Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress
Open accessAbstract
Background: Preconception, prenatal and postnatal maternal stress is associated with increased offspring psychopathology, but findings are inconsistent and need replication. We estimated associations between maternal bereavement stress and offspring autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, suicide attempt and completed suicide. Method: Using Swedish registers, we conducted the largest population-based study to date examining associations between stress exposure in 738 144 offspring born 1992–2000 for childhood outcomes and 2 155 221 offspring born 1973–1997 for adult outcomes with follow-up to 2009. Maternal stress was defined as death of a first-degree relative during ( a ) the 6 months before conception, ( b ) pregnancy or ( c ) the first two postnatal years. Cox proportional survival analyses were used to obtain hazard ratios (HRs) in unadjusted and adjusted analyses. Results: Marginal increased risk of bipolar disorder and schizophrenia following preconception bereavement stress was not significant. Third-trimester prenatal stress increased the risk of ASD [adjusted HR (aHR) 1.58, 95% confidence interval (CI) 1.15–2.17] and ADHD (aHR 1.31, 95% CI 1.04–1.66). First postnatal year stress increased the risk of offspring suicide attempt (aHR 1.13, 95% CI 1.02–1.25) and completed suicide (aHR 1.51, 95% CI 1.08–2.11). Bereavement stress during the second postnatal year increased the risk of ASD (aHR 1.30, 95% CI 1.09–1.55). Conclusions: Further research is needed regarding associations between preconception stress and psychopathological outcomes. Prenatal bereavement stress increases the risk of offspring ASD and ADHD. Postnatal bereavement stress moderately increases the risk of offspring suicide attempt, completed suicide and ASD. Smaller previous studies may have overestimated associations between early stress and psychopathological outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A large registry study from Sweden reported that third trimester prenatal stress increased ASD risk (OR 1.58, 95% CI 1.15-2.17).
“A large registry study from Sweden, not included in the review, reported that third trimester prenatal stress increased ASD risk (OR 1.58, 95% CI 1.15–2.17) [226].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [226]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The worldwide prevalence of ADHD: a systematic review and metaregression analysis
Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.942 · Cited by 5,346 · see citing works
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399 · see citing works
Goodman, S. H., & Gotlib, I. H. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.458 · Cited by 2,493 · see citing works
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125 · see citing works
Self-citationLiving with the Past: Evolution, Development, and Patterns of Disease
Gluckman, P. D., & Hanson, M. A. (2004) · Science · doi:10.1126/science.1095292 · Cited by 1,921 · see citing works
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works
Long-Term Medical and Social Consequences of Preterm Birth
Moster, D., Lie, R. T., & Markestad, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706475 · Cited by 1,402 · see citing works
Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why?
Talge, N. M., Neal, C., Glover, V., & the Early Stress, T. R. A. P. S. N. F. A. N. E. O. C. A. A. M. H. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01714.x · Cited by 1,349 · see citing works
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260 · cited 1× · see citing works
“…depression (Whiffen & Gotlib, 1989; Bagner et al. 2010) may adversely affect offspring 80 Q. A. Class et al. problem-solving abilities, cognitive ability, attachment and/or compound genetic vulnerability to suicide (Goodman & Gotlib, 1999; Williams & Pollock, 2000; Mann, 2003; Brent & Mann, 2005).”
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239 · see citing works
Caspi, A. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830110071009 · Cited by 1,159 · see citing works
Van den Bergh, B. R. H., Mulder, E. J. H., Mennes, M., & Glover, V. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.007 · Cited by 1,104 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
A quality study of a medical birth registry
Cnattingius, S., Ericson, A., Gunnarskog, J., & Källén, B. (1990) · Scandinavian Journal of Social Medicine · doi:10.1177/140349489001800209 · Cited by 972 · cited 1× · see citing works
“The Medical Birth Registry (Centre for Epidemiology, 2003; Cnattingius et al. 1990) included data on more than 99% of all births in Sweden from 1973 to 2008 and was used to obtain information on gestational length and birth complications.”
