Examination of AVPR1a as an autism susceptibility gene
Abstract
Impaired reciprocal social interaction is one of the core features of autism. While its determinants are complex, one biomolecular pathway that clearly influences social behavior is the arginine-vasopressin (AVP) system. The behavioral effects of AVP are mediated through the AVP receptor 1a (AVPR1a), making the AVPR1a gene a reasonable candidate for autism susceptibility. We tested the gene's contribution to autism by screening its exons in 125 independent autistic probands and genotyping two promoter polymorphisms in 65 autism affected sibling pair (ASP) families. While we found no nonconservative coding sequence changes, we did identify evidence of linkage and of linkage disequilibrium. These results were most pronounced in a subset of the ASP families with relatively less severe impairment of language. Thus, though we did not demonstrate a disease-causing variant in the coding sequence, numerous nontraditional disease-causing genetic abnormalities are known to exist that would escape detection by traditional gene screening methods. Given the emerging biological, animal model, and now genetic data, AVPR1a and genes in the AVP system remain strong candidates for involvement in autism susceptibility and deserve continued scrutiny.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There have been three independent reports of a genetic association between polymorphisms in the human AVPR1A and symptoms of ASD.
“In addition, there have now been three independent reports of a genetic association between these polymorphisms in the human AVPR1A and symptoms of ASD [47–49].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [48]
Cites
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Parametric and nonparametric linkage analysis: a unified multipoint approach.
Kruglyak, L., Daly, M. J., Daly, M. J., & Lander, E. S. (1996) · PubMed Central · Cited by 2,883 · see citing works
Fast and sensitive silver staining of DNA in polyacrylamide gels
Bassam, B. J., Caetano‐Anollés, G., & Gresshoff, P. M. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90120-i · Cited by 2,857 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · see citing works
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488 · see citing works
Cerebrospinal Fluid Vasopressin Levels
Coccaro, E. F., Kavoussi, R. J., Hauger, R. L., Cooper, T. B., & Ferris, C. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.708 · Cited by 392 · see citing works
Diagnosing Autism: Analyses of Data from the Autism Diagnostic Interview
Lord, C., Pickles, A. R., McLennan, J. D., Rutter, M. L., Bregman, J. D., Folstein, S. E., Fombonne, E. J., Leboyer, M., & Minshew, N. J. (1997) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025873925661 · Cited by 374 · see citing works
Self-citationThibonnier, M., Auzan, C., Madhun, Z. T., Wilkins, P. L., Berti‐Mattera, L. N., & Clauser, É. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41863-1 · Cited by 281 · see citing works
Kim, S.-J., Young, L. J., Gonen, D., Veenstra-VanderWeele, J., Courchesne, R., Courchesne, E., Lord, C., Leventhal, B. L., Cook Jr, E. H., & Insel, T. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001125 · Cited by 265 · see citing works
Neuropeptides and the evolution of social behavior
Insel, T. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00146-x · Cited by 264 · see citing works
A Major Susceptibility Locus for Specific Language Impairment Is Located on 13q21
Bartlett, C. W., Flax, J. F., Logue, M. W., Vieland, V. J., Bassett, A. S., Tallal, P. A., & Brzustowicz, L. M. (2002) · The American Journal of Human Genetics · doi:10.1086/341095 · Cited by 210 · see citing works
Self-citationIncorporating language phenotypes strengthens evidence of linkage to autism
Bradford, Y., Haines, J. L., Hutcheson, H. B., Gardiner, M., Braun, T. A., Sheffield, V. C., Cassavant, T., Huang, W. Q., Wang, K., Vieland, V. J., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1497 · Cited by 206 · see citing works
Self-citationEfficient Multipoint Linkage Analysis through Reduction of Inheritance Space
Markianos, K., Daly, M. J., & Kruglyak, L. (2001) · The American Journal of Human Genetics · doi:10.1086/319507 · Cited by 134 · see citing works
Wang, Z., Liu, Y., Young, L. J., & Insel, T. R. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00435.x · Cited by 134 · see citing works
Chromosome 7q: Where Autism Meets Language Disorder?
