Localization of Vasopressin (V1a) Receptor Binding and mRNA in the Rhesus Monkey Brain
Abstract
Centrally released arginine vasopressin (AVP) has been associated with various behavioural and cognitive effects, such as scent marking, aggression, and memory, which are believed to be mediated by the V 1a subtype of the vasopressin receptor. Although the distribution of V 1a receptors is conserved in a few brain regions, the pattern of expression of this receptor is, in general, highly species‐specific. We have used receptor autoradiography with the linear V 1a receptor ligand (125 I‐Phenylacetyl‐D‐Tyr(Me)‐Phe‐Gln‐Asn‐Arg‐Pro‐Arg‐Tyr‐NH 2) to characterize the pattern of receptor binding in the rhesus monkey brain. Brain sites of V 1a receptor synthesis were defined using in‐situ hybridization. The regions of highest V 1a receptor density included the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mamillary bodies. In addition, V 1a receptor binding and mRNA were detected in several regions reported to have V 1a receptor in most rodents, including the amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus and the brainstem. The distribution is consistent with a role for vasopressin in higher cognitive functions, especially memory, in primates.
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Before the pharmacological limitations were understood, these radioligands were used for receptor autoradiography in the common marmoset, rhesus macaque, and human.
“Nevertheless, before these pharmacological limitations were fully understood, these radioligands (as well as the older tritiated versions of the endogenous neuropeptides themselves) were used for receptor autoradiography in three primate species: in the common marmoset for OXTR and AVPR1a (29,30), in the rhesus macaque for AVPR1a (31), and in human for OXTR and AVPR1a (32,33).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [31]
The rhesus macaque brain exhibits extremely sparse oxytocin receptor expression relative to vasopressin receptor 1a, with the densest oxytocin receptor binding in the nucleus basalis of Meynert and superficial grey layer of the superior colliculus.
“The rhesus macaque brain in general exhibits extremely sparse OXTR expression relative to AVPR1a (27,31), with the most dense OXTR binding seen in the NBM and superficial grey layer of the SC (Fig. 2c,f).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [31]
V1aR is widely distributed throughout the brain of Macaca, with notable expression in the social-decision making network and in regions within social/cognitive circuits, including CeA, PFC, CC, and IC.
“Similar to Callithrix and Callicebus, V1aR is widely distributed throughout the brain of Macaca, with notable expression in the social-decision making network as well in regions conventionally identified within social/cognitive circuits, including the CeA, PFC, CC, and IC (confirmed by in situ hybridization; Young et al., 1999).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Young et al., 1999
Male and female Macaca and Homo display similar density and distribution of V1aR.
“The limited information on sex differences in V1aR shows that male and female Macaca (Young et al., 1999) and Homo (Loup et al., 1991) display similar density and distribution of V1aR.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Young et al., 1999
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“…the monogmous marmoset monkey and the monogamous California ouse (Peromyscus californicus) both have receptors ere, but the non-monogamous rhesus monkey and the on-monogamous white-footed mouse (P. leucopus) do ot (Wang et al., 1997b; Bester-Meredith et al., 1999; oung, 1999; Young et al., 1999).”
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“In this same region, relatively little V1aR binding is detectable in related nonmonogamous montane (M. montanus) and meadow (M. pennsylvanicus) voles, white-footed mice (Peromyscus leucopus), and rhesus monkeys (Insel et al., 1994; Bester-Meredith et al., 1999; Young, 1999; Young et al., 1999b ).”
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“This analysis was conducted in brain sections from the same HAB and LAB males used for AVP and OXT mRNA hybridization following procedures previously described (Young et al, 1999, 2000).”
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“exhibit dense OTR expression in the NAc, while socially monogamous and alloparental coppery titi monkeys exhibit dense V1aR expression in this region (Freeman and Young, 2016); in contrast, non-monogamous rhesus macaques exhibit low levels of OTR and V1aR binding in the NAc (Figure 2) (Freeman et al., 2014; Young et a…”
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“Interestingly, the ventral forebrain expression of V1aR is also higher in the monogamous California deer mouse and marmoset monkey when compared with that of closely related promiscuous species, which suggests convergent evolution of AVP-mediated circuits as a proximate mechanism for social attachment in monogamous sp…”
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“Nevertheless, before these pharmacological limitations were fully understood, these radioligands (as well as the older tritiated versions of the endogenous neuropeptides themselves) were used for receptor autoradiography in three primate species: in the common marmoset for OXTR and AVPR1a (29,30), in the rhesus macaqu…”
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“In support of this hypothesis, comparative analysis of the V1a receptor gene in several species of voles found the microsatellite region to be significantly longer in monogamous species compared to non-monogamous species (Young et al., 1999a; Hammock and Young, 2002, 2004, 2005).”