MethodEarly Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works
Neuroanatomic observations of the brain in autism: a review and future directions
Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919 · see citing works
Continuities and discontinuities in psychopathology between childhood and adult life
Rutter, M., Kim‐Cohen, J., & Maughan, B. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01614.x · Cited by 824 · see citing works
The International Handbook of Suicide and Attempted Suicide
(2000) · doi:10.1002/9780470698976 · Cited by 819 · see citing works
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
Clair, D. S. (2005) · JAMA · doi:10.1001/jama.294.5.557 · Cited by 817 · see citing works
O’Connor, T. G., Heron, J., Golding, J., Glover, V. A. S., & the AL SPAC Study Team (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00187 · Cited by 703 · see citing works
Impaired adult myelination in the prefrontal cortex of socially isolated mice
Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685 · see citing works
Buss, C., Davis, E. P., Shahbaba, B., Pruessner, J. C., Head, K., & Sandman, C. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201295109 · Cited by 652 · see citing works
The Lifetime Distribution of the Incremental Societal Costs of Autism
Ganz, M. L. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.4.343 · Cited by 623 · see citing works
Family genetic studies, suicide, and suicidal behavior
Brent, D. A., & Mann, J. J. (2005) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30042 · Cited by 618 · see citing works
Khashan, A. S., Abel, K. M., McNamee, R., Pedersen, M. G., Webb, R. T., Baker, P. N., Kenny, L. C., & Mortensen, P. B. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.20 · Cited by 576 · see citing works
Self-citationPrenatal stress and brain development
Charil, A., Laplante, D. P., Vaillancourt, C., & King, S. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.06.002 · Cited by 554 · see citing works
End-of-Life Care and the Effects of Bereavement on Family Caregivers of Persons with Dementia
Schulz, R., Mendelsohn, A. B., Haley, W. E., Mahoney, D., Allen, R. S., Zhang, S., Thompson, L., & Belle, S. H. (2003) · New England Journal of Medicine · doi:10.1056/nejmsa035373 · Cited by 543 · see citing works
The population impact of severe mental illness on violent crime
Fazel, S., & Grann, M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.8.1397 · Cited by 539 · cited 2× · see citing works
“…Register (Statistics Sweden, 2011) provided information on parental level (highest) of formal education completed, and the National Crime Register (Fazel & Grann, 2006) provided data on parental criminal convictions since the age of 15, the Swedish age of criminal responsibility, from 1973…”
BackgroundWhen stress happens matters: Effects of earthquake timing on stress responsivity in pregnancy
Glynn, L. M., Wadhwa, P. D., Dunkel-Schetter, C., Chicz-DeMet, A., & Sandman, C. A. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111066 · Cited by 508 · see citing works
Prenatal exposure to maternal stress and subsequent schizophrenia
van Os, J., & Selten, J. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.4.324 · Cited by 481 · see citing works
Epidemiology of schizophrenia: the global burden of disease and disability
Jablensky, A. V. (2000) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060070002 · Cited by 465 · see citing works
Prenatal stress and risk for autism
KINNEY, D., MUNIR, K., CROWLEY, D., & MILLER, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.004 · Cited by 440 · see citing works
Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.010 · Cited by 435 · see citing works
Van den Bergh, B. R. H., Van Calster, B., Smits, T., Van Huffel, S., & Lagae, L. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301450 · Cited by 434 · see citing works
Psychoneuroendocrine processes in human pregnancy influence fetal development and health
Wadhwa, P. D. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.004 · Cited by 420 · see citing works
Beydoun, H. A., & Saftlas, A. F. (2008) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2008.00951.x · Cited by 413 · see citing works
The Swedish Medical Birth Register - a summary of content and quality
Källén, B. A. J., & Källén, K. (2003) · Lund University Publications (Lund University) · Cited by 398 · see citing works
Proceeding From Observed Correlation to Causal Inference: The Use of Natural Experiments
Rutter, M. L. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00050.x · Cited by 397 · see citing works
Rice, F. J., Harold, G. T., Boivin, J., van den Bree, M. B. M., Hay, D. F., & Thapar, A. (2009) · Psychological Medicine · doi:10.1017/s0033291709005911 · Cited by 377 · see citing works
Prenatal Loss of Father and Psychiatric Disorders
HUTTUNEN, M. O. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770280039004 · Cited by 372 · see citing works
Further Evidence of Relation Between Prenatal Famine and Major Affective Disorder
Brown, A. S., van Os, J., Driessens, C., Hoek, H. W., & Susser, E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.190 · Cited by 371 · see citing works
Tidemalm, D., Långström, N., Lichtenstein, P., & Runeson, B. (2008) · BMJ · doi:10.1136/bmj.a2205 · Cited by 365 · see citing works
Self-citationPiven, J., & Palmer, P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.557 · Cited by 364 · see citing works
Timing of Prenatal Stressors and Autism
Beversdorf, D. Q., Manning, S. E., Hillier, A. J., Anderson, S. L., Nordgren, R. E., Walters, S., Nagaraja, H. N., Cooley, W. C., Gaelic, S. E., & Bauman, M. L. (2005) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-5037-8 · Cited by 359 · see citing works
Interpregnancy interval and risk of preterm birth and neonatal death: retrospective cohort study
Smith, G. C. S., Pell, J. P., & Dobbie, R. (2003) · BMJ · doi:10.1136/bmj.327.7410.313 · Cited by 348 · see citing works
Preterm birth and attention-deficit/hyperactivity disorder in schoolchildren
Lindström, K., Lindblad, F., & Hjern, A. (2011) · Pediatrics · doi:10.1542/peds.2010-1279 · Cited by 334 · see citing works
Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?