Folstein, S. E., & Mankoski, R. E. (2000) · The American Journal of Human Genetics · doi:10.1086/303034 · Cited by 95 · see citing works
Self-citationThibonnier, M., Graves, M. K., Wagner, M., Chatelain, N., Soubrier, F., Corvol, P. L., Willard, H. F., & Jeunemaı̂tre, X. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1108 · Cited by 73 · see citing works
Bluthé, R.-M., & Dantzer, R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90480-w · Cited by 47 · see citing works
Arolt, V., Lencer, R., Purmann, S., Sch�rmann, M., M�ller-Myhsok, B., Krecker, K., & SCHWINGER, E. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19991215)88:6 · Cited by 46 · see citing works
Vasopressin modulates male squirrel monkeys' behavior during social separation
Winslow, J., & Insel, T. R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90671-c · Cited by 37 · see citing works
Twin and adoption studies in child and adolescent psychiatric disorders
Folstein, S. E. (1996) · Current Opinion in Pediatrics · doi:10.1097/00008480-199608000-00007 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · see citing works
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624 · see citing works
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Eriksson, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803081105 · Cited by 460 · see citing works
The genetics of sex differences in brain and behavior
Ngun, T. C., Ghahramani, N., Sánchez, F. J., Bocklandt, S., & Vilain, E. J. N. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.10.001 · Cited by 437 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism
Patrick, R. P., & Ames, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.13-246546 · Cited by 414 · see citing works
Neurochemistry in the pathophysiology of autism.
McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005) · PubMed · Cited by 408 · see citing works
The molecular genetic architecture of human personality: beyond self-report questionnaires
Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001814 · Cited by 362 · see citing works
Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352 · see citing works
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343 · see citing works
“In addition to ASD, studies have begun to investigate the effectiveness of intranasal OT as a treatment for schizophrenia, social anxiety disorder and depression (Striepens, et al., 2011).”
BackgroundInfluentialDopaminergic-neuropeptide interactions in the social brain
Skuse, D. H., & Gallagher, L. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.09.007 · Cited by 340 · see citing works
Lam, K. S. L., Bodfish, J. W., & Piven, J. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01944.x · Cited by 320 · see citing works
Self-citationThe journal of developmental processes
Disorders, L., & Milton (2006) · Medical Entomology and Zoology · Cited by 325 · see citing works
Sex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., Bachner-Melman, R., Maril, A., Bornstein, G., Knafo, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005535 · Cited by 278 · see citing works
The prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276 · see citing works
AUTISM AS A PARADIGMATIC COMPLEX GENETIC DISORDER
Veenstra-VanderWeele, J. M., Christian, S. L., & Cook, E. H. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.180050 · Cited by 271 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
Yirmiya, N., Rosenberg, C., Levi, S., Salomon, S., Shulman, C., Nemanov, L., Dina, C., & Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001812 · Cited by 232 · see citing works
Meyer‐Lindenberg, A., Kolachana, B. S., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V. S., Dean, M. C., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.54 · Cited by 219 · see citing works
AVPR1a and SLC6A4 Gene Polymorphisms Are Associated with Creative Dance Performance
Bachner‐Melman, R., Christian Dina, C., Zohar, A. H., Constantini, N., Lerer, E., Hoch, S., Sella, S., Nemanov, L., Gritsenko, I., Lichtenberg, P., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010042 · Cited by 222 · see citing works
Genetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213 · see citing works
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 199 · see citing works
Arginine Vasopressin and Oxytocin Modulate Human Social Behavior
Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., Riebold, M., Salomon, S., & Yirmiya, N. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04541.x · Cited by 194 · see citing works
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Santangelo, S. L., & Tsatsanis, K. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505020-00001 · Cited by 183 · see citing works
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176 · see citing works
Hus, V., Pickles, A., Cook, E. H., Risi, S., & Lord, C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.044 · Cited by 172 · see citing works
Anatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163 · see citing works
The vasopressin system — From antidiuresis to psychopathology
Frank, E., & Landgraf, R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.063 · Cited by 159 · see citing works
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works
Badcock, C., & Crespi, B. J. (2006) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2006.01091.x · Cited by 148 · see citing works
Oxytocin and experimental therapeutics in autism spectrum disorders
BARTZ, J., & HOLLANDER, E. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00435-4 · Cited by 139 · see citing works
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 136 · see citing works
Social Neuroscience: Progress and Implications for Mental Health
Cacioppo, J. T., Amaral, D. G., Blanchard, J. J., Cameron, J. L., Carter, C. S., Crews, D. P., Fiske, S. T., Heatherton, T. F., Johnson, M. K., Kozak, M. J., et al. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00032.x · Cited by 132 · see citing works
