Sex-specific influences of vasopressin on human social communication

Thompson, R. R.; George, K.; Walton, J. C.; Orr, S. P.; Benson, J.

doi:10.1073/pnas.0600406103

Cited by 312Neuroendocrine regulation and behaviorEvolutionary Psychology and Human BehaviorFace Recognition and Perception

Sex-specific influences of vasopressin on human social communication

Thompson, R. R., George, K., Walton, J. C., Orr, S. P., Benson, J.·2006·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0600406103

Open this paper in CoChat — free account

Abstract

Arginine vasopressin (AVP) and related peptides affect social behaviors in numerous species, but AVP influences on human social functions have not yet been established. Here, we describe how intranasal AVP administration differentially affects social communication in men and women, and we propose a mechanism through which it may exert those influences. In men, AVP stimulates agonistic facial motor patterns in response to the faces of unfamiliar men and decreases perceptions of the friendliness of those faces. In contrast, in women, AVP stimulates affiliative facial motor patterns in response to the faces of unfamiliar women and increases perceptions of the friendliness of those faces. AVP also affected autonomic responsiveness to threatening faces and increased anxiety, which may underlie both communication patterns by promoting different social strategies in stressful contexts in men and women.

Integrity signals

Registry

Crossref · 10.1073/pnas.0600406103

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sex differences in the effects of AVP and OXT manipulations on behavioral and brain responses have been reported in adult humans.
“Likewise, sex differences in the effects of AVP and OXT manipulations on behavioral and brain responses have been reported in adult humans (Thompson et al., 2006; Domes et al., 2007, 2010; Lischke et al., 2012; Rilling et al., 2014).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Thompson et al., 2006
In humans, AVP has sex-specific effects on social communication and V1aR polymorphisms correlate with pair-bonding behavior in men, but not women.
“In humans, AVP has sex-specific effects on social communication (Thompson et al., 2006) and V1aR polymorphisms correlate with pair-bonding behavior in men, but not in women (Walum et al., 2008).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Thompson et al., 2006
In humans, intranasal VP has sex-specific effects during social communication and cooperation interactions.
“In humans, intranasal VP had sex-specific effects during social communication and cooperation interactions”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Thompson et al., 2006
Intranasal VP produced opposite effects on facial perception in humans.
“intranasal VP produced opposite effects on facial perception in humans (Thompson et al., 2006)”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Thompson et al., 2006

