Cited by 838Inflammasome and immune disordersImmune Response and InflammationAutoimmune and Inflammatory Disorders Research

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NLRP3 inflammasome and its inhibitors: a review

Open access

Shao, Bo-Zong, Xu, Zhe-Qi, Han, Bin-Ze, Su, Ding-Feng, Liu, Chong·2015·Frontiers in Pharmacology

DOI 10.3389/fphar.2015.00262PMC PMC4633676

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Abstract

Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as "pyrin domain-containing protein 3". The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome, as well as other auto-immune and auto-inflammatory diseases. Several NLRP3 inflammasome inhibitors have been described, some of which show promise in the clinic. The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto-inflammatory diseases, and the state of research into NLRP3 inflammasome inhibitors.

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BackgroundMethod
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Background
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Background
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Background
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Background
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The Use of Acupuncture as an Alternative Treatment Method for Ovarian Dysfunction: A Narrative Review
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“In contrast, NLRP3 promotes the secretion of pro-inflammatory cytokines, exacerbates cell damage, and induces apoptosis [23].”
Background
The NLRP3 Inflammasome as a promising target for Coronary Artery Disease: Current and Pipeline NLRP3 Inhibitors
McGilligan, V. (2019) · Online Journal of Cardiology Research & Reports · doi:10.33552/ojcrr.2019.03.000556 · Cited by 1
Platelet-rich plasma alleviates skin photoaging and oxidative stress in rats by regulating autophagy and inhibiting the NLRP 3 inflammasome pathway
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Pro-inflammatory Cytokines and the Depressive Phenotype
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Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity Athletes
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Advances in regulation mechanism of inflammasomes
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Expression of NLRP3 inflammasome proteins in ExpiCHO‐S mammalian cells reveals oligomerization properties that are highly sensitive to solution conditions
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“Interactions between the three inflammasome proteins enable the activation and proper function of the overall complex upon stimulation by a dangerassociated molecular pattern molecule.(5) Activation of the inflammasome results in autoproteolytic cleavage of procaspase-1 into active caspase-1.”
Background
Avaliação da ativação do inflamassoma no contexto da infecção por HPV e do câncer cervical associado ao HPV
Fernandes, F. P. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2020.tde-01072021-115731
Leptin Signalling in the Ovary of Diet-Induced Obese Mice Regulates Activation of Nod-Like Receptor Protein 3 InflammasomePreprint
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Studies on Prediction Systems for Revealing Biological Functions of Drug Candidates
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Investigating the functions and interactions of Salmonella effector SspH2 with intracellular innate immune receptors
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The role of jaboticaba (Plinia jaboticaba (VELL.) Berg) phenolic compounds in obesity-associated intestinal inflammation
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Editorial :1.NLRP3 INFLAMMASOME: A PROMISING THERANOSTIC TARGET IN INFLAMMATORY DISEASES
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“inhibiting the NLRP3 inflammasome may reduce their pathogenesis (3,8,16).”
Background
NLRP3 İnflamazom Aktivasyon ve Düzenleme Mekanizmalarına Genel Bir Bakış
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Interação do NLRP3-Inflamassoma com doenças autoimunes: uma revisão de literatura
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The NLRP3 activation-related signature predict the diagnosis and indicate immune characteristics in endometriosisPreprint
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Rich2 inhibits the NLRP3 inflammasome in epilepsy formation by regulating autophagyPreprint
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IVT-mRNA reprogramming of myeloid cells for cancer immunotherapy
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Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli
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“Several drugs have been proposed as potential inhibitors of this inflammasome (Shao et al. 2015), with MCC950 being the most widely reported NLRP3 inhibitor.”
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Additional file 1 of Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway
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Additional file 1 of Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling pathway
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Additional file 4 of Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis
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Additional file 3 of Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis
Fu, R., Guo, X., Pan, Z., Wang, Y., Xu, J., Zhang, L., & Li, J. (2024) · Figshare · doi:10.6084/m9.figshare.26635827

Authors: Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C.
Affiliations: Second Military Medical University (CN)
Corresponding author: Liu, Chong
ORCID: Shao, Bo-Zong
Su, Ding-Feng
Liu, Chong
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2015-11-05
Volume: 6
Pages: 262-262
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2015.00262
PMC: PMC4633676
OpenAlex: W2137444266
Cited by: 836
References: 115
Citations by year: 2026: 42 · 2025: 62 · 2024: 102 · 2023: 107 · 2022: 114 · 2021: 105 · 2020: 91 · 2019: 68 · 2018: 61 · 2017: 57 · 2016: 24 · 2015: 2
FWCI: 4.60
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Frontiers in Pharmacology (cc-by)
Funders: Natural Science Foundation of Shanghai (13ZR1448400)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: NLRP3 inflammasome, inflammasome inhibitors, innate immunity, autoinflammatory disease, autoimmune disease, metabolic disorders, multiple sclerosis, inflammatory bowel disease

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NLRP3 inflammasome and its inhibitors: a review

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