Cited by 227Pain Mechanisms and TreatmentsFibromyalgia and Chronic Fatigue Syndrome ResearchPain Management and Treatment

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Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions

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Eller-Smith, Olivia C., Nicol, Andrea L., Christianson, Julie A.·2018·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2018.00035PMC PMC5816755

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Abstract

Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic functional disorders that are often categorized as centralized pain syndromes include fibromyalgia, chronic pelvic pain syndromes, migraine, and temporomandibular disorder. Patients often suffer from widespread pain, associated with more than one specific syndrome, and report fatigue, mood and sleep disturbances, and poor quality of life. The high degree of symptom comorbidity and a lack of definitive underlying etiology make these syndromes notoriously difficult to treat. The main purpose of this review article is to discuss potential mechanisms of centrally-driven pain amplification and how they may contribute to increased comorbidity, poorer pain outcomes, and decreased quality of life in patients diagnosed with centralized pain syndromes, as well as discuss emerging non-pharmacological therapies that improve symptomology associated with these syndromes. Abnormal regulation and output of the hypothalamic-pituitary-adrenal (HPA) axis is commonly associated with centralized pain disorders. The HPA axis is the primary stress response system and its activation results in downstream production of cortisol and a dampening of the immune response. Patients with centralized pain syndromes often present with hyper- or hypocortisolism and evidence of altered downstream signaling from the HPA axis including increased Mast cell (MC) infiltration and activation, which can lead to sensitization of nearby nociceptive afferents. Increased peripheral input via nociceptor activation can lead to "hyperalgesic priming" and/or "wind-up" and eventually to central sensitization through long term potentiation in the central nervous system. Other evidence of central modifications has been observed through brain imaging studies of functional connectivity and magnetic resonance spectroscopy and are shown to contribute to the widespreadness of pain and poor mood in patients with fibromyalgia and chronic urological pain. Non-pharmacological therapeutics, including exercise and cognitive behavioral therapy (CBT), have shown great promise in treating symptoms of centralized pain.

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Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.
(1985) · Europe PMC (PubMed Central) · Cited by 9,143
1969 Cancer Facts and Figures
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1×
“…enhances pain-related afferent input to the central nervous system; however, they also generate and maintain peripheral neurogenic inflammation by releasing neuropeptides, including SP and CGRP, which perpetuates inflammatory mediator release in the proximate milieu (Julius and Basbaum, 2001).”
Background
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The Economic Costs of Pain in the United States
Gaskin, D. J., & Richard, P. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.03.009 · Cited by 2,359
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434
Cognitive-Behavioral Therapy for Adult Anxiety Disorders: A Meta-Analysis of Randomized Placebo-Controlled Trials
Hoffman, S. G., & Smits, J. A. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0415 · Cited by 1,420
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257
A new view on hypocortisolism
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204
Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161
Protease-Activated Receptors: Contribution to Physiology and Disease
Ossovskaya, V., & Bunnett, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,089
Corticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Steinhoff, M. S., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., et al. (2000) · Nature Medicine · doi:10.1038/72247 · Cited by 936
Estimates of Pain Prevalence and Severity in Adults: United States, 2012
Nahin, R. L. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.05.002 · Cited by 918 · cited 1×
“There are currently 120 million chronic pain patients (Nahin, 2015), which is greater than those suffering from cardiovascular disease (85.6 million, Mozaffarian et al., 2016), diabetes (29.1 million, ADA, 2016), or cancer (14.5 million, ACS, 2016).”
BackgroundInfluential
The Triggers or Precipitants of the Acute Migraine Attack
Kelman, L. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01303.x · Cited by 871
Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 820
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction
Silverman, M. N., & Sternberg, E. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06633.x · Cited by 775
Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A., Wang, E., Ruiz, G. W., de Groat, W. C., Apodaca, G. L., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703
AUA Guideline for the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Hanno, P. M., Burks, D., Clemens, J. Q., Dmochowski, R. R., Erickson, D. R., FitzGerald, M. P., Forrest, J. B., Gordon, B., GRAY, M. L., Mayer, R. D., et al. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.03.064 · Cited by 689
Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome
Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., Lopez, Y., & Mackillip, F. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371106 · Cited by 679
Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus
Steward, O., & Levy, W. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00284.1982 · Cited by 676
Neurobiology of fibromyalgia and chronic widespread pain
Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671
Mast cells synthesize, store, and release nerve growth factor.
