NLRP3 inflammasome and its inhibitors: a review

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1. Metaflammation’s Role in Systemic Dysfunction in Obesity: A Comprehensive Review
   Ioana-Maria Crasan, Matei Tanase, Corina Delia, Grațiela Grădișteanu Pîrcălăbioru, Anișoara Cîmpean, Elena Ionica · 2025 · International Journal of Molecular Sciences
2. Aberrant NLRP3 inflammasome associated with aryl hydrocarbon receptor potentially contributes to the imbalance of T‑helper cells in patients with acute myeloid leukemia
   Yan Jia, Chen Zhang, Mingqiang Hua, Min Wang, Ping Chen, Daoxin Ma · 2017 · Oncology Letters
3. Identification of Metabolites Associated with Onset of CAD in Diabetic Patients Using CE-MS Analysis: A Pilot Study
   Kazuo Omori, Naoto Katakami, Yuichi Yamamoto, Hiroyo Ninomiya, Mitsuyoshi Takahara, Taka‐aki Matsuoka, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura · 2018 · Journal of Atherosclerosis and Thrombosis
4. Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation
   Jeongeun Kim, Huijeong Ahn, Byung-Cheol Han, Hyunjung Shin, Jin‐Chul Kim, Eui‐Man Jung, Juyeol Kim, Heejung Yang, Jeonghyun Lee, Seung Goo Kang et al. · 2019 · Phytomedicine
5. Kefir peptides alleviate particulate matter <4 μm (PM4.0)-induced pulmonary inflammation by inhibiting the NF-κB pathway using luciferase transgenic mice
   Hsiao‐Ling Chen, Kuan-Fei Hung, Chih‐Ching Yen, Chun-Huei Laio, Jiun-Long Wang, Ying‐Wei Lan, Kowit‐Yu Chong, Hueng‐Chuen Fan, Chuan‐Mu Chen · 2019 · Scientific Reports
6. Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation
   Yi Zhang, Ziqing Song, Shan Huang, Li Zhu, Tianyi Liu, Hongyan Shu, Lei Wang, Yi Huang, Yang Chen · 2020 · Journal of Leukocyte Biology
7. NLRP3 Inflammasome Biomarker—Could Be the New Tool for Improved Cardiometabolic Syndrome Outcome
   Andra‐Iulia Suceveanu, Laura Mazilu, Niki Katsiki, Irinel R. Parepa, Felix Voinea, Anca Pantea Stoian, Manfredi Rizzo, Florin Botea, Vlad Herlea, Dragoş Şerban et al. · 2020 · Metabolites
8. Alpha‐lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats
   Chih‐Yuan Ko, Yang-Ming Martin Lo, Jianhua Xu, Wen‐Chang Chang, Da‐Wei Huang, James Swi‐Bea Wu, Cho‐Hua Yang, Wen‐Chung Huang, Szu‐Chuan Shen · 2021 · Food Science & Nutrition
9. Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome
   Liang Yin, Haoxin Zhao, Huiyu Zhang, Yi Li, Yuhao Dong, Huijin Ju, Feng Kong, Shengtian Zhao · 2021 · Frontiers in Immunology
10. Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
    Li Li, Sainan Liu, Jianying Tan, Lai Wei, Dimeng Wu, Shuai Gao, Yajun Weng, Junying Chen · 2022 · Journal of Tissue Engineering
11. Cannabinoids and terpenes for diabetes mellitus and its complications: from mechanisms to new therapies
    Esmaeel Ghasemi Gojani, Igor Kovalchuk, Olga Kovalchuk · 2022 · Trends in Endocrinology and Metabolism
12. New insights into anti-diabetes effects and molecular mechanisms of dietary saponins
    Yifan Zhou, Baojun Xu · 2022 · Critical Reviews in Food Science and Nutrition
13. The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications
    Huiqin Zhou, Li Wang, Wei Lv, Hongmeng Yu · 2024 · Clinical and Experimental Medicine
14. All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage
    Ahmad Alatshan, Gergő E. Kovács, Azzam Aladdin, Zsolt Czimmerer, Krisztina Tar, Szilvia Benkő · 2020 · Cells
15. NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice
    Michiya Sano, Hiromu Komiyama, Riina Shinoda, Ren Ozawa, Hiroyuki Watanabe, Tadayoshi Karasawa, Masafumi Takahashi, Yasushi Torii, Hisataka Iwata, Takehito Kuwayama et al. · 2022 · American Journal of Reproductive Immunology
16. Inflammasomes as mediators of inflammation in HIV-1 infection
