The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index, and 2 are not checked yet.
CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment
Open accessAbstract
In recent years several evidence demonstrated that some features of hippocampal biology, like neurogenesis, synaptic transmission, learning, and memory performances are deeply modulated by social, motor, and sensorial experiences. Fractalkine/CX(3)CL1 is a transmembrane chemokine abundantly expressed in the brain by neurons, where it modulates glutamatergic transmission and long-term plasticity processes regulating the intercellular communication between glia and neurons, being its specific receptor CX(3)CR1 expressed by microglia. In this paper we investigated the role of CX(3)CL1/CX(3)CR1 signaling on experience-dependent hippocampal plasticity processes. At this aim wt and CX(3)CR1(GFP/GFP) mice were exposed to long-lasting-enriched environment (EE) and the effects on hippocampal functions were studied by electrophysiological recordings of long-term potentiation of synaptic activity, behavioral tests of learning and memory in the Morris water maze paradigm and analysis of neurogenesis in the subgranular zone of the dentate gyrus (DG). We found that CX(3)CR1 deficiency increases hippocampal plasticity and spatial memory, blunting the potentiating effects of EE. In contrast, exposure to EE increased the number and migration of neural progenitors in the DG of both wt and CX(3)CR1(GFP/GFP) mice. These data indicate that CX(3)CL1/CX(3)CR1-mediated signaling is crucial for a normal experience-dependent modulation of hippocampal functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“evidence suggests it plays an important role in the regulation of synaptic function, with CX3CR1 deficiency resulting in cognitive and LTP impairments indicative of altered synaptic plasticity [42, 43].”
From Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses (2022) · cites this paper as [43]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Self-citationMicroglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,837
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · cited 2×
“A strong association between LTP and cognition has been widely described in previous studies illustrating LTP as prime candidate for the cellular mechanisms of learning and memory (Tsien et al., 1996; Malenka, 2003).”
BackgroundEnriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771
Transient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,540
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
Cameron, H. A., Woolley, C. S., McEwen, B. S., & Gould, E. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90335-d · Cited by 1,215
Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209
Bezzi, P., Domercq, M., Brambilla, L., Galli, R., Schols, D., De Clercq, E., Vescovi, A., Bagetta, G., Kollias, G., Meldolesi, J., et al. (2001) · Nature Neuroscience · doi:10.1038/89490 · Cited by 1,102
A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853
Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
Meucci, O., Fatatis, A., Simen, A. A., Bushell, T. J., Gray, P. W., & Miller, R. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14500 · Cited by 704
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies
Garthe, A., Behr, J., & Kempermann, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005464 · Cited by 597
Effects of differential experience on dendritic spine counts in rat cerebral cortex
Globus, A., Rosenzweig, M. R., Bennett, E. L., & Diamond, M. C. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0033910 · Cited by 436
Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats
Bachstetter, A. D., Morganti, J. M., Jernberg, J., Schlunk, A., Mitchell, S. H., Brewster, K. W., Hudson, C. E., Cole, M. J., Harrison, J. K., Bickford, P. C., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.022 · Cited by 364
Duffy, S. N., Craddock, K. J., Abel, T. G., & Nguyen, P. (2001) · Learning & Memory · doi:10.1101/lm.36301 · Cited by 349
Chemokines in the CNS: plurifunctional mediators in diverse states
Asensio, V. C., & Campbell, I. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01453-8 · Cited by 348
Chemokines: a new class of neuromodulator?
Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2255 · Cited by 321
Otto, T., Eichenbaum, H., Wible, C. G., & Wiener, S. I. (1991) · Hippocampus · doi:10.1002/hipo.450010206 · Cited by 311
Chemokine receptors: signposts to brain development and disease
Tran, P. B., & Miller, R. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1116 · Cited by 295
Cxcr7 controls neuronal migration by regulating chemokine responsiveness
Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.006 · Cited by 290
Spine loss and other dendritic abnormalities in epilepsy
Swann, J. W., Al‐Noori, S., Jiang, M., & Lee, C. L. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:5 · Cited by 268
Paradoxical influence of hippocampal neurogenesis on working memory
Saxe, M., Malleret, G., Vronskaya, S., Mendez‐David, I., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., & Hen, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611718104 · Cited by 244
The long-term potential of LTP
Malenka, R. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1258 · Cited by 229
Short-Term Synaptic Plasticity
Zucker, R. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.12.1.13 · Cited by 202
Green, E. J., & Greenough, W. T. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.55.4.739 · Cited by 180
Genome gymnastics: unique modes of dna evolution and processing in ciliates
Prescott, D. M. (2000) · Nature Reviews Genetics · doi:10.1038/35042057 · Cited by 170
Spatial Memory and Learning in Transgenic Mice: Fact or Artifact?
