The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
In the citing paper
“Although the level of miR-9-5p was downregulated in AD brains and EVs from CSF [47,48,49]”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Similar to miR-146a-5p, miR-132-3p was reported to be downregulated in AD in five independent studies [48,72,80,84] but up-regulated in AD in only one independent study [81].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Among these miRNAs, miR-146a-5p [50,70,73,74,83] and miR-132-3p [48,72,80,81,84] were reported to be dysregulated in six independent AD studies, respectively.”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“miR-125b-5p was upregulated in brains [36,48,50] and EVs from CSF of AD patients compared to HC [49,66].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [48]
In the citing paper
“Substantial recent evidence has demonstrated that microRNAs (miRNAs) are dysregulated already early on in AD pathology [2–7].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [4]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“miR-92a-1-5p expression in AD brain is enhanced, while miR-501-3p expression is increased in both brain and serum of AD patients [41–43].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Both miRNAs are expressed in the human brain and are deregulated in AD [41–43, 54].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [43]
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
Citations
Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
RAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 401–500 of 945
Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients
Chang, K., Wu, Y., & Chen, C. (2017) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-017-0742-x · Cited by 45
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain
Raihan, M. O., Brishti, A., Molla, M. R., Li, W., Zhang, Q., Xu, P., Khan, M. I., Zhang, J., & Liu, Q. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.08.003 · Cited by 44
Haghani, A., Johnson, R. G., Woodward, N. C., Feinberg, J. I., Lewis, K., Ladd‐Acosta, C., Safi, N., Jaffe, A. E., Sioutas, C., Allayee, H., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00907-1 · Cited by 44
Li, Q. S., & Cai, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.620899 · Cited by 45
Walker, R. M., Rybka, J., Anderson, S. M., Torrance, H. S., Boxall, R., Sussmann, J. E., Porteous, D. J., McIntosh, A. M., & Evans, K. L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.01.006 · Cited by 46
Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: The Present and the Future
Ghidoni, R., Benussi, L., Paterlini, A., Albertini, V., Binetti, G. G., & Emanuele, E. (2011) · Neurodegenerative Diseases · doi:10.1159/000327756 · Cited by 44
Deciphering the Function and Regulation of microRNAs in Alzheimer’s Disease and Parkinson’s Disease
Qiu, L., Zhang, W., Tan, E., & Zeng, L. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500149w · Cited by 45
MiRComb: An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers
Vila-Casadesús, M., Gironella, M., & Lozano, J. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151127 · Cited by 44
Micro RNA ‐146a represses LRP 2 translation and leads to cell apoptosis in Alzheimer's disease
Zhang, B., Wang, L., Ren, R., Dammer, E. B., Zhang, Y., Huang, Y. M., Chen, S., & Wang, G. (2016) · FEBS Letters · doi:10.1002/1873-3468.12229 · Cited by 47
Macro roles for microRNAs in neurodegenerative diseases
Rajgor, D. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.07.001 · Cited by 47
The Role of microRNAs in Drug Addiction
Pietrzykowski, A. Z. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91001-5 · Cited by 44
Sandau, U. S., McFarland, T. J., Smith, S. J., Galasko, D. R., Quinn, J. F., & Saugstad, J. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.864022 · Cited by 46
Exosome-based approaches in the management of Alzheimer’s disease
Kandimalla, R., Saeed, M., Tyagi, N., Gupta, R. C., & Aqil, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104974 · Cited by 45
microRNA-132 regulates gene expression programs involved in microglial homeostasis
Walgrave, H., Penning, A., Tosoni, G., Snoeck, S., Davie, K., Davis, E., Wolfs, L., Sierksma, A., Mars, M., Bu, T., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106829 · Cited by 41
Azam, H. M. H., Rößling, R., Geithe, C., Khan, M. M., Dinter, F., Hanack, K., Prüß, H., Husse, B., Roggenbuck, D., Schierack, P., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1386735 · Cited by 49
