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Adrenergic regulation of innate immunity: a review

Scanzano, Angela, Cosentino, Marco·2015·Frontiers in Pharmacology
DOI 10.3389/fphar.2015.00171PMC PMC4534859
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Figure 1 Biosynthetic pathway of the catecholamines noradrenaline and adrenaline from the aminoacid tyrosine. The synthesizing enzymes are shown to the right of each arrow, while enzyme cofactors are shown to the left (reproduced from the Wikimedia Commons—http://commons.wikimedia.org).
Figure 1 Biosynthetic pathway of the catecholamines noradrenaline and adrenaline from the aminoacid tyrosine. The synthesizing enzymes are shown to the right of each arrow, while enzyme cofactors are shown to the left (reproduced from the Wikimedia Commons—http://commons.wikimedia.org).CC BY · PubMed Central

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Research works printed but not linked: 206

  1. Ahlquist, 1948, A study of the adrenotropic receptors, Am. J. Physiol., 153, 586, 10.1152/ajplegacy.1948.153.3.586 · DOI
  2. Anane, 2009, Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion, Brain Behav. Immun., 23, 823, 10.1016/j.bbi.2009.03.003 · DOI
  3. Arias-Montaño, 1999, Characterisation of alpha1B-adrenoceptors linked to inositol phosphate formation and calcium mobilisation in human astrocytoma U373 MG cells, Naunyn Schmiedebergs Arch. Pharmacol, 360, 533, 10.1007/s002109900125 · DOI
  4. Armaiz-Pena, 2015, Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth, Oncotarget, 6, 4266, 10.18632/oncotarget.2887 · DOI
  5. Auffray, 2009, Blood monocytes: development, heterogeneity, and relationship with dendritic cells, Annu. Rev. Immunol., 27, 669, 10.1146/annurev.immunol.021908.132557 · DOI
  6. Baker, 1995, Loss of response to beta-adrenoceptor agonists during the maturation of human monocytes to macrophages in vitro, J. Leukoc. Biol., 57, 395, 10.1002/jlb.57.3.395 · DOI
  7. Balsa, 1989, Characterization of monoamine oxidase activity present in human granulocytes and lymphocytes, Biochim. Biophys. Acta, 992, 140, 10.1016/0304-4165(89)90002-0 · DOI
  8. Barnes, 1993, Beta-adrenoceptors on smooth muscle, nerves and inflammatory cells, Life Sci., 52, 2101, 10.1016/0024-3205(93)90725-I · DOI
  9. Ben-Eliyahu, 2012, Can we really know if a stressor increases or decreases natural killer cell activity?, Brain Behav. Immun., 26, 1224, 10.1016/j.bbi.2012.08.004 · DOI
  10. Ben-Eliyahu, 2000, Suppression of NK cell activity and of resistance to metastasis by stress: a role for adrenal catecholamines and beta-adrenoceptors, Neuroimmunomodulation, 8, 154, 10.1159/000054276 · DOI
  11. Benschop, 1994, The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium, Br. J. Pharmacol., 113, 1311, 10.1111/j.1476-5381.1994.tb17141.x · DOI
  12. Benschop, 1997, Adrenergic control of natural killer cell circulation and adhesion, Brain Behav. Immun., 11, 321, 10.1006/brbi.1997.0499 · DOI
  13. Biswas, 2010, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Nat. Immunol., 11, 889, 10.1038/ni.1937 · DOI · Paper page
  14. Boman, 2003, Antimicrobial peptides: basic facts and emerging concepts, J. Intern. Med., 254, 197, 10.1046/j.1365-2796.2003.01228.x · DOI
  15. Borda, 1998, Role of arachidonic acid metabolites in the action of a beta adrenergic agonist on human monocyte phagocytosis, Prostaglandins Leukot. Essent. Fatty Acids, 58, 85, 10.1016/S0952-3278(98)90145-4 · DOI
  16. Botta, 2008, Adrenergic modulation of dendritic cell cancer vaccine in a mouse model: role of dendritic cell maturation, J. Immunother., 31, 263, 10.1097/CJI.0b013e318160995e · DOI
  17. Bowden Sulakvelidze, 1994, Inhibition of neutrophil and eosinophil adhesion to venules of rat trachea by beta 2-adrenergic agonist formoterol, J. Appl. Physiol., 77, 397, 10.1152/jappl.1994.77.1.397 · DOI
  18. Brenner, 1992, Sympathetic nervous system modulation of tumor metastases and host defense mechanisms, J. Neuroimmunol., 37, 191, 10.1016/0165-5728(92)90003-4 · DOI
  19. Brunskole Hummel, 2013, Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity, PLoS ONE, 8, e64556, 10.1371/journal.pone.0064556 · DOI
  20. Bylund, 1994, International union of pharmacology nomenclature of adrenoceptors, Pharmacol. Rev., 46, 121, 10.1016/S0031-6997(25)06780-8 · DOI