Léon, A., Buriani, A., Toso, R. D., Fabris, M., Romanello, S., Aloe, L., & Levi‐Montalcini, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3739 · Cited by 669
Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases
Tekataş, A., & Mungen, B. (2013) · European Neurology · doi:10.1159/000354165 · Cited by 665
Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy
Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601
Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres
Mendell, L. M., & Wall, P. D. (1965) · Nature · doi:10.1038/206097a0 · Cited by 586
Conditioned Pain Modulation in Populations With Chronic Pain: A Systematic Review and Meta-Analysis
Lewis, G. N., Rice, D. A., & McNair, P. J. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.07.005 · Cited by 564
Neurophysiologic evidence for a central sensitization in patients with fibromyalgia
Desmeules, J. A., Cedraschi, C., Rapiti, E., Baumgartner, E., Finckh, A., Cohen, P., Dayer, P., & VISCHER, T. L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10893 · Cited by 561
Cortical excitation and chronic pain
Zhuo, M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.003 · Cited by 534
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526
H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
Waldmann, R., & Lazdunski, M. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80070-6 · Cited by 511
The effect of exercise on depression, anxiety and other mood states: A review
Byrne, A., & Byrne, D. G. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90050-p · Cited by 497
Critical role of nociceptor plasticity in chronic pain
Reichling, D. B., & Levine, J. D. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.007 · Cited by 495
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
Vellani, V., Mapplebeck, S., Moriondo, A., Davis, J. B., & McNaughton, P. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00813.x · Cited by 488
Heterogeneity of Mast Cells and Phenotypic Change Between Subpopulations
Kitamura, Y. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.000423 · Cited by 475
Voluntary wheel running: a review and novel interpretation
Sherwin, C. M. (1998) · Animal Behaviour · doi:10.1006/anbe.1998.0836 · Cited by 459
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
Bhave, G. B., Hu, H., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S., & Gereau, R. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2032100100 · Cited by 459
Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn
Ikeda, H., Stark, J., Fischer, H., Wagner, M. W., Drdla-Schutting, R., Jäger, T., & Sandkühler, J. (2006) · Science · doi:10.1126/science.1127233 · Cited by 451
Mast cells are closely apposed to nerves in the human gastrointestinal mucosa
Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445
Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury
Scholz, J., Broom, D. C., Youn, D. H., Mills, C. D., Kohno, T., Suter, M. R., Moore, K. A., Décosterd, I., Coggeshall, R. E., & Woolf, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-05.2005 · Cited by 437
Physical Activity Improves Symptoms in Irritable Bowel Syndrome: A Randomized Controlled Trial
Johannesson, E., Simrén, M., Strid, H., Bajor, A., & Sadik, R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.480 · Cited by 431
Clinical Importance of Pain and Stress in Preterm Neonates
Anand, K. J. S. (1997) · Neonatology · doi:10.1159/000013953 · Cited by 427
A comparison of cognitive-behavioral therapy and relaxation training for the treatment of depression in adolescents.
Reynolds, W. M., & Coats, K. I. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.54.5.653 · Cited by 425
TRPA1: A Gatekeeper for Inflammation
Bautista, D. M., Pellegrino, M., & Tsunozaki, M. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183811 · Cited by 411
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405
Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
Galli, S. J., & Tsai, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040559 · Cited by 403
Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: Effects of naloxone
Janal, M. N., Colt, E. W. D., Clark, C. W., & Glusman, M. (1984) · Pain · doi:10.1016/0304-3959(84)90061-7 · Cited by 400
Prevalence of Fibromyalgia: A Population‐Based Study in Olmsted County, Minnesota, Utilizing the Rochester Epidemiology Project
Vincent, A., Lahr, B. D., Wolfe, F., Clauw, D. J., Whipple, M. O., Oh, T. H., Barton, D. L., & Sauver, J. L. S. (2012) · Arthritis Care & Research · doi:10.1002/acr.21896 · Cited by 385
The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology
Hillhouse, E. W., & Grammatopoulos, D. K. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0034 · Cited by 358
Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes
Amir, R. E., den Veyver, I. B. V., Schultz, R., Malicki, D. M., Tran, C. Q., Dahle, E. J., Philippi, A., Tímár, L., Percy, A. K., Motil, K. J., et al. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200005)47:5 · Cited by 351
Windup leads to characteristics of central sensitization
Li, J., Simone, D. A., & Larson, A. A. (1999) · Pain · doi:10.1016/s0304-3959(98)00154-7 · Cited by 343
Forced and voluntary exercise differentially affect brain and behavior
Leasure, J. L., & Jones, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.041 · Cited by 335
Exercise therapy for fibromyalgia
Busch, A. J., Webber, S. C., Brachaniec, M., Bidonde, J., Bello-Haas, V. D., Danyliw, A. D., Overend, T. J., Richards, R. S., Sawant, A., & Schachter, C. L. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0214-2 · Cited by 333
Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation
Petzke, F. W., Clauw, D. J., Ambrose, K., Khine, A. H., & Gracely, R. H. (2003) · Pain · doi:10.1016/s0304-3959(03)00204-5 · Cited by 332
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327
Characterization of Protease-activated Receptor-2 Immunoreactivity in Normal Human Tissues
D’Andrea, M. R., Derian, C. K., Leturcq, D. J., Baker, S. M., Brunmark, A. B., Ling, P., Darrow, A. L., Santulli, R. J., Brass, L. F., & Andrade‐Gordon, P. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600204 · Cited by 320
Abuse-Related Posttraumatic Stress Disorder and Alterations of the Hypothalamic-Pituitary-Adrenal Axis in Women With Chronic Pelvic Pain
Heim, C., Ehlert, U., Hanker, J. P., & Hellhammer, D. H. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00017 · Cited by 309
Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.07.020 · Cited by 305 · cited 2×
“One study found that 11 weeks of CBT in a mixed group of chronic pain patients resulted in significant gray matter differences in sensory, motor, and affective brain areas as measured using voxelbased morphometry (Seminowicz et al., 2013).”
