Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity
Open accessAbstract
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) metabolism through dietary provision of NAD+ precursor vitamins translates to improved glucose handling in rodent models of obesity and diabetes. Preclinical evidence suggests that the NAD+/SIRT1 axis may be implicated in modulating important gut-related aspects of glucose regulation. We sought to test whether NAD+ precursor supplementation with nicotinamide riboside (NR) affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Design: A 12-week randomized, double-blind, placebo-controlled, parallel-group trial in 40 males with obesity and insulin resistance allocated to NR at 1000 mg twice daily (n = 20) or placebo (n = 20). Two-hour 75-g oral glucose tolerance tests were performed before and after the intervention, and plasma concentrations of glucose, insulin, C-peptide, glucagon, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were determined. β-Cell function indices were calculated based on glucose, insulin, and C-peptide measurements. Fasting plasma concentrations of bile acids were determined. Results: NR supplementation during 12 weeks did not affect fasting or postglucose challenge concentrations of glucose, insulin, C-peptide, glucagon, GLP-1, or GIP, and β-cell function did not respond to the intervention. Additionally, no changes in circulating adipsin or bile acids were observed following NR supplementation. Conclusion: The current study does not provide evidence to support that dietary supplementation with the NAD+ precursor NR serves to impact glucose tolerance, β-cell secretory capacity, α-cell function, and incretin hormone secretion in nondiabetic males with obesity. Moreover, bile acid levels in plasma did not change in response to NR supplementation.
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Participants in neither study showed any signs of weight loss, increased insulin sensitivity or enhanced mitochondrial function, among other metabolic parameters studied.
“Unfortunately, while NR could effectively increase NAD+ levels in these individuals94, participants in neither study showed any signs of weight loss, increased insulin sensitivity or enhanced mitochondrial function, among other metabolic parameters studied.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [93]
Two recent randomized and double-blind studies treated patients with overweight and obesity with NR for 6 weeks and 12 weeks.
“However, two recent randomized and double-blind studies treated patients with over-weight and obesity with NR for 6 weeks and 12 weeks93,94.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [93]
NR has shown little to no effect in aged men with obesity.
“NR has shown little to no effect in aged men with obesity93,186,188”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [93]
One trial showed short-term NR administration has some beneficial effects in healthy elderly individuals, and another showed positive results in patients with ALS.
“One trial showed that short-term NR administration has some beneficial effects in healthy elderly individuals185, and another showed positive results in patients with ALS93,186,187.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [93]
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- Authors
- Dollerup, O. L., Trammell, S. A. J., Hartmann, B., Holst, J. J., Christensen, B., Møller, N., Gillum, M. P., Treebak, J. T., & Jessen, N.
- Affiliations
- University of Copenhagen (DK)
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Corresponding author
- Treebak, Jonas T
- Jessen, Niels
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2019-08-07
- Volume
- 104
- Issue
- 11
- Pages
- 5703-5714
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2964680034
- Cited by
- 77
- References
- 70
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 15 · 2020: 13 · 2019: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Foundation (NNF14OC0009315, NNF13OC0003882)
- Danish Council for Independent Research (DFF 4004-00235)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- nicotinamide riboside, NAD+ precursors, obesity, insulin resistance, beta-cell function, alpha-cell function, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, glucagon, bile acids, adipsin, glucose tolerance, non-diabetic men
- MeSH terms
- Blood Glucose, C-Peptide, Double-Blind Method, Gastric Inhibitory Polypeptide, Glucagon, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Male, Middle Aged, Niacinamide, Obesity, Pyridinium Compounds, Glucagon-Like Peptide 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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