BackgroundResultInfluentialNeural circuits underlying crying and cry responding in mammals
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“Both OT and AVP have been localized to the amygdala , both with respect to receptors and to the effects of these neuropeptides on specific neuronal populations, e.g., [38] and [125].”
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“Our results with (125)I-LVA fully match the previously reported distribution of AVPR1A binding in the rhesus macaque (Young et al., 1999).”
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“AVPR1a in the central amygdala We observed dense AVPR1a binding in the CeA in titi monkeys, which is an area of dense AVPR1a expression in rhesus macaques as well (Freeman et al., in press; Young et al., 1999b).”
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“Disruption in AVPR1A expression in the brain has been associated with major behavioural changes [8-11].”
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“…of vasopressin (VP) V1a receptors in the ventral pallidum than do non-monogamous comparators (Insel, 1992; Insel et al., 1994; Wang et al., 1997; Young et al., 1997, 1999; Bester-Meredith et al., 1999; this area was identified as the diagonal band in some earlier reports; see Young et al.,…”
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“…OTR and V1aR density and distribution in the pri880 mate brain (Loup et al., 1989, 1991; Schorscher-Petcu et al., 2009; 881 Wang et al., 1997b; Young et al., 1999) should be cautiously eval882 uated in light of the limitations of radioligands utilized for receptor 883 autoradiography in…”
Oxytocin modulates fMRI responses to facial expression in macaques
Liu, N., Hadj-Bouziane, F., Jones, K. B., Turchi, J. N., Averbeck, B. B., & Ungerleider, L. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508097112 · Cited by 65 · see citing works
“AVP1A receptors are densely located in the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mammillary bodies, but are also found in the amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus, and brainstem (43).”
BackgroundJiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25607-1 · Cited by 66 · see citing works
Arginine vasopressin: Direct and indirect action on metabolism
Yoshimura, M., Conway-Campbell, B. L., & Ueta, Y. (2021) · Peptides · doi:10.1016/j.peptides.2021.170555 · Cited by 64 · see citing works
“consistent with a role for AVP in higher cognitive functions, including the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mamillary bodies in rhesus monkeys [40].”
Titi Monkeys as a Novel Non-Human Primate Model for the Neurobiology of Pair Bonding .
Bales, K. L., Razo, R. A., Conklin, Q. A., Hartman, S., Mayer, H. S., Rogers, F. D., Simmons, T. C., Smith, L. K., Williams, A. V., Williams, D. R., et al. (2017) · Europe PMC (PubMed Central) · Cited by 62 · see citing works
Vasopressin modulates neural responses related to emotional stimuli in the right amygdala
Brunnlieb, C., Münte, T. F., Tempelmann, C., & Heldmann, M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.009 · Cited by 63 · see citing works
“…Vasopressin V1 receptors can be found in the hypothalamus itself, the brain stem, the lateral septum, and the nucleus accumbens, but also in the hippocampus, the amygdala, and in parts of the extended amygdala complex, the bed nucleus of the stria terminalis (Loup et al., 1991; Young et al., 1999).”
Donaldson, Z. R., Kondrashov, F. A., Putnam, A. S., Bai, Y., Stoinski, T., Hammock, E. A. D., & Young, L. J. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-180 · Cited by 61 · see citing works
“However, the distribution of V1aR differs strikingly between humans and rhesus macaque, mirroring differences we identified in the AVPR1A upstream region of these two species [29].”
BackgroundSmith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
“, 2006), macaques (Young et al., 1999), or humans (Table 2; Loup et al.”
BackgroundYilmazer‐Hanke, D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10022-7 · Cited by 60 · see citing works
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 60 · see citing works
“…fear, and anxiety) appear to be mediated centrally by the AVP1A receptor (Zink et al., 2010), present in the lateral septum, hypothalamus, BNST, hippocampus, amygdala, brainstem (Loup et al., 1991; Young et al., 1999), and in monkey prefrontal cortex and cingulate cortex (Young et al., 1999).”
BackgroundNeural distribution of nonapeptide binding sites in two species of songbird
Leung, C. H., Goode, C. T., Young, L. J., & Maney, D. L. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.21947 · Cited by 58 · see citing works
Putnam, P. T., Roman, J. M., Zimmerman, P. E., & Gothard, K. M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.016 · Cited by 53 · see citing works
“OT is known to also bind to vasopressin-1A receptors (AVPR1A), which are amply expressed in the amygdala and the cortex (Young et al., 1999), implying that the behavioral effects seen in this study might be explained independently of OXTR activation (Schorscher-Petcu et al.”
Ratni, H., Rogers‐Evans, M., Bissantz, C., Grundschober, C., Moreau, J., Schuler, F., Fischer, H., Sánchez, R. A., & Schnider, P. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501745f · Cited by 53 · see citing works
Duque‐Wilckens, N., Steinman, M. Q., Laredo, S. A., Hao, R., Perkeybile, A. M., Bales, K. L., & Trainor, B. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.018 · Cited by 52 · see citing works
“…in V1aR binding (Bester-Meredith et al., 1999; Hammock and Young, 2006), dense V1aR binding in the bed nucleus of the stria terminalis (BNST) is observed in a diverse group of rodents (Bales et al., 2007; Bosch et al., 2010) and primates (Freeman et al., 2014a, 2014b; Young et al., 1999).”
Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem
Freeman, S. M., Smith, A. L., Goodman, M. M., & Bales, K. L. (2017) · Social Neuroscience · doi:10.1080/17470919.2016.1156570 · Cited by 51 · see citing works
Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
Szczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., & Żera, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111465 · Cited by 53 · see citing works
Flattery, C. N. R., Ross, A. P., Sahu, S. P., Siegel, E. R., Dooyema, J. M., Cree, M. A., Stopa, E. G., Young, L. J., Rilling, J. K., Albers, H. E., et al. (2018) · American Journal of Primatology · doi:10.1002/ajp.22875 · Cited by 50 · see citing works
Lee, R. J., Coccaro, E. F., Cremers, H., McCarron, R., Lu, S.-F., Brownstein, M. J., & Simon, N. G. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00100 · Cited by 50 · see citing works
“…directly by AVPR1a in the region itself or indirectly via connected substructures such as the amygdala, lateral septum, posterior cingulate, or thalamus that, based on studies in rodents and non-human primates, are known to express vasopressin receptors (Young et al., 1999; Phelps and Young, 2003).”
BackgroundPotasiewicz, A., Hołuj, M., Litwa, E., Gzieło, K., Socha, L., Popik, P., & Nikiforuk, A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108040 · Cited by 39 · see citing works
Prounis, G. S., Thomas, K., & Ophir, A. G. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24450 · Cited by 36 · see citing works
Otero-Garcia, M., Martín-Sánchez, A., Fortes-Marco, L., Martínez-Ricós, J., Agustín-Pavón, C., Lanuza, E., & Martínez-García, F. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0553-3 · Cited by 38 · see citing works
“This fits the fact that, when compared with promiscuous, monogamous species show higher levels of V1aR in the mvStP in voles (Young et al. 1997), rodents of the genus Peromyscus (Bester-Meredith et al. 1999) and primates (Young et al. 1999b; Schorscher- Petcu et al. 2009).”
BackgroundThe acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors
Caldwell, H. K., Stewart, J., Wiedholz, L. M., Millstein, R. A., Iacangelo, A. L., Holmes, A., Young, W. S., & Wersinger, S. R. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.001 · Cited by 39 · see citing works
Fox, A. S., Oakes, T. R., Shelton, S. E., Converse, A. K., Davidson, R. J., & Kalin, N. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409470102 · Cited by 36 · see citing works
Beyond romance: Neural and genetic correlates of altruism in pair-bonds.
Acevedo, B. P., Poulin, M. J., & Brown, L. L. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000293 · Cited by 35 · see citing works
“The septum, for example, has been identified in studies of monogamous voles (Liu, Curtis, & Wang, 2001), and is rich in OT and AVP receptors (Loup et al., 1991; Young et al., 1999).”