Liu, H., Tian, T., Qin, S., Li, W., Zhang, X., Wang, X., Gao, Y., & Huang, G. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.020 · Cited by 43
Non-Coding RNAs: Functional Aspects and Diagnostic Utility in Oncology
Kim, T., & Reitmair, A. H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034934 · Cited by 46
Long, J. M., & Lahiri, D. K. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.043 · Cited by 44
Ge, Y., Song, X., Liu, J., Liu, C., & Xu, C. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02947-6 · Cited by 43
MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease
Li, W., & Zheng, Y. (2023) · Cells · doi:10.3390/cells12101378 · Cited by 43
Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121122910 · Cited by 42
Zhou, L., Pupo, G. M., Gupta, P. S., Liu, B., Tran, S. L., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A. P., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-677 · Cited by 42
Epigenetic-based therapies for Friedreich ataxia
Sandi, C., Sandi, M., Virmouni, S. A., Al-Mahdawi, S., & Pook, M. A. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00165 · Cited by 42
MmPalateMiRNA, an R package compendium illustrating analysis of miRNA microarray data
Brock, G. N., Mukhopadhyay, P., Pihur, V., Webb, C. L., Greene, R. M., & Pisano, M. (2013) · Source Code for Biology and Medicine · doi:10.1186/1751-0473-8-1 · Cited by 42
Zhuang, J., Chen, Z., Cai, P., Wang, R., Yang, Q., Li, L., Yang, H., & Zhu, R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.587747 · Cited by 41
Yuen, S. C., Liang, X., Zhu, H., Jia, Y., & Leung, S.-W. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00862-z · Cited by 42
Platelet MicroRNAs: An Overview
Dahiya, N., Sarachana, T., Vu, L. T., Becker, K. G., Wood, W. H., Zhang, Y., & Atreya, C. D. (2015) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2015.08.002 · Cited by 42
Methodology for Discovery of Alzheimer's Disease Blood-Based Biomarkers
Maes, O. C., Schipper, H. M., Chertkow, H. M., & Wang, E. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp045 · Cited by 42
Spencer, P. S., Fry, R. C., & Kisby, G. E. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00192 · Cited by 43
Zhang, L., Dong, H., Si, Y., Wu, N., Cao, H., Mei, B., & Meng, B. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.011 · Cited by 39
miR-886-3p Levels Are Elevated in Friedreich Ataxia
Mahishi, L., Hart, R. P., Lynch, D. R., & Ratan, R. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0059-12.2012 · Cited by 42
Wakabayashi, K., Mori, F., Kakita, A., Takahashi, H., Utsumi, J., & Sasaki, H. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0173-z · Cited by 41
Müller, M., Kuiperij, H. B., Versleijen, A. A. M., Chiasserini, D., Farotti, L., Baschieri, F., Parnetti, L., Struyfs, H., De Roeck, N., Luyckx, J., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160038 · Cited by 41
Choline the brain and neurodegeneration insights from epigenetics
Bekdash, R. A. (2017) · Frontiers in bioscience · doi:10.2741/4636 · Cited by 43
Plasma microRNA vary in association with the progression of Alzheimer's disease
Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12251 · Cited by 43
Predict MiRNA-Disease Association with Collaborative Filtering
Jiang, Y., Liu, B., Yu, L., Yan, C. C., & Bian, H. (2018) · Neuroinformatics · doi:10.1007/s12021-018-9386-9 · Cited by 40
Kim, Y. A., Siddiqui, T., Blaze, J., Coşacak, M. İ., Winters, T., Kumar, A., Tein, E., Sproul, A. A., Teich, A. F., Bartolini, F., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02511-7 · Cited by 44
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150451 · Cited by 29
Biomarkers and evolution in Alzheimer disease
Rapoport, S. I., & Nelson, P. T. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.07.006 · Cited by 40
Liu, Y., He, X., Li, Y., & Wang, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.122 · Cited by 39
Jia, H.-L., He, C.-H., Wang, Z., Xu, Y., Yin, G., Mao, L.-J., Liu, C.-W., & Deng, L. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-506 · Cited by 40
Shah, S. Z. A., Zhao, D., Hussain, T. A., Sabir, N., & Yang, L. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00139 · Cited by 41
Unveiling the Complex Role of Exosomes in Alzheimer’s Disease
Sun, M., & Chen, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s466821 · Cited by 39
Tatro, E. T., Scott, E. R., Nguyen, T. B., Salaria, S., Banerjee, S., Moore, D. J., Masliah, E., Achim, C. L., & Everall, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010337 · Cited by 40
Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-376 · Cited by 44
MicroRNA (miRNA): Sequence and stability, viroid-like properties, and disease association in the CNS
Pogue, A. I., Hill, J. M., & Lukiw, W. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.042 · Cited by 39
miRNAs Identify Shared Pathways in Alzheimer’s and Parkinson’s Diseases
Sadlon, A., Takousis, P., Alexopoulos, P., Εvangelou, Ε., Prokopenko, I., & Perneczky, R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.006 · Cited by 40
van Harten, A. C., Mulders, J., Scheltens, P., van der Flier, W. M., & Oudejans, C. B. M. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-140075 · Cited by 41
Cancer-Related Neuropathic Pain
Davis, M. P. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2018.01.005 · Cited by 37
Çongur, G., Ekşin, E., & Erdem, A. (2018) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2018.06.026 · Cited by 38
Modulation in miR-200a/SIRT1axis is associated with apoptosis in MPP+-induced SH-SY5Y cells
Salimian, N., Peymani, M., Ghaedi, K., & Nasr‐Esfahani, M. H. (2018) · Gene · doi:10.1016/j.gene.2018.06.061 · Cited by 38
Regulatory roles of the miR-200 family in neurodegenerative diseases
Fu, J., Peng, L., Tao, T., Chen, Y., Li, Z., & Li, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109409 · Cited by 39
Wang, Y., & Chang, Q. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-02915-z · Cited by 38
The role of microRNAs regulatory network in Alzheimer’s disease: a bioinformatics analysis
Sun, C., Qi, X., Liu, J., Duan, F., & Cong, L. (2021) · Archives of Medical Science · doi:10.5114/aoms/80619 · Cited by 40
Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases
Pérez-García, A., Torrecilla-Parra, M., Frutos, M. F.-D., Martín-Martín, Y., Pardo, V., & Ramírez, C. M. (2022) · Biomolecules · doi:10.3390/biom12020208 · Cited by 45
Epigenetics of Alzheimer's Disease and Frontotemporal Dementia
Veerappan, C. S., Sleiman, S. F., & Coppola, G. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0219-0 · Cited by 38
MicroRNAs in brain development and degeneration
Enciu, A., Popescu, B. O., & Gheorghisan-Galateanu, A. A. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0973-1 · Cited by 37
Modern cerebrospinal fluid analyses for the diagnosis of diffuse large B-cell lymphoma of the CNS
Baraniskin, A., & Schroers, R. (2014) · CNS Oncology · doi:10.2217/cns.13.63 · Cited by 37
Tumor-Associated CSF MicroRNAs for the Prediction and Evaluation of CNS Malignancies
Shalaby, T., & Grotzer, M. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226150 · Cited by 37
Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders
Lardenoije, R., Pishva, E., Lunnon, K., & van den Hove, D. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.008 · Cited by 37
Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far
Bazzari, F. H., Abdallah, D. M., & El-Abhar, H. S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190301111120 · Cited by 39
Yang, Y., Li, Y., Yang, H., Guo, J., & Li, N. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.631553 · Cited by 37
miR-146a Dysregulates Energy Metabolism During Neuroinflammation
Kim, S. J., Russell, A. E., Wang, W., Gemoets, D. E., Sarkar, S. N., Simpkins, J. W., & Brown, C. M. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-09999-y · Cited by 41
The Role of miRNAs in Metabolic Diseases
Mačvanin, M., Obradovic, M. M., Zafirovic, S. S., Stanimirović, J., & Isenović, E. R. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220801161536 · Cited by 40
Imaging Epigenetics in Alzheimer’s Disease
Lista, S., Garaci, F. G., Toschi, N., & Hampel, H. J. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990370 · Cited by 36
Targeting microRNAs in neurons: Tools and perspectives
Ruberti, F., Barbato, C., & Cogoni, C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.031 · Cited by 36
Differentially expressed miRNAs in retinoblastoma
Martin, J., Bryar, P. J., Mets, M. B., Weinstein, J. L., Jones, A., Martin, A., Vanin, E. F., Scholtens, D. M., Costa, F. F., Soares, M. B., et al. (2012) · Gene · doi:10.1016/j.gene.2012.09.129 · Cited by 36
microRNAs as novel biomarkers of schizophrenia (Review)
Wang, J., Wang, Y., YANG, J., & Huang, Y. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2014 · Cited by 37
Multiple System Atrophy: Genetic or Epigenetic?
Sturm, E., & Stefanova, N. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.4.277 · Cited by 38
Circulating microRNAs as novel biomarkers of Alzheimer's disease
Zendjabil, M. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.05.039 · Cited by 38
Tau Abnormalities and the Potential Therapy in Alzheimer’s Disease
Almansoub, H. A. M. M., Tang, H. R., Wu, Y., Wang, D., Mahaman, Y. A. R., Wei, N., Almansob, Y. A. M., He, W., & Liu, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180868 · Cited by 39
miRNA degradation in the mammalian brain
Kim, C. K., & Pak, T. R. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00303.2020 · Cited by 36
Makarova, J. A., Shkurnikov, M. Y., Turchinovich, A. A., Tonevitsky, A., & Grigoriev, A. I. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915090035 · Cited by 35
Current progress on microRNAs ‐based therapeutics in neurodegenerative diseases
Pereira, P., Queiroz, J. A., Figueiras, A., & de Sousa, F. P. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1409 · Cited by 37
microRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease
Zhao, Y., Bhattacharjee, S., Dua, P., Alexandrov, P. N., & Lukiw, W. J. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00162 · Cited by 36
Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00116 · Cited by 34
Prediction of microRNA-disease associations based on distance correlation set
Zhao, H., Kuang, L., Wang, L., Ping, P., Xuan, Z., Pei, T., & Wu, Z. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2146-x · Cited by 35
Hsu, H.-W., Rodríguez‐Ortiz, C. J., Lim, S., Zumkehr, J., Kilian, J., Vidal, J., & Kitazawa, M. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz084 · Cited by 36
PAMAM dendrimer modified screen printed electrodes for impedimetric detection of miRNA-34a
Çongur, G., & Erdem, A. (2019) · Microchemical Journal · doi:10.1016/j.microc.2019.05.040 · Cited by 35
Identification of serum microRNAs as diagnostic biomarkers for schizophrenia
He, K., Guo, C., Guo, M., Tong, S., Zhang, Q., Sun, H., He, L., & Shi, Y. (2019) · Hereditas · doi:10.1186/s41065-019-0099-3 · Cited by 35
Shigemizu, D., Akiyama, S., Asanomi, Y., Boroevich, K. A., Sharma, A. K., Tsunoda, T., Sakurai, T., Ozaki, K., Ochiya, T., & Niida, S. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0607-3 · Cited by 36
Nguyen, L. D., Chau, R. K., & Krichevsky, A. M. (2021) · Genes · doi:10.3390/genes12122005 · Cited by 37
Circulating miRNAs profiles in tourette syndrome: molecular data and clinical implications
Rizzo, R., Ragusa, M., Barbagallo, C., Sammito, M., Gulisano, M., Calì, P. V., Pappalardo, C., Barchitta, M., Granata, M., Condorelli, A. G., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0133-y · Cited by 35
Holm, A., Bang‐Berthelsen, C. H., Knudsen, S., Kornum, B. R., Modvig, S., Jennum, P., & Gammeltoft, S. (2014) · SLEEP · doi:10.5665/sleep.4004 · Cited by 35
Li, X., Zhao, J., Li, Z., Zhang, L., & Huo, Z. (2020) · Neural Plasticity · doi:10.1155/2020/8850653 · Cited by 35
Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease
Leszek, J., Sochocka, M., & Gąsiorowski, K. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.09.010 · Cited by 34
Shalaby, T., Fiaschetti, G., Baumgartner, M., & Grotzer, M. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121554 · Cited by 35
Chanudet, E., Wozniak, M. B., Bouaoun, L., Byrnes, G. B., Феликсовна, М. А., Zaridze, D. G., Brennan, P., Muller, D. C., & Scélo, G. (2017) · International Journal of Cancer · doi:10.1002/ijc.30845 · Cited by 34
MicroRNA predicts cognitive performance in healthy older adults
Gullett, J. M., Chen, Z., O’Shea, A. M., Akbar, M., Bian, J., Rani, A., Porges, E. C., Foster, T. C., Woods, A. J., Modave, F. P., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.07.023 · Cited by 34
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Codocedo, J. F., Ríos, J. A., Godoy, J. A., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9201-7 · Cited by 34
Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer’s Disease
Arora, T., Prashar, V., Singh, R., Barwal, T. S., Changotra, H., Sharma, A., & Parkash, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02950-z · Cited by 37
Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy
Sandi, C., Al‐Mahdawi, S., & Pook, M. A. (2013) · Genetics Research International · doi:10.1155/2013/852080 · Cited by 38
MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS
Baraniskin, A., Chomiak, M., Ahle, G., Gress, T. M., Buchholz, M., Turewicz, M., Eisenacher, M., Margold, M., Schlegel, U. S., Schmiegel, W., et al. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2749-0 · Cited by 34
MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer’s Disease
Raffaele, I., Silvestro, S., & Mazzon, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054736 · Cited by 33
Pharmacological potential of RNAi — Focus on miRNA
Pfeifer, A., & Lehmann, H. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.03.006 · Cited by 32
Circular RNA in Aging and Age-Related Diseases
Yang, D., Yang, K., & Yang, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_2 · Cited by 33
Non-coding RNA influences in dementia
Ayers, D., & Scerri, C. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.09.002 · Cited by 32
Vergallo, A., Lista, S., Zhao, Y., Lemercier, P., Teipel, S. J., Potier, M., Habert, M., Dubois, B., Lukiw, W. J., Hampel, H. J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01184-8 · Cited by 35
microRNA: human disease and development
Gomase, V. S., & Parundekar, A. N. (2009) · International Journal of Bioinformatics Research and Applications · doi:10.1504/ijbra.2009.028678 · Cited by 33
A microRNA diagnostic biomarker for amyotrophic lateral sclerosis
Banack, S. A., Dunlop, R. A., Mehta, P., Mitsumoto, H., Wood, S. P., Han, M., & Cox, P. A. (2024) · Brain Communications · doi:10.1093/braincomms/fcae268 · Cited by 34
Metadata
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