Rodriguez, A., & Bohlin, G. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00359.x · Cited by 333 · see citing works
The Economic Impact of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Pelham, W. E., Foster, E. M., & Robb, J. A. (2007) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsm022 · Cited by 326 · see citing works
Individual and Familial Risk Factors for Bipolar Affective Disorders in Denmark
Mortensen, P. B., Pedersen, C. B., Melbye, M., Mors, O. N., & Ewald, H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1209 · Cited by 308 · see citing works
Autism Prevalence Following Prenatal Exposure to Hurricanes and Tropical Storms in Louisiana
Kinney, D. K., Miller, A. M., Crowley, D. J., Huang, E., & Gerber, E. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0414-0 · Cited by 295 · see citing works
Pre‐, peri‐ and neonatal risk factors for autism
GUINCHAT, V., THORSEN, P., LAURENT, C., CANS, C., BODEAU, N., & COHEN, D. (2012) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2011.01325.x · Cited by 294 · see citing works
Prenatal Maternal Stress Associated with ADHD and Autistic Traits in early Childhood
Ronald, A., Pennell, C. E., & Whitehouse, A. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2010.00223 · Cited by 289 · see citing works
The effects of prenatal maternal stress on children's cognitive development: Project Ice Storm
King, S., & Laplante, D. P. (2005) · Stress · doi:10.1080/10253890500108391 · Cited by 286 · see citing works
Infants of postpartum depressed mothers: Temperament and cognitive status.
Whiffen, V. E., & Gotlib, I. H. (1989) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.98.3.274 · Cited by 265 · see citing works
Monk, C. E., Georgieff, M., & Osterholm, E. A. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12000 · Cited by 260 · see citing works
Smith, G. D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00191.x · Cited by 257 · see citing works
Brown, A. S., Susser, E., Lin, S. P., Neugebauer, R., & Gorman, J. M. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.5.601 · Cited by 246 · see citing works
Short interpregnancy intervals and unfavourable pregnancy outcome: role of folate depletion
Smits, L. J. M., & Essed, G. G. M. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07105-7 · Cited by 246 · see citing works
Correlates of Adverse Childhood Events Among Adults With Schizophrenia Spectrum Disorders
Rosenberg, S. D., Lu, W., Mueser, K. T., Jankowski, M. K., & Cournos, F. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.2.245 · Cited by 220 · see citing works
Birth Weight, Schizophrenia, and Adult Mental Disorder
Abel, K. M., Wicks, S., Susser, E., Dalman, C., Pedersen, M. G., Mortensen, P. B., & Webb, R. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.100 · Cited by 219 · see citing works
Self-citationBauman, M. L. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3225 · Cited by 215 · see citing works
Effect of Maternal Depression on Child Behavior: A Sensitive Period?
Bagner, D. M., Pettit, J. W., Lewinsohn, P. M., & Seeley, J. R. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.03.012 · Cited by 215 · cited 4× · see citing works
“…(Liu et al. 2012) or susceptibility to diminished parenting resources, sensitivity and/or stimulation as a consequence of maternal stress (Goodman & Gotlib, 1999; Bagner et al. 2010) may be particularly important for ASD risk during the second postnatal year of development (Mantymaa et al. 2012).”
BackgroundInfluentialClass, Q. A., Lichtenstein, P., Långström, N., & D'Onofrio, B. M. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820a62ce · Cited by 211 · see citing works
Self-citationInfants of postpartum depressed mothers: Temperament and cognitive status.
