAs as Biomarker in Depression Pathogenesis.
Dwivedi, Y. (2013) · PubMed · Cited by 19
MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice
Boscher, E., Goupil, C., Petry, S., Keraudren, R., Loiselle, A., Planel, E., & Hébert, S. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.591138 · Cited by 21
Preliminary Study of hsa-mir-626 Change in the Cerebrospinal Fluid in Parkinson's Disease
Qin, L., Tan, J., Zhang, H., Tang, J., Jiang, B., Shen, X., Guo, J., Tan, L., Tang, B., & Wang, C. (2021) · Neurology India · doi:10.4103/0028-3886.310102 · Cited by 19
Marín‐Müller, C., Yao, Q. C., & Chen, C. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021433 · Cited by 19
Differentially Expressed miRNAs in Age-Related Neurodegenerative Diseases: A Meta-Analysis
Noronha, O., Mesarosovo, L., Anink, J. J., Iyer, A., Aronica, E., & Mills, J. D. (2022) · Genes · doi:10.3390/genes13061034 · Cited by 21
microRNA‐based predictor for diagnosis of frontotemporal dementia
Magen, I., Yacovzada, N., Warren, J. D., Heller, C., Swift, I., Bobeva, Y., Malaspina, A., Rohrer, J. D., Fratta, P., & Hornstein, E. (2023) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12916 · Cited by 12
The role of micro-RNAs in neuropathic pain—a scoping review
Sampath, K. K., Belcher, S., Hales, J., Thomson, O. P., Farrell, G., Gisselman, A. S., Katare, R., & Tumilty, S. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001108 · Cited by 18
Printed Biosensors for the Detection of Alzheimer’s Disease Based on Blood Biomarkers
Zeng, Y., Huang, Z., Liu, Y., & Xu, T. (2023) · Journal of Analysis and Testing · doi:10.1007/s41664-023-00277-9 · Cited by 18
Garza-Manero, S., Arias, C., Bermúdez‐Rattoni, F., Vaca, L. A., & Zepeda, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00053 · Cited by 20
Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders
Cacabelos, R., Cacabelos, P., & Carril, J. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00038-3 · Cited by 18
MicroRNAs mediate the anti-tumor and protective effects of ginsenosides
Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1675722 · Cited by 18
Microribonucleic acid dysregulations in children and adolescents with obsessive–compulsive disorder
Kandemır, H., Erdal, M. E., Selek, S., Ay, Ö. İ., Karababa, İ. F., Ay, M. E., Kandemir, S. B., Bayazıt, H., Taşdelen, B., Ekinci, S., et al. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s81884 · Cited by 19
Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches
Galasko, D. R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00256 · Cited by 19
Minhas, G., Mathur, D., Balakrishnan, R., Sharma, N. K., Paanu, V., & Anand, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00386 · Cited by 20
Barros, L., Eichwald, T., Solano, A. F., Scheffer, D. D. L., da Silva, R. A., Gaspar, J. M., & Latini, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.009 · Cited by 18
The Link Among Neurological Diseases: Extracellular Vesicles as a Possible Brain Injury Footprint
Ciccocioppo, F., Lanuti, P., Centonze, D., Miscia, S., & Marchisio, M. (2019) · Neurosignals · doi:10.33594/000000116 · Cited by 17
Jiang, Y., Li, R., He, W., Li, Q., Yang, X., Li, S., Bai, W., & Li, Y. (2022) · Microchimica Acta · doi:10.1007/s00604-022-05246-0 · Cited by 17
Circulating MicroRNAs in the Cerebrospinal Fluid of Patients with Brain Diseases
Machida, A., Ohkubo, T., & Yokota, T. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-453-1_16 · Cited by 17
Circulating Plasma microRNAs are Altered with Amyloidosis in a Mouse Model of Alzheimer’s Disease
Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180385 · Cited by 20
Yan, J., Hua, P., Chen, Y., Li, L., Yu, C., Yan, L., Zhang, H., He, Y., Zheng, H., Chen, H., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.03.163 · Cited by 17
Donati, S., Ciuffi, S., Marini, F., Palmini, G., Miglietta, F., Aurilia, C., & Brandi, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207592 · Cited by 17
Performance of Validated MicroRNA Biomarkers for Alzheimer’s Disease in Mild Cognitive Impairment
Sandau, U. S., Wiedrick, J. T., Smith, S. J., McFarland, T. J., Lusardi, T. A., Lind, B., Harrington, C. A., Lapidus, J., Galasko, D. R., Quinn, J. F., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200396 · Cited by 16
Gao, Z., Zhang, R., Jiang, L., Zhou, H., Wang, Q., Ma, Y., Zhang, D., Qin, Y., Tian, P., Zhang, N., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215301 · Cited by 16
Is liquid biopsy mature enough for the diagnosis of Alzheimer’s disease?