Background
Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome
Seminowicz, D. A., Labus, J. S., Bueller, J. A., Tillisch, K., Naliboff, B. D., Bushnell, M. C., & Mayer, E. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.049 · Cited by 303
Mast cells as targets of corticotropin-releasing factor and related peptides
Theoharides, T. C., Donelan, J., Papadopoulou, N., Cao, J., Kempuraj, D., & Conti, P. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.09.007 · Cited by 301
Striatal grey matter increase in patients suffering from fibromyalgia – A voxel-based morphometry study
Schmidt‐Wilcke, T., Luerding, R., Weigand, T., Jürgens, T. P., Schuierer, G. R., Leinisch, E., & Bogdahn, U. (2007) · Pain · doi:10.1016/j.pain.2007.05.010 · Cited by 301
A comparison of cognitive-behavioral therapy and relaxation training for the treatment of depression in adolescents.
Reynolds, W. M., & Coats, K. I. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.54.5.653 · Cited by 300
Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia)
Vierck, C. J. (2006) · Pain · doi:10.1016/j.pain.2006.06.001 · Cited by 297
Stress‐induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells
Gué, M., Rio-Lacheze, C. D., Eutamène, H., Théodorou, V., Fioramonti, J., & Bueno, L. P. (1997) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1997.d01-63.x · Cited by 282
The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model
Ke, Z., Yip, S. P., Li, L., Zheng, X., & Tong, R. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016643 · Cited by 281
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.
Galli, S. J., Tsai, M. M., & Wershil, B. K. (1993) · PubMed · Cited by 278
Vulvodynia
Arnold, L. D., Bachmann, G. A., Rosen, R. C., Kelly, S., & Rhoads, G. G. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000199951.26822.27 · Cited by 277
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence
Theoharides, T. C., Kempuraj, D., & Sant, G. R. (2001) · Urology · doi:10.1016/s0090-4295(01)01129-3 · Cited by 277
Pool exercise combined with an education program for patients with fibromyalgia syndrome. A prospective, randomized study.
Mannerkorpi, K., Nyberg, B., Ahlmén, M., & Ekdahl, C. S. (2000) · PubMed · Cited by 277
Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic–pituitary–adrenal axis
Tasker, J. G., & Herman, J. P. (2011) · Stress · doi:10.3109/10253890.2011.586446 · Cited by 277
Mast cells: The immune gate to the brain
Theoharides, T. C. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90129-f · Cited by 276
Psychological therapies (Internet-delivered) for the management of chronic pain in adults
Eccleston, C., Fisher, E., Craig, L., Duggan, G. B., Rosser, B. A., & Keogh, E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010152.pub2 · Cited by 271 · cited 2×
“…Hofmann and Smits (2008) Chronic pelvic pain Pelvic pain, widespread pain, dyschezia, dyspareunia, quality of life, disability, depression, anxiety Eccleston et al. (2014) and Meissner et al. (2016) Migraine Headache frequency, headache duration, headache intensity, anxiety, depression,…”
Background
The role of mast cells in migraine pathophysiology
Theoharides, T. C., Donelan, J., Kandere‐Grzybowska, K., & Konstantinidou, A. D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.11.006 · Cited by 271
Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms
Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268
The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
Brierley, S. M., Hughes, P. A., Page, A. J., Kwan, K. Y., Martin, C. M., O’Donnell, T. A., Cooper, N. J., Harrington, A. M., Adam, B., Liebregts, T., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.048 · Cited by 266
Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression
Adlard, P. A., & Cotman, C. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.039 · Cited by 265
Fibromyalgia and related conditions
Clauw, D. J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.03.014 · Cited by 259
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Chang, L., Sundaresh, S., Elliott, J. E., Anton, P. A., Baldi, P., Licudine, A., Mayer, M., Vuong, T., Hirano, M., Naliboff, B. D., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01171.x · Cited by 254
Childhood parental loss and adult hypothalamic-pituitary-adrenal function
Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250
Understanding fibromyalgia: lessons from the broader pain research community.