Pictures of Facial Affect
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345 · see citing works
Facial expression and emotion
Ekman, P. (1993) · American Psychologist · doi:10.1037/0003-066x.48.4.384 · Cited by 3,441 · see citing works
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308 · see citing works
Statistical difficulties of detecting interactions and moderator effects.
McClelland, G. H., & Judd, C. M. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.2.376 · Cited by 3,270 · see citing works
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
The polyvagal theory: phylogenetic substrates of a social nervous system.
Porges, S. W. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00162-3 · Cited by 1,582 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · see citing works
A method for obtaining 3-dimensional facial expressions and its standardization for use in neurocognitive studies
Gur, R. C., Šára, R., Hagendoorn, M., Marom, O., Hughett, P., Macy, L., Turner, T. H., Bajcsy, R., Posner, A., & Gur, R. E. (2002) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(02)00006-7 · Cited by 647 · see citing works
Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates
Goodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 632 · see citing works
Microsatellite instability generates diversity in brain and sociobehavioral traits
Hammock, E. A. D., & Young, L. J. (2005) · Science · doi:10.1126/science.1111427 · Cited by 545 · see citing works
Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster)
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529 · see citing works
Cerebrospinal Fluid Vasopressin Levels
Coccaro, E. F., Kavoussi, R. J., Hauger, R. L., Cooper, T. B., & Ferris, C. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.708 · Cited by 392 · see citing works
Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).
Wang, Z., Ferris, C. F., & De Vries, G. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.400 · Cited by 381 · see citing works
V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats
Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J., Wotjak, C., Holsboer, F., & Engelmann, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04250.1995 · Cited by 341 · see citing works
Duchenne smile, emotional experience, and autonomic reactivity: A test of the facial feedback hypothesis.
Soussignan, R. (2002) · Emotion · doi:10.1037/1528-3542.2.1.52 · Cited by 313 · see citing works
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295 · see citing works
Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster)
Liu, Y., Curtis, J. T., & Wang, Z. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.910 · Cited by 282 · see citing works
Neuroendocrine bases of monogamy
Young, L. J., Wang, Z., & Insel, T. R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01167-3 · Cited by 265 · see citing works
Oxytocin and Social Bondinga
CARTER, C. S., WILLIAMS, J. R., WITT, D. M., & INSEL, T. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34356.x · Cited by 237 · see citing works
Oxytocin, vasopressin, and autism: Is there a connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00142-5 · Cited by 226 · see citing works
Examination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212 · see citing works
Oxytocin, Vasopressin, and Autism: Is There a Connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0049 · Cited by 211 · see citing works
The effects of vasopressin on human facial responses related to social communication
Thompson, R. R., Gupta, S., Miller, K., Mills, S. D., & Orr, S. P. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00133-6 · Cited by 184 · see citing works
Self-citation
Oxytocin, Vasopressin, and the Neuroendocrine Basis of Pair Bond Formation
Insel, T. R., Winslow, J. T., Wang, Z., & Young, L. J. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_28 · Cited by 173 · see citing works
Effect of Intraseptal Vasotocin and Vasoactive Intestinal Polypeptide Infusions on Courtship Song and Aggression in the Male Zebra Finch ( Taeniopygia guttata )
Goodson, & Adkins‐Regan (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00284.x · Cited by 171 · see citing works
Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans
Pietrowsky, R., Strüben, C., Mölle, M., Fehm, H. L., & Jan Born, A. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00180-8 · Cited by 133 · see citing works
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129 · see citing works
Extrahypothalamic vasopressin and oxytocin in the human brain; presence of vasopressin cells in the bed nucleus of the stria terminalis
Fliers, E., Guldenaar, S. E. F., Wal, N. V. D., & Swaab, D. F. (1986) · Brain Research · doi:10.1016/0006-8993(86)90759-6 · Cited by 114 · see citing works
Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.08.002 · Cited by 87 · see citing works
Septo-hypothalamic organization of a stereotyped behavior controlled by vasopressin in golden hamsters
Ferris, C. F., Delville, Y., Irvin, R. W., & Potegal, M. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90056-6 · Cited by 43 · see citing works
Facial EMG in an anger-provoking situation: individual differences in directing anger outwards or inwards
Jäncke, L. (1996) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(96)00062-1 · Cited by 37 · see citing works
Effects of testosterone on the behavioral response to arginine vasopressin microinjected into the central gray and septum
Albers, H. E., & Cooper, T. T. (1995) · Peptides · doi:10.1016/0196-9781(94)00188-x · Cited by 33 · see citing works

