The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Open accessAbstract
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common acute and severe cases of the respiratory system with complicated pathogenesis and high mortality. Sepsis is the leading indirect cause of ALI/ARDS in the intensive care unit (ICU). The pathogenesis of septic ALI/ARDS is complex and multifactorial. In the development of sepsis, the disruption of the intestinal barrier function, the alteration of gut microbiota, and the translocation of the intestinal microbiome can lead to systemic and local inflammatory responses, which further alter the immune homeostasis in the systemic environment. Disruption of homeostasis may promote and propagate septic ALI/ARDS. In turn, when ALI occurs, elevated levels of inflammatory cytokines and the shift of the lung microbiome may lead to the dysregulation of the intestinal microbiome and the disruption of the intestinal mucosal barrier. Thus, the interaction between the lung and the gut can initiate and potentiate sepsis-induced ALI/ARDS. The gut–lung crosstalk may be a promising potential target for intervention. This article reviews the underlying mechanism of gut-lung crosstalk in septic ALI/ARDS.
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“The inflammatory cascade stemming from GI-released bacteria and endotoxins can exacerbate pulmonary dysfunction, leading to acute respiratory distress syndrome (ARDS) [27], worsening pulmonary outcomes [28].”
From Gastrointestinal function and nutritional interventions in septic shock (2025) · cites this paper as [27]
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Cites
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Metadata
- Authors
- Zhou, X., & Liao, Y.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Zhou, Xin
- ORCID
- Zhou, Xin
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-12-23
- Volume
- 12
- Pages
- 779620-779620
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC8733643
- OpenAlex
- W4200159901
- Cited by
- 153
- References
- 115
- Citations by year
- 2026: 36 · 2025: 48 · 2024: 38 · 2023: 25 · 2022: 6
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- sepsis, acute lung injury, acute respiratory distress syndrome, intestinal barrier dysfunction, gut microbiota, lung microbiome, inflammatory cytokines, immune dysregulation, sepsis pathogenesis
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