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Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders
Open accessAbstract
The fornix is a part of the limbic system and constitutes the major efferent and afferent white matter tracts from the hippocampi. The underdevelopment of or injuries to the fornix are strongly associated with memory deficits. Its role in memory impairments was suggested long ago with cases of surgical forniceal transections. However, recent advances in brain imaging techniques, such as diffusion tensor imaging, have revealed that macrostructural and microstructural abnormalities of the fornix correlated highly with declarative and episodic memory performance. This structure appears to provide a robust and early imaging predictor for memory deficits not only in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease and multiple sclerosis, but also in schizophrenia and psychiatric disorders, and during neurodevelopment and "typical" aging. The objective of the manuscript is to present a systematic review regarding published brain imaging research on the fornix, including the development of its tracts, its role in various neurological diseases, and its relationship to neurocognitive performance in human studies.
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“Compared with other limbic white matter pathways, correlations between white matter microstructure and episodic memory in healthy populations are much more reliably found for the fornix than the cingulum (e.g., Douet and Chang, 2015; Metzler-Baddeley et al., 2011; Rudebeck et al., 2009).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Douet and Chang, 2015
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Metadata
- Authors
- Douet, V., & Chang, L.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- Douet, Vanessa
- Chang, Linda
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-01-14
- Volume
- 6
- Pages
- 343-343
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC4294158
- OpenAlex
- W2070157918
- Cited by
- 122
- References
- 145
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 21 · 2022: 11 · 2021: 14 · 2020: 17 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 5 · 2015: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (MD007601)
- National Institute on Drug Abuse (K24DA016170)
- National Institute on Minority Health and Health Disparities (G12MD007601)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- fornix, episodic memory, memory impairment, healthy aging, Alzheimer's disease, multiple sclerosis, schizophrenia, neuroinflammation, neurodegeneration, diffusion tensor imaging, white matter microstructure, hippocampal connectivity, limbic system, brain development, imaging biomarkers
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