Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

Spiers, Jereme G.; Chen, Hsiao-Jou Cortina; Sernia, Conrad; Lavidis, Nickolas A.

doi:10.3389/fnins.2014.00456

Cited by 292Stress Responses and CortisolRedox biology and oxidative stressAdrenal Hormones and Disorders

Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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Spiers, Jereme G., Chen, Hsiao-Jou Cortina, Sernia, Conrad, Lavidis, Nickolas A.·2015·Frontiers in Neuroscience

DOI 10.3389/fnins.2014.00456PMC PMC4298223

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Abstract

Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.

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Chronic prenatal stress produces affective abnormalities together with HPA axis hyperactivity and epigenetic disruptions, illustrating the interplay between inflammation, endocrine function, and chromatin regulation in stress vulnerability.
“Chronic prenatal stress produces affective abnormalities together with HPA axis hyperactivity and epigenetic disruptions, illustrating the interplay between inflammation, endocrine function, and chromatin regulation in stress vulnerability (Possamai-Della et al., 2023; Glover et al., 2009; Spiers et al., 2014).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Spiers et al., 2014
The Introduction describes HPA-axis activation as part of the stress response, and the Adrenal glucocorticoids and oxidative stress section discusses how oxidative conditions can increase HPA-axis activity. Neither passage establishes that chronic prenatal stress produces affective abnormalities, HPA-axis hyperactivity, or epigenetic disruptions; the claimed interplay with inflammation and chromatin regulation is also unsupported by this copy. No page numbers are available in the indexed passages. (LLM, conf=0.82)
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Authors: Spiers, J. G., Chen, H.-J. C., Sernia, C., & Lavidis, N. A.
Affiliations: The University of Queensland (AU)
Corresponding author: Spiers, Jereme G.
ORCID: Spiers, Jereme G.
Chen, Hsiao-Jou Cortina
Sernia, Conrad
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2015-01-19
Volume: 8
Pages: 456-456
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2014.00456
PMC: PMC4298223
OpenAlex: W1984410984
Cited by: 292
References: 73
Citations by year: 2026: 24 · 2025: 39 · 2024: 23 · 2023: 33 · 2022: 30 · 2021: 39 · 2020: 29 · 2019: 21 · 2018: 17 · 2017: 20 · 2016: 11 · 2015: 6
FWCI: 1.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoids, oxidative stress, redox systems, hippocampus, stress, adrenal cortex, neuroendocrinology

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Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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