A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: An fMRI study
Open accessAbstract
BACKGROUND: We hypothesized that SRX246, a vasopressin V1a receptor antagonist, blocks the effect of intranasally administered vasopressin on brain processing of angry Ekman faces. An interaction of intranasal and oral drug was predicted in the amygdala. METHODS: Twenty-nine healthy male subjects received a baseline fMRI scan while they viewed angry faces and then were randomized to receive oral SRX246 (120 mg PO twice a day) or placebo. After an average of 7 days of treatment, they were given an acute dose of intranasal vasopressin (40 IU) or placebo and underwent a second scan. The primary outcome was BOLD activity in the amygdala in response to angry faces. Secondary analyses were focused on ROIs in a brain regions previously linked to vasopressin signaling. RESULTS: In subjects randomized to oral placebo-intranasal vasopressin, there was a significantly diminished amygdala BOLD response from the baseline to post-drug scan compared with oral placebo-intranasal placebo subjects. RM-ANOVA of the BOLD signal changes in the amygdala revealed a significant oral drug × intranasal drug × session interaction (F (1, 25) = 4.353, p < 0.05). Follow-up tests showed that antagonism of AVPR1a with SRX246 blocked the effect of intranasal vasopressin on the neural response to angry faces. Secondary analyses revealed that SRX246 treatment was associated with significantly attenuated BOLD responses to angry faces in the right temporoparietal junction, precuneus, anterior cingulate, and putamen. Exploratory analyses revealed that the interactive and main effects of intranasal vasopressin and SRX246 were not seen for happy or neutral faces, but were detected for aversive faces (fear + anger) and at a trend level for fear faces. CONCLUSION: We found confirmatory evidence that SRX246 has effects on the amygdala that counter the effects of intranasal vasopressin. These effects were strongest for angry faces, but may generalize to other emotions with an aversive quality.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SRX246 attenuated amygdala activation in response to angry faces and vasopressin administration, indicating a role of amygdalar V1A receptors in the processing of aversive emotional information.
“and attenuated amygdala activation in response to angry faces (Fig. 3) and vasopressin administration indicating a role of amygdalar V 1A receptors in the processing of aversive emotional information (Lee et al., 2013).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Lee et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Maldjian, J., Laurienti, P., Kraft, R., & Burdette, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,453 · see citing works
Posner, K., Brown, G. K., Stanley, B., Brent, D. A., Yershova, K. V., Oquendo, M. A., Currier, G. W., Melvin, G. A., Greenhill, L., Shen, S., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111704 · Cited by 5,157 · see citing works
The precuneus: a review of its functional anatomy and behavioural correlates
Cavanna, A. E., & Trimble, M. R. (2006) · Brain · doi:10.1093/brain/awl004 · Cited by 5,128 · see citing works
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,494 · see citing works
People thinking about thinking peopleThe role of the temporo-parietal junction in “theory of mind”
Saxe, R., & Kanwisher, N. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00230-1 · Cited by 2,316 · cited 2× · see citing works
“These novel findings provide the first evidence for AVPR1a signaling in a neural circuit that mediates processing of social and emotional information (Saxe and Kanwisher, 2003; Zink and Meyer-Lindenberg, 2012).”
