Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice
Open accessAbstract
Nicotinic acetylcholine receptors (nAChRs) are essentially involved in learning and memory. A neurobiologically and behaviorally well-characterized measure of learning and memory, eyeblink classical conditioning, is sensitive to disruptions in acetylcholine neurotransmission. The two most common forms of eyeblink classical conditioning - the delay and trace paradigms - differentially engage forebrain areas densely-populated with nAChRs. The present study used genetically modified mice to investigate the effects of selective nAChR subunit deletion on delay and trace eyeblink classical conditioning. α7 and β2 nAChR subunit knockout (KO) mice and their wild-type littermates were trained for 10 daily sessions in a 500-ms delay or 500-ms trace eyeblink conditioning task, matched for the interstimulus interval between conditioned stimulus and unconditioned stimulus onset. Impairments in conditioned responding were found in α7 KO mice trained in trace - but not delay - eyeblink conditioning. Relative to littermate controls, β2 KO mice were unimpaired in the trace task but displayed higher levels of conditioned responding in delay eyeblink conditioning. Elevated conditioned response levels in delay-conditioned β2 KOs corresponded to elevated levels of alpha responding in this group. These findings suggest that α7 nAChRs play a role in normal acquisition of 500 ms trace eyeblink classical conditioning in mice. The prominent distribution of α7 nAChRs in the hippocampus and other forebrain regions may account for these genotype-specific acquisition effects in this hippocampus-dependent trace paradigm.
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Mice lacking the α7 subunit have impaired trace eye-blink conditioning.
“Mice lacking the α7 subunit have been shown to have impaired trace eye-blink conditioning (Brown et al. 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Brown et al. 2010
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Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
Ndiaye, M., Lespez, L., Tribolo, C., Rassé, M., Hadjas, I., Davidoux, S., Huysecom, É., & Douze, K. (2024) · Monash University Research Portal (Monash University) · doi:10.3929/ethz-b-000667478 · Cited by 24,015 · see citing works
Theta oscillations in the hippocampus
Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332 · see citing works
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
The Neurobiology of Learning and Memory
Thompson, R. F. (1986) · Science · doi:10.1126/science.3738519 · Cited by 1,159 · see citing works
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Hasselmo, M. E., Bodelón, C., & Wyble, B. P. (2002) · Neural Computation · doi:10.1162/089976602317318965 · Cited by 875 · see citing works
Solomon, P. R., Schaaf, E. R. V., Thompson, R. F., & Weisz, D. J. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.5.729 · Cited by 724 · see citing works
Solomon, P. R., Vander Schaaf, E. R., Thompson, R. F., & Weisz, D. J. (1986) · Behavioral Neuroscience · doi:10.1037/0735-7044.100.5.729 · Cited by 724 · see citing works
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668 · see citing works
Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
Moyer, J. R., Deyo, R. A., & Disterhoft, J. F. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000079 · Cited by 664 · see citing works
Neural Substrates of Eyeblink Conditioning: Acquisition and RetentionPreprint
Christian, K. M., & Thompson, R. F. (2003) · Learning & Memory · doi:10.1101/lm.59603 · Cited by 609 · see citing works
Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
Moyer, J. R., Deyo, R. A., & Disterhoft, J. F. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.2.243 · Cited by 609 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Self-citationNicotinic receptors in the brain: correlating physiology with function
Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 447 · see citing works
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387 · see citing works
Frazier, C. J., Rollins, Y. D., Breese, C. R., Leonard, S., Freedman, R., & Dunwiddie, T. V. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01187.1998 · Cited by 374 · see citing works
Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus
Fabian‐Fine, R., Skehel, P., Errington, M. L., Davies, H. A., Sher, E., Stewart, M. G., & Fine, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07993.2001 · Cited by 361 · see citing works
A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity
Paulsen, O., & Moser, E. I. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01205-8 · Cited by 338 · see citing works
Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329 · see citing works
Solomon, P. R., Solomon, S. D., Schaaf, E. R. V., & Perry, H. E. (1983) · Science · doi:10.1126/science.6836277 · Cited by 326 · see citing works
Prediction of Learning Rate from the Hippocampal Electroencephalogram
Berry, S. D., & Thompson, R. F. (1978) · Science · doi:10.1126/science.663612 · Cited by 311 · see citing works
Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A. (1998) · Learning & Memory · doi:10.1101/lm.5.4.302 · Cited by 298 · see citing works
Nicotinic receptor function: new perspectives from knockout mice
Cordero‐Erausquin, M., Marubio, L. M., Klink, R., & Changeux, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01489-9 · Cited by 293 · see citing works
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00880-4 · Cited by 263 · see citing works
Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat Hippocampus
McQuiston, A. R., & Madison, D. V. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02887.1999 · Cited by 239 · see citing works
Chen, L., Bao, S., Lockard, J. M., Kim, J. K., & Thompson, R. F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02829.1996 · Cited by 223 · see citing works
Cortical involvement in acquisition and extinction of trace eyeblink conditioning.