Williams, D. A., & Clauw, D. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.001 · Cited by 250
Increased number of substance P positive nerve fibres in interstitial cystitis
Pang, X., Marchand, J. E., Sant, G. R., Kream, R. M., Theoharides, T. C., & J. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07384.x · Cited by 248
Migraine Symptoms: Results of a Survey of Self‐Reported Migraineurs
Silberstein, S. D. (1995) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.1995.hed3507387.x · Cited by 243
Psychosocial treatments for adolescent depression
Lewinsohn, P. M. (1999) · Clinical Psychology Review · doi:10.1016/s0272-7358(98)00055-5 · Cited by 237
The relationship between fibromyalgia and interstitial cystitis
Clauw, D. J., Schmidt, M., Radulovic, D., Singer, A., Katz, P., & Bresette, J. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00051-9 · Cited by 230
Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders
Tak, L. M., Cleare, A. J., Ormel, J., Manoharan, A., Kok, I. C., Wessely, S., & Rosmalen, J. G. M. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.02.002 · Cited by 230
Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome
de Lange, F. P., Koers, A., Kalkman, J. S., Bleijenberg, G., Peter Hagoort, A., van der Meer, J. W. M., & Toni, I. (2008) · Brain · doi:10.1093/brain/awn140 · Cited by 229
IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex
Melemedjian, O. K., Asiedu, M. N., Tillu, D. V., Peebles, K. A., Yan, J., Ertz, N., Dussor, G. O., & Price, T. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3947-10.2010 · Cited by 225
Stress-induced intracranial mast cell degranulation: A corticotropin-releasing hormone-mediated effect
Theoharides, T. C., Spanos, C., Pang, X., Alferes, L., Ligris, K., Letourneau, R., Rozniecki, J. J., Webster, E., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588332 · Cited by 214
Morphological and functional demonstration of rat dura mater mast cell–neuron interactions in vitro and in vivo
Rózniecki, J., Dimitriadou, V., Lambracht-Hall, M., Pang, X., & Theoharides, T. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01855-7 · Cited by 214
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., Jiang, Z., Wang, H., Wang, Z., Cornelisson, G., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.007 · Cited by 212
The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine
Nassini, R., Materazzi, S., Benemei, S., & Geppetti, P. (2014) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2014_18 · Cited by 210
CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α
Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039935 · Cited by 207
Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability
Gunnar, M. R., & Quevedo, K. M. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67010-1 · Cited by 199
Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome
Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198
Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia.
Giovengo, S. L., Russell, I. J., & Larson, A. A. (1999) · PubMed · Cited by 195
Increased gray matter density in young women with chronic vulvar pain
Schweinhardt, P., Kuchinad, A., Pukall, C. F., & Bushnell, M. C. (2008) · Pain · doi:10.1016/j.pain.2008.09.014 · Cited by 194
Ventral subiculum regulates hypothalamo–pituitary–adrenocortical and behavioural responses to cognitive stressors
Herman, J. P., Dolgas, C. M., & Carlson, S. L. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00055-4 · Cited by 193
Migraine pain, meningeal inflammation, and mast cells
Levy, D. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0040-y · Cited by 191
Exercise, Not to Exercise, or How to Exercise in Patients With Chronic Pain? Applying Science to Practice
Daenen, L., Varkey, E., Kellmann, M., & Nijs, J. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000099 · Cited by 190
Evidence for Overlap Between Urological and Nonurological Unexplained Clinical Conditions
Rodríguez, M. Á. B., Afari, N., & Buchwald, D. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.11.019 · Cited by 185
Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation
Schwartz, E. S., Christianson, J. A., Chen, X., La, J., Davis, B. M., Albers, K. M., & Gebhart, G. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.033 · Cited by 178
Self-citation
Prolonged Gabapentin Analgesia in an Experimental Mouse Model of Fibromyalgia
Nishiyori, M., & Ueda, H. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-52 · Cited by 176
Pain Mechanisms and Centralized Pain in Temporomandibular Disorders
Harper, D., Schrepf, A., & Clauw, D. J. (2016) · Journal of Dental Research · doi:10.1177/0022034516657070 · Cited by 174
Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia
Svensson, M., Rosvall, P., Boza‐Serrano, A., Andersson, E., Lexell, J. E., & Deierborg, T. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.002 · Cited by 174
Forebrain Glucocorticoid Receptors Modulate Anxiety-Associated Locomotor Activation and Adrenal Responsiveness
Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2173-05.2006 · Cited by 172
Self-reported Physical Activity Predicts Pain Inhibitory and Facilitatory Function
Naugle, K. M., & Riley, J. L. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a69cf1 · Cited by 170
Untitled work
(2002) · PubMed · Cited by 167
Psychosocial Phenotyping in Women With Interstitial Cystitis/Painful Bladder Syndrome: A Case Control Study
Nickel, J. C., Tripp, D. A., Pontari, M. A., Moldwin, R., Mayer, R., Carr, L. K., Doggweiler, R., Yang, C. C., Mishra, N. N., & Nordling, J. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.08.133 · Cited by 163
Electron microscopical evidence for a direct contact between nerve fibres and mast cells
Wiesner-Menzel, L., Schulz, B., Vakilzadeh, F., & Bm, C. (1981) · Acta Dermato Venereologica · doi:10.2340/0001555561465469 · Cited by 158
Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study
Kutch, J. J., Ichesco, E., Hampson, J. P., Labus, J. S., Farmer, M. A., Martucci, K. T., Ness, T. J., DEUTSCH, G., Apkarian, A. V., Mackey, S., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001001 · Cited by 156
The MAPP research network: a novel study of urologic chronic pelvic pain syndromes
The MAPP Research Network Study Group, Clemens, J. Q., Mullins, C., Kusek, J. W., Kirkali, Z., Mayer, E. A., Rodríguez, L. V., Klumpp, D. J., Schaeffer, A. J., Kreder, K. J., et al. (2014) · BMC Urology · doi:10.1186/1471-2490-14-57 · Cited by 155 · cited 2×
“…particularly from the Multidisciplinary Approach to Pelvic Pain (MAPP) network, have greatly increased our knowledge of phenotypic and central changes that occur in patients with centralized pain syndromes (Clemens et al., 2014; Kutch et al., 2017a,b; Lai et al., 2017; Harper et al., 2018).”
