Regional white matter damage predicts speech fluency in chronic post-stroke aphasia
Open accessAbstract
RECENTLY, TWO DIFFERENT WHITE MATTER REGIONS THAT SUPPORT SPEECH FLUENCY HAVE BEEN IDENTIFIED: the aslant tract and the anterior segment of the arcuate fasciculus (ASAF). The role of the ASAF was demonstrated in patients with post-stroke aphasia, while the role of the aslant tract shown in primary progressive aphasia. Regional white matter integrity appears to be crucial for speech production; however, the degree that each region exerts an independent influence on speech fluency is unclear. Furthermore, it is not yet defined if damage to both white matter regions influences speech in the context of the same neural mechanism (stroke-induced aphasia). This study assessed the relationship between speech fluency and quantitative integrity of the aslant region and the ASAF. It also explored the relationship between speech fluency and other white matter regions underlying classic cortical language areas such as the uncinate fasciculus and the inferior longitudinal fasciculus (ILF). Damage to these regions, except the ILF, was associated with speech fluency, suggesting synergistic association of these regions with speech fluency in post-stroke aphasia. These observations support the theory that speech fluency requires the complex, orchestrated activity between a network of pre-motor, secondary, and tertiary associative cortices, supported in turn by regional white matter integrity.
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Damage to each of the selected white/grey matter regions has been associated with speech production impairments in prior lesion studies.
“Damage to each of these white/grey matter regions has been associated with speech production impairments in prior lesion studies”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Basilakos et al., 2014
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- Authors
- Basilakos, A., Fillmore, P. T., Rorden, C., Guo, D., Bonilha, L., & Fridriksson, J.
- Affiliations
- University of South Carolina (US)
- Medical University of South Carolina (US)
- Corresponding author
- Basilakos, Alexandra
- ORCID
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-10-17
- Volume
- 8
- Pages
- 845-845
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC4201347
- OpenAlex
- W2060713022
- Cited by
- 122
- References
- 48
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (UL1TR000062, DC009571)
- National Institute on Deafness and Other Communication Disorders (R01DC009571, DC-009571, R01DC014021)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- post-stroke aphasia, speech fluency, white matter integrity, arcuate fasciculus, uncinate fasciculus, inferior longitudinal fasciculus, language network, stroke, white matter injury
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