Cited by 838Inflammasome and immune disordersImmune Response and InflammationAutoimmune and Inflammatory Disorders Research

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NLRP3 inflammasome and its inhibitors: a review

Open access

Shao, Bo-Zong, Xu, Zhe-Qi, Han, Bin-Ze, Su, Ding-Feng, Liu, Chong·2015·Frontiers in Pharmacology

DOI 10.3389/fphar.2015.00262PMC PMC4633676

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Abstract

Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as "pyrin domain-containing protein 3". The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome, as well as other auto-immune and auto-inflammatory diseases. Several NLRP3 inflammasome inhibitors have been described, some of which show promise in the clinic. The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto-inflammatory diseases, and the state of research into NLRP3 inflammasome inhibitors.

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MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · cited 1×
“These endogenous non-coding RNAs are 20– 23 nt long and bind to the 3′ untranslated region (3′ UTR) of protein-coding mRNAs to regulate their translation (Bartel, 2009; Chen and Sun, 2013).”
The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · cited 1×
“A newly identified PRR, first described in detail in 2002, is the inflammasome (Martinon et al., 2002; Gentile et al., 2015; Jorgensen and Miao, 2015; Sanders et al., 2015).”
Background
The Inflammasomes
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · cited 3×
“Formation of the inflammasome also triggers a process of inflammation-related cell death termed pyroptosis (Willingham et al., 2009; Schroder and Tschopp, 2010; Zhong et al., 2013a; Jorgensen and Miao, 2015).”
BackgroundMethod
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · cited 1×
“…protect against disease and death, inappropriate activation of the NLRP3 inflammasome can contribute to the onset and progression of various diseases, particularly age-related diseases such as metabolic disorders and metabolic syndrome (Franceschi et al., 2000; Goldberg and Dixit, 2015).”
Background
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · cited 1×
“…in macrophages and animal models have shown that oxidized low-density lipoprotein and cholesterol crystals trigger NLRP3 inflammasome activation (Duewell et al., 2010; Liu et al., Frontiers in Pharmacology | www.frontiersin.org 2 November 2015 | Volume 6 | Article 262 FIGURE 1 | Schematic…”
Background
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,087 · cited 1×
“…PAMPs or DAMPs are recognized by TLRs, leading to activation of nuclear factor kappa B (NF-κB)-mediated signaling, which in turn up-regulates transcription of inflammasome-related components, including inactive NLRP3, proIL-1β, and proIL18 (Bauernfeind et al., 2009; Franchi et al., 2012, 2014).”
Background
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · cited 2×
“…damage or dysfunction caused by mitochondrial Ca2+ overload (Iyer et al., 2013; Miao et al., 2014; Zhuang et al., 2015), lysosomal disruption (Hornung et al., 2008; Sheedy et al., 2013; Tseng et al., 2013), autophagic dysfunction (Cho et al., 2014; Shao et al., 2014; Jabir et al., 2015) and…”
Background
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · cited 3×
“Coll et al. (2015) discovered that MCC950, a diarylsulfonylurea-containing compound known to inhibit caspase-1-dependent processing of IL-1β (Perregaux et al., 2001), also inhibits both canonical and non-canonical activation of the NLRP3 inflammasome.”
Background
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · cited 2×
“Youm et al. (2015) discovered that the ketone metabolite β-hydroxybutyrate (BHB), but not acetoacetate or the shortchain fatty acids butyrate and acetate, reduced IL-1β, and IL-18 production by the NLRP3 inflammasome in human monocytes.”
Background
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079