Whiffen, V. E., & Gotlib, I. H. (1989) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.98.3.274 · Cited by 199 · see citing works
Psychiatric Morbidity in Adolescents and Young Adults Born Preterm: A Swedish National Cohort Study
Lindström, K., Lindblad, F., & Hjern, A. (2008) · PEDIATRICS · doi:10.1542/peds.2008-1654 · Cited by 193 · see citing works
Li, J., Olsen, J., Vestergaard, M., & Obel, C. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0113-9 · Cited by 190 · see citing works
Mittendorfer‐Rutz, E., Rasmussen, F. E., & Wasserman, D. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17099-2 · Cited by 183 · see citing works
BRAND, S. R., ENGEL, S. M., CANFIELD, R. L., & YEHUDA, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.041 · Cited by 163 · see citing works
Reduced Infant Birthweight Consequent Upon Maternal Exposure to Severe Life Events
Khashan, A. S., McNamee, R., Abel, K. M., Pedersen, M. G., Webb, R. T., Kenny, L. C., Mortensen, P. B., & Baker, P. N. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318177940d · Cited by 138 · see citing works
Self-citationFamilial Pathways to Suicidal Behavior — Understanding and Preventing Suicide among Adolescents
Brent, D. A., & Mann, J. J. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068195 · Cited by 136 · see citing works
Birth Weight and Attention-Deficit/Hyperactivity Symptoms in Childhood and Early Adolescence
Hultman, C. M., Torrång, A., Tuvblad, C., Cnattingius, S., Larsson, J., & Lichtenstein, P. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000246059.62706.22 · Cited by 130 · see citing works
Self-citationKhashan, A. S., McNamee, R., Abel, K. M., Mortensen, P. B., Kenny, L. C., Pedersen, M. G., Webb, R. T., & Baker, P. N. (2009) · Human Reproduction · doi:10.1093/humrep/den418 · Cited by 119 · see citing works
Self-citationMäntymaa, M., Puura, K., Luoma, I., Latva, R., Salmelin, R. K., & Tamminen, T. (2011) · Child Psychiatry & Human Development · doi:10.1007/s10578-011-0255-0 · Cited by 114 · see citing works
The Long-Term Effects of Later Life Spousal and Parental Bereavement on Personal Functioning
Arbuckle, N. W., & de Vries, B. (1995) · The Gerontologist · doi:10.1093/geront/35.5.637 · Cited by 111 · see citing works
A Nationwide Study on the Risk of Autism After Prenatal Stress Exposure to Maternal Bereavement
Li, J., Vestergaard, M., Obel, C., Christensen, J., Precht, D. H., Lu, M., & Olsen, J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1734 · Cited by 111 · see citing works
Pregnancy Alters Blood Pressure Responses to Psychological and Physical Challenge
Matthews, K. A., & Rodin, J. (1992) · Psychophysiology · doi:10.1111/j.1469-8986.1992.tb01691.x · Cited by 95 · see citing works
Associated features of Asperger Syndrome and their relationship to parenting stress
Epstein, T. G., Saltzman-Benaiah, J., O'Hare, A. E., Goll, J. C., & Tuck, S. (2008) · Child Care Health and Development · doi:10.1111/j.1365-2214.2008.00834.x · Cited by 87 · see citing works
Ward, A. J. (1990) · Child Psychiatry & Human Development · doi:10.1007/bf00706020 · Cited by 74 · see citing works
Lower birth weight indicates higher risk of autistic traits in discordant twin pairs
Losh, M. C., Esserman, D., Anckarsäter, H. S., Sullivan, P. F., & Lichtenstein, P. (2011) · Psychological Medicine · doi:10.1017/s0033291711002339 · Cited by 73 · see citing works
Self-citationRai, D., Golding, J., Magnusson, C., Steer, C. D., Lewis, G., & Dalman, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038893 · Cited by 72 · see citing works
Self-citationThe Pschology of Suicidal Behaviour
Williams, J. M. G., & Pollock, L. R. (2000) · Wiley eBooks · doi:10.1002/9780470698976.ch5 · Cited by 71 · see citing works
Khashan, A. S., McNamee, R., Henriksen, T. B., Pedersen, M. G., Kenny, L. C., Abel, K. M., & Mortensen, P. B. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.12.005 · Cited by 59 · see citing works
Self-citationAdversity before conception will affect adult progeny in rats.