    Alice K. Min, Trinisia Fortune, Natalia Rodriguez, Esha Hedge, Talia H. Swartz · 2022 · Translational research
17. Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice
    Lingcui Meng, Jia-Yi Zheng, Yu-Hui Qiu, Zheng Li, Jue-Yan Zheng, Yuqing Liu, Xiao-Lu Miao, Xinyi Lu · 2022 · International Immunopharmacology
18. Rubia cordifolia L. ameliorates DSS-induced ulcerative colitis in mice through dual inhibition of NLRP3 inflammasome and IL-6/JAK2/STAT3 pathways
    Wei Qin, Han Luo, Liu Yang, Di Hu, Suping Jiang, Daiyin Peng, Jiang‐Miao Hu, Shou‐Jin Liu · 2022 · Heliyon
19. Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure
    Sunny Malhotra, Laura Hurtado‐Navarro, Agustín Pappolla, Luisa María Villar, Jordi Río, Xavier Montalbán, Pablo Pelegrı́n, Manuel Comabella · 2023 · Neurology Neuroimmunology & Neuroinflammation
20. Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review
    Direito, Rosa, Barbalho, Sandra Maria, Figueira, Maria Eduardo, Minniti, Giulia, de Carvalho, Gabriel Magno, de Oliveira Zanuso, Bárbara, de Oliveira dos Santos, Ana Rita, de Góes Corrêa, Natália, Rodrigues, Victória Dogani, de Alvares Goulart, Ricardo et al. · 2023 · Metabolites
21. The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers
    Mahdi Gouravani, Nastaran Khalili, Sepideh Razi, Mahsa Keshavarz‐Fathi, Neda Khalili, Nima Rezaei · 2020 · Expert Review of Clinical Immunology
22. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis
    Sharon Angela Tanuseputero, Ming‐Tsan Lin, Sung‐Ling Yeh, Chiu‐Li Yeh · 2020 · Mediators of Inflammation
23. Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway
    Wenhua Gan, Xiaohe Li, Yunyao Cui, Ting Xiao, Rui Liu, Ming Wang, Yiying Wei, Mengqi Cui, Shanfa Ren, Kaiyue Helian et al. · 2020 · International Immunopharmacology
24. NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation
    Bo‐Zong Shao, Haiyan Xu, Yi-Cheng Zhao, Xiao-Rui Zheng, Fang Wang, Guan-Ren Zhao · 2022 · Inflammation
25. Cardamonin protects against iron overload induced arthritis by attenuating ROS production and NLRP3 inflammasome activation via the SIRT1/p38MAPK signaling pathway
    Shaocong Li, Qi He, Bai‐Hao Chen, Jiaxu Zeng, Xiangyun Dou, Zhaofeng Pan, Jiacong Xiao, Miao Li, Fanchen Wang, Chuyi Chen et al. · 2023 · Scientific Reports
26. Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
    Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward M. Jenkins, Frederik Heymann Lassen, Sam J. Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou et al. · 2024 · Cell Reports
27. Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome
    Wen Ying Yu, Guangjun Jin, Jiancheng Zhang, Wei Wei · 2018 · Inflammation
28. Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3
    Xin Li, Meng-Qi Shi, Chu Chen, Junrong Du · 2020 · International Immunopharmacology
29. NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia
    Jing Li, Junxiang Wang, Yuanliang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan Li · 2021 · Ecotoxicology and Environmental Safety
30. Elaidic acid induced NLRP3 inflammasome activation via ERS-MAPK signaling pathways in Kupffer cells.
    Hui Liu, Bo Nan, Chaoyue Yang, Xue-Nan Li, Haiyang Yan, Yuan Yuan · 2021 · Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
31. The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence
    Fatemeh Rezaei‐Tazangi, Hossein Roghani‐Shahraki, Mahdi Khorsand Ghaffari, Firoozeh Abolhasani Zadeh, Aynaz Boostan, Reza Arefnezhad, Hossein Motedayyen · 2021 · Pharmaceuticals
32. BtpB inhibits innate inflammatory responses in goat alveolar macrophages through the TLR/NF-κB pathway and NLRP3 inflammasome during Brucella infection.
