Cited by 838Inflammasome and immune disordersImmune Response and InflammationAutoimmune and Inflammatory Disorders Research

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

NLRP3 inflammasome and its inhibitors: a review

Open access

Shao, Bo-Zong, Xu, Zhe-Qi, Han, Bin-Ze, Su, Ding-Feng, Liu, Chong·2015·Frontiers in Pharmacology

DOI 10.3389/fphar.2015.00262PMC PMC4633676

Open this paper in CoChat — free account Open PDF

Abstract

Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as "pyrin domain-containing protein 3". The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome, as well as other auto-immune and auto-inflammatory diseases. Several NLRP3 inflammasome inhibitors have been described, some of which show promise in the clinic. The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto-inflammatory diseases, and the state of research into NLRP3 inflammasome inhibitors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fphar.2015.00262

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · cited 1×
“These endogenous non-coding RNAs are 20– 23 nt long and bind to the 3′ untranslated region (3′ UTR) of protein-coding mRNAs to regulate their translation (Bartel, 2009; Chen and Sun, 2013).”
The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · cited 1×
“A newly identified PRR, first described in detail in 2002, is the inflammasome (Martinon et al., 2002; Gentile et al., 2015; Jorgensen and Miao, 2015; Sanders et al., 2015).”
Background
The Inflammasomes
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · cited 3×
“Formation of the inflammasome also triggers a process of inflammation-related cell death termed pyroptosis (Willingham et al., 2009; Schroder and Tschopp, 2010; Zhong et al., 2013a; Jorgensen and Miao, 2015).”
BackgroundMethod
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · cited 1×
“…protect against disease and death, inappropriate activation of the NLRP3 inflammasome can contribute to the onset and progression of various diseases, particularly age-related diseases such as metabolic disorders and metabolic syndrome (Franceschi et al., 2000; Goldberg and Dixit, 2015).”
Background
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · cited 1×
“…in macrophages and animal models have shown that oxidized low-density lipoprotein and cholesterol crystals trigger NLRP3 inflammasome activation (Duewell et al., 2010; Liu et al., Frontiers in Pharmacology | www.frontiersin.org 2 November 2015 | Volume 6 | Article 262 FIGURE 1 | Schematic…”
Background
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,087 · cited 1×
“…PAMPs or DAMPs are recognized by TLRs, leading to activation of nuclear factor kappa B (NF-κB)-mediated signaling, which in turn up-regulates transcription of inflammasome-related components, including inactive NLRP3, proIL-1β, and proIL18 (Bauernfeind et al., 2009; Franchi et al., 2012, 2014).”
Background
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · cited 2×
“…damage or dysfunction caused by mitochondrial Ca2+ overload (Iyer et al., 2013; Miao et al., 2014; Zhuang et al., 2015), lysosomal disruption (Hornung et al., 2008; Sheedy et al., 2013; Tseng et al., 2013), autophagic dysfunction (Cho et al., 2014; Shao et al., 2014; Jabir et al., 2015) and…”
Background
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · cited 3×
“Coll et al. (2015) discovered that MCC950, a diarylsulfonylurea-containing compound known to inhibit caspase-1-dependent processing of IL-1β (Perregaux et al., 2001), also inhibits both canonical and non-canonical activation of the NLRP3 inflammasome.”
Background
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · cited 2×
“Youm et al. (2015) discovered that the ketone metabolite β-hydroxybutyrate (BHB), but not acetoacetate or the shortchain fatty acids butyrate and acetate, reduced IL-1β, and IL-18 production by the NLRP3 inflammasome in human monocytes.”
Background
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079

Flagged first, then by citations

Show all 115 references

Sorted by citations

Items 101–200 of 838

Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss
Zang, Y., Song, J. H., Oh, S., Kim, J. W., Lee, M. N., Piao, X., Yang, J.-W., Kim, O. S., Kim, T. S., Kim, S. H., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520933533 · Cited by 81
Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway
Wu, D., Wu, K., Zhu, Q., Xiao, W., Shan, Q., Yan, Z., Wu, J., Deng, B., Xue, Y., Gong, W., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/3048532 · Cited by 81
NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture
Cornelius, D. C., Travis, O. K., Tramel, R. W., Borges-Rodriguez, M., Baik, C., Greer, M., Giachelli, C., Tardo, G. A., & Williams, J. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234039 · Cited by 82
“MCC950 is a well characterized specific inhibitor of NLRP3 [35], and very few studies have examined in a role for this NLRP3 specific inhibitor to protect against sepsis induced multi-organ injury in a prolonged model of sepsis [36, 37].”
Background
MicroRNAs as important regulators of the NLRP3 inflammasome
Zamani, P., Oskuee, R. K., Atkin, S. L., Navashenaq, J. G., & Sahebkar, A. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.05.004 · Cited by 80
Human periodontal ligament stem cells secretome from multiple sclerosis patients suppresses NALP3 inflammasome activation in experimental autoimmune encephalomyelitis
Rajan, T. S., Giacoppo, S., Diomede, F., Bramanti, P., Trubiani, O., & Mazzon, E. (2017) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632017722332 · Cited by 80
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high‐fat high cholesterol diet via regulating NF‐κB and NLRP3 inflammasome pathway
Huang, Y., Wan, T., Pang, N., Zhou, Y., Jiang, X., Li, B., Gu, Y., Huang, Y., Ye, X., Lian, H., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28728 · Cited by 79
“NLRP3 inflammasome is mainly expressed in immune and inflammatory cells, such as macrophages, which represent a major source of proinflamma- tory mediators (Shao et al., 2015).”
BackgroundInfluential
Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome–autophagy–exosomal pathway
Chen, Y., Lee, Y., Wang, B.-J., Chen, R.-J., & Wang, Y. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00443-w · Cited by 84
“as in sterile inflammation mediated by DAMPs and upon exposure to environmental irritants such as nanoparticles [14, 16].”
BackgroundInfluential
Role of NLRP3 Inflammasome in Cardiac Inflammation and Remodeling after Myocardial Infarction
Takahashi, M. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00369 · Cited by 79
Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis
Pan, X., Liu, Y., Cen, Y., Xiong, Y., Li, J., Ding, Y., Tong, Y.-F., Liu, T., Chen, X., & Zhang, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020360 · Cited by 79
Pathological ATPergic Signaling in Major Depression and Bipolar Disorder
Illés, P., Verkhratsky, A., & Tang, Y. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00331 · Cited by 78
Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics
Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 80
“Studies have demonstrated that the abundance of Bacteroides decreased and that of Pseudomonas increased in the intestinal flora of MS patients, while the protein levels of NLRP3, ASC and cleaved caspase-1 increased in the CNS, and the mRNA levels of ASC and caspase-1 increased in the circulation (Pellegrini et al., 20…”
BackgroundInfluential
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
Ye, J., Lu, S., Wang, M., Ge, W., Liu, H., Qi, Y., Fu, J.-H., Zhang, Q., Zhang, B., Sun, G., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01170 · Cited by 76
Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention
Gross, E. C., Klement, R. J., Schoenen, J. E., D’Agostino, D. P., & Fischer, D. (2019) · Nutrients · doi:10.3390/nu11040811 · Cited by 78
Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages
Maruyama, K., Nemoto, E., & Yamada, S. (2019) · Inflammation and Regeneration · doi:10.1186/s41232-019-0092-2 · Cited by 74
The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury
Ishrat, T., Ismael, S., Ahmed, H. A., Adris, T., Parveen, K., & Thakor, P. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286951 · Cited by 74
“Finally, type I IFNs, including IFN-α and IFN-β, are NLRP3-specific inflammasome inhibitors that have been used to inhibit NLRP3 and other inflammasomes in various auto-immune and autoinflammatory diseases (Shao et al., 2015), however they have not been validated in the setting of TBI.”
Background
Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase‐ and mitochondria‐dependent ROS production
Wang, K., Yao, Y., Zhu, X., Zhang, K., Zhou, F., & Zhu, L. (2016) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21887 · Cited by 73
The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome
Trotta, M. C., Maisto, R., Guida, F., Boccella, S., Luongo, L., Baltă, C., D’Amico, G., Herman, H., Hermenean, A. O., Bucolo, C., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211005 · Cited by 78
NLRP3 inflammasome activity is required for wound healing after burns
Vinaik, R., Abdullahi, A., Barayan, D., & Jeschke, M. G. (2019) · Translational research · doi:10.1016/j.trsl.2019.11.002 · Cited by 74
“In addition to exogenous pathogen-associated molecular patterns (PAMPs), they are capable of recognizing endogenous, non-infectious, damage-associated molecular patterns (DAMPs) [3].”
Background
Sodium Butyrate Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Down-Regulation of NF-κB, NLRP3 Signaling Pathway, and Activating Histone Acetylation in Bovine Macrophages
Jiang, L., Wang, J., Liu, Z., Jiang, A., Li, S., Wu, D., Zhang, Y., Zhu, X., Zhou, E., Wei, Z., et al. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.579674 · Cited by 77
Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 77
“Oligomerization of NLR3P inflammasome (296)”
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Possemato, E., Barbera, L. L., Nobili, A., Krashia, P., & D’Amelio, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101907 · Cited by 76
First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor
Gatlik, E., Mehes, B., Voltz, E., Sommer, U., Tritto, E., Lestini, G., Liu, X., Pal, P., Velinova, M. J., Denney, W. S., et al. (2024) · Clinical and Translational Science · doi:10.1111/cts.13789 · Cited by 79
Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0501-z · Cited by 72
“into active caspase-1, which then cleaves pro-IL-1β and proIL-18 to their active forms [14, 15].”
Background
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
Qin, Z., Song, J., Lin, A., Yang, W. L., Zhang, W., Zhong, F., Huang, L., Lü, Y., & Yu, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02482-2 · Cited by 76
“Recently, the activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome has been found to be associated with various neurological disorders, such as Alzheimer’s disease [14], cerebrovascular disease [15, 16] and epilepsy [17].”
Background
Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease
Ke, P., Shao, B., Xu, Z., Chen, X., & Liu, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00695 · Cited by 71
“Interactions among these three proteins tightly regulate inflammasome functions through inducing the production and secretion of IL-1 β and IL-18, whose maturity is triggered by caspase-1 from their “pro” forms (110).”
BackgroundSelf-citation
Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model
He, Q., Jiang, L., Man, S., Wu, L., Hu, Y., & Chen, W. (2018) · Current Neurovascular Research · doi:10.2174/1567202615666180731100224 · Cited by 72
NLRP3 inflammasome and its role in autoimmune diseases: A promising therapeutic target
Ren, W., Sun, Y., Zhao, L., & Shi, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116679 · Cited by 80
The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection
Marim, F. M., Franco, M. M. C., Gomes, M. T. R., Miraglia, M. C., Giambartolomei, G. H., & Oliveira, S. C. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0581-1 · Cited by 70
“Thus, the NLRP3-activated inflammasome complex is a three-part structure assembled by NLRP3-ASC-caspase-1 proteins [39].”
mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus
Li, X., Zhang, B., Pan, Y., Shi, G., Ren, J., Fan, H., Dou, H., & Hou, Y. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy088 · Cited by 71
Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid
Aparicio‐Trejo, O. E., Avila-Rojas, S. H., Tapia, E., Rojas‐Morales, P., León‐Contreras, J. C., Martínez‐Klimova, E., Hernández‐Pando, R., Sánchez‐Lozada, L. G., & Pedraza‐Chaverrí, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.016 · Cited by 70
Plants as a Source of Anticancer Agents: From Bench to Bedside
Talib, W. H., Daoud, S., Mahmod, A. I., Hamed, R. A., Awajan, D., Abuarab, S. F., Odeh, L. H., Khater, S. H., & Kury, L. T. A. (2022) · Molecules · doi:10.3390/molecules27154818 · Cited by 75
The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment
Li, L., & Tian, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114504 · Cited by 75
Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production
Jia, X., Cao, B., An, Y., Zhang, X., & Wang, C. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.017 · Cited by 70
NLRP3 inflammasome: a new therapeutic target for high-risk reproductive disorders?
Zhou, F., Li, C., & Zhang, S. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001214 · Cited by 71
Gut Microbiota in NSAID Enteropathy: New Insights From Inside
Wang, X., Tang, Q., Hou, H., Zhang, W., Li, M., Chen, D., Gu, Y., Wang, B., Hou, J., Liu, Y., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.679396 · Cited by 75
“So, it is associated with sundry diseases, such as metabolic disorders, multiple sclerosis, and inflammatory bowel disease, etc. (Shao et al., 2015).”
Background
Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice
Wei, A., Liu, J., Li, D., Lu, Y., Yang, L., Zhuo, Y., Tian, W., & Cong, H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174644 · Cited by 69
Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
Jiang, Y., Liu, H., Green, J., Blevins, H., Guo, C., Patel, S., Halquist, M. S., McRae, M., Venitz, J., Wang, X., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01155 · Cited by 69
Ketosis an Old Story Under a New Approach
Zhang, G., & Ametaj, B. N. (2020) · Dairy · doi:10.3390/dairy1010005 · Cited by 68
The Effects of a High-Fat Diet on Inflammatory Bowel Disease
Dang, Y., Ma, C., Chen, K., Chen, Y., Jiang, M., Hu, K., Li, L., Zeng, Z., & Zhang, H. (2023) · Biomolecules · doi:10.3390/biom13060905 · Cited by 69
Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
Schüller, S. S., Kramer, B. W. W., Villamor, E., Spittler, A., Berger, A., & Levy, O. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00199 · Cited by 70
Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway
Liu, X., Wang, Y., Wu, D., Li, S., Wang, C., Han, Z., Wang, J., Wang, K., Yang, Z., & Wei, Z. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01459 · Cited by 67
“NLRP3 recruits and activates the pro-inflammatory protein Caspase-1, and activated Caspase-1 stimulates macrophage secretion of IL-1b to induce liver damage (Shao et al., 2015).”
Background
Inflammasome as a promising therapeutic target for cancer
Lee, C., Do, H. T. T., Her, J., Kim, Y., Seo, D., & Rhee, I. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116593 · Cited by 66
Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection
Fu, S., Xu, L., Li, S., Qiu, Y., Liu, Y., Wu, Z., Ye, C., Hou, Y., & Hu, C. A. (2016) · Veterinary Research · doi:10.1186/s13567-016-0359-4 · Cited by 67
“Although innate adaptive immune response can efficiently protect the animal from certain diseases, inappropriate activation of the NLRP3 inflammasome can lead to progression of various diseases [16, 23].”
Background
Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome
Chiu, H., Li, L.-H., Hsieh, C., Rao, Y. K., Chen, F.-H., Chen, A., Ka, S., & Hua, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-42130-z · Cited by 68
Profile of crosstalk between glucose and lipid metabolic disturbance and diabetic cardiomyopathy: Inflammation and oxidative stress
Chen, M., Meng, X., Han, Y.-P., Yan, J.-L., Xiao, C., & Qian, L.-B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.983713 · Cited by 66
Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms
Dolunay, A., Şenol, Ş. P., Temiz-Reşitoğlu, M., Güden, D. S., Sari, A. N., Şahan-Fırat, S., & Tunçtan, B. (2016) · Inflammation · doi:10.1007/s10753-016-0483-3 · Cited by 65
NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection
Hung, S.-C., Huang, P.-R., Almeida-da-Silva, C. L. C., Atanasova, K. R., Yilmaz, Ö., & Ojcius, D. M. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.09.014 · Cited by 65
“nucleatum could destabilize host-cell mitochondria, which results in mROS production, which in turn is regulated by NLRX1 [54, 39, 51, 12, 27].”
Background
Hydrogen sulfide inhibits ATP-induced neuroinflammation and Aβ1–42 synthesis by suppressing the activation of STAT3 and cathepsin S
Cao, L., Cao, X., Zhou, Y., Nagpure, B. V., Wu, Z., Hu, L. F., Yang, Y., Sethi, G., Moore, P. K., & Bian, J. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.005 · Cited by 64
Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
Hu, M., Lin, Y., Zhang, B., Lu, D., Lu, Z., & Cai, W. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13262 · Cited by 67
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway
Xu, X., Huang, X., Zhang, L., Huang, X., Qin, Z., & Hua, F. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02391-1 · Cited by 64