Uzefovsky, F., Shalev, I., Israel, S., Edelman, S., Raz, Y., Mankuta, D., Knafo-Noam, A., & Ebstein, R. P. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.11.007 · Cited by 131 · see citing works
Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior
Hammock, E. A. D., Lim, M. M., Nair, H. P., & Young, L. J. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00119.x · Cited by 128 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129 · see citing works
Musical Aptitude Is Associated with AVPR1A-Haplotypes
Ukkola, L. T., Onkamo, P., Raijas, P., Karma, K., & Järvelä, I. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005534 · Cited by 127 · see citing works
Neurobiological correlates of social functioning in autism
Neuhaus, E., Beauchaine, T. P., & Bernier, R. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.05.007 · Cited by 122 · see citing works
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Reibold, M., Bachner‐Melman, R., Granot, R., Bornstein, G., KNAFO, A., & Yirmiya, N. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00434-2 · Cited by 119 · see citing works
Yang, M. S., & Gill, M. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.12.002 · Cited by 118 · see citing works
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
Oxytocin and Vasopressin: Genetics and Behavioral Implications
Caldwell, H. K., & Young, W. S. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_25 · Cited by 113 · see citing works
Impact of prosocial neuropeptides on human brain function
MEYERLINDENBERG, A. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00436-6 · Cited by 109 · see citing works
Heroin addiction in African Americans: a hypothesis‐driven association study
Levran, O., Londoño, D., O’Hara, K., Randesi, M., Rotrosen, J., Casadonte, P. P., Linzy, S., Ott, J., Adelson, M., & Kreek, M. J. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00501.x · Cited by 107 · see citing works
Lerer, E., Levi, S., Israel, S., Yaari, M., Nemanov, L., Mankuta, D., Yirmiya, N., & Ebstein, R. P. (2010) · Autism Research · doi:10.1002/aur.156 · Cited by 104 · see citing works
Barrett, C. E., Keebaugh, A. C., Ahern, T. H., Bass, C. E., Terwilliger, E. F., & Young, L. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.005 · Cited by 100 · see citing works
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 95 · see citing works
Murakami, G., Hunter, R. G., Fontaine, C., Ribeiro, A., & Pfaff, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07761.x · Cited by 99 · see citing works
Tansey, K. E., Hill, M., Cochrane, L. E., Gill, M., Anney, R., & Gallagher, L. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-3 · Cited by 94 · see citing works
Telescoping of caregiver report on the Autism Diagnostic Interview – Revised
Hus, V., Taylor, A., & Lord, C. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02398.x · Cited by 87 · see citing works
AVPR1A Variant Associated with Preschoolers' Lower Altruistic Behavior
Avinun, R., Israel, S., Shalev, I., Gritsenko, I., Bornstein, G., Ebstein, R. P., & Knafo‐Noam, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025274 · Cited by 85 · see citing works
Umbricht, D., Rubido, M. D. V., Hollander, E., McCracken, J. T., Shic, F., Scahill, L. D., Noeldeke, J., Boak, L. M., Khwaja, O., Squassante, L., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.232 · Cited by 80 · see citing works
Nicot, A. B., Otto, T. A., Brabet, P., & DiCicco-Bloom, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1910-04.2004 · Cited by 79 · see citing works
Zhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
Social Circuits: Peptidergic Regulation of Mammalian Social Behavior
Storm, E. E., & Tecott, L. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.004 · Cited by 73 · see citing works
Levin, R., Heresco-Levy, U., Bachner-Melman, R., Israel, S., Shalev, I., & Ebstein, R. P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.014 · Cited by 68 · see citing works
Tabak, B. A., Meyer, M. L., Castle, E., Dutcher, J. M., Irwin, M. R., Han, J. H., Lieberman, M. D., & Eisenberger, N. I. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.006 · Cited by 67 · see citing works
Spence, S. J. (2004) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2004.07.003 · Cited by 66 · see citing works
Schnider, P., Bissantz, C., Bruns, A., Dolente, C., Goetschi, E., Jakob‐Roetne, R., Künnecke, B., Mueggler, T., Muster, W., Parrott, N. J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01478 · Cited by 64 · see citing works
Caldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58 · see citing works
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 63 · see citing works
Harony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62 · see citing works
Donaldson, Z. R., Kondrashov, F. A., Putnam, A. S., Bai, Y., Stoinski, T., Hammock, E. A. D., & Young, L. J. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-180 · Cited by 61 · see citing works
ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR
Francis, S. M., Kim, S., Kistner‐Griffin, E., Guter, S. J., Cook, E. H., & Jacob, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00516 · Cited by 62 · see citing works
The role of oxytocin and vasopressin in emotional and social behaviors
Bachner‐Melman, R., & Ebstein, R. P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00004-6 · Cited by 62 · see citing works
On switches and knobs, microsatellites and monogamy
Young, L. J., & Hammock, E. A. D. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.02.010 · Cited by 58 · see citing works
Teltsh, O., Kanyas, K., Rigbi, A., Greenbaum, L., Lerer, B., & Kohn, Y. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001374 · Cited by 58 · see citing works
Toward a Behavior of Reciprocity.
