Cited by 489Neurological disorders and treatmentsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons

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Wall, Nicholas R., De La Parra, Mauricio, Callaway, Edward M., Kreitzer, Anatol C.·2013·Neuron

Abstract

The striatum integrates information from multiple brain regions to shape motor learning. The two major projection cell types in striatum target different downstream basal ganglia targets and have opposing effects on motivated behavior, yet differential innervation of these neuronal subtypes is not well understood. To examine whether input specificity provides a substrate for information segregation in these circuits, we used a monosynaptic rabies virus system to generate brain-wide maps of neurons that form synapses with direct- or indirect-pathway striatal projection neurons. We discovered that sensory cortical and limbic structures preferentially innervated the direct pathway, whereas motor cortex preferentially targeted the indirect pathway. Thalamostriatal input, dopaminergic input, as well as input from specific cortical layers, was similar onto both pathways. We also confirm synaptic innervation of striatal projection neurons by the raphe and pedunculopontine nuclei. Together, these findings provide a framework for guiding future studies of basal ganglia circuit function.

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Crossref · 10.1016/j.neuron.2013.05.014

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  • The failure to observe vasopressinergic input to CA2 from the paraventricular nucleus may reflect an inability of the transsynaptic rabies tracing system to label peptidergic inputs.

    “we failed to observe vasopressinergic input to CA2 from the paraventricular nucleus of the hypothalamus13, which may reflect an inability of the transsynaptic rabies tracing system to label peptidergic inputs15.”

    From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [15]

  • The CeA sends a direct, likely inhibitory projection to the striatum.

    “It sends a direct, likely inhibitory33, projection to the striatum30,34,35 and is, thus, poised to oppose striatal activity.”
  • DMS D1 and A2A neurons receive projections from BLA and CeA.

    “rabies-labeled, DMS D1-projecting cell bodies in the BLA and CeA (right), consistent with prior reports30,34.”

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Authors
Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C.
Affiliations
  • Salk Institute for Biological Studies (US)
  • Gladstone Institutes (US)
Corresponding author
  • Callaway, Edward M.
  • Kreitzer, Anatol C.
Venue
Neuron
Publisher
Elsevier BV
Published
2013-07
Volume
79
Issue
2
Pages
347-360
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2074651284
Cited by
489
References
69
Citations by year
2026: 19 · 2025: 33 · 2024: 39 · 2023: 40 · 2022: 28 · 2021: 44 · 2020: 38 · 2019: 36 · 2018: 42 · 2017: 48 · 2016: 53 · 2015: 34 · 2014: 32 · 2013: 3
FWCI
25.83
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Gatsby Charitable Foundation
  • National Institutes of Health
  • National Institute of Mental Health (MH063912, R01MH063912)
  • National Institute on Drug Abuse (P01DA010154, DA-010154)
  • National Institute of Neurological Disorders and Stroke (NS064984, R01NS078435, R01NS064984)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
striatum, direct pathway, indirect pathway, striatal projection neurons, synaptic innervation, basal ganglia, dopaminergic input, motor cortex, sensory cortex, limbic structures, raphe nuclei, information segregation, motor learning
MeSH terms
Animals, Cerebral Cortex, Corpus Striatum, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neural Pathways, Neurons, Mice, HEK293 Cells

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