Cited by 95Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationPrenatal Substance Exposure Effects

Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal

De Biasi, Mariella, Salas, Ramiro·2008·Experimental Biology and Medicine

Abstract

Cigarette smoking represents an enormous, global public health threat. Nearly five million premature deaths during a single year are attributable to smoking. Despite the resounding message of risks associated with smoking and numerous public health initiatives, cigarette smoking remains the most common preventable cause of disease in the United States. Fortunately, even in an adult smoker, smoking cessation can reverse many of the potential harmful effects. The symptoms associated with nicotine withdrawal represent the major obstacle to smoking cessation. This minireview examines the roles of various nicotinic receptors in the mechanisms of nicotine dependence, discusses the potential role of the habenula-interpeduncular nucleus axis in nicotine withdrawal, and highlights nicotinic receptors containing the β4 subunit as a potential pharmacological target for smoking cessation strategies.

Integrity signals

Registry

Crossref · 10.3181/0712-mr-355

Cites

212 of 212 references verified0 citation errors · 0 not checkable

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  • The highest densities of α5, α3, and α4 nAChR subunit expression in the brain are detected in the MHb and/or IPN.

    “In particular, the highest densities of α5, α3, and α4 nAChR subunits expression in brain are detected in MHb and/or IPN (De Biasi and Salas 2008).”

    From Mechanisms of Nicotine Addiction (2021) · cites this paper as De Biasi and Salas 2008

  • In mice, after at least a week of chronic nicotine, stopping nicotine or giving an nAChR antagonist produces affective, somatic, and cognitive withdrawal signs.

    “After at least a week of chronic nicotine administration in mice, cessation of nicotine exposure or administration of a nAChR antagonist induces affective, somatic, and cognitive signs of withdrawal (Malin et al. 1994; De Biasi and Salas 2008).”

    From Nicotine Withdrawal (2015) · cites this paper as De Biasi and Salas 2008

  • Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome that can occur spontaneously or be precipitated by mecamylamine.

    “Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome which develops spontaneously, after removing the nicotine source, or can be precipitated by administration of a nAChR antagonist such as mecamylamine [7, 11, 81, 163–166].”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [7]

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Authors
De Biasi, M., & Salas, R.
Affiliations
  • Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
  • Baylor College of Medicine (US)
Venue
Experimental Biology and Medicine
Published
2008-08
Volume
233
Issue
8
Pages
917-929
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
OpenAlex
W2011582085
Cited by
95
References
212
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 11
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (R21DA029157, R01DA017173, DA17173)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
neuronal nicotinic acetylcholine receptors, nicotine dependence, nicotine withdrawal, smoking cessation, therapeutic target, cigarette smoking
MeSH terms
Animals, Dopamine, Humans, Mesencephalon, Mice, Mutant Strains, Neurons, Receptors, Nicotinic, Substance Withdrawal Syndrome, Tobacco Use Disorder, Smoking Cessation, Habenula, Feedback, Physiological, Mice, Rats

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