  21. Chaitidis, 2004, Th2 response of human peripheral monocytes involves isoform-specific induction of monoamine oxidase-A, J. Immunol., 173, 4821, 10.4049/jimmunol.173.8.4821 · DOI
  22. Chaitidis, 2005, Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13, Cytokine, 30, 366, 10.1016/j.cyto.2005.02.004 · DOI
  23. Chávez-Sánchez, 2014, Innate immune system cells in atherosclerosis, Arch. Med. Res., 45, 1, 10.1016/j.arcmed.2013.11.007 · DOI
  24. Chijioke, 2013, Dendritic cell derived cytokines in human natural killer cell differentiation and activation, Front. Immunol., 4, 10.3389/fimmu.2013.00365 · DOI
  25. Choi, 2014, Meta-analysis of the effects of beta blocker on survival time in cancer patients, J. Cancer Res. Clin. Oncol., 140, 1179, 10.1007/s00432-014-1658-7 · DOI
  26. Chong, 2002, Pharmacological characterisation of the beta-adrenoceptor expressed by human lung mast cells, Eur. J. Pharmacol., 437, 1, 10.1016/S0014-2999(02)01263-3 · DOI
  27. Chong, 2000, Influence of genetic polymorphisms in the beta2-adrenoceptor on desensitization in human lung mast cells, Pharmacogenetics, 10, 153, 10.1097/00008571-200003000-00007 · DOI
  28. Chong, 1995, Functional desensitization of beta agonist responses in human lung mast cells, Am. J. Respir. Cell Mol. Biol., 13, 540, 10.1165/ajrcmb.13.5.7576689 · DOI
  29. Chou, 1998, Adrenergic regulation of macrophage-derived tumor necrosis factor-alpha generation during a chronic polyarthritis pain model., J. Neuroimmunol., 82, 140, 10.1016/S0165-5728(97)00196-3 · DOI
  30. Cnop, 2005, Mechanisms of pancreatic beta-cell death in Type 1 and Type 2 diabetes: many differences, few similarities., Diabetes, 54, S97, 10.2337/diabetes.54.suppl_2.S97 · DOI · Paper page
  31. Corradi, 1981, Decreased beta-adrenoceptors in polymorphonucleates in essential hypertension, Boll. Soc. Ital. Biol. Sper., 57, 1766
  32. Cosentino, 2013, Adrenergic and dopaminergic modulation of immunity in multiple sclerosis: teaching old drugs new tricks?, J. Neuroimmune Pharmacol., 8, 163, 10.1007/s11481-012-9410-z · DOI
  33. Cosentino, 1999, Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils, Life Sci., 64, 975, 10.1016/S0024-3205(99)00023-5 · DOI
  34. Cotter, 1983, Decreased neutrophil cyclic AMP response to isoprenaline stimulation in the elderly, Clin Sci. (Lond.), 65, 155, 10.1042/cs0650155 · DOI
  35. Courties, 2014, The innate immune system after ischemic injury: lessons to be learned from the heart and brain, JAMA Neurol, 71, 233, 10.1001/jamaneurol.2013.5026 · DOI
  36. Cruse, 2010, Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor, J. Allergy Clin. Immunol., 125, 257, 10.1016/j.jaci.2009.08.020 · DOI
  37. da Silva, 2014, Mast cell function: a new vision of an old cell, J. Histochem. Cytochem., 62, 698, 10.1369/0022155414545334 · DOI
  38. De Giorgi, 2011, Treatment with β-blockers and reduced disease progression in patients with thick melanoma, Arch. Intern. Med., 171, 779, 10.1001/archinternmed.2011.131 · DOI
  39. De Keyser, 2010, Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis, Neurochem. Int., 57, 446, 10.1016/j.neuint.2010.02.012 · DOI
  40. De Keyser, 2008, Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance, J. Cereb. Blood Flow Metab., 28, 1645, 10.1038/jcbfm.2008.72 · DOI
  41. De Keyser, 1999, Astrocytes in multiple sclerosis lack beta-2 adrenergic receptors, Neurology, 53, 1628, 10.1212/WNL.53.8.1628 · DOI
  42. De Keyser, 2003, Are astrocytes central players in the pathophysiology of multiple sclerosis?, Arch. Neurol., 60, 132, 10.1001/archneur.60.1.132 · DOI
  43. De Keyser, 2004, Astrocytic beta2-adrenergic receptors and multiple sclerosis, Neurobiol. Dis., 15, 331, 10.1016/j.nbd.2003.10.012 · DOI
  44. De Kleer, 2014, Ontogeny of myeloid cells, Front. Immunol., 5, 10.3389/fimmu.2014.00423 · DOI
  45. Del Rio-Hortega, 1932, Microglia, 482
  46. Dimitrov, 2010, Selective mobilization of cytotoxic leukocytes by epinephrine, J. Immunol., 184, 503, 10.4049/jimmunol.0902189 · DOI
  47. Du, 2012, β1 -adrenergic receptor autoantibodies from heart failure patients enhanced TNF-α secretion in RAW264.7 macrophages in a largely PKA-dependent fashion, J. Cell. Biochem., 113, 3218, 10.1002/jcb.24198 · DOI
  48. Elenkov, 2000, The sympathetic nerve–an integrative interface between two supersystems: the brain and the immune system, Pharmacol. Rev., 52, 595, 10.1016/S0031-6997(24)01470-4 · DOI · Paper page
  49. Endo, 2015, Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells., Cell Rep., 11, 592, 10.1016/j.celrep.2015.03.053 · DOI · Paper page
  50. Ezeamuzie, 2011, Loss of surface beta-2 adrenoceptors accounts for the insensitivity of cultured human monocytes to beta-2 adrenoceptor agonists, Int. Immunopharmacol., 11, 1189, 10.1016/j.intimp.2011.03.017 · DOI
  51. Farrar, 2013, The innate immune system and transplantation, Cold Spring Harb. Perspect. Med., 3, a015479, 10.1101/cshperspect.a015479 · DOI
  52. 1997, Catecholamines, 277
  53. Flierl, 2008b, The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis, PLoS ONE, 3, e2560, 10.1371/journal.pone.0002560 · DOI
  54. Flierl, 2009, Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response, PLoS ONE, 4, e4414, 10.1371/journal.pone.0004414 · DOI
  55. Flierl, 2008a, Adrenergic regulation of complement-induced acute lung injury, Adv. Exp. Med. Biol., 632, 93, 10.1007/978-0-387-78952-1_8 · DOI
  56. Fragala, 2011, Leukocyte β2-adrenergic receptor expression in response to resistance exercise, Med. Sci. Sports Exerc., 43, 1422, 10.1249/MSS.0b013e31820b88bc · DOI
  57. Gantt, 2014, The role of myeloid-derived suppressor cells in immune ontogeny, Front. Immunol., 5, 10.3389/fimmu.2014.00387 · DOI
  58. Gauthier, 1996, Functional beta (3)-adrenoceptor in the human heart, J. Clin. Invest., 98, 556, 10.1172/JCI118823 · DOI
  59. Gebhardt, 2005, beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics, Eur. J. Immunol., 35, 1124, 10.1002/eji.200425869 · DOI
  60. Geissmann, 2010, Development of monocytes, macrophages, and dendritic cells, Science, 327, 656, 10.1126/science.1178331 · DOI · Paper page
  61. Glac, 2006, Amphetamine enhances natural killer cytotoxic activity via beta-adrenergic mechanism, J. Physiol. Pharmacol., 11, 125
  62. Goldfarb, 2009, CpG-C oligodeoxynucleotides limit the deleterious effects of beta-adrenoceptor stimulation on NK cytotoxicity and metastatic dissemination, J. Immunother., 32, 280, 10.1097/CJI.0b013e31819a2982 · DOI
  63. Goldfarb, 2011, Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses, Ann. Surg., 253, 798, 10.1097/SLA.0b013e318211d7b5 · DOI
  64. Goyarts, 2008, Norepinephrine modulates human dendritic cell activation by altering cytokine release, Exp. Dermatol., 17, 188, 10.1111/j.1600-0625.2007.00677.x · DOI
  65. Grisanti, 2010, Pro-inflammatory responses in human monocytes are beta1-adrenergic receptor subtype dependent, Mol. Immunol., 47, 1244, 10.1016/j.molimm.2009.12.013 · DOI
  66. Grisanti, 2011, {alpha}1-adrenergic receptors positively regulate toll-like receptor cytokine production from human monocytes and macrophages, J. Pharmacol. Exp. Ther., 338, 648, 10.1124/jpet.110.178012 · DOI
  67. Gross, 2010, Beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells, BMC Pulm. Med., 10, 30, 10.1186/1471-2466-10-30 · DOI
  68. Guimarães, 2001, Vascular adrenoceptors: an update, Pharmacol. Rev., 53, 319, 10.1016/S0031-6997(24)01495-9 · DOI
  69. Guirao, 1997, Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation, Am. J. Physiol., 273, E1203
  70. Harms, 1974, β-Adrenoceptor studies. III. On the β-adrenoceptors in rat adipose tissue., Eur. J. Pharmacol., 25, 87, 10.1016/0014-2999(74)90098-3 · DOI
  71. Heijnen, 2002, Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells, J. Neuroimmunol., 125, 66, 10.1016/S0165-5728(02)00034-6 · DOI
  72. Hellstrand, 1985, Evidence for a beta-adrenoceptor-mediated regulation of human natural killer cells, J. Immunol., 134, 4095, 10.4049/jimmunol.134.6.4095 · DOI
  73. Hertz, 2010, Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i, Neurochem. Int., 57, 411, 10.1016/j.neuint.2010.03.019 · DOI
  74. Hervé, 2013, β2-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells, J. Immunol., 190, 3163, 10.4049/jimmunol.1201391 · DOI
  75. Humphreys, 1950, Response of circulating eosinophils to nor-epinephrine, epinephrine and emotional stress in humans, Proc. Soc. Exp. Biol. Med., 74, 302, 10.3181/00379727-74-17884 · DOI
  76. Inbar, 2011, Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity, PLoS ONE, 6, e19246, 10.1371/journal.pone.0019246 · DOI
  77. Izeboud, 1999, Participation of beta-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release, J. Recept. Signal Transduct. Res., 19, 191, 10.3109/10799899909036645 · DOI
  78. Jetschmann, 1997, Expression and in-vivo modulation of alpha- and beta-adrenoceptors on human natural killer (CD16+) cells, J. Neuroimmunol., 74, 159, 10.1016/S0165-5728(96)00221-4 · DOI
  79. Jones, 2013, The role of the innate immune system in psychiatric disorders, Mol. Cell. Neurosci., 53, 52, 10.1016/j.mcn.2012.10.002 · DOI · Paper page
  80. Kalinichenko, 1999, Norepinephrine-mediated inhibition of antitumor cytotoxic T lymphocyte generation involves a beta-adrenergic receptor mechanism and decreased TNF-alpha gene expression., J. Immunol., 163, 2492, 10.4049/jimmunol.163.5.2492 · DOI
  81. Kanemi, 2005, Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation, Clin. Exp. Immunol., 139, 25, 10.1111/j.1365-2249.2005.02672.x · DOI
  82. Karasuyama, 2014, Basophils have emerged as a key player in immunity, Curr. Opin. Immunol., 31C, 1, 10.1016/j.coi.2014.07.004 · DOI
  83. Katsumoto, 2014, Ontogeny and Functions of Central Nervous System Macrophages, J. Immunol., 193, 2615, 10.4049/jimmunol.1400716 · DOI · Paper page
  84. Kavelaars, 1997, Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes, J. Neuroimmunol., 77, 211, 10.1016/S0165-5728(97)00076-3 · DOI
  85. Kawai, 2010, The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat. Immunol., 11, 373, 10.1038/ni.1863 · DOI · Paper page
  86. Kay, 2005, Mast cell beta2-adrenoceptors, Chem. Immunol. Allergy, 87, 145, 10.1159/000087641 · DOI
  87. Kenney, 2014, Autonomic nervous system and immune system interactions, Compr. Physiol., 4, 1177, 10.1002/cphy.c130051 · DOI
  88. Kim, 2010, Epinephrine-primed murine bone marrow-derived dendritic cells facilitate production of IL-17A and IL-4 but not IFN-γ by CD4+ T cells, Brain Behav. Immun., 24, 1126, 10.1016/j.bbi.2010.05.003 · DOI
  89. Kimelberg, 2010, Functions of astrocytes and their potential as therapeutic targets, Neurotherapeutics, 7, 338, 10.1016/j.nurt.2010.07.006 · DOI
  90. Kita, 2013, Eosinophils: multifunctional and distinctive properties, Int. Arch. Allergy Immunol., 2, 3, 10.1159/000350662 · DOI
  91. Kobayashi, 2011, Propranolol as a modulator of M2b monocytes in severely burned patients., J. Leukoc. Biol., 89, 797, 10.1189/jlb.1010553 · DOI
  92. Koch-Weser, 1968, Beta adrenergic blockade and circulating eosinophils, Arch. Intern. Med., 121, 255, 10.1001/archinte.1968.03640030047007 · DOI
  93. Kohm, 2001, Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo, Pharmacol. Rev., 53, 487, 10.1016/S0031-6997(24)01510-2 · DOI
  94. Kong, 2010, Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme, J. Neurosci., 30, 11848, 10.1523/JNEUROSCI.2985-10.2010 · DOI
  95. Kozlov, 1998, Inhibition of formation of complement C5-convertase, Bioorg. Khim., 24, 350
  96. Kozlov, 2000, Inhibition of binding of activated compliment component C4b with its target, Bioorg. Khim., 26, 817
  97. Kuebler, 2013, Acute stress reduces wound-induced activation of microbicidal potential of ex vivo isolated human monocyte-derived macrophages, PLoS ONE, 8, e55875, 10.1371/journal.pone.0055875 · DOI
  98. Lappin, 1982, Adrenergic receptors on monocytes modulate complement component synthesis, Clin. Exp. Immunol., 47, 606
  99. Laureys, 2010, Astrocytic beta (2)-adrenergic receptors: from physiology to pathology, Prog. Neurobiol., 91, 189, 10.1016/j.pneurobio.2010.01.011 · DOI
  100. Laureys, 2014, β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations, J. Neuroinflammation, 11, 21, 10.1186/1742-2094-11-21 · DOI
  101. Le Provost, 2015, β2-adrenoceptor activation modulates skin wound healing processes to reduce scarring., J. Invest. Dermatol., 135, 279, 10.1038/jid.2014.312 · DOI
  102. Lee, 2014, Role of innate immunity in the pathogenesis of type 1 and type 2 diabetes, J. Korean Med. Sci., 29, 1038, 10.3346/jkms.2014.29.8.1038 · DOI
  103. Lee, 2011, The relaxing effect of α-defensin 1 on the adrenergic responses of rat bladder, Korean J. Physiol. Pharmacol., 15, 143, 10.4196/kjpp.2011.15.3.143 · DOI
  104. Levine, 2013, What is wrong with granulocytes in inflammatory bowel diseases?, Dig. Dis., 31, 321, 10.1159/000354686 · DOI