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Wen, C., Wang, J., Sun, Z., Zhong, R., Li, M., Shen, X., Ye, Q., Qin, K., & Peng, X. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03715-y · Cited by 23
“NLRP3 activates Caspase-1, and then induces the production and secretion of IL-1β and IL-18, which causes an inflammatory response [52].”
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He, K.-L., Yu, X., Xia, L., Xie, Y., Qi, E., Wan, L., Hua, X., & Jing, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526786 · Cited by 25
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Han, Y., Sun, Y., Peng, S., Tang, T., Zhang, B., Yu, R., Sun, X., Guo, S., Ma, L., Li, P., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177505 · Cited by 27
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Nishiguchi, T., Iwata, M., Kajitani, N., Miura, A., Matsuo, R., Murakami, S., Nakada, Y., Pu, S., Shimizu, Y., Tsubakino, T., et al. (2021) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12164 · Cited by 24
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Exploring the role of the inflammasomes on prostate cancer: Interplay with obesity
Pérez‐Gómez, J. M., Montero‐Hidalgo, A. J., Fuentes-Fayos, A. C., Sarmento‐Cabral, A., Guzmán‐Ruiz, R., Malagón, M. M., Herrera-Martínez, A. D., Gahete, M. D., & Luque, R. M. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09838-w · Cited by 23
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Chen, K., Li, B., Xu, H. F., Wu, J., Li, J., Sun, W., Fang, M., Wang, W., Wang, S., & Xiao, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128388 · Cited by 23
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Gong, X., Gu, W., Fu, S., Zou, G., & Jiang, Z. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012805 · Cited by 21
“Although targeting NLRP3 is a promising way, only a few inhibitors of NLRP3 inflammasome are currently available in clinical [62].”
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34173-5 · Cited by 22
Astragaloside IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation.
Zhang, T., Wang, H., Lü, M., Zhao, K., Yin, J., Liu, Y., & Sun, Y. (2020) · PubMed Central · Cited by 22
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Wada, A., Higashiyama, M., Kurihara, C., Ito, S., Tanemoto, R., Mizoguchi, A., Nishii, S., Inaba, K., Sugihara, N., Hanawa, Y., et al. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06848-z · Cited by 22
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Chen, F.-F., Liu, X.-T., Tao, J., Mao, Z., Wang, H., Tan, Y. C. R. S., Qu, Z., & Yu, F. (2023) · Clinical Immunology · doi:10.1016/j.clim.2022.109221 · Cited by 22
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Wang, M., Zhang, F., Ning, X., Wu, C., Zhou, Y., Gou, Z., Yang, F., Duan, R., Li, Z., Shao, C., et al. (2023) · Inflammation · doi:10.1007/s10753-023-01885-4 · Cited by 23
“…and contains several special domains, such as the central nucleotide domain and oligomerization (NACHT), cysteine protease recruitment (CARD), leucine-rich repeat sequence (lrr), and hot protein (PYD) domains embedded with apoptosis-associated spot-like proteins (ASCs) and Caspase-1 [17, 18].”
Background
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis
Gu, Q., Xia, H., Song, Y.-Q., Duan, J., Chen, Y., You, Z., Chen, H., & Zhang, L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i3.252 · Cited by 22
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“In contrast, activation of NF-κB -related pathways mediated by NLRP3 inflammatory vesicles may reduce the polarity of AQP-4, which in turn leads to impaired normal function of the brain lymphatic system [14, 65, 165-168].”
NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model
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Background
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Background
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Merighi, S., Nigro, M., Travagli, A., Pasquini, S., Borea, P. A., Varani, K., Vincenzi, F., & Gessi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095056 · Cited by 23
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Background
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Background
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“NLRP3 assembles with linker molecules and effector molecules (caspase-1) to form NLRP3 inflammasomes [4].”
