The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Brain and Retinal Pericytes: Origin, Function and Role
Open accessAbstract
Pericytes are specialized mural cells located at the abluminal surface of capillary blood vessels, embedded within the basement membrane. In the vascular network these multifunctional cells fulfil diverse functions, which are indispensable for proper homoeostasis. They serve as microvascular stabilizers, are potential regulators of microvascular blood flow and have a central role in angiogenesis, as they for example regulate endothelial cell proliferation. Furthermore, pericytes, as part of the neurovascular unit, are a major component of the blood-retina/brain barrier. CNS pericytes are a heterogenic cell population derived from mesodermal and neuro-ectodermal germ layers acting as modulators of stromal and niche environmental properties. In addition, they display multipotent differentiation potential making them an intriguing target for regenerative therapies. Pericyte-deficiencies can be cause or consequence of many kinds of diseases. In diabetes, for instance, pericyte-loss is a severe pathological process in diabetic retinopathy (DR) with detrimental consequences for eye sight in millions of patients. In this review, we provide an overview of our current understanding of CNS pericyte origin and function, with a special focus on the retina in the healthy and diseased. Finally, we highlight the role of pericytes in de- and regenerative processes.
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“PDGFRβ expression in pericytes is noticeably higher than in SMCs18,25,26.”
From Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction (2019) · cites this paper as [26]
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RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
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RetractedRetracted Article: Pericyte-mediated vasoconstriction underlies TBI-induced hypoperfusion
Dore‐Duffy, P., Wang, S. S., Mehedi, A., Katyshev, V., Cleary, K., Tapper, A., Reynolds, C. A., Ding, Y., Zhan, P., Rafols, J. A., et al. (2011) · Neurological Research · doi:10.1179/016164111x12881719352372 · Cited by 69
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“As these cells, next to pericyte markers (NG2+, CD146+, aSMA+), also expressed markers typical for MSCs, the authors suggested that MSCs may have developed from perivascular cells/pericytes (Caplan, 2008; Crisan et al., 2008).”
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Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Pericytes regulate the blood–brain barrier
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Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
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Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128
Endothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048
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Metadata
- Authors
- Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K. A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., Aigner, L., Rivera, F. J., & Reitsamer, H. A.
- Affiliations
- Paracelsus Medical University (AT)
- Corresponding author
- Reitsamer, Herbert A.
- ORCID
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-02-04
- Volume
- 10
- Pages
- 20-20
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4740376
- OpenAlex
- W2312261107
- Cited by
- 244
- References
- 141
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 20 · 2023: 23 · 2022: 25 · 2021: 27 · 2020: 24 · 2019: 33 · 2018: 26 · 2017: 26 · 2016: 8
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Glaucoma Research Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- pericytes, retinal pericytes, brain pericytes, neurovascular unit, blood-retinal barrier, blood-brain barrier, angiogenesis, pericyte loss, diabetic retinopathy, pericyte heterogeneity, multipotent differentiation, regenerative therapy
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