Background
A new animal model for assessing mechanisms and management of muscle hyperalgesia
Kehl, L. J., Trempe, T. M., & Hargreaves, K. (2000) · Pain · doi:10.1016/s0304-3959(99)00282-1 · Cited by 150
Commonalities Between Pain and Memory Mechanisms and Their Meaning for Understanding Chronic Pain
Price, T. J., & Inyang, K. E. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.11.010 · Cited by 149
Association Among Clinical Response, Hippocampal Volume, and FKBP5 Gene Expression in Individuals with Posttraumatic Stress Disorder Receiving Cognitive Behavioral Therapy
Levy‐Gigi, E., Szabó, C., Kelemen, O., & Kéri, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.017 · Cited by 149
Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: Role of hippocampus
Maniam, J., & Morris, M. J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.012 · Cited by 149
Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome
MILLER, L. J., FISCHER, K. A., GORALNICK, S. J., Litt, M. D., Burleson, J. A., Albertsen, P. C., & Kreutzer, D. L. (2002) · Urology · doi:10.1016/s0090-4295(01)01597-7 · Cited by 147
Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
Bardin, L., Malfetes, N., Newman‐Tancredi, A., & Depoortère, R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.005 · Cited by 146
CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon
Chatzaki, Ε., Crowe, P. D., Wang, L., Million, M., Taché, Y., & Grigoriadis, D. E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02490.x · Cited by 146
Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial
Mannerkorpi, K., Nordeman, L., Cider, Å., & Jonsson, G. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3159 · Cited by 142
Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls
Staud, R. M., Price, D. D., Robinson, M. E., Mauderli, A. P., & Vierck, C. J. (2004) · Pain · doi:10.1016/j.pain.2004.05.009 · Cited by 139
Allodynia in Migraine: Association With Comorbid Pain Conditions
Tietjen, G. E., Brandes, J. L., Peterlin, B. L., Eloff, A., Dafer, R. M., Stein, M. R., Drexler, E. D., Martin, V. T., Hutchinson, S. L., Aurora, S. K., et al. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01521.x · Cited by 137
Transient Receptor Potential Vanilloid 1 Mediates Hyperalgesia and Is Up-Regulated in Rats With Chronic Pancreatitis
Xu, G., Winston, J. H., Shenoy, M. M., Yin, H., Pendyala, S., & Pasricha, P. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.015 · Cited by 136
Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients
Kaplan, C. M., Nascimento, T. D., Foerster, B. R., Clauw, D. J., Zubieta, J., Harris, R. E., & DaSilva, A. F. M. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0934-0 · Cited by 135
Assessing psychological factors, social aspects and psychiatric co-morbidity associated with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in men — A systematic review
Riegel, B., Bruenahl, C. A., Ahyai, S., Bingel, U., Fisch, M. M., & Löwe, B. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.09.012 · Cited by 134
Differences in Mast Cell Infiltration, E-cadherin, and Zonula Occludens-1 Expression Between Patients With Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome
Liu, H., Shie, J., Chen, S., Wang, Y., & Kuo, H. (2012) · Urology · doi:10.1016/j.urology.2012.01.047 · Cited by 129
Occurrence and distribution of calcitonin gene-related peptide in the mammalian respiratory tract and middle ear
Uddman, R., Luts, A., & Sundler, F. (1985) · Cell and Tissue Research · doi:10.1007/bf00214575 · Cited by 129
Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome
Jiang, Y., Peng, C., Liu, H., & Kuo, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076779 · Cited by 128
Effects of Exercise Intensity on Spatial Memory Performance and Hippocampal Synaptic Plasticity in Transient Brain Ischemic Rats
Shih, P.-C., Yang, Y., & Wang, R.-Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078163 · Cited by 126
Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients
Sarchielli, P., Alberti, A., Floridi, A., & Gallai, V. (2001) · Neurology · doi:10.1212/wnl.57.1.132 · Cited by 126
Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia
Woolf, C. J., & Walters, E. T. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90024-o · Cited by 123
The Association Between a History of Lifetime Traumatic Events and Pain Severity, Physical Function, and Affective Distress in Patients With Chronic Pain
Chadwick, A. L., Sieberg, C. B., Clauw, D. J., Hassett, A. L., Moser, S. E., & Brummett, C. M. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.09.003 · Cited by 123
The Effects of Exercise upon Symptoms and Quality of Life in Patients Diagnosed with Irritable Bowel Syndrome: A Randomised Controlled Trial
Daley, A., Grimmett, C., Roberts, L., Wilson, S., Fatek, M., Roalfe, A., & Singh, S. (2008) · International Journal of Sports Medicine · doi:10.1055/s-2008-1038600 · Cited by 118
Interactions of mast cells with the nervous system ?Recent advances
Johnson, D. K., & Krenger, W. (1992) · Neurochemical Research · doi:10.1007/bf00993271 · Cited by 116
Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
Kim, Y., Son, J. Y., Kim, T. H., Paik, S. K., Dai, Y., Noguchi, K., Ahn, D. K., & Bae, Y. C. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22238 · Cited by 115
Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?