    Junmei Li, Guangdong Zhang, Fei-Jie Zhi, Yun-Yi Zhai, Dong Zhou, Hua-Tao Chen, P. Lin, Keqiong Tang, Wei Liu, Ya-Ping Jin et al. · 2022 · Microbial Pathogenesis
33. AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway
    Ming Zhang, Xintao Zhu, Huasheng Tong, Anni Lou, Yue Li, Yang Li, Lei Su, Xu Li · 2019 · BioMed Research International
34. Negative regulation of Nod‐like receptor protein 3 inflammasome activation by T cell Ig mucin‐3 protects against peritonitis
    Wei Wang, Qingzhu Shi, Shuaijie Dou, Ge Li, Xinhui Shi, Xingwei Jiang, Zhiding Wang, Dandan Yu, Guojiang Chen, Renxi Wang et al. · 2017 · Immunology
35. Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis
    Liliana-Roxana Balahura, Aida Șelaru, Sorina Dinescu, Marieta Costache · 2020 · Journal of Immunology Research
36. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain
    Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua Ou · 2021 · Shock
37. Intra‐articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model
    Hui Bai, Rui Yuan, Zhiheng Zhang, Lin Liu, Xinyu Wang, Xiaopeng Song, Tianwen Ma, Jilang Tang, Chunpeng Liu, Li Gao · 2021 · Oxidative Medicine and Cellular Longevity
38. Inflammasome Molecular Insights in Autoimmune Diseases
    Monica Neamţu, Veronica Bild, Alexandru Vasincu, Oana Dana Arcan, Delia Bulea, Daniela Carmen Ababei, Răzvan-Nicolae Rusu, Ioana Macadan, Ana Maria Sciucă, Andrei Neamțu · 2024 · Current Issues in Molecular Biology
39. Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model
    Elnaz Hajipour, Farideh Jalali Mashayekhi, Ghasem Mosayebi, Maryam Baazm, Adib Zendedel · 2018 · Europe PMC (PubMed Central)
40. NLRP3 inflammasome mediates white adipose tissue browning after burn
    Roohi Vinaik, Dalia Barayan, Abdikarim Abdullahi, Marc G. Jeschke · 2019 · American Journal of Physiology-Endocrinology and Metabolism
41. Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor
    Sungwoo Chei, Ji-Hyeon Song, Hyun‐Ji Oh, Kippeum Lee, Heegu Jin, Sun-Hye Choi, Seung-Yeol Nah, Boo-Yong Lee · 2020 · Molecules
42. Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1‐ and SIRT3‐mediated autophagy induction
    Chung-Yao Wu, Kuo‐Feng Hua, Shin‐Ruen Yang, Yi‐Shan Tsai, Shun‐Min Yang, Chih‐Yu Hsieh, Chia‐Chao Wu, Jia‐Feng Chang, Jack L. Arbiser, Chiz‐Tzung Chang et al. · 2020 · Journal of Cellular and Molecular Medicine
43. Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease
    Stefania Cicolari, Alberico Luigi Catapano, Paolo Magni · 2021 · Mechanisms of Ageing and Development
44. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells
    Man Liu, Shanshan Zhang, Dong-Ni Liu, Yinglin Yang, Yuehua Wang, Guanhua Du · 2021 · International Journal of Molecular Sciences
45. Focus on the role of NLRP3 inflammasome in the pathology of endometriosis: a review on molecular mechanisms and possible medical applications
    Elnaz Irandoost, Shaparak Najibi, Saba Talebbeigi, Saina Nassiri · 2022 · Naunyn-Schmiedeberg s Archives of Pharmacology
46. STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation
    Dandan Wu, Yan Deng, Juan Liao, Shanshan Xie, Hui Meng, Wei‐Fang Lan · 2023 · Immunobiology
47. Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora
    Kefei Li, Xin Ran, Yiruo Zeng, Shubo Li, Guiqiu Hu, Xiaoxuan Wang, Ying Li, Zhan‐Qing Yang, Juxiong Liu, Shoupeng Fu · 2023 · International Immunopharmacology
48. NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury
    Teng Xue, Weiwei Chen, Zhihan Liu, Tao Feng, Hui Li, Sheng Ding, Yonggang Chen, Ying Zhang, Xianping Tang, Deqin Geng · 2018 · Neurochemical Research