Rogers Flattery, C. N., Coppeto, D. J., Inoue, K., Rilling, J. K., Preuss, T. M., & Young, L. J. (2022) · Brain Structure and Function · doi:10.1007/s00429-021-02369-7 · Cited by 31 · see citing works
“Neither AVPR1a or OXTR are expressed in the ventral pallidum or nucleus accumbens of non-monogamous rhesus macaques (Freeman et al. 2014a; Young et al. 1999).”
BackgroundCushing, B. S., Okorie, U., & Young, L. J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01097.x · Cited by 31 · see citing works
Editorial: Neuroendocrinology With Feeling
Russell, J. A. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2001.00760.x · Cited by 31 · see citing works
Seasonal Variation in Group Size Is Related to Seasonal Variation in Neuropeptide Receptor Density
Wilson, L. C., Goodson, J. L., & Kingsbury, M. A. (2016) · Brain Behavior and Evolution · doi:10.1159/000448372 · Cited by 30 · see citing works
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28 · see citing works
“It appears that in primates AVPRs are expressed more widely, or at least more easily detectable, and in areas where OXTR is not abundantly detectable, notably the amygdala, and throughout the cortex (Freeman et al., 2017; Schorscher-Petcu et al., 2009; Young, Toloczko, & Insel, 1999).”
BackgroundFebo, M., & Ferris, C. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.019 · Cited by 29 · see citing works
“In nonhuman primates the expression of their receptors may include regions of the neocortex (Young et al., 1999).”
BackgroundYang, S. Y., Kim, S. A., Hur, G. M., Park, M., Park, J., & Yoo, H. J. (2017) · Molecular Autism · doi:10.1186/s13229-017-0161-9 · Cited by 29 · see citing works
The Hypothalamic–Pituitary–Adrenal Axis and Neuroendocrine Responses to Stress
Aguilera, G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10008-3 · Cited by 26 · see citing works
Szczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., Czarzasta, K., & Żera, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11040908 · Cited by 26 · see citing works
Finger, E. C. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9550-2 · Cited by 28 · see citing works
“The main vasopressin receptor subtype in the brain is the V1a receptor, with the greatest concentration of these receptors found in the amygdala, hippocampus, bed nucleus of the stria terminalis, and regions of the prefrontal and cingulate cortex (Buijs et al. 1983; Hallbeck et al. 1999; Loup et al. 1991; Young et al.…”
BackgroundJentsch, J. D., Arguello, P. A., & Anzivino, L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300194 · Cited by 23 · see citing works
“In rodents and primates, there is no vasopressin input to these forebrain regions (Wang et al, 1997; Young et al, 1999), suggesting that the effects of vasopressin are indirectly mediated by other neuronal systems, such as monoaminergic and/or cholinergic nuclei (Boer et al, 1995; Caffe et al,…”
BackgroundAVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees
Mulholland, M. M., Navabpour, S., Mareno, M. C., Schapiro, S. J., Young, L. J., & Hopkins, W. D. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12631 · Cited by 22 · see citing works
Charles, R., Sakurai, T., Takahashi, N., Elder, G. A., Sosa, M. A. G., Young, L. J., & Buxbaum, J. D. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017053 · Cited by 23 · see citing works
“Furthermore, transgenic mice harboring the prairie Avpr1a locus display ligand binding to AVPR1A in a pattern similar to that seen in prairie voles and also display increased pro-social behavior in response to an AVP challenge, as compared with wild-type mice (Young et al., 1999a).”
BackgroundResultInfluentialSzczepanska‐Sadowska, E. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214414 · Cited by 22 · see citing works
DiBenedictis, B. T., Cheung, H. K., Nussbaum, E. R., & Veenema, A. H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104462 · Cited by 20 · see citing works
The Biology of Positive Emotions and Health
Marques, A. H., & Sternberg, E. M. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195182910.003.0012 · Cited by 20 · see citing works
Motoki, K., Sugiura, M., Takeuchi, H., Kotozaki, Y., Nakagawa, S., Yokoyama, R., & Kawashima, R. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00480 · Cited by 20 · see citing works
Oxytocin, vasopressin, and the evolution of mating systems in mammals
Freeman, S. M., & Young, L. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.011 · Cited by 19 · see citing works
Banegas, I., Prieto, I., Alba, F., Vives, F., Araque, A., Segarra, A. B., Durán, R., Marc De Gasparo, B., & Ramírez, M. R. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.002 · Cited by 19 · see citing works
Kulkarni, P., Bhosle, M. R., Lu, S., Simon, N., Iriah, S. C., Brownstein, M., & Ferris, C. F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.10.001 · Cited by 18 · see citing works
“The AVP V1a (V1a) receptor subtype is highly expressed in cortical and subcortical brain areas across all mammals [52, 77] and AVP signaling through this receptor is strongly tied to the pathology of cerebral edema in TBI.”