BackgroundDevelopment and neurophysiology of mentalizing
Frith, U., & Frith, C. D. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1218 · Cited by 2,306 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Fusar‐Poli, P., Placentino, A., Carletti, F., Landi, P., Allen, P., Surguladze, S., Benedetti, F., Abbamonte, M., Gasparotti, R., Barale, F., et al. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0953 · Cited by 1,292 · see citing works
Neural processing of emotional faces requires attention
Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172403899 · Cited by 1,155 · see citing works
The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes
Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1179 · Cited by 984 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
The power of simulation: Imagining one's own and other's behavior
Decety, J., & Grèzes, J. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.115 · Cited by 790 · see citing works
Neuromodulation by Oxytocin and Vasopressin
Stoop, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.025 · Cited by 506 · see citing works
Facial emotion processing in major depression: a systematic review of neuroimaging findings
Stuhrmann, A., Suslow, T., & Dannlowski, U. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-10 · Cited by 440 · see citing works
Beyond threat: amygdala reactivity across multiple expressions of facial affect
Fitzgerald, D. A., Angstadt, M., Jelsone, L. M., Nathan, P. J., & Phan, K. L. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.003 · Cited by 427 · see citing works
Neural mechanisms of social risk for psychiatric disorders
Meyer‐Lindenberg, A., & Tost, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3083 · Cited by 342 · see citing works
Sex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
Hamilton, J. P., Chen, M. C., & Gotlib, I. H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.015 · Cited by 293 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior
Garrison, J. L., Macosko, E. Z., Bernstein, S., Pokala, N., Albrecht, D. R., & Bargmann, C. I. (2012) · Science · doi:10.1126/science.1226201 · Cited by 266 · see citing works
Kim, S.-J., Young, L. J., Gonen, D., Veenstra-VanderWeele, J., Courchesne, R., Courchesne, E., Lord, C., Leventhal, B. L., Cook Jr, E. H., & Insel, T. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001125 · Cited by 265 · see citing works
Decoding moral judgments from neural representations of intentions
Koster-Hale, J., Saxe, R. R., Dungan, J. A., & Young, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207992110 · Cited by 227 · see citing works
Meyer‐Lindenberg, A., Kolachana, B. S., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V. S., Dean, M. C., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.54 · Cited by 219 · see citing works
Examination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212 · see citing works
Similarities and differences in perceiving threat from dynamic faces and bodies. An fMRI study
Kret, M. E., Pichon, S., Grèzes, J., & de Gelder, B. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.012 · Cited by 204 · see citing works
Habel, U., Windischberger, C., Derntl, B., Robinson, S., Kryspin‐Exner, I., Gur, R. C., & Moser, E. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.01.023 · Cited by 197 · see citing works
Functional brain networks and white matter underlying theory-of-mind in autism
Kana, R. K., Libero, L. E., Hu, C. P., Deshpande, H. D., & Colburn, J. S. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss106 · Cited by 196 · see citing works
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Griebel, G., & Holsboer, F. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3702 · Cited by 194 · see citing works
The effects of vasopressin on human facial responses related to social communication
Thompson, R. R., Gupta, S., Miller, K., Mills, S. D., & Orr, S. P. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00133-6 · Cited by 184 · see citing works
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176 · see citing works
Stability of amygdala BOLD response to fearful faces over multiple scan sessions
Johnstone, T., Somerville, L. H., Alexander, A. L., Oakes, T. R., Davidson, R. J., Kalin, N. H., & Whalen, P. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.016 · Cited by 155 · see citing works
Localization of Vasopressin (V<sub>1a</sub>) Receptor Binding and mRNA in the Rhesus Monkey Brain
Young, Toloczko, & Insel (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00332.x · Cited by 139 · cited 2× · see citing works
“…directly by AVPR1a in the region itself or indirectly via connected substructures such as the amygdala, lateral septum, posterior cingulate, or thalamus that, based on studies in rodents and non-human primates, are known to express vasopressin receptors (Young et al., 1999; Phelps and Young, 2003).”
BackgroundZink, C. F., Stein, J. L., Kempf, L., Hakimi, S., & Meyer‐Lindenberg, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4899-09.2010 · Cited by 131 · see citing works
Imaging the neural circuitry and chemical control of aggressive motivation
Ferris, C. F., Stolberg, T. L., Kulkarni, P. P., Murugavel, M., Blanchard, R. J., Blanchard, D. C., Febo, M., Brevard, M. E., & Simon, N. G. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-111 · Cited by 124 · see citing works
Phelps, S. M., & Young, L. J. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10902 · Cited by 116 · see citing works
CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression
Rogers, J., Raveendran, M., Fawcett, G. L., Fox, A. S., Shelton, S. E., Oler, J. A., Cheverud, J. M., Muzny, D. M., Gibbs, R. A., Davidson, R. J., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.152 · Cited by 114 · see citing works
Dyck, M., Loughead, J., Kellermann, T., Boers, F., Gur, R. C., & Mathiak, K. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.013 · Cited by 112 · see citing works
fMRI of sensitization to angry faces
Strauss, M., Makris, N., Aharon, I., Vangel, M. G., GOODMAN, J., Kennedy, D. W., Gasic, G. P., & BREITER, H. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.053 · Cited by 92 · see citing works
Derntl, B., Habel, U., Windischberger, C., Robinson, S., Kryspin‐Exner, I., Gur, R. C., & Moser, E. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-91 · Cited by 90 · see citing works
Neural responses to facial expressions support the role of the amygdala in processing threat
Mattavelli, G. C., Sormaz, M., Flack, T. R., Asghar, A. U. R., Fan, S., Frey, J. N., Manssuer, L. R., Usten, D., Young, A. W., & Andrews, T. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst162 · Cited by 82 · see citing works
Griebel, G., Beeské, S., & Stahl, S. M. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07804 · Cited by 81 · see citing works
Zink, C. F., Kempf, L., Hakimi, S., Rainey, C. A., Stein, J. L., & Meyer‐Lindenberg, A. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.2 · Cited by 74 · see citing works
Reducing susceptibility artifacts in fMRI using volume‐selective z‐shim compensation
Du, Y. P., Dalwani, M. S., Wylie, K. P., Claus, E. D., & Tregellas, J. R. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21150 · Cited by 63 · see citing works
Vasopressin modulates neural responses related to emotional stimuli in the right amygdala
Brunnlieb, C., Münte, T. F., Tempelmann, C., & Heldmann, M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.009 · Cited by 63 · see citing works
Vasopressin Antagonists as Anxiolytics and Antidepressants: Recent Developments
Simon, N. G., Guillon, C., Fabio, K. M., Heindel, N. D., Lu, S., Miller, M., Ferris, C. F., Brownstein, M., Garippa, C., & KOPPEL, G. A. (2008) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488908784534586 · Cited by 51 · see citing works
Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects
Riekkinen, P. J., Legros, J., Sennef, C., Jolkkonen, J., Smitz, S., & Soininen, H. S. (1987) · Peptides · doi:10.1016/0196-9781(87)90101-x · Cited by 49 · see citing works
Douglas, A. J. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80014-8 · Cited by 48 · see citing works
Vasopressin modulates neural responses during human reactive aggression
Brunnlieb, C., Münte, T. F., Krämer, U. M., Tempelmann, C., & Heldmann, M. (2013) · Social Neuroscience · doi:10.1080/17470919.2013.763654 · Cited by 37 · see citing works
I want to lie about not knowing you, but my precuneus refuses to cooperate
Lee, T. M. C., Leung, M.-K., Lee, T. M. Y., Raine, A., & Chan, C. C. H. (2013) · Scientific Reports · doi:10.1038/srep01636 · Cited by 34 · see citing works
Pharmacokinetics and metabolism of SRX246: a potent and selective vasopressin 1a antagonist
Fabio, K. M., Guillon, C. D., Lu, S.-F., Heindel, N. D., Brownstein, M. J., Lacey, C. J., Garippa, C., & Simon, N. G. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23495 · Cited by 34 · see citing works
Allaman‐Exertier, G., Reymond‐Marron, I., Tribollet, E., & Raggenbass, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05866.x · Cited by 31 · see citing works
Tone, E. B., Nawa, N. E., Nelson, E. E., Detloff, A. M., Fromm, S. J., Pine, D. S., & Monique Ernst, D. (2011) · Developmental Neuropsychology · doi:10.1080/87565641.2010.549876 · Cited by 23 · see citing works
Thomas, E., DeWolfe, M., Sancar, F., Todi, N., & Yadin, E. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.07.008 · Cited by 17 · see citing works
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The neurobiology of aggression and violence
Rosell, D. R., & Siever, L. J. (2015) · CNS Spectrums · doi:10.1017/s109285291500019x · Cited by 443 · see citing works
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.595584 · Cited by 440 · see citing works
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