Flagged first, then by citations

Sorted by citations

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743 · see citing works
The Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585 · see citing works
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“In humans, intranasal VP had sex-specific effects during social communication and cooperation interactions (Thompson et al., 2006; Rilling et al., 2014; Feng et al., 2014), while AVP1A gene variants had sex-specific effects on pair-bondng and prepulse inhibition (Walum et al.”
BackgroundInfluential
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429 · see citing works
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Oxytocin, vasopressin and sociality
CARTER, C., GRIPPO, A., POURNAJAFINAZARLOO, H., RUSCIO, M., & PORGES, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00427-5 · Cited by 380 · see citing works
Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343 · see citing works
“However, in women, AVP enhanced affiliative facial motor patterns in response to unfamiliar female faces and increased perception of friendliness in those faces (Thompson et al., 2006).”
BackgroundResultInfluentialSelf-citation
MDMA enhances emotional empathy and prosocial behavior
Hysek, C. M., Schmid, Y., Simmler, L. D., Domes, G., Heinrichs, M., Eisenegger, C., Preller, K. H., Quednow, B. B., & Liechti, M. E. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst161 · Cited by 356 · see citing works
Dopaminergic-neuropeptide interactions in the social brain
Skuse, D. H., & Gallagher, L. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.09.007 · Cited by 340 · see citing works
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338 · see citing works
Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318 · see citing works
Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
The neuroscience of affiliation: forging links between basic and clinical research on neuropeptides and social behavior
A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311 · see citing works
Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
The regulation of social recognition, social communication and aggression: vasopressin in the social behavior neural network
Albers, H. E. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.007 · Cited by 288 · see citing works
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273 · see citing works
Attachment, aggression and affiliation: the role of oxytocin in female social behavior
Campbell, A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.001 · Cited by 269 · see citing works
Oxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232 · see citing works
Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers
Di Simplicio, M., Massey-Chase, R., Cowen, P., & Harmer, C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108095705 · Cited by 229 · see citing works
Nonapeptides and the evolutionary patterning of sociality
GOODSON, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00401-9 · Cited by 228 · see citing works
Synchrony and specificity in the maternal and the paternal brain: relations to oxytocin and vasopressin
Atzil, S., Hendler, T., Zagoory-Sharon, O., Winetraub, Y., & Feldman, R. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.06.008 · Cited by 225 · see citing works
Oxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211 · see citing works
Deconstructing sociality, social evolution and relevant nonapeptide functions
Goodson, J. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.005 · Cited by 206 · see citing works
Hormonal mechanisms of cooperative behaviour
Soares, M. C., Bshary, R., Fusani, L., Goymann, W., Hau, M., Hirschenhauser, K., & Oliveira, R. F. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0151 · Cited by 173 · see citing works
Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans
Feng, C., Hackett, P. D., DeMarco, A. C., Chen, X., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9333-9 · Cited by 157 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“In humans, AVP has sex-specific effects on social communication (Thompson et al., 2006) and V1aR polymorphisms correlate with pair-bonding behavior in men, but not in women (Walum et al., 2008).”
Background
Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context
Bredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 157 · see citing works
Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149 · see citing works
“Specifically, plasma/serum (Rubin et al., 2014), saliva (Fujisawa et al., 2014), urine (Hoffman et al., 2012) or cerebrospinal fluid (CSF) (Sasayama et al., 2012) OT and ADH levels have been recently tested as putative biomarkers in ASD (Alabdali et al., 2014; Boso et al., 2007; Modahl et al., 1998), Psychosis (Elman…”
Influential
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150 · see citing works
Intranasal oxytocin modulates EEG mu/alpha and beta rhythms during perception of biological motion
Perry, A., Bentin, S., Shalev, I., Israel, S., Uzefovsky, F., Bar-On, D., & Ebstein, R. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.011 · Cited by 143 · see citing works
Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety
Beiderbeck, D. I., Neumann, I. D., & Veenema, A. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05974.x · Cited by 142 · see citing works
Vasopressin innervation of the mouse ( <i>Mus musculus</i> ) brain and spinal cord
Rood, B. D., & De Vries, G. J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22635 · Cited by 134 · see citing works
A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome
Einfeld, S. L., Smith, E., McGregor, I. S., Steinbeck, K., Taffe, J., Rice, L. J., Horstead, S. K., Rogers, N., Hodge, M. A., & Guastella, A. J. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36653 · Cited by 131 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.002 · Cited by 129 · see citing works
Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128 · see citing works
A phase 2 clinical trial of a vasopressin V1a receptor antagonist shows improved adaptive behaviors in men with autism spectrum disorder
Bolognani, F., del Valle Rubido, M., Squassante, L., Wandel, C., Derks, M., Murtagh, L., Sevigny, J., Khwaja, O., Umbricht, D., & Fontoura, P. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat7838 · Cited by 128 · see citing works
Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats
Lukas, M., Bredewold, R., Landgraf, R., Neumann, I. D., & Veenema, A. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.11.007 · Cited by 122 · see citing works
Oxytocin and vasopressin support distinct configurations of social synchrony
Apter-Levi, Y., Zagoory-Sharon, O., & Feldman, R. (2014) · Brain Research · doi:10.1016/j.brainres.2013.10.052 · Cited by 116 · see citing works
Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers
Li, T., Chen, X., Mascaro, J., Haroon, E., & Rilling, J. K. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.01.006 · Cited by 105 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
Oxytocin, but not vasopressin, increases both parochial and universal altruism
Israel, S., Weisel, O., Ebstein, R. P., & Bornstein, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.001 · Cited by 88 · see citing works
Sex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00308 · Cited by 85 · see citing works
Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women.
Chen, X., Hackett, P. D., DeMarco, A. C., Feng, C., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9411-7 · Cited by 81 · see citing works
A polymorphic indel containing the RS3 microsatellite in the 5′ flanking region of the vasopressin V1a receptor gene is associated with chimpanzee (<i>Pan troglodytes</i>) personality
Hopkins, W. D., Donaldson, Z. R., & Young, L. J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00799.x · Cited by 78 · see citing works
Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin
FERRIS, C. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00425-1 · Cited by 75 · see citing works
Vasopressin, but not oxytocin, increases empathic concern among individuals who received higher levels of paternal warmth: a randomized controlled trial
Tabak, B. A., Meyer, M. L., Castle, E., Dutcher, J. M., Irwin, M. R., Han, J. H., Lieberman, M. D., & Eisenberger, N. I. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.006 · Cited by 67 · see citing works
Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition
Levin, R., Heresco-Levy, U., Bachner-Melman, R., Israel, S., Shalev, I., & Ebstein, R. P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.014 · Cited by 68 · see citing works
Gender moderates the effect of oxytocin on social judgments
Hoge, E. A., Anderson, E., Lawson, E. A., Bui, E., Fischer, L. E., Khadge, S. D., Barrett, L. F., & Simon, N. M. (2014) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2402 · Cited by 64 · see citing works
Interaction of Stress, Corticotropin-Releasing Factor, Arginine Vasopressin and Behaviour
Beurel, E., & Nemeroff, C. B. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_306 · Cited by 64 · see citing works
Neurobiology of sociability
Caldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58 · see citing works
Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: An fMRI study
Lee, R. J., Coccaro, E. F., Cremers, H., McCarron, R., Lu, S.-F., Brownstein, M. J., & Simon, N. G. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00100 · Cited by 50 · see citing works
Explicit and implicit caregiving interests in expectant fathers: Do endogenous and exogenous oxytocin and vasopressin matter?
Cohen-Bendahan, C. C. C., Beijers, R., van Doornen, L. J. P., & de Weerth, C. (2015) · Infant Behavior and Development · doi:10.1016/j.infbeh.2015.06.007 · Cited by 50 · see citing works
Intranasal oxytocin modulates neural functional connectivity during human social interaction
Rilling, J. K., Chen, X., Chen, X., & Haroon, E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22740 · Cited by 40 · see citing works
Effects of vasopressin on neural processing of infant crying in expectant fathers
Thijssen, S., Van 't Veer, A. E., Witteman, J., Meijer, W. M., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.014 · Cited by 31 · see citing works
Oxytocin and vasopressin modulate risk-taking
Patel, N., Grillon, C., Pavletic, N., Rosen, D., Pine, D. S., & Ernst, M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.018 · Cited by 29 · see citing works
Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice
Rigney, N., Zbib, A., de Vries, G. J., & Petrulis, A. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13083 · Cited by 29 · see citing works
Vasopressin differentially affects handgrip force of expectant fathers in reaction to own and unknown infant faces
Alyousefi-van Dijk, K., van ‘t Veer, A. E., Meijer, W. M., Lotz, A. M., Rijlaarsdam, J., Witteman, J., & Bakermans-Kranenburg, M. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00105 · Cited by 22 · see citing works
Pleiotropic Contribution of MECOM and AVPR1A to Aggression and Subcortical Brain Volumes
van Donkelaar, M. M. J., Hoogman, M., Pappa, I., Tiemeier, H., Buitelaar, J. K., Franke, B., & Bralten, J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00061 · Cited by 16 · see citing works
Changes in social functioning and circulating oxytocin and vasopressin following the migration to a new country
Gouin, J.-P., Pournajafi-Nazarloo, H., & Carter, C. S. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.021 · Cited by 9 · see citing works

Authors: Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J.
Affiliations: Bowdoin College (US)
Harvard University (US)
ORCID: Thompson, R. R.
Walton, J. C.
Orr, S. P.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2006-05-16
Volume: 103
Issue: 20
Pages: 7889-7894
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0600406103
OpenAlex: W2106348525
Cited by: 312
References: 34
Citations by year: 2026: 10 · 2025: 14 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 15 · 2020: 4 · 2019: 20 · 2018: 16 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 28 · 2013: 28 · 2012: 25
FWCI: 18.55
Type: journal article
Language: en
Open access: closed
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R03MH063996-01A, R03MH063996)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords: vasopressin, sex differences, social communication, facial expressions, intranasal administration, face perception, affiliative behavior, agonistic behavior, anxiety, threatening faces, social behavior
MeSH terms: Administration, Intranasal, Adolescent, Adult, Animals, Arginine Vasopressin, Communication, Electromyography, Facial Expression, Female, Humans, Male, Motor Activity, Sex Factors, Social Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex-specific influences of vasopressin on human social communication

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks