Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm
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Attention deficit hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder characterized by a definite behavioral pattern that might lead to performance problems in the social, educational, or work environments. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of ADHD were restricted to those associated with cognitive (attention deficit) and behavioral (hyperactivity/impulsivity) deficits, while deficient emotional self-regulation, a relevant source of morbidity, was left out. The etiology of it is complex, as its exact causes have not yet been fully elucidated. ADHD seems to arise from a combination of various genetic and environmental factors that alter the developing brain, resulting in structural and functional abnormalities. The aim of this paper was to review epigenetics and ADHD focused on how multidimensional mechanisms influence the behavioral phenotype.
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In humans, epigenetic mechanisms implicated in ASD may be a key mechanism through which valproate influences neurodevelopment.
“In humans epigenetic mechanisms implicated in ASD may be a key mechanism through which valproate influences neurodevelopment [34–37].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [37]
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The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
Cimino, S., Cerniglia, L., Ballarotto, G., Marzilli, E., Pascale, E., D’Addario, C., Adriani, W., & Tambelli, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00303 · Cited by 48 · see citing works
- Authors
- Schuch, V., Utsumi, D. A., Costa, T. V. M. M., Kulikowski, L. D., & Muszkat, M.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Muszkat, Mauro
- ORCID
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2015-09-17
- Volume
- 6
- Pages
- 126-126
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC4585002
- OpenAlex
- W1842524283
- Cited by
- 60
- References
- 80
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/05350-5, 2014/, 2015/, 14/02565-8)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Division of Graduate Education
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, epigenetics, emotion regulation, neurodevelopmental disorders, ADHD etiology, genetic and environmental factors, behavioral phenotypes, DSM-5 diagnostic criteria
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