Shachar-Dadon, A., Schulkin, J. A., & Leshem, M. (2009) · Developmental Psychology · doi:10.1037/a0014030 · Cited by 50 · see citing works
Selten, J., Cantor‐Graae, E., Nahon, D., Levav, I., Aleman, A., & Kahn, R. S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00375-4 · Cited by 44 · see citing works
Repeat Teen Childbearing: Differences Across States and by Race and Ethnicity
Schelar, E., Franzetta, K., & Manlove, J. S. (2007) · PsycEXTRA Dataset · doi:10.1037/e407272008-001 · Cited by 19 · see citing works
Parenting of 7‐month‐old infants at familial risk for attention deficit/hyperactivity disorder
Landau, R., Avital, M., Berger, A., Atzaba‐Poria, N., Arbelle, S., Faroy, M., & Auerbach, J. G. (2010) · Infant Mental Health Journal · doi:10.1002/imhj.20249 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181 · see citing works
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
The impact of environmental factors in severe psychiatric disorders
Schmitt, A., Malchow, B., Hasan, A., & Falkai, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00019 · Cited by 322 · see citing works
Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk
Hantsoo, L., Kornfield, S., Anguera, M. C., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.018 · Cited by 269 · see citing works
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works
Davis, E. P., & Pfaff, D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.014 · Cited by 159 · see citing works
Lifetime stress experience: Transgenerational epigenetics and germ cell programming
Bale, T. L. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/tbale · Cited by 129 · see citing works
Stress, cortisol and suicide risk
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.11.006 · Cited by 108 · see citing works
Provenzi, L., Grumi, S., Altieri, L., Bensi, G., Bertazzoli, E., Biasucci, G., Cavallini, A., Decembrino, L., Falcone, R., Freddi, A., et al. (2023) · Development and Psychopathology · doi:10.1017/s0954579421000766 · Cited by 99 · see citing works
Beversdorf, D. Q., & MISSOURI AUTISM SUMMIT CONSORTIUM* (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000351 · Cited by 74 · see citing works
Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm
Schuch, V., Utsumi, D. A., Costa, T. V. M. M., Kulikowski, L. D., & Muszkat, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00126 · Cited by 60 · see citing works
Neural correlates of prenatal stress in young women
Favaro, A., Tenconi, E., Degortes, D., Manara, R., & Santonastaso, P. (2015) · Psychological Medicine · doi:10.1017/s003329171500046x · Cited by 51 · see citing works
Developmental pathways from prenatal tobacco and stress exposure to behavioral disinhibition
Clark, C. A. C., Espy, K. A., & Wakschlag, L. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.11.009 · Cited by 43 · see citing works
“…likelihood of aggression, conduct disorder and ADHD in children and, more recently, to externalizing behavior in young adults (Talge et al. 2007; Li et al. 2010; Bekkhus et al. 2011; Blair et al. 2011; Glover 2011; Ronald et al. 2011; Grizenko et al. 2012; Class et al. 2014; Betts et al. 2015).”
BackgroundBreen, M. S., Wingo, A. P., Koen, N., Donald, K. A., Nicol, M., Zar, H. J., Ressler, K. J., Buxbaum, J. D., & Stein, D. J. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.05.016 · Cited by 35 · see citing works
Possamai-Della, T., Cararo, J. H., Aguiar-Geraldo, J. M., Peper-Nascimento, J., Zugno, A. I., Fries, G. R., Quevedo, J., & Valvassori, S. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03348-1 · Cited by 16 · see citing works
- Authors
- Class, Q. A., Abel, K. M., Khashan, A. S., Rickert, M. E., Dalman, C., Larsson, H., Hultman, C. M., Långström, N., Lichtenstein, P., & D‘Onofrio, B. M.
- Affiliations
- Indiana University Bloomington (US)
- University of Manchester (GB)
- University College Cork (IE)
- Karolinska Institutet (SE)
- Corresponding author
- Class, Q. A.
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-04-17
- Volume
- 44
- Issue
- 1
- Pages
- 71-84
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC3766407
- OpenAlex
- W2119320045
- Cited by
- 213
- References
- 87
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 17 · 2023: 13 · 2022: 22 · 2021: 19 · 2020: 13 · 2019: 24 · 2018: 20 · 2017: 11 · 2016: 16 · 2015: 18 · 2014: 12 · 2013: 2
- FWCI
- 16.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Vetenskapsrådet
- Svenska Läkaresällskapet
- National Institutes of Health
- National Institute of Mental Health (F31MH094011, MH 094011)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061817, HD061817)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
- Social Sciences › Sociology and Political Science › Family Support in Illness
- Keywords
- offspring psychopathology, autism spectrum disorder, attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, suicide attempts, suicide mortality, prenatal stress, postpartum stress, offspring mental health
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Bereavement, Bipolar Disorder, Child, Child Development Disorders, Pervasive, Female, Humans, Male, Mothers, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Schizophrenia, Stress, Psychological, Suicide, Suicide, Attempted, Sweden, Proportional Hazards Models, Databases, Factual, Maternal Exposure, Postpartum Period, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