Wolfer, D. P., Stagljar, M., Errington, M. L., & Lipp, H. (1998) · Physiology · doi:10.1152/physiologyonline.1998.13.3.118 · Cited by 169
Cognitive function in young and adult IL (interleukin)-6 deficient mice
Braida, D., Sacerdote, P., Panerai, A. E., Bianchi, M., Aloisi, A. M., Iosuè, S., & Sala, M. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.018 · Cited by 164
Giovannelli, A., Limatola, C., Ragozzino, D., Mileo, A. M., Ruggieri, A., Ciotti, M. T., Mercanti, D., Santoni, A., & Eusebi, F. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00192-1 · Cited by 150
Temporally-specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology
Kapur, N., & Brooks, D. J. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:3 · Cited by 142
Ragozzino, D., Angelantonio, S. D., Trettel, F., Bertollini, C., Maggi, L., Gross, C., Charo, I., Limatola, C., & Eusebi, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3192-06.2006 · Cited by 131
Self-citationMechanism of altered synaptic strength due to experience: relation to long-term potentiation
Foster, T. C., Gagné, J., & Massicotte, G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00707-x · Cited by 131
SDF‐1α‐mediated modulation of synaptic transmission in rat cerebellum
Limatola, C., Giovannelli, A., Maggi, L., Ragozzino, D., Castellani, L., Ciotti, M. T., Vacca, F., Mercanti, D., Santoni, A., & Eusebi, F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00139.x · Cited by 127
Self-citationCBP is required for environmental enrichment‐induced neurogenesis and cognitive enhancement
López‐Atalaya, J. P., Ciccarelli, A., Viosca, J., Valor, L. M., Jimenez-Minchan, M., Canals, S., Giustetto, M., & Barco, Á. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.299 · Cited by 111
Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1995) · Learning & Memory · doi:10.1101/lm.2.1.40 · Cited by 104
Harris, A. P., D’Eath, R. B., & Healy, S. D. (2009) · Animal Behaviour · doi:10.1016/j.anbehav.2009.02.019 · Cited by 102
Maggi, L., Trettel, F., Scianni, M., Bertollini, C., Eusebi, F., Fredholm, B. B., & Limatola, C. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.07.016 · Cited by 84
Self-citationEpigenetic regulation of neurogenesis in the adult hippocampus
Covic, M., Karaca, E., & Lie, D. C. (2010) · Heredity · doi:10.1038/hdy.2010.27 · Cited by 83
Goshen, I., Avital, A., Kreisel, T., Licht, T., Segal, M., & Yirmiya, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5352-08.2009 · Cited by 82 · cited 2×
“Interestingly, it has been recently reported that mice lacking type 1 receptor for interleukin 1 (IL-1) display impaired hippocampal memory and LTP that are restored by EE (Goshen et al., 2009).”
BackgroundFractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices
Bertollini, C., Ragozzino, D., Gross, C. T., Limatola, C., & Eusebi, F. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.05.027 · Cited by 82
Regulation of calcium currents by chemokines and their receptors
Oh, S. B., Endoh, T., Simen, A. A., Ren, D., & Miller, R. J. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00485-4 · Cited by 81
Pacteau, C., Einon, D. F., & Sinden, J. D. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80092-0 · Cited by 73
Lax, P., Limatola, C., Fucile, S., Trettel, F., Bartolomeo, S. D., Renzi, M., Ragozzino, D., & Eusebi, F. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00178-9 · Cited by 52
Engellenner, W. J., Goodlett, C. R., Burright, R. G., & Donovick, P. J. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90339-0 · Cited by 28
Johnson, F. A., Dawson, A. J., & Meyer, R. L. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990419)406:4 · Cited by 23
Tremml, P., Lipp, H., Müller, U., & Wolfer, D. P. (2002) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2002.10405.x · Cited by 22
Cited by
Sorted by citations
Maphis, N., Xu, G., Kokiko-Cochran, O. N., Jiang, S., Cardona, A., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Brain · doi:10.1093/brain/awv081 · Cited by 595
Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K., & Tremblay, M. (2017) · The Journal of Physiology · doi:10.1113/jp272134 · Cited by 562
Hoshiko, M., Arnoux, I., Avignone, E., Yamamoto, N., & Audinat, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1167-12.2012 · Cited by 384
“Several studies on adult rodents have reported that CX3CL1/R1 signaling, probably by controlling the activation state of MGCs, has an impact on functional properties and plasticity of hippocampal glutamate synapses (Ragozzino et al., 2006; Maggi et al., 2011; Rogers et al., 2011).”
BackgroundBeumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347
Neuron–glia crosstalk in health and disease: fractalkine and CX 3 CR1 take centre stage
Sheridan, G. K., & Murphy, K. J. (2013) · Open Biology · doi:10.1098/rsob.130181 · Cited by 358
Metadata
- Authors
- Maggi, L.
- Affiliations
- Istituto Pasteur (IT)
- Corresponding author
- Maggi, Laura
- ORCID
- Maggi, Laura
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 22-22
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3198035
- OpenAlex
- W2005933589
- Cited by
- 149
- References
- 56
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 6 · 2022: 14 · 2021: 17 · 2020: 7 · 2019: 14 · 2018: 7 · 2017: 15 · 2016: 13 · 2015: 8 · 2014: 16 · 2013: 7 · 2012: 10
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- Ministero della Salute
- Fondazione Pierfranco e Luisa Mariani
- Istituto Pasteur-Fondazione Cenci Bolognetti
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CX3CR1, fractalkine, microglia, environmental enrichment, hippocampal plasticity, long-term potentiation, spatial memory, dentate gyrus neurogenesis, experience-dependent plasticity, learning and memory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