“The concentrations of IL-18 and IL-1β in mouse kidney samples were measured using Mouse IL-18 Valukine ELISA Kit (Abcam, #ab216165) and Mouse IL-1β Valukine ELISA Kit (R&D, #VAL601), respectively, following the manufacturer’s protocols.”
BackgroundInfluential
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice
Lu, M., Yin, J., Xu, T., Dai, X., Liu, T., Zhang, Y., Wang, S., Liu, Y., Shi, H., Zhang, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117262 · Cited by 64
Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-κB signaling pathway in RAW264.7 macrophages
Liao, W., He, X., Yi, Z.-W., Xiang, W., & Ding, Y. P. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.094 · Cited by 65
The Effects of Acute and Chronic Aerobic Activity on the Signaling Pathway of the Inflammasome NLRP3 Complex in Young Men
Abkenar, I. K., Rahmani‐Nia, F., & Lombardi, G. (2019) · Medicina · doi:10.3390/medicina55040105 · Cited by 64
Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review
Olcum, M., Tastan, B., Ercan, İ., Eltutan, B. I., & Genç, Ş. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153238 · Cited by 63
The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases
Zhao, J., Li, J., Li, G., & Chen, M. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1059576 · Cited by 69
Curcumin ameliorates monosodium urate‐induced gouty arthritis through Nod‐like receptor 3 inflammasome mediation via inhibiting nuclear factor‐kappa B signaling
Li, X., Xu, D., Sun, D., Zhang, T., He, X. J., & Xiao, D. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27969 · Cited by 63
Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes
Shirasuna, K., Karasawa, T., & Takahashi, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27475 · Cited by 62
Pattern recognition receptors as potential drug targets in inflammatory disorders
McKernan, D. P. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.09.001 · Cited by 65
Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy
de Araújo, F. M., Cuenca‐Bermejo, L., Fernández‐Villalba, E., Costa, S. L., da Silva, V. D. A., & Herrero, M. T. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01027-6 · Cited by 63
Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy
Xu, D., Zhang, X., Chen, X., Yang, S., & Chen, H. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117980 · Cited by 61
Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction
Martínez‐Klimova, E., Aparicio‐Trejo, O. E., Gómez‐Sierra, T., Jiménez‐Uribe, A. P., Bellido, B., & Pedraza‐Chaverrí, J. (2020) · BioFactors · doi:10.1002/biof.1673 · Cited by 62
Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates Myocardial Fibrosis and High Glucose‐Induced Cardiomyocyte Injury by Regulating Intestinal Flora and Mitochondrial Dysfunction
Wang, J., Chen, P., Cao, Q., Wang, W., & Chang, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9205908 · Cited by 62
“It plays a vital role in the process of myocardial fibrosis [45].”
Mitochondria-associated membranes: A hub for neurodegenerative diseases
Liu, J., & Yang, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112890 · Cited by 67
PAMPs and DAMPs as the Bridge Between Periodontitis and Atherosclerosis: The Potential Therapeutic Targets
Zhu, X., Huang, H., & Жао, Л. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.856118 · Cited by 65
Reviewing the importance of TLR‐NLRP3‐pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors
Kinra, M., Nampoothiri, M., Arora, D. S., & Mudgal, J. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13124 · Cited by 60
Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
Yu, X., Zhao, Q., Zhang, X., Zhang, H., Liu, Y., Wu, X., Li, M., Li, X., Zhang, J., Ruan, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18619 · Cited by 60
“Thus, characterization of the NLRP3 inflammasome inhibitor may provide novel insights into the control of inflammatory processes [28].”
Background
Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome
Uchinaka, A., Azuma, N., Mizumoto, H., Nakano, S., Minamiya, M., Yoneda, M., Aoyama, K., Komatsu, Y., Yamada, Y., Murohara, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26588-x · Cited by 59
Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation
Chang, W., Chu, M.-T., Hsu, C., Wu, Y. J., Lee, J.-Y., Chen, T.-J., Chung, W., Chen, D., & Chung, W. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500071 · Cited by 61
NLRP 3 inflammasome activation in platelets in response to sepsis