  105. Li, 2003, Adrenaline inhibits lipopolysaccharide-induced macrophage inflammatory protein-1 alpha in human monocytes: the role of beta-adrenergic receptors, Anesth. Analg., 96, 518, 10.1213/00000539-200302000-00040 · DOI
  106. Loegering, 1988, Effect of beta-receptor stimulation on Kupffer cell complement receptor clearance function, Circ. Shock, 25, 325
  107. Lumeng, 2013, Innate immune activation in obesity, Mol. Aspects Med., 34, 12, 10.1016/j.mam.2012.10.002 · DOI
  108. Maestroni, 2004, Modulation of skin norepinephrine turnover by allergen sensitization: impact on contact hypersensitivity and T helper priming, J. Inverst. Dermatol., 122, 119, 10.1046/j.0022-202X.2003.22132.x · DOI
  109. Maestroni, 2005, Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis, Curr. Neurovasc. Res., 2, 169, 10.2174/1567202053586776 · DOI
  110. Maestroni, 2006, Sympathetic nervous system influence on the innate immune response., Ann. N.Y. Acad. Sci., 1069, 195, 10.1196/annals.1351.017 · DOI
  111. Maisel, 1990, Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure, Circulation, 82, 2003, 10.1161/01.CIR.82.6.2003 · DOI
  112. Mannaioni, 2010, Adrenaline inhibits the immunological activation of human basophils at pharmacological and ultra-low doses, Med. Sci. Monit., 16, BR227
  113. Manni, 2008, Sympathetic nervous modulation of the skin innate and adaptive immune response to peptidoglycan but not lipopolysaccharide: involvement of beta-adrenoceptors and relevance in inflammatory diseases, Brain Behav. Immun., 22, 80, 10.1016/j.bbi.2007.06.016 · DOI
  114. Manni, 2011, β2-Adrenergic agonists bias TLR-2 and NOD2 activated dendritic cells towards inducing an IL-17 immune response, Cytokine, 55, 380, 10.1016/j.cyto.2011.05.013 · DOI
  115. Mantyh, 1995, Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human, J. Neurosci., 15, 152, 10.1523/JNEUROSCI.15-01-00152.1995 · DOI
  116. Marcus, 2014, Recognition of tumors by the innate immune system and natural killer cells, Adv. Immunol., 122, 91, 10.1016/B978-0-12-800267-4.00003-1 · DOI
  117. Marino, 2013, Adrenergic modulation of immune cells: an update, Amino Acids, 45, 55, 10.1007/s00726-011-1186-6 · DOI
  118. Marino, 2015, Production of IL-8, VEGF and elastase by circulating and intraplaque neutrophils in patients with carotid atherosclerosis, PLoS ONE, 10, e0124565, 10.1371/journal.pone.0124565 · DOI
  119. Markus, 2010, β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices, J. Neuroinflammation, 7, 94, 10.1186/1742-2094-7-94 · DOI
  120. Martin-Ezquerra, 2011, Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and β-adrenergic mechanisms, Eur. J. Dermatol., 2, 48, 10.1684/ejd.2011.1273 · DOI
  121. Masini, 1982, Mast cell receptors controlling histamine release: influences on the mode of action of drugs used in the treatment of adverse drug reactions, Klin. Wochenschr., 60, 1031, 10.1007/BF01716967 · DOI
  122. Mayadas, 2014, The multifaceted functions of neutrophils, Annu. Rev. Pathol., 9, 181, 10.1146/annurev-pathol-020712-164023 · DOI · Paper page
  123. Mayo, 2012, The innate immune system in demyelinating disease, Immunol. Rev., 248, 170, 10.1111/j.1600-065X.2012.01135.x · DOI
  124. McNamee, 2010, Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity, Eur. J. Pharmacol., 626, 219, 10.1016/j.ejphar.2009.09.054 · DOI
  125. Mellman, 2001, Dendritic cells: specialized and regulated antigen processing machines, Cell, 106, 255, 10.1016/S0092-8674(01)00449-4 · DOI
  126. Mencia-Huerta, 1991, Beta-2-adrenoceptor agonists up-regulate the in vitro Fc epsilon receptor II/CD23 expression on, and release from, the promonocytic cell line U937 and human blood monocytes, Int. Arch. Allergy Appl. Immunol., 94, 91, 10.1159/000235334 · DOI
  127. Merad, 2002, Langerhans cells renew in the skin throughout life under steady-state conditions, Nat. Immunol., 3, 1135, 10.1038/ni852 · DOI
  128. Miadonna, 1989, Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes, Int. J. Immunopharmacol., 11, 473, 10.1016/0192-0561(89)90176-8 · DOI
  129. Miksa, 2005, Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine, Front. Biosci., 10, 2217, 10.2741/1691 · DOI
  130. Mishima, 2001, Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations, Jpn. J. Pharmacol., 85, 214, 10.1254/jjp.85.214 · DOI