Kokras, N., Hodes, G. E., Bangasser, D. A., & Dalla, C. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14710 · Cited by 94 · see citing works
Chen, X., Hackett, P. D., DeMarco, A. C., Feng, C., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9411-7 · Cited by 81 · see citing works
Steinman, M. Q., Laredo, S. A., Lopez, E. M., Manning, C. E., Hao, R. C., Doig, I. E., Campi, K. L., Flowers, A. E., Knight, J. K., & Trainor, B. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.009 · Cited by 73 · see citing works
Oxytocin and vasopressin: signalling, behavioural modulation and potential therapeutic effects
Rae, M., Lemos Duarte, M., Gomes, I., Camarini, R., & Devi, L. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15481 · Cited by 72 · see citing works
Ratni, H., Rogers‐Evans, M., Bissantz, C., Grundschober, C., Moreau, J., Schuler, F., Fischer, H., Sánchez, R. A., & Schnider, P. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501745f · Cited by 53 · see citing works
Duque‐Wilckens, N., Steinman, M. Q., Laredo, S. A., Hao, R., Perkeybile, A. M., Bales, K. L., & Trainor, B. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.018 · Cited by 52 · see citing works
Witkin, J. M., Lippa, A., Smith, J. L., Jin, X., Ping, X., Biggerstaff, A., Kivell, B. M., Knutson, D. E., Sharmin, D., Pandey, K. P., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173321 · Cited by 48 · see citing works
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38 · see citing works
DePierro, J. M., Lepow, L., Feder, A., & Yehuda, R. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.009 · Cited by 38 · see citing works
Zhuang, Q., Zheng, X., Becker, B., Lei, W. I., Xu, X., & Kendrick, K. M. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105412 · Cited by 37 · see citing works
Lago, T. R., Brownstein, M., Page, E., Beydler, E. M., Manbeck, A. B., Beale, A. M., Roberts, C., Balderston, N. L., Damiano, E. M., Pineles, S. L., et al. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05861-4 · Cited by 36 · see citing works
Marvar, P. J., Andero, R., Hurlemann, R., Lago, T. R., Zelikowsky, M., & Dabrowska, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-20.2020 · Cited by 29 · see citing works
Rubin, L. H., Li, Y., Keedy, S., Reilly, J. L., Bishop, J. R., Carter, C. S., Pournajafi‐Nazarloo, H., Drogos, L. L., Tamminga, C. A., Pearlson, G. D., et al. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23820 · Cited by 32 · see citing works
Effects of vasopressin on neural processing of infant crying in expectant fathers
Thijssen, S., Van 't Veer, A. E., Witteman, J., Meijer, W. M., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.014 · Cited by 31 · see citing works
Brownstein, M., Simon, N. G., Long, J. D., Yankey, J. W., Maibach, H. T., Cudkowicz, M., Coffey, C. S., CONWIT, R. A., Lungu, C., Anderson, K. E., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113682 · Cited by 30 · see citing works
Yang, S. Y., Kim, S. A., Hur, G. M., Park, M., Park, J., & Yoo, H. J. (2017) · Molecular Autism · doi:10.1186/s13229-017-0161-9 · Cited by 29 · see citing works
Lukito, S., Fortea, L., Groppi, F., Wykret, K. Z., Tosi, E., Oliva, V., Damiani, S., Raduà, J., & Fusar‐Poli, P. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230065 · Cited by 26 · see citing works
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C. R., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19203 · Cited by 27 · see citing works
Rubin, L. H., Li, S., Li, Y., Keedy, S., Reilly, J. L., Hill, S. K., Bishop, J. R., Carter, C. S., Pournajafi‐Nazarloo, H., Drogos, L. L., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.07.003 · Cited by 25 · see citing works
Motoki, K., Sugiura, M., Takeuchi, H., Kotozaki, Y., Nakagawa, S., Yokoyama, R., & Kawashima, R. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00480 · Cited by 20 · see citing works
Combination therapy with neuropeptides for the treatment of anxiety disorder
Gupta, P. R., & Prabhavalkar, K. S. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102127 · Cited by 17 · see citing works
Arginine Vasopressin, Synaptic Plasticity, and Brain Networks
Winklewski, P. J., Marcinkowska, A. B., & Biancardi, V. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220222143532 · Cited by 15 · see citing works
Vasopressin and post-traumatic stress disorder
Sipos, E., Török, B., Barna, I., Engelmann, M., & Zelena, D. (2020) · Stress · doi:10.1080/10253890.2020.1826430 · Cited by 15 · see citing works
Sex differences of oxytocin and vasopressin in social behaviors
Lu, Q., & Hu, S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00005-7 · Cited by 17 · see citing works
Imaging neuropeptide effects on human brain function
Lefèvre, A., Hurlemann, R., & Grinevich, V. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2899-6 · Cited by 16 · see citing works
Investigational agents for the management of Huntington’s disease
