Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal
Abstract
Cigarette smoking represents an enormous, global public health threat. Nearly five million premature deaths during a single year are attributable to smoking. Despite the resounding message of risks associated with smoking and numerous public health initiatives, cigarette smoking remains the most common preventable cause of disease in the United States. Fortunately, even in an adult smoker, smoking cessation can reverse many of the potential harmful effects. The symptoms associated with nicotine withdrawal represent the major obstacle to smoking cessation. This minireview examines the roles of various nicotinic receptors in the mechanisms of nicotine dependence, discusses the potential role of the habenula-interpeduncular nucleus axis in nicotine withdrawal, and highlights nicotinic receptors containing the β4 subunit as a potential pharmacological target for smoking cessation strategies.
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The highest densities of α5, α3, and α4 nAChR subunit expression in the brain are detected in the MHb and/or IPN.
“In particular, the highest densities of α5, α3, and α4 nAChR subunits expression in brain are detected in MHb and/or IPN (De Biasi and Salas 2008).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as De Biasi and Salas 2008
In mice, after at least a week of chronic nicotine, stopping nicotine or giving an nAChR antagonist produces affective, somatic, and cognitive withdrawal signs.
“After at least a week of chronic nicotine administration in mice, cessation of nicotine exposure or administration of a nAChR antagonist induces affective, somatic, and cognitive signs of withdrawal (Malin et al. 1994; De Biasi and Salas 2008).”
From Nicotine Withdrawal (2015) · cites this paper as De Biasi and Salas 2008
Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome that can occur spontaneously or be precipitated by mecamylamine.
“Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome which develops spontaneously, after removing the nicotine source, or can be precipitated by administration of a nAChR antagonist such as mecamylamine [7, 11, 81, 163–166].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [7]
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Mesolimbic Dopamine and Habenulo-Interpeduncular Pathways in Nicotine Withdrawal
Dani, J. A., & De Biasi, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012138 · Cited by 34 · see citing works
Brown, K. L., Comalli, D. M., Biasi, M. D., & Woodruff-Pak, D. S. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00166 · Cited by 24 · see citing works
Self-citationThe β4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion
Radhakrishnan, R., Santamaría, A., Escobar, L., & Arias, H. R. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.08.009 · Cited by 12 · see citing works
- Authors
- De Biasi, M., & Salas, R.
- Affiliations
- Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
- Baylor College of Medicine (US)
- ORCID
- Salas, Ramiro
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2008-08
- Volume
- 233
- Issue
- 8
- Pages
- 917-929
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2011582085
- Cited by
- 95
- References
- 212
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 11
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R21DA029157, R01DA017173, DA17173)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- neuronal nicotinic acetylcholine receptors, nicotine dependence, nicotine withdrawal, smoking cessation, therapeutic target, cigarette smoking
- MeSH terms
- Animals, Dopamine, Humans, Mesencephalon, Mice, Mutant Strains, Neurons, Receptors, Nicotinic, Substance Withdrawal Syndrome, Tobacco Use Disorder, Smoking Cessation, Habenula, Feedback, Physiological, Mice, Rats
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