Gong, X., Zhang, H., Liu, X., Liu, Y., Liu, J., Fapohunda, F. O., Lü, P., Wang, K., & Tang, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.977999 · Cited by 17
Novel insights regarding the role of noncoding RNAs in diabetes
Mačvanin, M., Gluvic, Z. M., Bajić, V., & Isenović, E. R. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i7.958 · Cited by 16
The role of the heterochronic microRNA let-7 in the progression of aging
Toledano, H. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.006 · Cited by 19
miRNA profiles in cerebrospinal fluid from patients with central hypersomnias
Holm, A., Bang‐Berthelsen, C. H., Knudsen, S., Modvig, S., Kornum, B. R., Gammeltoft, S., & Jennum, P. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.09.047 · Cited by 16
Thatcher, T. H., Woeller, C. F., Thakar, J., Khan, A. A., Hopke, P. K., Smith, M. R., Uppal, K., Walker, D. I., Go, Y., Jones, D. P., et al. (2019) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001715 · Cited by 17
Potashkin, J. A., Bottero, V., Santiago, J. A., & Quinn, J. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113787 · Cited by 17
Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs
Belli, R., Ferraro, E., Molfino, A., Carletti, R., Tambaro, F., Costelli, P., & Muscaritoli, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169007 · Cited by 20
microRNA as a new agent for regulating neuronal glutathione synthesis and metabolism
Kinoshita, C., Aoyama, K., & Nakaki, T. (2015) · AIMS molecular science · doi:10.3934/molsci.2015.2.124 · Cited by 16
Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells
Xu, T., Xie, H. Q., Li, Y., Xia, Y., Sha, R., Wang, L., Chen, Y., Xu, S. L., & Zhao, B. (2017) · Journal of Environmental Sciences · doi:10.1016/j.jes.2017.06.038 · Cited by 16
Han, S., Shin, J., Jung, H., Ryu, J., Minassie, H., Nho, K., Koh, I., & Lee, Y. (2021) · npj Systems Biology and Applications · doi:10.1038/s41540-021-00177-7 · Cited by 16
Asanomi, Y., Shigemizu, D., Akiyama, S., Sakurai, T., Ozaki, K., Ochiya, T., & Niida, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-00424-1 · Cited by 15
Chia, S. Y., Vipin, A., Ng, K. P., Tu, H., Bommakanti, A. S., Wang, B. Z., Tan, Y. J., Zailan, F. Z., Ng, A. S. L., Ling, S., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220116 · Cited by 17
Ullah, H., Tian, Y., Arbab, S., Li, K., Khan, M. I. U., Rahman, S. U., Qadeer, A., Muhammad, N., Suleman, S., & Hassan, I. U. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1018872 · Cited by 16
Shen, H., Chen, J., Liu, M., Zhao, M., Hu, D., Xie, F., Jin, Q., Xiao, D., Peng, Z., Qin, T., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1496304 · Cited by 17
Delay, C., Grenier‐Boley, B., Amouyel, P., Dumont, J., & Lambert, J. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0186-x · Cited by 15
Erdal, M. E., Yılmaz, Ş. G., Gürgül, S., Uzun, Ç., Yıldırım, D. D., & Erdal, N. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.08.001 · Cited by 15
miR-151-5p modulates APH1a expression to participate in contextual fear memory formation
Xu, X., Wang, Y., Zong, L., & Wang, X. (2019) · RNA Biology · doi:10.1080/15476286.2019.1572435 · Cited by 15
Traumatic Brain Injury Leads to Alterations in Contusional Cortical miRNAs Involved in Dementia
Naseer, S., Abelleira, L. E., Savani, D., de Burgh, R., Aleksynas, R., Donat, C. K., Syed, N., & Sastre, M. (2022) · Biomolecules · doi:10.3390/biom12101457 · Cited by 15
Significance and Therapeutic Value of miRNAs in Embryonal Neural Tumors
Shalaby, T., Fiaschetti, G., Baumgartner, M., & Grotzer, M. A. (2014) · Molecules · doi:10.3390/molecules19055821 · Cited by 16
Petracci, I., Bellini, S., Goljanek‐Whysall, K., Quinlan, L. R., Fiszer, A., Cakmak, A., Njume, C. M., Borroni, B., & Ghidoni, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073399 · Cited by 16
