Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation

Artinian, Julien; McGauran, Anne‐Marie T.; De Jaeger, Xavier; Mouledous, Lionel; Frances, Bernard; Roullet, Pascal

doi:10.1111/j.1460-9568.2008.06262.x

Cited by 145Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation

Artinian, Julien, McGauran, Anne‐Marie T., De Jaeger, Xavier, Mouledous, Lionel, Frances, Bernard, Roullet, Pascal·2008·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2008.06262.x

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Abstract

The formation of long-term memory requires protein synthesis, particularly during initial memory consolidation. This process also seems to be dependant upon protein degradation, particularly degradation by the ubiquitin-proteasome system. The aim of this study was to investigate the temporal requirement of protein synthesis and degradation during the initial consolidation of allocentric spatial learning. As memory returns to a labile state during reactivation, we also focus on the role of protein synthesis and degradation during memory reconsolidation of this spatial learning. Male CD1 mice were submitted to massed training in the spatial version of the Morris water maze. At various time intervals after initial acquisition or after a reactivation trial taking place 24 h after acquisition, mice received an injection of either the protein synthesis inhibitor anisomycin or the protein degradation inhibitor lactacystin. This injection was performed into the hippocampal CA3 region, which is specifically implicated in the processing of spatial information. Results show that, in the CA3 hippocampal region, consolidation of an allocentric spatial learning task requires two waves of protein synthesis taking place immediately and 4 h after acquisition, whereas reconsolidation requires only the first wave. However, for protein degradation, both consolidation and reconsolidation require only one wave, taking place immediately after acquisition or reactivation, respectively. These finding…

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“Early studies revealed impairments in one-trial avoidance learning, spatial learning, and aversive taste memory formation on treatment with proteasome inhibitors (Lopez-Salon et al., 2001; Artinian et al., 2008; Rodriguez-Ortiz et al., 2011).”
From Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning (2021) · cites this paper as Artinian et al., 2008
Memory destabilisation depends upon the ubiquitin- and proteasome-dependent degradation of pre-existing postsynaptic proteins, as shown for fear, spatial, object recognition, and drug memories.
“Memory destabilisation depends upon the ubiquitin- and proteasome-dependent degradation of pre-existing postsynaptic proteins, as shown for fear (Lee et al., 2008; Fukushima et al., 2014; Fustiñana et al., 2014; Jarome et al., 2015; Orsi et al., 2019; Tay et al., 2019), spatial (Artinian et al., 2008), object recognition (Furini et al., 2015; Stiver et al., 2017) and drug memories (Ren et al., 201”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Artinian et al., 2008

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Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation
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Authors: Artinian, J., McGauran, A. T., De Jaeger, X., Mouledous, L., Frances, B., & Roullet, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Artinian, Julien
Roullet, Pascal
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2008-06
Volume: 27
Issue: 11
Pages: 3009-3019
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2008.06262.x
OpenAlex: W2117847158
Cited by: 145
References: 41
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 10
FWCI: 4.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche
Centre National de la Recherche Scientifique
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: protein degradation, protein synthesis, memory consolidation, memory reconsolidation, spatial memory, ubiquitin-proteasome system, hippocampal CA3, anisomycin, lactacystin, memory reactivation, Morris water maze
MeSH terms: Acetylcysteine, Animals, Anisomycin, Hippocampus, Male, Memory, Nerve Tissue Proteins, Neurons, Protein Synthesis Inhibitors, Space Perception, Cysteine Proteinase Inhibitors, Long-Term Potentiation, Maze Learning, Mice

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Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation

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