The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
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In the citing paper
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
In the citing paper
“Although the level of miR-9-5p was downregulated in AD brains and EVs from CSF [47,48,49]”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Similar to miR-146a-5p, miR-132-3p was reported to be downregulated in AD in five independent studies [48,72,80,84] but up-regulated in AD in only one independent study [81].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Among these miRNAs, miR-146a-5p [50,70,73,74,83] and miR-132-3p [48,72,80,81,84] were reported to be dysregulated in six independent AD studies, respectively.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“miR-125b-5p was upregulated in brains [36,48,50] and EVs from CSF of AD patients compared to HC [49,66].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Substantial recent evidence has demonstrated that microRNAs (miRNAs) are dysregulated already early on in AD pathology [2–7].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [4]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Both miRNAs are expressed in the human brain and are deregulated in AD [41–43, 54].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
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“…or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; ∗p < 0.001 (ANOVA). contribute to the down-regulation of selective miRNA-7-sensitive messenger RNA (mRNA) targets (Cogswell et al., 2008; unpublished observations).”
BackgroundInfluential
Metadata
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
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