Müller, T. H. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1270266 · Cited by 14 · see citing works
Vasopressin as Possible Treatment Option in Autism Spectrum Disorder
László, K., Vörös, D., Correia, P., Fazekas, C. L., Török, B., Plangár, I., & Zelena, D. (2023) · Biomedicines · doi:10.3390/biomedicines11102603 · Cited by 13 · see citing works
Advances in Psychopharmacology for Anxiety Disorders
Garakani, A., Murrough, J. W., & Iosifescu, D. V. (2014) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.12.2.152 · Cited by 13 · see citing works
The Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington’s Disease
Maibach, H. T., Brownstein, M., Hersch, S. M., Anderson, K. E., Itzkowitz, D. E., Damiano, E. M., & Simon, N. G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101561 · Cited by 11 · see citing works
Norred, M. A., Zuschlag, Z. D., & Hamner, M. B. (2024) · Drugs · doi:10.1007/s40265-023-01983-5 · Cited by 11 · see citing works
ANXIOLYTICS: Origins, drug discovery, and mechanisms
Witkin, J. M., & Barrett, J. E. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173858 · Cited by 12 · see citing works
Anxiety and the brain: Neuropeptides as emerging factors
Satao, K. S., & Doshi, G. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173878 · Cited by 12 · see citing works
Novel targets for Huntington’s disease: future prospects
Mason, S., & Barker, R. A. (2016) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s83808 · Cited by 10 · see citing works
Thompson, R. R., Price, D., Burris, D., Cloutier, A., & Rilling, J. K. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06551-7 · Cited by 8 · see citing works
Cognition and psychological wellbeing in hypopituitary patients
Imran, S. A., & Wilkinson, M. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09869-3 · Cited by 7 · see citing works
Neurotransmitters and Intermittent Explosive Disorder
Lee, R., & Coccaro, E. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813858-8.00005-x · Cited by 7 · see citing works
Difede, J., McAleavey, A. A., Emrich, M., Jick, A. R., Ovalles, A., Wyka, K., Spielman, L. A., Olden, M., Peskin, M., Becket-Davenport, C., et al. (2023) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2023.101116 · Cited by 6 · see citing works
The Vasopressin V1A Receptor and Aggression
Tan, O., & Bowen, M. T. (2023) · Springer eBooks · doi:10.1007/978-3-030-98711-4_90-1 · Cited by 1 · see citing works
Shokr, M. M., Fawzy, M. N., & Abdelaziz, A. M. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104076 · Cited by 2 · see citing works
Li, X., ZHENG, Z., Tian, X., Long, A., Yang, B., Gu, R., Ma, Y., Luo, W., & Feng, C. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121832 · Cited by 1 · see citing works
Hayes, D. J., Northoff, G., & Greenshaw, A. J. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00147 · Cited by 1 · see citing works
Lago, T. R., & Bolognani, F. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010066 · Cited by 1 · see citing works
Translational Medicine Strategies for Drug Development for Impulsive Aggression
Coccaro, E. F., Lee, R., & Simon, N. G. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-803161-2.00029-1
The Vasopressin V1A Receptor and Aggression
Tan, O., & Bowen, M. T. (2023) · Springer eBooks · doi:10.1007/978-3-031-31547-3_90
Nazarloo, H. P., Kingsbury, M. A., Lamont, H., Dale, C. V., Nazarloo, P., Davis, J. M., Porges, E. C., Cuffe, S. P., & Carter, C. S. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020194
Simon, N. G., Brownstein, M., Anderson, K. E., Lu, S., & Maibach, H. T. (2026) · Biomedicines · doi:10.3390/biomedicines14040889
Arginine-vasopressin in the management of brain disorders: recent advancement and future perspective
Kumar, S., Sanap, S., Vasoya, M., Chormale, J., Pandey, P., Khopade, A. J., Sawant, K. K., & Handa, M. (2026) · iPharma · doi:10.1016/j.iphar.2026.100007
- Authors
- Lee, R. J., Coccaro, E. F., Cremers, H., McCarron, R., Lu, S.-F., Brownstein, M. J., & Simon, N. G.
- Affiliations
- University of Chicago (US)
- Lehigh University (US)
- Azevan Pharmaceuticals (United States) (US)
- Corresponding author
- Lee, Royce J.
- Venue
- Frontiers in Systems Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 100-100
- ISSN
- 1662-5137 (ISSN-L)
- PMC
- PMC3859978
- OpenAlex
- W2056814513
- Cited by
- 50
- References
- 56
- Citations by year
- 2026: 6 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 2
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Systems Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Mental Health (R44MH063663, MH063663, R44MH087001)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin, V1a receptor antagonist, AVPR1A, amygdala, angry faces, emotional face processing, aversive emotions, temporoparietal junction, precuneus, anterior cingulate cortex, putamen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