Cornelius, D. C., Baik, C., Travis, O. K., White, D. L., Young, C. M., Pierce, W. A., Shields, C. A., Poudel, B., & Williams, J. M. (2019) · Physiological Reports · doi:10.14814/phy2.14073 · Cited by 64
Neuroprotective Effect of Oridonin on Traumatic Brain Injury via Inhibiting NLRP3 Inflammasome in Experimental Mice
Yan, C., Yan, H., Mao, J., Liu, Y., Li, X., Zhao, H., Shen, J., Cao, Y. W., Gao, Y., Li, K., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.557170 · Cited by 58
“NLRs, one subclass of pattern recognition receptors (PRRs), play a critical role in the innate immune/inflammatory response by forming inflammasomes (Shao et al., 2015).”
Background
XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis‐Induced Renal Inflammation and Oxidative Injury via the miR‐223/NLRP3 Pathway
Lv, P., Liu, H., Ye, T., Yang, X., Duan, C., Yao, X., Li, B., Tang, K., Chen, Z., Liu, J., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1676152 · Cited by 60
“Activation of the NLRP3 inflammasome leads to the initial stages and progression of many diseases, including kidney stones [30, 31].”
Background
Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling pathway
Zhang, P., Wu, P., Khan, U. Z., Zhou, Z., Sui, X., Li, C., Dong, K., Liu, Y.-J., Qing, L., & Tang, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02087-8 · Cited by 62
“It can respond to pathogens (PAMPs) and endogenous activators (DAMPs), such as microbes, extracellular ATP, viral RNA, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and lysosomal rupture [47–50].”
Background
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
Xu, Y., Yang, Y., Chen, X., Jiang, D., Zhang, F., Guo, Y., Hu, B., Xu, G., Peng, S., Wu, L., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00381-x · Cited by 65
“The upstream events that activate NLRP3 include potassium, calcium, and chloride ion efflux [33–37], production of reactive oxygen species (ROS), mitochondrial dysfunction [38–41], and lysosomal disruption [25].”
Background
Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update
Yu, Q., Zhao, T., Liu, M., Cao, D., Li, J., Li, Y., Xia, M., Wang, X., Zheng, T., Liu, C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.707696 · Cited by 61
Self-citation
Discovery of Quinazolin-4(3H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation
Abdullaha, M., Mohammed, S., Ali, M., Kumar, A., Vishwakarma, R. A., & Bharate, S. B. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.9b00138 · Cited by 57
A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress
Zhang, Y., Sun, C., Duan, J., Yang, H., Zhang, C., Xiong, J., Zhong, W., Zu, C., Guan, X., Jiang, H., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109907 · Cited by 57
The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases
Feng, Y.-S., Tan, Z., Wu, L., Dong, F., & Zhang, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111428 · Cited by 59
Corrigendum to “Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway”
Wu, D., Wu, K., Zhu, Q., Xiao, W., Shan, Q., Yan, Z., Wu, J., Deng, B., Xue, Y., Gong, W., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/9878120 · Cited by 57
Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors
Agarwal, S., Sasane, S., Shah, H. A., Pethani, J. P., Deshmukh, P. H., Vyas, V., Iyer, P. S., Bhavsar, H., Viswanathan, K., Bandyopadhyay, D., et al. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00433 · Cited by 55
Targeting regulated cell death in aortic aneurysm and dissection therapy
Chen, Y., He, Y., Wei, X., & Jiang, D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106048 · Cited by 59
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway
Liu, Y., Sun, R., Lin, X., Wu, L., Chen, H., Shen, S., Li, Y., Wei, Y., & Deng, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113078 · Cited by 56
Myocardial ischemia-reperfusion injury: The balance mechanism between mitophagy and NLRP3 inflammasome
Chen, L., Mao, L., Xue, J.-Y., Jian, Y.-H., Deng, Z.-W., Mazhar, M., Zou, Y., Liu, P., Chen, M., Luo, G., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122998 · Cited by 59
Extracellular vesicles derived from bone marrow mesenchymal stem cells alleviate neuroinflammation after diabetic intracerebral hemorrhage via the miR-183-5p/PDCD4/NLRP3 pathway
Ding, H., Jia, Y., Lv, H., Chang, W., Liu, F., & Wang, D. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01583-8 · Cited by 55
Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
Li, Z., Yang, H., Hai, Y., & Cheng, Y. (2023) · Mediators of Inflammation · doi:10.1155/2023/6210885 · Cited by 55
“NLRP3, a member of the inflammasome, is a crucial component of innate immunity and participates in several proinflammatory processes [224].”