BackgroundOxytocin and vasopressin in non-human primates
Ragen, B., & Bales, K. L. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.019 · Cited by 18 · see citing works
Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2
Hovey, D., Henningsson, S., Cortes, D. S., Bänziger, T., Zettergren, A., Melke, J., Fischer, H., Laukka, P., & Westberg, L. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx141 · Cited by 17 · see citing works
“These receptors are expressed in different regions in different species in a manner that suggests that its involvement in social attention is conserved through evolution (Young et al., 1999; Yoshida et al., 2009; Roper et al., 2011; Boccia et al., 2013; Freeman et al., 2014).”
BackgroundSaavedra, J. M., & Pavel, J. (2005) · Drug Development Research · doi:10.1002/ddr.20027 · Cited by 16 · see citing works
Treating head injury using a novel vasopressin 1a receptor antagonist
Morrison, T. R., Kulkarni, P. P., Cai, X., Iriah, S. C., Aggarwal, D., Lu, S., Simon, N. G., Madularu, D., & Ferris, C. F. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134565 · Cited by 15 · see citing works
Coen, C. W., Bennett, N. C., Holmes, M. M., & Faulkes, C. G. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_3 · Cited by 15 · see citing works
Distribution of the vasotocin type 4 receptor throughout the brain of the chicken, Gallus gallus
Selvam, R., Jurkevich, A., & Kuenzel, W. J. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23684 · Cited by 14 · see citing works
Effects of arginine vasopressin on musical working memory
Granot, R., Uzefovsky, F., Bogopolsky, H., & Ebstein, R. P. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00712 · Cited by 12 · see citing works
“It has been proposed that these social/emotional effects of AVP are mediated in rodents by vasopressin V1a receptors in the lateral septum, hypothalamus, bed nucleus of the stria terminalis, hippocampus, amygdala, and brainstem (Loup et al., 1991; Young et al., 1999).”
BackgroundThe Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington’s Disease
Maibach, H. T., Brownstein, M., Hersch, S. M., Anderson, K. E., Itzkowitz, D. E., Damiano, E. M., & Simon, N. G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101561 · Cited by 11 · see citing works
“SRX246 targets the V1a receptor, the most abundant VP receptor subtype in the brain [7,8].”
BackgroundNeuromodulation of Cardiac Ischemic Pain: Role of the Autonomic Nervous System and Vasopressin
Szczepanska‐Sadowska, E. K. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2303049 · Cited by 11 · see citing works
“They are also present in several peripheral organs, including the cardiovascular system, lungs, kidney, liver, and gastrointestinal system [ 61,74– 80].”
BackgroundSzczepanska‐Sadowska, E. K., Cudnoch‐Jędrzejewska, A., & Sadowski, B. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102046 · Cited by 11 · see citing works
Wade, M., Hoffmann, T. J., & Jenkins, J. M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.06.002 · Cited by 11 · see citing works
Szczepanska‐Sadowska, E. K., Cudnoch‐Jędrzejewska, A., & Żera, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413307 · Cited by 9 · see citing works
- Authors
- Young, Toloczko, & Insel
- Affiliations
- Emory University (US)
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 11
- Issue
- 4
- Pages
- 291-297
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2085176718
- Cited by
- 139
- References
- 33
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 6
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (56897)
- National Center for Research Resources (P51RR000165)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, vasopressin V1a receptor, receptor mRNA expression, rhesus monkey brain, prefrontal cortex, cingulate cortex, amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus, brainstem, memory, higher mental functions
- MeSH terms
- Amino Acid Sequence, Animals, Arginine Vasopressin, Base Sequence, Binding Sites, Brain, Female, Humans, Iodine Radioisotopes, Macaca mulatta, Male, Molecular Sequence Data, Radioligand Assay, RNA, Messenger, Sequence Homology, Nucleic Acid, Sequence Homology, Amino Acid, Receptors, Vasopressin, DNA, Complementary
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