  131. Mizuno, 2005, Beta2-adrenergic receptor stimulation inhibits LPS-induced IL-18 and IL-12 production in monocytes, Immunol. Lett., 101, 168, 10.1016/j.imlet.2005.05.008 · DOI
  132. Mócsai, 2013, Diverse novel functions of neutrophils in immunity, inflammation, and beyond, J. Exp. Med., 210, 1283, 10.1084/jem.20122220 · DOI
  133. Motojima, 1992, Effect of eosinophil peroxidase on beta-adrenergic receptor density on guinea pig lung membrane, Biochem. Biophys. Res. Commun., 189, 1613, 10.1016/0006-291X(92)90261-I · DOI
  134. Munoz, 1994, Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4, J. Pharmacol. Exp. Ther., 268, 139, 10.1016/S0022-3565(25)38457-0 · DOI
  135. Musgrave, 1994, Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors, Biochem Pharmacol., 47, 233, 10.1016/0006-2952(94)90011-6 · DOI
  136. Nguyen, 2011, Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis, Nature, 480, 104, 10.1038/nature10653 · DOI · Paper page
  137. Nielson, 1987, Beta-adrenergic modulation of the polymorphonuclear leukocyte respiratory burst is dependent upon the mechanism of cell activation, J. Immunol., 139, 2392, 10.4049/jimmunol.139.7.2392 · DOI
  138. Nijhuis, 2014, Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro, PLoS ONE, 9, e85086, 10.1371/journal.pone.0085086 · DOI
  139. O'Reilly, 2014, Innate immunity in systemic sclerosis pathogenesis, Clin. Sci., 126, 329, 10.1042/CS20130367 · DOI
  140. Page, 2000, Natural killer cell activity and resistance to tumor metastasis in prepubescent rats: deficient baselines, but invulnerability to stress and beta-adrenergic stimulation, Neuroimmunomodulation, 7, 160, 10.1159/000026434 · DOI
  141. Page, 2008, Male-female differences in the impact of beta-adrenoceptor stimulation on resistance to experimental metastasis: exploring the effects of age and gonadal hormone involvement, J. Neuroimmunol., 193, 113, 10.1016/j.jneuroim.2007.10.023 · DOI
  142. Panina-Bordignon, 1997, Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12, J. Clin. Invest., 100, 1513, 10.1172/JCI119674 · DOI
  143. Paul-Eugène, 1993, Functional interaction between beta 2-adrenoceptor agonists and interleukin-4 in the regulation of CD23 expression and release and IgE production in human, Mol. Immunol., 30, 157, 10.1016/0161-5890(93)90087-R · DOI
  144. Paul-Eugène, 1992, Ligation of CD23 triggers cAMP generation and release of inflammatory mediators in human monocytes, J. Immunol., 149, 3066, 10.4049/jimmunol.149.9.3066 · DOI
  145. Paul-Eugène, 1994, Beta 2-adrenoceptor agonists regulate the IL-4-induced phenotypical changes and IgE-dependent functions in normal human monocytes, J. Leukoc. Biol., 55, 313, 10.1002/jlb.55.3.313 · DOI
  146. Pedersen, 1989, Protein synthesis in liver following infusion of the catabolic hormones corticosterone, epinephrine, and glucagon in rats, Metabolism, 38, 927, 10.1016/0026-0495(89)90001-2 · DOI
  147. Pohl, 1991, Beta-2-adrenoceptors of polymorphonuclear leukocytes in children with atopic dermatitis. Their number and affinity to the radioligand [125I]-cyanopindolol, Int. Arch. Allergy Appl. Immunol., 95, 261, 10.1159/000235439 · DOI
  148. Powe, 2010, Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival, Oncotarget, 1, 628, 10.18632/oncotarget.197 · DOI
  149. Prey, 2014, Mast cells as possible targets of propranolol therapy: an immunohistological study of beta-adrenergic receptors in infantile haemangiomas, Histopathology, 65, 436, 10.1111/his.12421 · DOI
  150. Prösch, 2000, A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation, Virology, 272, 357, 10.1006/viro.2000.0367 · DOI
  151. Radojcic, 1991, Changes in beta-adrenergic receptor distribution on immunocytes during differentiation: an analysis of T cells and macrophages, J. Neurosci. Res., 30, 328, 10.1002/jnr.490300208 · DOI
  152. Rainer, 1999, Adrenaline upregulates monocyte L-selectin in vitro, Resuscitation, 43, 47, 10.1016/S0300-9572(99)00121-5 · DOI
  153. Ramsay, 1999, Association of polymorphisms in the beta2-adrenoreceptor gene with higher levels of parasitic infection, Hum. Genet., 104, 269, 10.1007/s004390050947 · DOI
  154. Ratge, 1988, Alterations of beta-adrenoceptors on human leukocyte subsets induced by dynamic exercise: effect of prednisone, Clin. Exp. Pharmacol. Physiol., 15, 43, 10.1111/j.1440-1681.1988.tb01007.x · DOI