49. Deciphering the ATP-binding mechanism(s) in NLRP-NACHT 3D models using structural bioinformatics approaches
    Jitendra Maharana, Debashis Panda, Sachinandan De · 2018 · PLoS ONE
50. Mesenchymal stem cells ( MSCs ) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome
    Shahrzad Nazari, Seyed Mahmoud Pourmand, Elahe Motevaseli, Gholamreza Hassanzadeh · 2023 · IUBMB Life
51. Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
    Shobhit Gairola, Antarip Sinha, Ravinder Kumar Kaundal · 2023 · Inflammopharmacology
52. Advances in the Understanding of the Correlation Between Neuroinflammation and Microglia in Alzheimer’s Disease
    Huiying Yan, Wei Wang, Tingting Cui, Yanxin Shao, Mingquan Li, Limei Fang, Lina Feng · 2024 · ImmunoTargets and Therapy
53. Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor
    Ai Hua Zhang, Wen Liu, Nan Jiang, Qiang Xu, Ren Xiang Tan · 2016 · Organic Letters
54. Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice
    Jonghae Lee, Yang Lee, Emily C. P. LaVoy, Michihisa Umetani, Junyoung Hong, Yoonjung Park · 2018 · Physiological Reports
55. Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth
    Silvana Pereyra, Claudio Sosa, Bernardo Bertoni, Rossana Sapiro · 2019 · BMC Medical Genomics
56. Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives
    Daniela Pedicino, Ada Francesca Giglio, Aureliano Ruggio, Gianluca Massaro, Alessia d’Aiello, Francesco Trotta, Claudia Lucci, Francesca Graziani, Luigi Marzio Biasucci, Filippo Crea et al. · 2018 · Thrombosis and Haemostasis
57. NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase
    Roohi Vinaik, Mile Stanojcic, Marc G. Jeschke · 2018 · Scientific Reports
58. Glibenclamide attenuates 2,5-hexanedione-induced neurotoxicity in the spinal cord of rats through mitigation of NLRP3 inflammasome activation, neuroinflammation and oxidative stress
    Liyan Hou, Jie Yang, Sheng Li, Ruixue Huang, Dongdong Zhang, Jie Zhao, Qingshan Wang · 2020 · Toxicology Letters
59. Inhibition of thioredoxin-interacting protein and inflammasome assembly using verapamil mitigates diabetic retinopathy and pancreatic injury
    Lina D. Eissa, Waleed A. Ghobashy, Mona F. El-Azab · 2021 · European Journal of Pharmacology
60. Role of stilbenes against insulin resistance: A review
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61. Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic
    Eui‐Man Jung, Geun‐Shik Lee · 2022 · Journal of Ginseng Research
62. Neferine, an Alkaloid from Lotus Seed Embryos, Exerts Antiseizure and Neuroprotective Effects in a Kainic Acid-Induced Seizure Model in Rats
    Tzu‐Yu Lin, Chih-Yu Hung, Kuan‐Ming Chiu, Ming-Yi Lee, Cheng-Wei Lü, Su‐Jane Wang · 2022 · International Journal of Molecular Sciences
63. Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail
    Hao Wu, Yu Wang, Zhixin Ren, Yaolei Li, Jingjian Huang, Zhijian Lin, Bing Zhang · 2022 · Frontiers in Immunology
64. A clinical update on inflammasomopathies
    H. Sönmez, Seza Özen · 2017 · International Immunology
65. Inhibition of NLRP3 inflammasome—A potential mechanistic therapeutic for treatment of polycystic ovary syndrome?
    Solmaz Chamanara, Vahid Hozouri, Elnaz Irandoost · 2023 · Journal of Biochemical and Molecular Toxicology
66. Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome in systemic lupus erythematosus
    Xiaoxiao Wu, Junhao Yang, Juanjie Wu, Xuyan Yang · 2024 · Biomedicine & Pharmacotherapy
67. Exploring complexities of Alzheimer's disease: New insights into molecular and cellular mechanisms of neurodegeneration and targeted therapeutic interventions.