Background
Interaction Between Autophagy and Porphyromonas gingivalis-Induced Inflammation
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Yan, J., Feng, G., Yang, Y., Ding, D., Ma, L., Zhao, X. S., Chen, X., Wang, H., Chen, Z., & Jin, Q. (2022) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2022.7677 · Cited by 20
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Background
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“In the presence of immune activators such as pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), or other exogenous invaders, the pyrin domains of NLRP3 binds to that of ASC, and subsequently the caspase recruitment domain of ASC recruits and interacts with pro-caspase-1 (Shao…”
Background
Single and combined effects of high-fat diet and ammonia nitrogen on oxidative stress, lipid accumulation and inflammation in liver of grass carp Ctenopharyngodon idella
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Self-citation
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Background
Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome
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“Inflammasome as a newly identified pattern-recognition receptors, was firstly described in detail by Martinon in 2002 (Martinon et al., 2002; Shao et al., 2015).”
BackgroundSelf-citation
Picroside II protects against sepsis via suppressing inflammation in mice.
(2016) · PubMed Central · Cited by 19
Can we use interleukin-1β blockade for lung cancer treatment?
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Background
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice
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“The inflammasome also plays a role in a number of psoriasis-related comorbidities such as metabolic syndrome, atherosclerosis, and cardiovascular disease (20).”
Background
Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation
Mohamed, R. A., Abdallah, D. M., El-Brairy, A. I., Ahmed, K. A., & El-Abhar, H. S. (2021) · Molecules · doi:10.3390/molecules26165068 · Cited by 18
A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB)/Interleukin-18 (IL-18)
ElMahdy, M. K., Antar, S. A., Elmahallawy, E. K., Abdo, W. S., Hijazy, H. H. A., Albrakati, A., & Khodir, A. E. (2021) · Biomedicines · doi:10.3390/biomedicines10010040 · Cited by 18
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation
Ning, W., Gao, G., Zhou, Y., Li, W., Yang, H., Duan, X.-B., Li, X., Gong, Y.-B., Li, D., & Guo, R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109747 · Cited by 19
Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
Wang, X., Lin, J., Wang, Z., Li, Z., & Wang, M. (2023) · Discover Oncology · doi:10.1007/s12672-023-00701-7 · Cited by 20
“Through CRISPR/Cas9 gene editing, NLRP3 can be eliminated directly at the genomic level [118].”
Background
Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis
Fu, R., Guo, X., Pan, Z., Wang, Y., Xu, J., Zhang, L., & Li, J. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04200-x · Cited by 18
“…or danger signals, the NLRP3 inflammasome has played critical roles in various disease processes, being implicated in the onset and progression of diseases such as diabetes, obesity, rheumatoid arthritis, Alzheimer’s disease, Parkinson’s disease, and other autoimmune and inflammatory diseases [10].”
Background
Discovery of anti-inflammatory agents from 3, 4-dihydronaphthalene-1(2H)-one derivatives by inhibiting NLRP3 inflammasome activation
Li, W.-X., Yu, L. S., Chi, J.-B., Wang, J., Liu, Y., Wang, C., Zhang, M., & Hou, G. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116284 · Cited by 18
Puerarin inhibits Staphylococcus aureus ‐induced endometritis through attenuating inflammation and ferroptosis via regulating the P2X7 / NLRP3 signalling pathway
Yuan, C., Liu, L., Zhao, Y., & Wang, K. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18550 · Cited by 18
“11 In addition, NLRP3 is also involved in other chronic inflammatory diseases, such as gout or atherosclerosis.”
Background
Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages
Cristo, L. D., Carthy, S. M., Paton, K. R., Movia, D., & Prina‐Mello, A. (2018) · 2D Materials · doi:10.1088/2053-1583/aadf45 · Cited by 18
“It is well know that autophagy inhibits the inflammasome activation [39].”
Background
Analysis of the Immune and Antioxidant Response of Cellulose Nanocrystals Grafted with β-Cyclodextrin in Myeloid Cell Lines
Sunasee, R., Carson, M., Despres, H. W., Pacherille, A., Nunez, K. D., & Ckless, K. (2019) · Journal of Nanomaterials · doi:10.1155/2019/4751827 · Cited by 18
“Activation of the NLRP3 inflammasome plays an important role in innate immunity, and the inflammatory response and the secretion of IL-1β by immune cells can be indicative of this immunological response [34, 35].”
Background
The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells
Jiao, P., Li, W., Shen, L., Li, Y., Yu, L., & Liu, Z. (2020) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2020.1730391 · Cited by 18
Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer’s Type Neurodegeneration
Komleva, Y. K., Lopatina, O. L., Gorina, Y. V., Черных, А. И., Труфанова, Л. В., Vais, E. F., Kharitonova, E. V., Жуков, Е. Л., Vahtina, L. Y., Медведева, Н. Н., et al. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01021-y · Cited by 18
High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice
Mizoguchi, A., Banno, R., Sun, R., Yaginuma, H., Taki, K., Kobayashi, T., Sugiyama, M., Tsunekawa, T., Onoue, T., Takagi, H., et al. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.009 · Cited by 20
Therapeutic Implications of NLRP3-Mediated Inflammation in Coronary Artery Disease
Hemenway, G., & Frishman, W. H. (2021) · Cardiology in Review · doi:10.1097/crd.0000000000000391 · Cited by 18
“a diarylsulfonylurea-containing small molecule inhibitor that blocks ASC oligomerization.(5) In both mouse models and ex vivo human”
Influential
RETRACTED: Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4
Zhang, H., Luan, S., Xiao, X., Lin, L., Zhao, X., & Liu, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118850 · Cited by 17
Retracted
miR-223-3p contributes to suppressing NLRP3 inflammasome activation in Streptococcus equi ssp. zooepidemicus infection
Li, G., Zong, X., Cheng, Y., Xu, J., Deng, J., Huang, Y., Ma, C., & Fu, Q. (2022) · Veterinary Microbiology · doi:10.1016/j.vetmic.2022.109430 · Cited by 17
Coelonin protects against PM 2 .5 ‐induced macrophage damage via suppressing TLR4 / NF‐κB / COX ‐2 signaling pathway and NLRP3 inflammasome activation in vitro
Bao, X., Zu, Y., Wang, B., Li, M., Jiang, F., Qian, C., Zhou, F., & Ding, Z. (2023) · Environmental Toxicology · doi:10.1002/tox.23772 · Cited by 17
NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation
Chen, X., Li, W., & Chang, C. (2023) · Autoimmunity · doi:10.1080/08916934.2023.2189135 · Cited by 17
“As for inflammation, the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome has also been demonstrated to be implicated in various auto-immune and auto-inflammatory diseases [10].”
Background
Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion
Liu, B., Wu, Y., Liang, T., Zhou, Y., Chen, G., He, J., Ji, C., Liu, P., Zhang, C., Lin, J., et al. (2023) · Mediators of Inflammation · doi:10.1155/2023/3706421 · Cited by 17
“Specifically, NLRP3 inflammasome activates caspase-1, causing maturation of pro-inflammatory IL-1β and IL-18 cytokines into their respective active forms, leading to further inflammatory responses [49, 50].”
Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway
Jiang, Y., Dong, B., Xing, J., Shan, J., Fang, C., Zhang, K., Li, D., Xu, C., & Zhang, Z. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170129 · Cited by 17
The significance of targeting lysosomes in cancer immunotherapy
Xu, Y., Shao, B., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1308070 · Cited by 21
Self-citation
TMAO is involved in kidney-yang deficiency syndrome diarrhea by mediating the “gut-kidney axis”
Xie, S., Deng, N., Fang, L., Shen, J., Tan, Z., & Cai, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35461 · Cited by 18
“Upon activation, macrophages release various cytokines, including IL-1 β and TGF-β 1 signaling the onset of fibrosis, which frequently occurs with organ inflammatory disorders [44,45].”
Background
The neurotrophic and antineuroinflammatory effects of phenylpropanoids from Zanthoxylum nitidum var. tomentosum (Rutaceae)
Qin, F., Wang, F., Wang, C., Chen, Y., Li, M.-S., Zhu, Y.-K., Huang, X., Fan, C.-W., & Wang, H. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.104990 · Cited by 17
Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
Liu, H., Bian, Z., Zhang, Q., Xiao, Z., Cao, Y., Sun, X., Qin, Y., Mao, L., Chu, X., Liao, W., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104862 · Cited by 18
A narrative review of positive regulation of NLRP3 inflammasome in rheumatoid arthritis.
Zhuang, Y.-P., Wang, H., Su, J., Zhang, J., Wang, Q., Chen, Y.-N., & Che, H. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-3472 · Cited by 15
“The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most widely studied (20), and triggers host autoimmune defenses by recognizing foreign danger signals.”
Background
Synthetic Agonists of Nod-Like, Rig-I-Like, and C-Type Lectin Receptors for Probing the Inflammatory Immune Response
Nielsen, A. E., Hantho, J. D., & Mancini, R. J. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0101 · Cited by 17
Cis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca²⁺-phagocytosis-ROS axis
Lei, S., Liu, K., Liu, C., An, R., Bao, Z., Zhang, H., Zou, M., Chen, J., Zhang, H., Wei, L., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157145 · Cited by 16
Self-citation
ASC modulates HIF-1α stability and induces cell mobility in OSCC
Wu, C., Chang, I. Y., Hung, J.-L., Liao, W., Lai, Y.-R., Chang, K., Li, H., & Chang, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02927-7 · Cited by 19
microRNA-135a-5p regulates NOD-like receptor family pyrin domain containing 3 inflammasome-mediated hypertensive cardiac inflammation and fibrosis via thioredoxin-interacting protein
Chen, H. H., Qiao, H., Zhao, Q., & Wei, F. (2022) · Bioengineered · doi:10.1080/21655979.2021.2024956 · Cited by 16
Effect of TRAF6 in acute pancreatitis-induced intestinal barrier injury via TLR4/NF-κB signal pathway
Wei, B., Wu, Q., Xuexia, Y., Lai, C., Zhou, S., & Liang, Z. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101792 · Cited by 16
Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs
Li, J.-S., Su, S., Xu, Z., Zhao, L.-H., Fan, R.-Y., Guo, J., Qian, D., & Duan, J. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221091177 · Cited by 18
Self-citation
The Organogermanium Compound 3-(Trihydroxygermyl) Propanoic Acid (THGP) Suppresses Inflammasome Activation Via Complexation with ATP
Azumi, J., Shimada, Y., Takeda, T., Aso, H., & Nakamura, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113364 · Cited by 16
NLRP3 deficiency protects against hypobaric hypoxia induced neuroinflammation and cognitive dysfunction
Zhu, X., Liu, H., Wang, D., Guan, R., Zou, Y., Li, M., Zhang, J., & Chen, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114828 · Cited by 16
HIV-Related Atherosclerosis: State-of-the-Art-Review
Арманович, А. А., Вачиковна, П. Н., Kakturskiy, L., Sheibani, M., Urazova, O. I., Трофименко, А. И., Navarsdyan, G., Jndoyan, Z., Abgaryan, K., Fogacci, F., et al. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.101783 · Cited by 16
Ru360 Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Inhibiting MCU-Mediated Mitochondrial Dysfunction
Xu, X., Zhou, B., Liu, J., Ma, Q., Zhang, T., & Wu, X. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s409568 · Cited by 16
“The activated NLRP3 inflammasome triggers the cleavage of the pro-caspase-1 to caspase-1, which is then released into the cytoplasm to further induce the conversion of the pro- IL-1β to active IL-1β (Figure 7).(29) There is a high concentration of inflammatory cytokine receptors in regions related to learning and memo…”
Background
Ruscogenin Exerts Anxiolytic‐Like Effect via Microglial NF ‐ κB / MAPKs / NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain
Qi, J., Jin, Y., Wang, X., Yang, L.-K., Lu, L., Yue, J., Yang, F., Liu, Y., Jiang, Y., Song, D., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8325 · Cited by 16
“The NLRP3 inflammasome plays an important role in inflammation and immunity (Shao et al. 2015).”
The application of procyanidins in diabetes and its complications: a review of preclinical studies
Zhang, Y., Li, M., Liu, H., Fan, Y., & Liu, H. H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1532246 · Cited by 17
New molecular targets for the treatment of sarcoidosis
Chiarchiaro, J., Chen, B. B., & Gibson, K. F. (2016) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000304 · Cited by 15
PM2.5 induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway
Jia, R., Wei, M., Lei, J., Meng, X., Du, R., Yang, M., Lu, X., Jiang, Y., Cao, R., Wang, L., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114699 · Cited by 15
Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory Activity
Morillo-Bargues, M. J., Osorno, A. O., Guerri, C., Pradas, M. M., & Martínez‐Ramos, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210340 · Cited by 15
Physical Activity as a Modern Intervention in the Fight against Obesity-Related Inflammation in Type 2 Diabetes Mellitus and Gestational Diabetes
Piotrowska, K., Zgutka, K., Tkacz, M., & Tarnowski, M. (2023) · Antioxidants · doi:10.3390/antiox12081488 · Cited by 18
“Khakroo Abkenar et al. [115] showed that chronic exercise with moderate intensity significantly reduced the expression of the NLRP3 gene and serum levels of IL-1β and IL-18 in a group of healthy, young men.”
BackgroundInfluential
Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing β-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions
Gojani, E. G., Wang, B., Li, D., Kovalchuk, O., & Kovalchuk, I. (2023) · Molecules · doi:10.3390/molecules28227619 · Cited by 15
Neutrophil extracellular traps in central nervous system (CNS) diseases
Shao, B., Jiang, J., Zhao, Y.-C., Zheng, X.-R., Xi, N., Zhao, G.-R., Huang, X., & Wang, S. (2024) · PeerJ · doi:10.7717/peerj.16465 · Cited by 15
“…kinds of inflammasomes have been reported, namely NOD-like receptor family, pyrin domain-containing (NLRP)1, NLRP2, NLRP3, NLR family caspase recruitment domain-containing protein 4 (NLRC4), and double-stranded DNA sensors absent in melanoma 2 (AIM2) ( Shao, Cao & Liu, 2018 ; Shao et al., 2015 ).”
BackgroundSelf-citation
Eriodictyol inhibits the motility, angiogenesis and tumor growth of hepatocellular carcinoma via NLRP3 inflammasome inactivation
Huang, W., Wang, C., & Zhang, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24401 · Cited by 15
“NLRP3 inflammasome, includes NLRP3, ASC, caspase-1, IL-1 β , and IL-18 proteins, and its activation is involved in the HCC progression [42 – 44].”
Background
Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights
Li, J., Wang, X., Bai, J., Wei, H., Wang, W., & Wang, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04877-6 · Cited by 15
“Nuclear factor kappa B (NF-κB) signaling is triggered in one way [9], while certain chemicals, such as mitochondrial reactive oxygen species, may activate a second signal [10].”
Background
Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice
Fu, Q., Zhang, J., Zhu, Q., Ling-ling, Y., Wang, F., Li, J., He, X. J., Ao, J.-L., Xu, G., Wei, M.-C., et al. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150038 · Cited by 16
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
Karmakar, V., Chain, M., Majie, A., Ghosh, A., Sengupta, P., Dutta, S., Mazumder, P. M., & Gorain, B. (2025) · Inflammopharmacology · doi:10.1007/s10787-024-01629-2 · Cited by 18
“2) and brings NLRP3, ASC, and procaspase-1 together (Shao et al. 2015).”
Design and Synthesis of an N-Benzyl 5-(4-Sulfamoylbenzylidene-2-thioxothiazolidin-4-one Scaffold as a Novel NLRP3 Inflammasome Inhibitor.
Zuo, D., Do, N., Hwang, I., Ann, J., Yu, J.-W., & Lee, J. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128693 · Cited by 10

Authors: Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C.
Affiliations: Second Military Medical University (CN)
Corresponding author: Liu, Chong
ORCID: Shao, Bo-Zong
Su, Ding-Feng
Liu, Chong
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2015-11-05
Volume: 6
Pages: 262-262
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2015.00262
PMC: PMC4633676
OpenAlex: W2137444266
Cited by: 836
References: 115
Citations by year: 2026: 42 · 2025: 62 · 2024: 102 · 2023: 107 · 2022: 114 · 2021: 105 · 2020: 91 · 2019: 68 · 2018: 61 · 2017: 57 · 2016: 24 · 2015: 2
FWCI: 4.60
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Frontiers in Pharmacology (cc-by)
Funders: Natural Science Foundation of Shanghai (13ZR1448400)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: NLRP3 inflammasome, inflammasome inhibitors, innate immunity, autoinflammatory disease, autoimmune disease, metabolic disorders, multiple sclerosis, inflammatory bowel disease

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NLRP3 inflammasome and its inhibitors: a review

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