The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
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In the citing paper
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
In the citing paper
“Although the level of miR-9-5p was downregulated in AD brains and EVs from CSF [47,48,49]”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Similar to miR-146a-5p, miR-132-3p was reported to be downregulated in AD in five independent studies [48,72,80,84] but up-regulated in AD in only one independent study [81].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Among these miRNAs, miR-146a-5p [50,70,73,74,83] and miR-132-3p [48,72,80,81,84] were reported to be dysregulated in six independent AD studies, respectively.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“miR-125b-5p was upregulated in brains [36,48,50] and EVs from CSF of AD patients compared to HC [49,66].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Substantial recent evidence has demonstrated that microRNAs (miRNAs) are dysregulated already early on in AD pathology [2–7].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [4]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Both miRNAs are expressed in the human brain and are deregulated in AD [41–43, 54].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
Citations
Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
RAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
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Rodriguez‐Emmenegger, C., Houška, M., Alles, A. B., & Brynda, E. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200171 · Cited by 99
Circulating miRNAs in Ageing and Ageing-Related Diseases
Jung, H. J., & Suh, Y. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.07.003 · Cited by 97
Circulating microRNAs as Biomarkers of Alzheimer’s Disease: A Systematic Review
Wu, H. Z. Y., Ong, K. L., Seeher, K. M., Armstrong, N. J., Thalamuthu, A., Brodaty, H., Sachdev, P. S., & Mather, K. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150619 · Cited by 104
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Qiu, L., Tan, E., & Zeng, L. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_6 · Cited by 102
Banack, S. A., Dunlop, R. A., & Cox, P. A. (2020) · Open Biology · doi:10.1098/rsob.200116 · Cited by 103
Increased miR-132-3p expression is associated with chronic neuropathic pain
Leinders, M., Üçeyler, N., Pritchard, R. A., Sommer, C., & Sorkin, L. S. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.025 · Cited by 97
MIRNAS in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity
Lafourcade, C., Ramírez, J. P., Luarte, A., Fernández, A., & Wyneken, Ú. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39916 · Cited by 105
Current strategies in the diagnosis of diffuse large B‐cell lymphoma of the central nervous system
Baraniskin, A., Deckert, M., Schulte‐Altedorneburg, G., Schlegel, U. S., & Schroers, R. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08928.x · Cited by 98
Memory formation and retention are affected in adult miR-132/212 knockout mice
Hernandez-Rapp, J., Smith, P. Y., Filali, M., Goupil, C., Planel, E., Magill, S. T., Goodman, R. H., & Hébert, S. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.032 · Cited by 81
Majer, A., Medina, S. J., Niu, Y., Abrenica, B., Manguiat, K., Frost, K. L., Phillipson, C. S., Sorensen, D. L., & Booth, S. A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003002 · Cited by 101
Cheng, L., Vella, L. J., Barnham, K. J., McLean, C., Masters, C. L., & Hill, A. F. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1766822 · Cited by 96
Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.001 · Cited by 95
Upregulation of miR-181 Decreases c-Fos and SIRT-1 in the Hippocampus of 3xTg-AD Mice
Rodríguez‐Ortiz, C. J., Baglietto‐Vargas, D., Martínez‐Coria, H., LaFerla, F. M., & Kitazawa, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140204 · Cited by 99
Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
François, A., Bilan, A. R., Quellard, N., Fernandez, B., Janet, T., Chassaing, D., Paccalin, M., Terro, F., & Page, G. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0139-x · Cited by 98
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Jia, L., & Liu, Y. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3184 · Cited by 95
Wang, Y., Veremeyko, T., Wong, A. H.-K., El Fatimy, R., Wei, Z., Cai, W., & Krichevsky, A. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.015 · Cited by 87
Lauretti, E., Dabrowski, K. R., & Praticò, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101425 · Cited by 97
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Dysregulated microRNAs in neurodegenerative disorders