    Payal Chauhan, Karan Wadhwa, Govind Singh, Saurabh Gupta, Danish Iqbal, M. Abomughaid, Abdulmajeed G. Almutary, P. Mishra, V. K. Nelson, N. Jha · 2024 · Ageing Research Reviews
68. Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome
    Roma Pahwa, Anand Narayan Singh, BEVERLEY A. ADAMS-HUET, Sridevi Devaraj, Ishwarlal Jialal · 2020 · Diabetes/Metabolism Research and Reviews
69. DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy
    Ming Yang, Shilu Luo, Na Jiang, Xi Wang, Yachun Han, Hao Zhao, Xiaofen Xiong, Yan Liu, Chanyue Zhao, Xuejing Zhu et al. · 2021 · Frontiers in Physiology
70. Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway
    Demei Huang, Zherui Shen, Sijing Zhao, Caixia Pei, Nan Jia, Yilan Wang, Yongcan Wu, Xiaomin Wang, Shihua Shi, Yacong He et al. · 2023 · Chemico-Biological Interactions
71. Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study
    Mengchan Su, Yidan Tang, Weishuang Kong, Shuangyi Zhang, Tao Zhu · 2023 · Frontiers in Microbiology
72. Salmeterol, agonist of β2-aderenergic receptor, prevents systemic inflammation via inhibiting NLRP3 inflammasome
    Nanshan Song, Yinquan Fang, Xiyang Sun, Qingling Jiang, Chenghuan Song, Miaomiao Chen, Jianhua Ding, Ming Lu, Gang Hu · 2018 · Biochemical Pharmacology
73. P2X7 Antagonists for CNS Indications: Recent Patent Disclosures
    Paolo Pevarello, Silvia Bovolenta, Paola Tarroni, Lorena Za, Elda Severi, Domenica Torino, Rocco Vitalone · 2017 · Pharmaceutical Patent Analyst
74. Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential
    Ma Su, Weiwei Wang, Feng Liu, Huanqiu Li · 2020 · Current Medicinal Chemistry
75. Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis
    Wangnan Sun, Aiqun Li, Zhiqiang Wang, Xuhong Sun, Menghua Dong, Qi Fu, Lin Wang, Yueheng Zhang, Pengchao Du · 2020 · Molecular Medicine Reports
76. Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor
    Sameer Agarwal, Jignesh P. Pethani, Hardik A. Shah, Vismit Vyas, Santosh Sasane, Harsh Bhavsar, Debdutta Bandyopadhyay, Poonam Giri, Kasinath Viswanathan, Mukul Rameshchandra Jain et al. · 2020 · Bioorganic & Medicinal Chemistry Letters
77. Prokineticin 2 via Calcium-Sensing Receptor Activated NLRP3 Inflammasome Pathway in the Testicular Macrophages of Uropathogenic Escherichia coli-Induced Orchitis
    Yufang Su, Yuan Zhang, Zhiyong Hu, Liting He, Wei Wang, Jia Meng Xu, Zunpan Fan, Chunyan Liu, Huiping Zhang, Kai Zhao · 2020 · Frontiers in Immunology
78. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review
    Valeria Di Battista, Maria Teresa Bochicchio, Giulio Giordano, Mariasanta Napolitano, Alessandro Lucchesi · 2021 · International Journal of Molecular Sciences
79. Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis
    Tao Xu, Li‐Ping Sheng, Xianwen Guo, Zhen Ding · 2021 · Digestive Diseases and Sciences
80. PM2.5 induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis
    Fei Ren, Jingbin Xu, Jingxin Zhang, Xin Yun Xu, Lanyi Huang, Wenping Sun, Runguang Li, Fasheng Li · 2022 · Immunobiology
81. Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway
    Heng Wen, Dongshi Lu, Hanjian Chen, Ye-Ke Zhu, Qing Xie, Zhao Zhang, Zhouyang Wu · 2022 · Drug Development Research
82. Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span
    Natalya V. Kaverina, Robert Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher Lund O'Connor et al. · 2023 · Aging
83. Enriched physical environment reverses spatial cognitive impairment of socially isolated APP swe/ PS 1dE9 transgenic mice before amyloidosis onset
    Min Cao, Panpan Hu, Yanli Zhang, Yixin Yan, Christopher B. Shields, Yi‐Ping Zhang, Gang Hu, Ming Xiao · 2017 · CNS Neuroscience & Therapeutics
84. Gallic and butyric acids modulated NLRP3 inflammasome markers in a co-culture model of intestinal inflammation
    Iván Luzardo‐Ocampo, Guadalupe Flavia Loarca-Piña, Elvira González de Mejı́a · 2020 · Food and Chemical Toxicology
85. Downregulation of IRAK1 Prevents the Malignant Behavior of Hepatocellular Carcinoma Cells by Blocking Activation of the MAPKs/NLRP3/IL-1β Pathway
    Wei Chen, Tao Wei, Yinghua Chen, Lan Yang, Xiaomin Wu · 2020 · OncoTargets and Therapy
86. Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer’s Disease
    Francesca La Rosa, Roberta Mancuso, Simone Agostini, Federica Piancone, Ivana Marventano, Marina Saresella, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Angelo Scarpini et al. · 2021 · Pharmaceuticals
87. Immunoproteasome modulates NLRP3 inflammasome‐mediated neuroinflammation under cerebral ischaemia and reperfusion conditions
    Xingyong Chen, Yinzhou Wang, Nannan Yao, Zejing Lin · 2021 · Journal of Cellular and Molecular Medicine
88. The protective effect of dopamine on ventilator-induced lung injury via the inhibition of NLRP3 inflammasome
    Xiaomei Yang, Xiaotong Sun, Hongli Chen, Guangmin Xi, Yonghao Hou, Jianbo Wu, Dejie Liu, Huanliang Wang, Yuedong Hou, Jingui Yu · 2017 · International Immunopharmacology
89. Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo
    Zehua Zhou, Cheng Hu, Bo Cui, Lisha You, Rui An, Kun Liang, Xinhong Wang · 2024 · Journal of Agricultural and Food Chemistry
90. Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway
    Ao Wang, Guangshang Zhong, Mengjiao Ying, Zhuling Fang, Ying Chen, Haojie Wang, Chunjing Wang, Changqing Liu, Yu Guo · 2024 · Neuropharmacology
91. Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases
    Cristina Municio, Gabriel Criado · 2021 · Frontiers in Immunology
92. Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection
    Nigeer Te, Jordi Rodon, María Ballester, Mónica Pérez, Lola Pailler‐García, Joaquím Segalés, Júlia Vergara‐Alert, Albert Bensaïd · 2021 · PLoS Pathogens
93. Melatonin as an immunomodulator in children with Down syndrome
    Dean Huggard, Lynne A. Kelly, Amy P Worrall, Eleanor Gallagher, Lida Fallah, Lucas Lu Yoo, Fiona McGrane, Niamh Lagan, Edna Frances Roche, Joanne Balfe et al. · 2021 · Pediatric Research
94. Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act
    Xujun Cao, Anthony F. Cordova, Lingyin Li · 2021 · Chemical Reviews
95. Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice
    Gayatri Puri, Amarjit Singh Naura · 2022 · Free Radical Research
96. Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics
    Jun‐Feng Cao, Xingyu Yang, Li Xiong, Mei Wu, Shengyan Chen, Hengxiang Xu, Yunli Gong, Lixin Zhang, Qilan Zhang, Xiao Li Zhang · 2022 · Frontiers in Physiology
97. Role of NLRP3 inflammasome in hepatocellular carcinoma: A double-edged sword
    Yingle Tang, Yan Tao, Lin Zhu, Jia-Lin Shen, Hong Cheng · 2023 · International Immunopharmacology
98. Disrupted gut microbiota aggravates spatial memory dysfunction induced by high altitude exposure: A link between plateau environment and microbiome–gut–brain axis
    Xufei Zhang, Xian‐Hao Jia, Shengnan Wang, Jinge Xin, Ning Sun, Yanyan Wang, Xingting Zhang, Zhiqiang Wan, Jing Fan, Hao Li et al. · 2023 · Ecotoxicology and Environmental Safety
99. Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice
    Ning Ding, Jing Hua Jiang, Menghan Lu, Jiatong Hu, Yiyuan Xu, Xiaoxiao Liu, Zhigang Li · 2017 · Evidence-based Complementary and Alternative Medicine
100. Clostridium difficile and Clostridium sordellii toxins, proinflammatory versus anti-inflammatory response.
     Popoff, Michel R. · 2018 · Toxicon