The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Microglia, seen from the CX3CR1 angle
Open accessAbstract
Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.
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“Activated microglia also support neuronal survival and function by engulfing pathogens, cellular debris, or other neurotoxic entities and can synthesize various neurotrophic factors to promote tissue maintenance and repair (63, 64). However, the excessive or sustained activation of microglial cells (such as in chronic neurodegenerative diseases) usually produces significant inflammatory collateral”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [64]
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Metadata
- Authors
- Wolf, Y., Yona, S., Kim, K.-W., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- University College London (GB)
- Yale University (US)
- Corresponding author
- Jung, Steffen
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 26-26
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3600435
- OpenAlex
- W1963664876
- Cited by
- 316
- References
- 76
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 27 · 2016: 20 · 2015: 20 · 2014: 28 · 2013: 10
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- microglia, CX3CR1, chemokine receptor signaling, CNS homeostasis
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