Weible, A. P., McEchron, M. D., & Disterhoft, J. F. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.6.1058 · Cited by 212 · see citing works
Walters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0295-x · Cited by 206 · see citing works
Oscillatory brain states and learning: Impact of hippocampal theta-contingent training
Seager, M. A., Johnson, L. D., Chabot, E. S., Asaka, Y., & Berry, S. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032662099 · Cited by 200 · see citing works
Alkondon, M., & Albuquerque, E. X. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45007-3 · Cited by 197 · see citing works
Cortical involvement in acquisition and extinction of trace eyeblink conditioning.
Weible, A. P., McEchron, M. D., & Disterhoft, J. F. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.6.1058 · Cited by 181 · see citing works
Nicotinic control of axon excitability regulates thalamocortical transmission
Kawai, H., Lazar, R., & Metherate, R. (2007) · Nature Neuroscience · doi:10.1038/nn1956 · Cited by 171 · see citing works
Dickinson, J. A., Kew, J. N. C., & Wonnacott, S. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046623 · Cited by 159 · see citing works
Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioningPreprint
Kalmbach, B. E., Ohyama, T., Kreider, J. C., Riusech, F., & Mauk, M. D. (2009) · Learning & Memory · doi:10.1101/lm.1178309 · Cited by 136 · see citing works
Trace eyeblink conditioning is hippocampally dependent in mice
Tseng, W., Guan, R., Disterhoft, J. F., & Weiss, C. (2003) · Hippocampus · doi:10.1002/hipo.10157 · Cited by 132 · see citing works
Griffin, A. L., Asaka, Y., Darling, R. D., & Berry, S. D. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.403 · Cited by 117 · see citing works
Hoffmann, L. C., & Berry, S. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908403106 · Cited by 104 · see citing works
Green, J. T., & Arenos, J. D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.08.014 · Cited by 98 · see citing works
Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal
De Biasi, M., & Salas, R. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-mr-355 · Cited by 95 · see citing works
Self-citationClaflin, D. I., & Stanton, M. E. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4027 · Cited by 94 · see citing works
Champtiaux, N., & Changeux, J. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339247 · Cited by 88 · see citing works
Development of ligands for in vivo imaging of cerebral nicotinic receptors
Sihver, W., Nordberg, A. K., Långström, B., Mukhin, A. G., Koren, A. O., Kimes, A. S., & London, E. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00209-6 · Cited by 86 · see citing works
Schreiber, R., Dalmus, M., & Vry, J. D. (2001) · Psychopharmacology · doi:10.1007/s00213-001-0927-8 · Cited by 84 · see citing works
Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M., & Yuzaki, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2553-07.2008 · Cited by 80 · see citing works
Rousseau, S., Jones, I. W., Pullar, I. A., & Wonnacott, S. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.030 · Cited by 77 · see citing works
Wanaverbecq, N., Semyanov, A. V., Pavlov, I., Walker, M. C., & Kullmann, D. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1732-07.2007 · Cited by 73 · see citing works
Cincotta, S. L., Yorek, M. S., Moschak, T. M., Lewis, S. R., & Rodefer, J. S. (2008) · PubMed · Cited by 71 · see citing works
Activation of α7 acetylcholine receptors augments stimulation‐induced hippocampal theta oscillation
Siok, C. J., Rogers, J. A., Kocsis, B., & Hajós, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04560.x · Cited by 68 · see citing works
Altered baroreflex responses in α7 deficient mice
Franceschini, D., Orr‐Urtreger, A., Yu, W., Mackey, L. Y., Bond, R. A., Armstrong, D. L., Patrick, J. W., Beaudet, A. L., & Biasi, M. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00195-9 · Cited by 68 · see citing works
Self-citationPortugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66 · see citing works
Hippocampal Theta Oscillations and Classical Conditioning
Berry, S. D., & Seager, M. A. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4025 · Cited by 63 · see citing works
Chen, L., Bao, S., & Thompson, R. F. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.1.204 · Cited by 60 · see citing works
Woodruff‐Pak, D. S., Green, J. T., Levin, S. I., & Meisler, M. H. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.2.229 · Cited by 58 · see citing works
Self-citationBuhler, A. V., & Dunwiddie, T. V. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00257-3 · Cited by 54 · see citing works
Champtiaux, N., & Changeux, J. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45016-4 · Cited by 53 · see citing works
Associative and motor learning in 12-month-old transgenic APP+PS1 mice
Ewers, M., Morgan, D., Gordon, M. N., & Woodruff‐Pak, D. S. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.019 · Cited by 50 · see citing works
Self-citationNicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits.
