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Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis

Cui, Yuanshan, Cai, Tong, Zhou, Zhongbao, Mu, Yingmei, Lu, Youyi, Gao, Zhenli, Wu, Jitao, Zhang, Yong·2020·Frontiers in Nutrition
DOI 10.3389/fnut.2020.586036PMC PMC7732631
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Abstract

Background: Alternate-day fasting (ADF) method is becoming more and more popular among adults. This meta-analysis aims to evaluate the effects of ADF on adults. Methods: Randomized controlled trials (RCTs) of ADF were searched using PubMed (1988 to March 2020), EMBASE (1995 to March 2020), and the Cochrane Controlled Trials Register. A systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-analyses. The datum was calculated by RevMan version 5.3.0. The original references for relating articles were also reviewed. Results: Seven randomized controlled trials involving 269 participants (152 in the ADF group and 117 in the control group) were studied. In this meta-analysis, compared with the control group, the ADF group showed statistically significant reductions in weight (p < 0.00001) and body mass index (p < 0.00001). Besides, the ADF group showed significant differences in terms of total cholesterol (p = 0.001), low-density lipoprotein (p = 0.01), triglycerides (p = 0.02), fat mass (p = 0.002), lean mass (p = 0.002), systolic blood pressure (p = 0.003), diastolic blood pressure (p = 0.007), and total calorie intake (p = 0.007). At the same time, the analysis demonstrated that the ADF group had a same effect compared with control group in aspects of high-density lipoprotein (p = 0.27), homeostasis model assessment-insulin resistance (p = 0.55), and fasting blood sugar (p = 0.09). Conclusions: This meta-analysis suggests that ADF is a viable diet strategy for weight loss, and it has a substantial improvement in risk indicators for diseases in obese or normal people.

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Sorted by citations

Metadata

Authors
Cui, Y., Cai, T., Zhou, Z., Mu, Y., Lu, Y., Gao, Z., Wu, J., & Zhang, Y.
Venue
Frontiers in Nutrition
Publisher
Frontiers Media SA
Published
2020-11-24
Volume
7
ISSN
2296-861X
DOI
10.3389/fnut.2020.586036
PMC
PMC7732631
Cited by
60
References
17
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Beijing Municipal Administration of Hospitals (DFL20190502)
  • Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201820)
  • National Natural Science Foundation of China (81572835, 81801429, 81870525)
  • Taishan Scholar Foundation of Shandong Province (tsqn201909199)

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