  155. Riepl, 2010, Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis, Arthritis Res. Ther., 12, R110, 10.1186/ar3044 · DOI
  156. Rosenne, 2014, In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins, Brain Behav. Immun., 37, 207, 10.1016/j.bbi.2013.12.007 · DOI
  157. Rouppe van der Voort, 1999, Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes, J. Neuroimmunol., 95, 165, 10.1016/S0165-5728(99)00011-9 · DOI
  158. Rouppe van der Voort, 2000, Noradrenaline induces the phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of α1-adrenergic receptors, J. Neuroimmunol., 108, 82, 10.1016/s0165-5728(00)00253-8 · DOI
  159. Sarigianni, 2011, Effect of epinephrine and insulin resistance on human monocytes obtained from lean and obese healthy participants: a pilot study, Angiology, 62, 38, 10.1177/0003319710371616 · DOI
  160. Saxena, 2014, NOD-Like receptors: master regulators of inflammation and cancer., Front. Immunol., 5, 10.3389/fimmu.2014.00327 · DOI
  161. Scanzano, 2015, Adrenergic modulation of migration, CD11b and CD18 expression, ROS and interleukin-8 production by human polymorphonuclear leukocytes, Inflamm. Res., 64, 127, 10.1007/s00011-014-0791-8 · DOI
  162. Schedlowski, 1996, Catecholamines modulate human NK cell circulation and function via spleen-independent beta 2-adrenergic mechanisms, J. Immunol., 156, 93, 10.4049/jimmunol.156.1.93 · DOI
  163. Schopf, 1983, Control of the production of oxygen intermediates of human polymorphonuclear leukocytes and monocytes by beta-adrenergic receptors, J. Immunopharmacol., 5, 203, 10.3109/08923978309039106 · DOI
  164. Schulze, 1996, Localization of alpha 1-adrenoceptors in rat and human hearts by immunocytochemistry., Mol. Cell. Biochem., 163–164, 159, 10.1007/BF00408653 · DOI
  165. Schupf, 1989, Binding specificity and presynaptic action of anaphylatoxin C5a in rat brain, Brain Behav. Immun., 3, 28, 10.1016/0889-1591(89)90003-2 · DOI
  166. Schwab, 1993, Decreased beta 2-adrenoceptor density and decreased isoproterenol induced c-AMP increase in juvenile type I diabetes mellitus: an additional cause of severe hypoglycaemia in childhood diabetes?, Eur. J. Pediatr., 152, 797, 10.1007/BF02073373 · DOI
  167. Serbina, 2008, Monocyte-mediated defense against microbial pathogens, Annu. Rev. Immunol., 26, 421, 10.1146/annurev.immunol.26.021607.090326 · DOI
  168. Shah, 2011, Does β-adrenoceptor blocker therapy improve cancer survival? Findings from a population-based retrospective cohort study., Br. J. Clin. Pharmacol., 72, 157, 10.1111/j.1365-2125.2011.03980.x · DOI
  169. Shakhar, 1998, In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats, J. Immunol., 160, 3251, 10.4049/jimmunol.160.7.3251 · DOI
  170. Speidl, 2004, Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937: possible implications for peri-operative plaque instability, FASEB J, 18, 603, 10.1096/fj.03-0454fje · DOI
  171. Spencer, 2010, Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella, J. Bacteriol., 192, 714, 10.1128/JB.01329-09 · DOI
  172. Spengler, 1994, Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro, J. Immunol., 152, 3024, 10.4049/jimmunol.152.6.3024 · DOI
  173. Spits, 2013, Innate lymphoid cells–a proposal for uniform nomenclature, Nat. Rev. Immunol., 13, 145, 10.1038/nri3365 · DOI
  174. Spooren, 2011, IL-1β potently stabilizes IL-6 mRNA in human astrocytes, Biochem. Pharmacol., 81, 1004, 10.1016/j.bcp.2011.01.019 · DOI
  175. Stefanski, 1996, Social confrontation and tumor metastasis in rats: defeat and beta-adrenergic mechanisms, Physiol. Behav., 60, 277, 10.1016/0031-9384(96)00014-5 · DOI
  176. Straub, 2004, Complexity of the bi-directional neuroimmune junction in the spleen, Trends Pharmacol. Sci., 25, 640, 10.1016/j.tips.2004.10.007 · DOI
  177. Suchánek, 2010, Intensive physical activity increases peripheral blood dendritic cells, Cell. Immunol., 266, 40, 10.1016/j.cellimm.2010.08.010 · DOI
  178. Swirski, 2013, Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure, Science, 339, 161, 10.1126/science.1230719 · DOI
  179. Szelenyi, 2006, Dual beta-adrenergic modulation in the immune system: stimulus-dependent effect of isoproterenol on MAPK activation and inflammatory mediator production in macrophages, Neurochem. Int., 49, 94, 10.1016/j.neuint.2006.01.009 · DOI