Lau, P., & Strooper, B. D. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.01.009 · Cited by 93
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Ye, Y., Xu, H., Su, X., & He, X. (2016) · Neural Plasticity · doi:10.1155/2016/4959523 · Cited by 93
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Paschon, V., Takada, S. H., Ikebara, J. M., de Sousa, É., Raeisossadati, R., Ulrich, H., & Kihara, A. H. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9142-1 · Cited by 94
Loveday, E.-K., Svinti, V., Diederich, S., Pasick, J. M. M., & Jean, F. (2012) · Journal of Virology · doi:10.1128/jvi.06892-11 · Cited by 90
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Collins, M. A., Riascos, D., Kovalik, T., An, J., Krupa, K., Krupa, K., Hood, B. L., Conrads, T. P., Renton, A. E., Traynor, B. J., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1045-x · Cited by 90
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Ma, X., Liu, L., & Meng, J. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.09.043 · Cited by 91
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Ochi, S., & Dwivedi, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01907-x · Cited by 94
Patrick, E., Rajagopal, S., Wong, H.-K. A., McCabe, C., Xu, J., Tang, A., Imboywa, S. H., Schneider, J. A., Pochet, N., Krichevsky, A. M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0191-y · Cited by 87
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Roshan, R., Ghosh, T., Scaria, V., & Pillai, B. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.09.009 · Cited by 88
Elton, T. S., Sansom, S. E., & Martin, M. M. (2010) · RNA Biology · doi:10.4161/rna.7.5.12685 · Cited by 83
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Weilner, S., Schraml, E., Redl, H. R., Grillari‐Voglauer, R., & Grillari, J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.017 · Cited by 82
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Lee, K., Kim, H.-J., An, K., Kwon, O.-B., Park, S., Cha, J. H., Kim, M., Lee, Y., Kim, J., Cho, K., et al. (2016) · Scientific Reports · doi:10.1038/srep34433 · Cited by 86
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Baby, N., Alagappan, N., Dheen, S. T., & Sajikumar, S. (2019) · Aging Cell · doi:10.1111/acel.13046 · Cited by 79
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Mendes‐Silva, A. P., Pereira, K. S., Araújo, G. T. T., Nicolau, E. D. S., Silva-Ferreira, C. M., Teixeira, A. L., & Diniz, B. S. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.07.017 · Cited by 76
Bland, C. L., Byrne-Hoffman, C. N. N., Fernández, A., Rellick, S. L., Deng, W., & Klinke, D. J. (2018) · FEBS Journal · doi:10.1111/febs.14396 · Cited by 79
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Barak, B., Shvarts-Serebro, I., Modai, S., Gilam, A., Okun, E., Michaelson, D. M., Mattson, M. P., Shomron, N., & Ashery, U. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.77 · Cited by 75
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Benigni, M., Ricci, C., Jones, A. R., Giannini, F., Al‐Chalabi, A., & Battistini, S. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8396-8 · Cited by 78
Jian, C., Lu, M., Zhang, Z., Liu, L., Li, X., Huang, F., Xu, N., Qin, L., Zhang, Q., & Zou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.05.023 · Cited by 77
Blanco, K., Salcidua, S., Orellana, P., Sauma-Pérez, T., León, T., Steinmetz, L. C. L., Ibañez, A., Duran-Aniotz, C., & de la Cruz, R. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01304-8 · Cited by 73
Xu, S., Zhang, R., Niu, J., Cui, D., Xie, B., Zhang, B., Lu, K., Yu, W., Wang, X., & Zhang, Q. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216945 · Cited by 75
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Yu, H.-C., Wu, J., Zhang, H.-X., Zhang, G.-L., Sui, J., Tong, W.-W., Zhang, X.-Y., Nie, L.-L., Duan, J.-H., Zhang, L.-R., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.05.007 · Cited by 71
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Mushtaq, G., H. Greig, N., Anwar, F., A. Zamzami, M., Choudhry, H., M. Shaik, M., A. Tamargo, I., & A. Kamal, M. (2016) · Medicinal Chemistry · doi:10.2174/1573406411666151030112140 · Cited by 78
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Stylli, S. S., Adamides, A. A., Koldej, R. M., Luwor, R. B., Ritchie, D. S., Ziogas, J., & Kaye, A. H. (2017) · Journal of Neurosurgery · doi:10.3171/2016.1.jns151454 · Cited by 71
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Gallego, J. A., Gordon, M. L., Claycomb, K., Bhatt, M., Lencz, T., & Malhotra, A. K. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9731-7 · Cited by 69
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Metadata
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
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