Lusardi, T. A., Sandau, U. S., Sakhanenko, N. A., Baker, S. C. B., Wiedrick, J. T., Lapidus, J., Raskind, M. A., Li, G., Peskind, E. R., Galas, D. J., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.720778 · Cited by 14
Xiao, Z., Yan, Z., Sun, X., Zhu, Z., Wang, B., Gao, M., Lu, F., Liu, J., Zong, Z., Zhang, H., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9173514 · Cited by 14
RNA‐Based Therapies for Neurodegenerative Diseases Targeting Pathogenic Proteins
Rabbani, S. A., El‐Tanani, M., Sharma, S., El‐Tanani, Y., Kumar, R., Saini, M., Yadav, M., Khan, M. A., & Parvez, S. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70110 · Cited by 15
Biomarkers for detection, prognosis and therapeutic assessment of neurological disorders
Singh, S. G., Gupta, S. K., & Seth, P. K. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0097 · Cited by 14
Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice
Liu, R., Wang, Y., Bai, L., Wang, R., Wu, Y., Liu, M., Li, Q., Ba, Y., Zhang, H., Zhou, G., et al. (2021) · Toxicology Research · doi:10.1093/toxres/tfab050 · Cited by 14
Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands
Raden, M., Wallach, T., Miladi, M., Zhai, Y., Krüger, C., Mossmann, Z. J., Dembny, P., Backofen, R., & Lehnardt, S. (2021) · RNA Biology · doi:10.1080/15476286.2021.1940697 · Cited by 14
Interplay between circular RNA, microRNA, and human diseases
Kour, B., Gupta, S., Singh, R., Sophiarani, Y., & Paul, P. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01856-8 · Cited by 14
Ebrahimi, R., & Golestani, A. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30624 · Cited by 14
Dong, R., Sun, L., Lu, Y., Yang, X., Peng, M., & Zhang, Z. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00200 · Cited by 14
Characterizing microRNA editing and mutation sites in Autism Spectrum Disorder
Wu, X., Yang, H., Lin, H., Suo, A., Wu, S., Xie, W., Zhou, N., Guo, S., Ding, H., Zhou, G., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1105278 · Cited by 13
Singh, R. J., Hussain, J., Kaur, A., Jamdare, B. G., Pathak, D., Garg, K., Kaur, R., Shankar, S., & Sunkaria, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102002 · Cited by 14
miR-183 as a molecular and protective biomarker for cancer in schizophrenic subjects
Rizos, E. N., Siafakas, N., Koumarianou, A. A., Katsantoni, E. Z., Filippopoulou, A., Ntounas, P., TOULOUMIS, C., Kastania, A., & Zoumpourlis, V. C. (2012) · Oncology Reports · doi:10.3892/or.2012.2052 · Cited by 14
Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases
You, H. J., Park, J. H., Pareja-Galeano, H., Lucía, A., & Shin, J. I. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8407-9 · Cited by 14
MicroRNA Exocytosis by Vesicle Fusion in Neuroendocrine Cells
Park, Y. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00355 · Cited by 260
Woeller, C. F., Thatcher, T. H., Thakar, J., Cornwell, A. B., Smith, M. R., Jones, D. P., Hopke, P. K., Sime, P. J., Krahl, P. K., Mallon, T. M., et al. (2019) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001691 · Cited by 13
The potential of microRNAs as putative biomarkers in major depressive disorder and suicidal behavior
Serafini, G., Trabucco, A., Corsini, G. P., Escelsior, A., Amerio, A., Aguglia, A., Nasrallah, H. A., & Amore, M. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100035 · Cited by 14
Hu, Y., Zhang, Y., Ren, R., Dammer, E. B., Xie, X., Chen, S., Huang, Q., Huang, W., Zhang, R., Chen, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13454 · Cited by 12
Selective secretion of microRNA in CNS system
Zhang, Q., Xu, J., Chen, Q., Chen, X., Zen, K., & Zhang, C. (2013) · Protein & Cell · doi:10.1007/s13238-013-3006-0 · Cited by 13