Background
Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
Yang, M., Lin, Y., Ho, W.-H., Liu, C., & Lee, W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0797-6 · Cited by 54
“The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. secretion of mature IL-1β and IL-18 [8].”
InfluentialSelf-citation
Activating α7 nicotinic acetylcholine receptor inhibits NLRP 3 inflammasome through regulation of β‐arrestin‐1
Ke, P., Shao, B., Xu, Z., Chen, X., Wei, W., & Liu, C. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12758 · Cited by 55
Self-citation
Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome
Kattah, M. G., Malynn, B. A., & Ma, A. I. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.10.001 · Cited by 57
The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection
Sarvestani, S. T., & McAuley, J. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.10.020 · Cited by 55
Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows
Shen, T., Li, X., Loor, J. J., Zhu, Y., Du, X., Wang, X., Xing, D., Shi, Z., Fang, Z., Li, X., et al. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16706 · Cited by 58
Therapeutic Strategies for Targeting IL-1 in Cancer
Gottschlich, A., Endres, S., & Kobold, S. (2021) · Cancers · doi:10.3390/cancers13030477 · Cited by 58
Inhibitory effects of sulforaphane on NLRP3 inflammasome activation
Kiser, C., Gonul, C. P., Olcum, M., & Genç, Ş. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.10.014 · Cited by 56
Bone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223
Yuan, X., Wang, X., Chen, C., Zhou, J. H., & Han, M. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0599-x · Cited by 54
“Thereafter, we investigated the levels of miR-223 target gene (NLRP3) expression in both RTECs and kidney tissue [20, 33].”
Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke
Giraud, A., Guiraut, C., Chevin, M., Chabrier, S., & Sébire, G. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00612 · Cited by 58
“well as the DAMPs can induce the activation of the inflammasome (82, 83).”
Background
The possible ameliorative effect of simvastatin versus sulfasalazine on acetic acid induced ulcerative colitis in adult rats
Soliman, N. A., Keshk, W. A., Rizk, F. H., & Ibrahim, M. A. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.002 · Cited by 54
Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy
Karan, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03028 · Cited by 55
Downregulation of lncRNA SNHG14 attenuates osteoarthritis by inhibiting FSTL-1 mediated NLRP3 and TLR4/NF-κB pathway through miR-124-3p
Wang, B., Li, J., & Tian, F. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119143 · Cited by 54
Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis
Yu, Q., Guo, M., Zeng, W., Zeng, M., Zhang, X., Zhang, Y., Zhang, W., Jiang, X., & Yu, B. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.581 · Cited by 52
Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus
Zhao, L., Hu, X., Xiao, F., Zhang, X., Zhao, L., & Wang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929520 · Cited by 54
Molecular mechanisms of cell death in bronchopulmonary dysplasia
Deng, X., Bao, Z., Yang, X., Mei, Y., Zhou, Q., Chen, A., Yu, R., & Zhang, Y. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01791-4 · Cited by 54
Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling
Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 54

Authors: Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C.
Affiliations: Second Military Medical University (CN)
Corresponding author: Liu, Chong
ORCID: Shao, Bo-Zong
Su, Ding-Feng
Liu, Chong
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2015-11-05
Volume: 6
Pages: 262-262
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2015.00262
PMC: PMC4633676
OpenAlex: W2137444266
Cited by: 836
References: 115
Citations by year: 2026: 42 · 2025: 62 · 2024: 102 · 2023: 107 · 2022: 114 · 2021: 105 · 2020: 91 · 2019: 68 · 2018: 61 · 2017: 57 · 2016: 24 · 2015: 2
FWCI: 4.60
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Frontiers in Pharmacology (cc-by)
Funders: Natural Science Foundation of Shanghai (13ZR1448400)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: NLRP3 inflammasome, inflammasome inhibitors, innate immunity, autoinflammatory disease, autoimmune disease, metabolic disorders, multiple sclerosis, inflammatory bowel disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NLRP3 inflammasome and its inhibitors: a review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks