The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
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In the citing paper
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
In the citing paper
“Although the level of miR-9-5p was downregulated in AD brains and EVs from CSF [47,48,49]”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Similar to miR-146a-5p, miR-132-3p was reported to be downregulated in AD in five independent studies [48,72,80,84] but up-regulated in AD in only one independent study [81].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Among these miRNAs, miR-146a-5p [50,70,73,74,83] and miR-132-3p [48,72,80,81,84] were reported to be dysregulated in six independent AD studies, respectively.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“miR-125b-5p was upregulated in brains [36,48,50] and EVs from CSF of AD patients compared to HC [49,66].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Substantial recent evidence has demonstrated that microRNAs (miRNAs) are dysregulated already early on in AD pathology [2–7].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [4]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Both miRNAs are expressed in the human brain and are deregulated in AD [41–43, 54].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
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Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
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Fonseca, Á. Y. G., Martín-Jiménez, C., Barreto, G. E., Aristizábal-Pachón, A. F., & González, J. (2021) · Biomolecules · doi:10.3390/biom11081132 · Cited by 48
Recent advances in optical label‐free characterization of extracellular vesicles
Imanbekova, M., Suarasan, S., Lu, Y. P., Jurchuk, S., & Wachsmann‐Hogiu, S. (2022) · Nanophotonics · doi:10.1515/nanoph-2022-0057 · Cited by 47
Erdem, A., & Çongur, G. (2013) · Talanta · doi:10.1016/j.talanta.2013.09.041 · Cited by 47
Meng, F., Dai, E., Yu, X., Zhang, Y., Chen, X., Liu, X., Wang, S., Wang, L., & Jiang, W. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.1057 · Cited by 47
Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain
Elramah, S., López‐González, M. J., Bastide, M. F., Dixmérias, F., Roca‐Lapirot, O., Wielanek-Bachelet, A.-C., Vital, A., Lesté-Lasserre, T., Brochard, A., Landry, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10224-1 · Cited by 47
Maldonado, I. C., Atienza, M., Sanchez-Espinosa, M. P., & Cantero, J. L. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy323 · Cited by 49
Wu, Y.-L., Li, H., Chen, H.-H., & Lin, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186738 · Cited by 49
Chen, M., Takano‐Maruyama, M., Pereira‐Smith, O. M., Gaufo, G. O., & Tominaga, K. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21976 · Cited by 47
MicroRNAs in Parkinson’s disease: a systematic review and diagnostic accuracy meta-analysis
Guévremont, D., Roy, J., Cutfield, N. J., & Williams, J. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-43096-9 · Cited by 51
The power of microRNAs as diagnostic and prognostic biomarkers in liquid biopsies
Quirico, L., & Orso, F. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2019.103 · Cited by 46
Whole-Blood Levels of MicroRNA-9 Are Decreased in Patients With Late-Onset Alzheimer Disease
Souza, V. C., Morais-Junior, G. S., Henriques, A. D., Machado‐Silva, W., Pérez, D. I. V., Brito, C. J., Camargos, E. F., Moraes, C. F., & Nóbrega, O. D. T. (2020) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317520911573 · Cited by 46
Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders
Khan, I., Kumari, P., Fernandes, V., Khatri, D. K., & Singh, S. B. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01093-4 · Cited by 49
Heterogeneity and Individuality: microRNAs in Mental Disorders
Hommers, L. G., Domschke, K., & Deckert, J. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1338-4 · Cited by 45
microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster
Busto, G. U., Guven-Ozkan, T., Fulga, T. A., Vactor, D. V., & Davis, R. L. (2015) · Genetics · doi:10.1534/genetics.114.169623 · Cited by 45
Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis
Jimenez‐Pacheco, A., Franco, J. M., Lopez, S., Gómez‐Zumaquero, J. M., Leal‐Lasarte, M., Caballero-Hernández, D. E., Cejudo‐Guillén, M., & Pozo, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_14 · Cited by 46
Metadata
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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