Maffioletti, E., Salvi, A., Conde, I., Maj, C., Gennarelli, M., Petro, G. D., & Bocchio‐Chiavetto, L. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.10.005 · Cited by 14
Titze-de-Almeida, S. S., Marina, C. L., Ramos, M. V., Silva, L. D. D. S., Brandão, P. R. D. P., Bispo, D. D. D. C., von Glehn, F., & Titze‐de‐Almeida, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178246 · Cited by 13
miR-34a regulates silent synapse and synaptic plasticity in mature hippocampus
Min, X., Wang, J., Zong, F., Zhao, J., Liu, N., & He, K. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102404 · Cited by 13
Role of viruses, prions and miRNA in neurodegenerative disorders and dementia
Sohrab, S. S., Suhail, M., Ali, A., Kamal, M. A., Husen, A., Ahmad, F., Azhar, E. I., & Greig, N. H. (2018) · VirusDisease · doi:10.1007/s13337-018-0492-y · Cited by 12
Deng, L.-J., Wu, D., Yang, X., & Li, T. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.06.004 · Cited by 13
Biofluid-based microRNA Biomarkers for Parkinsons Disease: an Overview and Update
Shinde, S., Mukhopadhyay, S., Mohsen, G. M., & Khoo, S. K. (2015) · AIMS Medical Science · doi:10.3934/medsci.2015.1.15 · Cited by 12
Annals of Psychiatry and Mental Health
Dwivedi, Y., & Neurobiology, B. (2013) · Cited by 12
Genetic Biomarkers in Alzheimer’s Disease
Khan, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804832-0.00004-3 · Cited by 13
Mosakhani, N., Sarhadi, V. K., Panula, P., Partinen, M., & Knuutila, S. (2017) · Acta Neurologica Scandinavica · doi:10.1111/ane.12749 · Cited by 12
Structural insights into Beclin 1 interactions with it's regulators for autophagy modulation
Sarmadhikari, D., & Asthana, S. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.06.044 · Cited by 13
Exploring the Role of Cerebrospinal Fluid As Analyte in Neurologic Disorders
Pingle, S. C., Lin, F., Anekoji, M., Patro, C. P. K., Datta, S., Jones, L. D., Kesari, S., & Ashili, S. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0006 · Cited by 11
McInvale, J. J., Canoll, P., & Hargus, G. (2024) · Brain Pathology · doi:10.1111/bpa.13231 · Cited by 11
Sromek, M., Rymkiewicz, G., Paziewska, A., Szafron, L. M., Kulecka, M., Zajdel, M., Kulińczak, M., Dąbrowska, M., Bałabas, A., Bystydzieński, Z., et al. (2021) · Biomolecules · doi:10.3390/biom11091395 · Cited by 11
Orzeł-Gajowik, K., Milewski, K., & Zielińska, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010224 · Cited by 12
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Poloni, T. E., Medici, V., Carlos, A. F., Davin, A., Ceretti, A., Mangieri, M., Cassini, P., Vaccaro, R., Zaccaria, D., Abbondanza, S., et al. (2020) · Journal of Visualized Experiments · doi:10.3791/60296-v · Cited by 11
The Role of Astrocytes in Tumor Growth and Progression
Gronseth, E. I., Wang, L., Harder, D. R., & Ramchandran, R. (2018) · InTech eBooks · doi:10.5772/intechopen.72720 · Cited by 12
Fu, S., Zhang, J., & Zhang, S. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2643-3 · Cited by 11
MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice
Watts, M. E., Williams, G., Lü, J., Nithianantharajah, J., & Claudianos, C. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02197-6 · Cited by 11
MicroRNAs as Potential Biomarkers in Pituitary Adenomas
Donati, S., Aurilia, C., Palmini, G., Miglietta, F., Falsetti, I., Iantomasi, T., & Brandi, M. L. (2021) · Non-Coding RNA · doi:10.3390/ncrna7030055 · Cited by 11
Xu, T., Xie, H. Q., Li, Y., Xia, Y., Chen, Y., Xu, S. L., Wang, L., & Zhao, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-10311-3 · Cited by 11
Targeting miRNAs in Alzheimer’s disease
Hugon, J., & Paquet, C. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1615 · Cited by 11
Metadata
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
