PreprintCited by 27Dietary Effects on HealthDiet and metabolism studiesNutritional Studies and Diet

Intermittent Fasting: Myths, Fakes and Truth on this Dietary Regimen Approach

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Brogi, Simone, Tabanelli, Rita, Puca, Sara, Calderone, Vincenzo·2024·Foods

Preprint — published as 10.3390/foods13131960 · Paper page

Abstract

Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathway targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated the concerns for human health related to the adoption of IF dietary regimen, highlighting the profound debate on weight loss regimens. We have examined and compared several clinical trials to formulate an updated conception regarding IF and its therapeutic potential.

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Authors
Brogi, S., Tabanelli, R., Puca, S., & Calderone, V.
Affiliations
University of Pisa (IT)
Corresponding author
Brogi, Simone
Venue
Foods
Publisher
MDPI AG
Published
2024-05-28
Volume
13
Issue
13
Pages
1960-1960
ISSN
2304-8158 (ISSN-L)
OpenAlex
W4399890745
Cited by
26
References
191
Citations by year
2026: 9 · 2025: 14 · 2024: 3
FWCI
1.48
Type
journal article
Language
en
Open access
Locations
  • Foods (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
intermittent fasting, alternate-day fasting, time-restricted feeding, caloric restriction, weight loss, obesity, metabolic syndrome, type 2 diabetes, cancer, hypertension, cardiovascular risk factors, oxidative stress, cellular signaling pathways

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