Gernsbacher, M. A. (2006) · PubMed · Cited by 58 · see citing works
Comparative endocrinology in the 21st century
Denver, R. J., Hopkins, P. M., McCormick, S. D., Propper, C. R., Riddiford, L. M., Sower, S. A., & Wingfield, J. C. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp082 · Cited by 57 · see citing works
Common and specific liability to addiction: Approaches to association studies of opioid addiction
Nielsen, D. A., & Kreek, M. J. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.03.026 · Cited by 55 · see citing works
Egashira, N., 三島, 健., Iwasaki, K., Oishi, R., & Fujiwara, M. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r14fm · Cited by 56 · see citing works
Donaldson, Z. R., & Young, L. J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003729 · Cited by 52 · see citing works
Bachner‐Melman, R., Zohar, A. H., Bacon-Shnoor, N., Elizur, Y., Nemanov, L., Gritsenko, I., & Ebstein, R. P. (2005) · Journal of Individual Differences · doi:10.1027/1614-0001.26.1.2 · Cited by 52 · see citing works
Vasopressin and social odor processing in the olfactory bulb and anterior olfactory nucleus
Wacker, D. W., Engelmann, M., Tobin, V. A., Meddle, S., & Ludwig, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05885.x · Cited by 51 · see citing works
Lee, R. J., Coccaro, E. F., Cremers, H., McCarron, R., Lu, S.-F., Brownstein, M. J., & Simon, N. G. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00100 · Cited by 50 · see citing works
Imaging-Genetics in Autism Spectrum Disorder: Advances, Translational Impact, and Future Directions
Ameis, S. H., & Szatmári, P. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00046 · Cited by 46 · see citing works
Hammock, E. A. D., & Levitt, P. R. (2006) · Human Development · doi:10.1159/000095581 · Cited by 46 · see citing works
Hu‐Lince, D., Craig, D. W., Huentelman, M. J., & Stephan, D. A. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505040-00004 · Cited by 47 · see citing works
Yang, S. Y., Cho, S.-C., Yoo, H. J., Cho, I. H., Park, M., Kim, B.-N., Kim, J.-W., Shin, M.-S., Park, T.-W., Son, J.-W., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.050 · Cited by 45 · see citing works
High variability and non-neutral evolution of the mammalian avpr1a gene
Fink, S., Excoffier, L., & Heckel, G. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-176 · Cited by 46 · see citing works
Yang, S. Y., Cho, S.-C., Yoo, H. J., Cho, I. H., Park, M., Yoe, J., & Kim, S. A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.11.007 · Cited by 44 · see citing works
Rodent models for autism: A critical review
Belzung, C., Leman, S., Vourc’h, P., & Andres, C. R. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.05.004 · Cited by 43 · see citing works
Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music
Ukkola‐Vuoti, L., Oikkonen, J., Onkamo, P., Karma, K., Raijas, P., & Järvelä, I. E. (2011) · Journal of Human Genetics · doi:10.1038/jhg.2011.13 · Cited by 42 · see citing works
Reduced Plasma Apelin Levels in Patients with Autistic Spectrum Disorder
Boso, M., Emanuele, E., Politi, P., Pace, A., Arra, M., Nemi, S. U. D., & Barale, F. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.08.003 · Cited by 42 · see citing works
Thompson, R. R., Walton, J. C., Bhalla, R., George, K., & Beth, E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06210.x · Cited by 41 · see citing works
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
Kim, K. C., Gonzales, E. L., Lázaro, M. T., Choi, C. S., Bahn, G. H., Yoo, H. J., & Shin, C. Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.061 · Cited by 40 · see citing works
- Authors
- Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C.
- Affiliations
- University of Iowa (US)
- University of North Carolina at Chapel Hill (US)
- Tufts University (US)
- Corresponding author
- Wassink, T H
- Venue
- Molecular Psychiatry
- Published
- 2004-04-06
- Volume
- 9
- Issue
- 10
- Pages
- 968-972
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2051055980
- Cited by
- 212
- References
- 21
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 12 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 16 · 2013: 11 · 2012: 14
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AVPR1A, autism susceptibility, autism spectrum disorder, reciprocal social interaction, linkage analysis, linkage disequilibrium, promoter polymorphism, language impairment, genetic risk
- MeSH terms
- Autistic Disorder, Codon, DNA Mutational Analysis, Exons, Family Health, Genetic Testing, Genotype, Humans, Language Disorders, Genetic Linkage, Lod Score, Polymorphism, Genetic, Promoter Regions, Genetic, United States, Linkage Disequilibrium, Receptors, Vasopressin, Genetic Predisposition to Disease, Siblings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