Sweetser, S. R., Camilleri, M., Nord, S. L., Burton, D. D., Castenada, L., Croop, R. S., Tong, G., Dockens, R. C., & Zinsmeister, A. R. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00011.2009 · Cited by 114
Unlearning chronic pain: A randomized controlled trial to investigate changes in intrinsic brain connectivity following Cognitive Behavioral Therapy
Shpaner, M., Kelly, C. A. M., Lieberman, G., Perelman, H., Davis, M., Keefe, F. J., & Naylor, M. R. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.07.008 · Cited by 113
Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study
Lai, H. H., Jemielita, T., Sutcliffe, S., Bradley, C. S., Naliboff, B., Williams, D. A., Gereau, R. W., Kreder, K., Clemens, J. Q., Rodriguez, L. V., et al. (2017) · Journal of Urology · doi:10.1016/j.juro.2017.03.132 · Cited by 113
What does the evidence show? Efficacy of behavioural treatments for recurrent headaches in adults
Andrasik, F. (2007) · Neurological Sciences · doi:10.1007/s10072-007-0754-8 · Cited by 110
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis
Wick, E. C., Hoge, S. G., Grahn, S. W., Kim, E. J., Divino, L., Grady, E. F., Bunnett, N. W., & Kirkwood, K. S. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2005 · Cited by 110
Fatigue of elbow flexor muscles in younger and older adults
Bilodeau, M., Erb, M., Nichols, J. M., Joiner, K. L., & Weeks, J. B. (2001) · Muscle & Nerve · doi:10.1002/1097-4598(200101)24:1 · Cited by 109
Physical exercise and depression
Rot, M. A. H., Collins, K. A., & Fitterling, H. (2009) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20094 · Cited by 106
Increased plasma histamine levels in migraine patients
Heatley, R. V., Denburg, J. A., BAYER, N., & Bienenstock, J. (1982) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1982.tb01633.x · Cited by 103
Long-term exercise is needed to enhance synaptic plasticity in the hippocampus
Patten, A. R., Sickmann, H., Hryciw, B. N., Kucharsky, T., Parton, R., Kernick, A., & Christie, B. R. (2013) · Learning & Memory · doi:10.1101/lm.030635.113 · Cited by 101
Fibromyalgia - New Concepts of Pathogenesis and Treatment
Lucas, H., Brauch, C. M., Settas, L., & Theoharides, T. C. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/205873920601900102 · Cited by 98
Corticotropin-Releasing Factor Receptor 1 Antagonist Alters Regional Activation and Effective Connectivity in an Emotional–Arousal Circuit during Expectation of Abdominal Pain
Hubbard, C. S., Labus, J. S., Bueller, J. A., Stains, J., Suyenobu, B. Y., Dukes, G. E., Kelleher, D. L., Tillisch, K., Naliboff, B. D., & Mayer, E. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1860-11.2011 · Cited by 97
Pathophysiologic mechanisms of fibromyalgia and its related disorders.
Bradley, L. A. (2008) · PubMed · Cited by 96
Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam
Kageyama, K., & Suda, T. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-075 · Cited by 95
Psychometric Profiles and Hypothalamic-Pituitary-Adrenal Axis Function in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Anderson, R. U., Orenberg, E. K., Chan, C. A., Morey, A., & Flores, V. L. (2008) · The Journal of Urology · doi:10.1016/j.juro.2007.10.084 · Cited by 92
Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study
Santiago, M. D. S., Carvalho, D. D. S., Gabbai, A. A., Pinto, M. M. P., Moutran, A. R. C., & Villa, T. R. (2014) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140148 · Cited by 91
The Role of Eosinophils and Mast Cells in Intestinal Functional Disease
Walker, M. M., Warwick, A., Ung, C. Y., & Talley, N. J. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0197-5 · Cited by 90
Causes of chronic pelvic pain
Moore, J. A., & Kennedy, S. (2000) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1053/beog.1999.0082 · Cited by 88
Traumatic experiences, major life stressors, and self-reporting a physician-given fibromyalgia diagnosis
Haviland, M. G., Morton, K. R., Oda, K., & Fraser, G. E. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.08.017 · Cited by 87
Exercise Strengthens Central Nervous System Modulation of Pain in Fibromyalgia
Ellingson, L. D., Stegner, A. J., Schwabacher, I. J., Koltyn, K. F., & Cook, D. B. (2016) · Brain Sciences · doi:10.3390/brainsci6010008 · Cited by 86
TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis
DeBerry, J. J., Schwartz, E. S., & Davis, B. M. (2014) · Pain · doi:10.1016/j.pain.2014.03.023 · Cited by 85
Role of Mast Cells in Male Chronic Pelvic Pain
Done, J. D., Rudick, C. N., Quick, M. L., Schaeffer, A. J., & Thumbikat, P. (2012) · The Journal of Urology · doi:10.1016/j.juro.2011.11.116 · Cited by 84
Mast cells: an expanding pathophysiological role from allergy to other disorders
Anand, P., Singh, B., Jaggi, A. S., & Singh, N. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0757-8 · Cited by 83
Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP
Kutch, J. J., Yani, M. S., Asavasopon, S., Kirages, D. J., Rana, M., Cosand, L., Labus, J. S., Kilpatrick, L. A., Ashe-McNalley, C., Farmer, M. A., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.05.013 · Cited by 81
Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways
Pan, X., Gonzalez, J. A., Chang, S., Chacko, S., Wein, A. J., & Malykhina, A. P. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.012 · Cited by 79
Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice
Cheng, S., Chen, C., Yang, H.-W., Chang, Y.-T., Bai, S.-W., Chen, C., Yen, C., & Min, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5564-10.2011 · Cited by 79
Comparison of the cortisol awakening response in women with shoulder and neck pain and women with fibromyalgia
Riva, R., Mork, P. J., Westgaard, R. H., & Lundberg, U. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.014 · Cited by 78
Differences in Primary Compared With Secondary Vestibulodynia by Immunohistochemistry
Leclair, C. M., Goetsch, M. F., Korcheva, V., Anderson, R. E., Peters, D., & Morgan, T. K. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821c33dc · Cited by 77
Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress
Myers, B., & Meerveld, B. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00353.2011 · Cited by 76
Psychotherapy With Somatosensory Stimulation for Endometriosis-Associated Pain: A Randomized Controlled Trial
Meissner, K., Schweizer-Arau, A., Limmer, A., Preibisch, C., Popovici, R. M., Lange, I., de Oriol, B., & Beissner, F. (2016) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001691 · Cited by 76
The Association of Abuse and Symptoms Suggestive of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Results from the Boston Area Community Health Survey
Hu, J. C., Link, C. L., McNaughton-Collins, M., Barry, M. J., & McKinlay, J. B. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0341-y · Cited by 75
Modulation of enteric neurons by interleukin‐6 and corticotropin‐releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome
Buckley, M. M., O’Halloran, K. D., Rae, M. G., Dinan, T. G., & O’Malley, D. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279968 · Cited by 74
Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
Price, T. J., & Géranton, S. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06786.x · Cited by 74
Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens
Corcoran, A. T., Yoshimura, N., Tyagi, V., Jacobs, B. L., Leng, W., & Tyagi, P. (2012) · World Journal of Urology · doi:10.1007/s00345-012-0852-y · Cited by 73
pH ‐Evoked Dural Afferent Signaling Is Mediated by ASIC3 and Is Sensitized by Mast Cell Mediators
Yan, J., Wei, X., Bischoff, C. M., Edelmayer, R. M., & Dussor, G. O. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12152 · Cited by 73
Divergent effects of amygdala glucocorticoid and mineralocorticoid receptors in the regulation of visceral and somatic pain
Myers, B., & Meerveld, B. G. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00298.2009 · Cited by 70
Stress in the Adult Rat Exacerbates Muscle Pain Induced by Early-Life Stress
Álvarez, P., Green, P. G., & Levine, J. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.006 · Cited by 69
Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress
Pierce, A. N., Silvestro, E. R. D., Eller, O. C., Wang, R., Ryals, J. M., & Christianson, J. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.039 · Cited by 68
Self-citation
Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study
Kutch, J. J., Labus, J. S., Harris, R. E., Martucci, K. T., Farmer, M. A., Fenske, S. J., Fling, C., Ichesco, E., Peltier, S., Petre, B., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000886 · Cited by 68
Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain
Kojima, R., Nozawa, K., Doihara, H., Keto, Y., Kaku, H., Yokoyama, T., & Itou, H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.020 · Cited by 67
Self-mutilation after dorsal rhizotomy in rats: Effects of prior pain and pattern of root lesions
Dennis, S. G., & Melzack, R. (1979) · Experimental Neurology · doi:10.1016/0014-4886(79)90108-0 · Cited by 66
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats
Wieseler, J. L., Ellis, A., Sprunger, D. B., Brown, K., McFadden, A., Mahoney, J. H., Rezvani, N., Maier, S. F., & Watkins, L. R. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.10.006 · Cited by 65
Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache
Burgos-Vega, C., Ahn, D. D.-U., Bischoff, C. M., Wang, W., Horne, D., Wang, L., Gavva, N. R., & Dussor, G. O. (2015) · Cephalalgia · doi:10.1177/0333102415584313 · Cited by 65
Further Validation of a Model of Fibromyalgia Syndrome in the Rat
Green, P. G., Álvarez, P., Gear, R. W., Mendoza, D., & Levine, J. D. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.01.006 · Cited by 63
Fibromyalgia syndrome.
Mease, P. J., Clauw, D. J., Arnold, L. M., Goldenberg, D. L., Witter, J. P., Williams, D. A., Simon, L. S., STRAND, C. V., Bramson, C., Martin, S. A., et al. (2005) · PubMed · Cited by 63
Physical Activity and Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Zhang, R., Chomistek, A. K., Dimitrakoff, J. D., Giovannucci, E. L., Willett, W. C., ROSNER, B. A., & Wu, K. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000472 · Cited by 62
Gender specific effects of neonatal limited nesting on viscerosomatic sensitivity and anxiety‐like behavior in adult rats
Prusator, D. K., & Meerveld, B. G. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12472 · Cited by 62
Chronic stress in women with localised provoked vulvodynia
Ehrström, S., Kornfeld, D., Rylander, E., & Bohm‐Starke, N. (2009) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/01674820802604359 · Cited by 61
From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain
Price, T. J., & Gold, M. S. (2017) · Pain Medicine · doi:10.1093/pm/pnx108 · Cited by 58
The effects of swimming in mice on pain perception and sleeping time in response to hypnotic drugs
Willow, M., CARMODY, J. J., & Carroll, P. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90296-9 · Cited by 58
Voluntary exercise alters GABAA receptor subunit and glutamic acid decarboxylase-67 gene expression in the rat forebrain
Hill, L., Droste, S., Nutt, D., Linthorst, A., & Reul, J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108096983 · Cited by 57
Knockdown of corticotropin-releasing factor in the central amygdala reverses persistent viscerosomatic hyperalgesia
Johnson, A. C., Tran, L., & Meerveld, B. G. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.16 · Cited by 56
Stress Induced Hypothalamus-Pituitary-Adrenal Axis Responses and Disturbances in Psychological Profiles in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Anderson, R. U., Orenberg, E. K., Morey, A., Chavez, N., & Chan, C. A. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.07.042 · Cited by 55
Vaginal hypersensitivity and hypothalamic–pituitary–adrenal axis dysfunction as a result of neonatal maternal separation in female mice
Pierce, A. N., Ryals, J. M., Wang, R., & Christianson, J. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.022 · Cited by 55
Self-citation
Neuroimmune Mechanisms of Intestinal Responses to Stress: Role of Corticotropin‐Releasing Factor and Neurotensin
Pothoulakis, C., Castagliuolo, I., & Leeman, S. E. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09602.x · Cited by 55

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Clauw, D. J., Essex, M. N., Pitman, V. W., & Jones, K. D. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1574403 · Cited by 300
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Do, T. P., Heldarskard, G. F., Kolding, L. T., Hvedstrup, J., & Schytz, H. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0913-8 · Cited by 188
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Authors: Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A.
Affiliations: University of Kansas Medical Center (US)
Corresponding author: Christianson, Julie A.
ORCID: Christianson, Julie A.
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2018-02-13
Volume: 12
Pages: 35-35
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2018.00035
PMC: PMC5816755
OpenAlex: W2793570991
Cited by: 227
References: 235
Citations by year: 2026: 31 · 2025: 24 · 2024: 20 · 2023: 31 · 2022: 31 · 2021: 31 · 2020: 26 · 2019: 23 · 2018: 10
FWCI: 2.95
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (DK099611, DK103872, GM123320, HD057850)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: fibromyalgia, chronic pelvic pain, migraine, temporomandibular disorders, central sensitization, HPA axis dysregulation, mast cells, hyperalgesic priming, wind-up, long-term potentiation, functional connectivity, non-pharmacological treatment, physical activity, cognitive behavioral therapy, comorbidities, quality of life

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Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions

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