  180. Tachibana, 2002, Inhibition by fenoterol of human eosinophil functions including beta2-adrenoceptor-independent actions, Clin. Exp. Immunol., 130, 415, 10.1046/j.1365-2249.2002.01997.x · DOI
  181. Takahashi, 2003, Effect of beta 2-adrenergic receptor stimulation on interleukin-18-induced intercellular adhesion molecule-1 expression and cytokine production, J. Pharmacol. Exp. Ther., 304, 634, 10.1124/jpet.102.042622 · DOI
  182. Takamoto, 1991, Norepinephrine inhibits human natural killer cell activity in vitro., Int. J. Neurosci., 58, 127, 10.3109/00207459108987189 · DOI
  183. Tarr, 2012, β-Adrenergic receptor mediated increases in activation and function of natural killer cells following repeated social disruption, Brain Behav. Immun., 26, 1226, 10.1016/j.bbi.2012.07.002 · DOI
  184. Theorell, 2014, Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation, Cancer Immunol. Immunother., 63, 627, 10.1007/s00262-014-1539-6 · DOI
  185. Tomozawa, 1995, Participation of cAMP and cAMP-dependent protein kinase in beta-adrenoceptor-mediated interleukin-1 beta mRNA induction in cultured microglia, Neurosci. Res., 22, 399, 10.1016/0168-0102(95)00922-G · DOI
  186. Trabold, 2010, Immunomodulation of neutrophil–endothelial interaction by inotropes, Injury, 41, 1079, 10.1016/j.injury.2010.05.034 · DOI
  187. Ueshima, 2013, Suppression of phagosome proteolysis and Matrigel migration with the α2-adrenergic receptor agonist dexmedetomidine in murine dendritic cells, Immunopharmacol. Immunotoxicol., 35, 558, 10.3109/08923973.2013.822509 · DOI
  188. Vago, 1990, Respiratory-burst stimulants desensitize beta-2 adrenoceptors on human polymorphonuclear leukocytes, Int. J. Tissue React., 12, 53
  189. Vasin, 1995, Change in the functional activity of the blood complement system after administration of adrenaline to animals, Patol. Fiziol. Eksp. Ter., 3, 16
  190. Wahle, 2005, Influence of catecholamines on cytokine production and expression of adhesion molecules of human neutrophils in vitro, Immunobiology, 210, 43, 10.1016/j.imbio.2005.02.004 · DOI
  191. Wallace, 1976, Alpha-adrenergic regulation of the secretion of an anticomplementary factor in mouse saliva, Proc. Soc. Exp. Biol. Med., 152, 99, 10.3181/00379727-152-39337 · DOI
  192. Wang, 2010, Beta-adrenoceptor mediated surgery-induced production of pro-inflammatory cytokines in rat microglia cells, J. Neuroimmunol., 223, 77, 10.1016/j.jneuroim.2010.04.006 · DOI
  193. Wang, 2006, Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells, Clin. Exp. Pharmacol. Physiol., 33, 746, 10.1111/j.1440-1681.2006.04435.x · DOI
  194. Whalen, 1990, Effects of beta-adrenergic receptor activation, cholera toxin and forskolin on human natural killer cell function, Biochem. J, 272, 327, 10.1042/bj2720327 · DOI
  195. Williams, 1985, Anaphylatoxin C5a modulation of an alpha-adrenergic receptor system in the rat hypothalamus, J. Neuroimmunol., 9, 29, 10.1016/S0165-5728(85)80004-7 · DOI
  196. Wrona, 2006, Neural-immune interactions: an integrative view of the bidirectional relationship between the brain and immune systems, J. Neuroimmunol., 172, 38, 10.1016/j.jneuroim.2005.10.017 · DOI
  197. Xiao, 2010, Modulation of natural killer cell function by alpha-adrenoreceptor-coupled signalling, Neuro Endocrinol. Lett., 31, 635
  198. Xu, 2010, Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis, Clin. Exp. Pharmacol. Physiol., 37, e158, 10.1111/j.1440-1681.2010.05426.x · DOI
  199. Xu, 1999, Interaction of the alpha(1B)-adrenergic receptor with gC1q-R, a multifunctional protein, J. Biol. Chem., 274, 21149, 10.1074/jbc.274.30.21149 · DOI
  200. Yanagawa, 2010, Enhanced dendritic cell antigen uptake via alpha2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline, J. Immunol., 185, 5762, 10.4049/jimmunol.1001899 · DOI

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Authors
Scanzano, A., & Cosentino, M.
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2015-08-13
Volume
6
ISSN
1663-9812
DOI
10.3389/fphar.2015.00171
PMC
PMC4534859
Cited by
323
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Scanzano, A., & Cosentino, M. (2015). Adrenergic regulation of innate immunity: a review. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2015.00171