Mitochondria as biosynthetic factories for cancer proliferation
Open accessAbstract
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for the synthesis of fundamental cellular components, including fatty acids, amino acids, and nucleotides. Despite the extensive interest in the glycolytic phenotype of many cancer cells, tumors contain fully functional mitochondria that support proliferation and survival. Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight specific cancers where these processes are activated.
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Mitochondria participate in the biosynthesis of nucleotides, fatty acids, cholesterol, amino acids, glucose, and heme.
“Mitochondria participate in the biosynthesis of nucleotides, FAs, cholesterol, amino acids, glucose, and heme (Figure 2).64”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [64]
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- Authors
- Ahn, C. S., & Metallo, C. M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Metallo, Christian M
- Venue
- Cancer & Metabolism
- Published
- 2015-01-25
- Volume
- 3
- Issue
- 1
- Pages
- 1-1
- ISSN
- 2049-3002 (ISSN-L)
- PMC
- PMC4305394
- OpenAlex
- W2157099092
- Cited by
- 399
- References
- 84
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 33 · 2023: 28 · 2022: 35 · 2021: 58 · 2020: 41 · 2019: 41 · 2018: 31 · 2017: 43 · 2016: 33 · 2015: 12
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer & Metabolism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Defense (W81XWH, W81XWH1310105, W81XWH-13)
- National Institutes of Health (W81XWH)
- National Cancer Institute (R01CA132847, R01CA188652)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial metabolism, tumor cell proliferation, biosynthesis, fatty acid synthesis, amino acid synthesis, nucleotide synthesis, cancer metabolism, mitochondrial dysfunction, metabolic reprogramming, cancer therapy
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