Woodruff‐Pak, D. S., Li, Y.-T., Kazmi, A., & Kem, W. R. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.3.486 · Cited by 46 · see citing works
Self-citationA general-purpose computer system for behavioral conditioning and neural recording experiments
Chen, G., & Steinmetz, J. E. (1998) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03200669 · Cited by 45 · see citing works
Woodruff‐Pak, D. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00039-1 · Cited by 44 · see citing works
Self-citationBehavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration
Maubourguet, N., Lesne, A., Changeux, J., Maskos, U., & Fauré, P. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000229 · Cited by 43 · see citing works
Neurobiology of Learning and Memory
Schiffer, R. B. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.6.792-a · Cited by 39 · see citing works
Woodruff‐Pak, D. S., Tobia, M. J., Jiao, X., Beck, K. D., & Servatius, R. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301259 · Cited by 35 · see citing works
Self-citationNicotine induction of theta frequency oscillations in rodent hippocampus in vitro
Lu, C., & Henderson, Z. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.072 · Cited by 34 · see citing works
Eyeblink Classical Conditioning: Volume I
Woodruff‐Pak, D. S., & Steinmetz, J. E. (2002) · Kluwer Academic Publishers eBooks · doi:10.1007/b108229 · Cited by 30 · see citing works
Self-citationWoodruff‐Pak, D. S., Li, Y.-T., Hinchliffe, R. M., & Port, R. L. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01191-2 · Cited by 28 · see citing works
Self-citationEyeblink Classical Conditioning
Brown, K. L., & Freeman, J. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-097086-8.55021-1 · Cited by 26 · see citing works
Self-citationNicotinic Acetylcholine Receptors and Modulation of Learning in 4- and 27-Month-Old Rabbits
Li, J., Lehr, M. A., Liu‐Chen, L., & Woodruff‐Pak, D. S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.1 · Cited by 22 · see citing works
Self-citationYakel, J. L., & Shao, Z. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45006-1 · Cited by 20 · see citing works
Woodruff‐Pak, D. S., Seta, S. E., Roker, L. A., & Lehr, M. A. (2007) · Learning & Memory · doi:10.1101/lm.504107 · Cited by 13 · see citing works
Self-citationWalker, M. (2007) · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Lindstrom J. Schoepfer R. Conroy W. Whiting P. Das M. Saedi M. Anand R. (1991). The nicotinic acetylcholine receptor gene family: structure of nicotinic receptors from muscle and neurons and neuronal α-bungarotoxin-binding proteins. Adv. Exp. Med. Biol. 287, 255– 278 1759611
- Woodruff-Pak D. S. Lehr M. A. Li J.-G. Liu-Chen L.-Y. (2010). Good learners have higher levels of brain nicotinic receptor binding than poor learners. Neurobiol. Aging 31, 1032– 1043 10.1016/j.neurobiolaging.2008.09.002 18950900 PMC2858226 · DOI
- Woodruff-Pak D. S. Steinmetz J. E. (2000b). Eyeblink Classical Conditioning, Vol. 2, Animal Models. Boston: Kluwer Academic Publishers
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Parfitt, G. M., Campos, R. C., Barbosa, Â. K., Koth, A. P., & Barros, D. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.12.001 · Cited by 43 · see citing works
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Self-citation
- Authors
- Brown, K. L., Comalli, D. M., Biasi, M. D., & Woodruff-Pak, D. S.
- Affiliations
- Temple University (US)
- Baylor College of Medicine (US)
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2010
- Volume
- 4
- Pages
- 166-166
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC2958052
- OpenAlex
- W2117143428
- Cited by
- 24
- References
- 69
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 2 · 2017: 1 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (R01AG023742, R01AG021925)
- National Institute on Drug Abuse (R01DA017173)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, alpha7 nAChR, beta2 nAChR, eyeblink classical conditioning, trace conditioning, delay conditioning, learning and memory, acetylcholine neurotransmission, hippocampus, conditioned responding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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