Advances in the research of comorbid insomnia and depression: mechanisms, impacts, and interventions
Open accessAbstract
Insomnia and depression, both significantly impacting public health, are common psychosomatic illnesses that frequently co-occur in the same individual. Not only do these two conditions commonly co-occur, but they also exhibit a bidirectional link, where the existence of one may heighten the risk for the other. Latest research offers compelling evidence of significant overlap in biological, psychological, and sociological aspects in the comorbidity of insomnia and depression. Building on this, we aim to examine the pathophysiology of insomnia and depression, along with their comorbid mechanisms, encompassing biological routes (like genetics, HPA axis, immune-inflammatory activation, neuroendocrine regulation, microbiome alterations, and neural circuits integrating sleep and emotion regulation), as well as psychosocial routes. Consequently, proposing a self-perpetuating and mutually reinforcing “snowball effect” model of comorbid insomnia and depression, and examining corresponding preventative intervention strategies to rectify associated imbalances. Finally, this article encapsulates the challenges in this field of study and the directions for future research. Finally, the paper points out the limitations of current research (cross-sectional data being dominant, and the mechanism of multi-omics dynamics being unknown) and the future direction (longitudinal cohort combined with computational modeling to resolve temporal interactions), which will provide a theoretical basis for precision interventions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Insomnia symptoms, including sleep-onset difficulties, are transdiagnostic phenomena maintaining psychiatric disorders through shared cognitive and physiological mechanisms.
“Emerging evidence supports insomnia symptoms, including sleep-onset difficulties, as transdiagnostic phenomena maintaining psychiatric disorders through shared cognitive and physiological mechanisms [6,7].”
From Pre-Sleep Anxiety: Mechanisms and Therapeutic Approaches in Clinical Practice. (2026) · cites this paper as [7]
The “Complicated relations between insomnia and depression” section describes insomnia as a possible transdiagnostic phenomenon, and “Biological pathways” includes difficulty falling asleep among its symptoms. The “Psycho-sociological pathways” section describes shared biological and psychological mechanisms through which insomnia and depression may maintain each other, but does not establish that insomnia maintains psychiatric disorders generally. Page numbers were not provided in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30925-9 · Cited by 19,358 · see citing works
Self-citationInsel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Ferrari, A. J., Santomauro, D. F., Aali, A., Abate, Y. H., Abbafati, C., Abbastabar, H., Abd ElHafeez, S., Abdelmasseh, M., Abd-Elsalam, S., Abdollahi, A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00757-8 · Cited by 5,112 · see citing works
A network theory of mental disorders
Borsboom, D. (2017) · World Psychiatry · doi:10.1002/wps.20375 · Cited by 3,482 · see citing works
Baglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., Lombardo, C., & Riemann, D. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.01.011 · Cited by 2,779 · see citing works
Bassett, D. S., & Sporns, O. (2017) · Nature Neuroscience · doi:10.1038/nn.4502 · Cited by 2,398 · see citing works
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136 · see citing works
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works
Sleep, insomnia, and depression
Riemann, D. W., Krone, L. B., Wulff, K., & Nissen, C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0411-y · Cited by 863 · see citing works
Jansen, P. R., Watanabe, K., Stringer, S., Skene, N., Bryois, J., Hammerschlag, A. R., de Leeuw, C., Benjamins, J. S., Muñoz‐Manchado, A. B., Nagel, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0333-3 · Cited by 839 · see citing works
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746 · see citing works
Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572 · see citing works
Brain mechanisms of insomnia: new perspectives on causes and consequences
Someren, E. J. W. V. (2020) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 558 · see citing works
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
Castrén, E., & Monteggia, L. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.008 · Cited by 540 · see citing works
Comorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481 · see citing works
The Study of Psychopathology from the Network Analysis Perspective: A Systematic Review
Contreras, A., Nieto, I., Valiente, C., Espinosa, R., & Vázquez, C. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000497425 · Cited by 455 · see citing works
Blake, M. J., Trinder, J. A., & Allen, N. B. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.05.006 · Cited by 452 · see citing works
Perlis, M. L., Posner, D. A., Riemann, D. W., Bastien, C., Teel, J., & Thase, M. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00879-0 · Cited by 398 · see citing works
Clarifying the role of sleep in depression: A narrative review
Pandi-Perumal, S. R., Monti, J. M., Burman, D., Ramanujam, K., BaHammam, A. S., Spence, D. W., Brown, G. M., & Narashimhan, M. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113239 · Cited by 335 · see citing works
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Sutton, E. L. (2021) · Annals of Internal Medicine · doi:10.7326/aitc202103160 · Cited by 292 · see citing works
BDNF in sleep, insomnia, and sleep deprivation
Schmitt, K., Holsboer‐Trachsler, E., & Eckert, A. (2016) · Annals of Medicine · doi:10.3109/07853890.2015.1131327 · Cited by 275 · see citing works
EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis
Zhao, W., Someren, E. J. W. V., Li, C., Chen, X., Gui, W., Tian, Y., Liu, Y., & Lei, X. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101457 · Cited by 274 · see citing works
Crouse, J. J., Carpenter, J. S., Song, Y. J. C., Hockey, S. J., Naismith, S. L., Grunstein, R. R., Scott, E. M., Merikangas, K. R., Scott, J. L., & Hickie, I. B. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(21)00034-1 · Cited by 266 · see citing works
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
The depressed brain: an evolutionary systems theory
Badcock, P. B., Davey, C. G., Whittle, S., Allen, N. B., & Friston, K. J. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.005 · Cited by 190 · see citing works
Major Depression: One Brain, One Disease, One Set of Intertwined Processes
Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 167 · see citing works
Liu, Z., Liu, R., Zhang, Y., Zhang, R., Liang, L., Wang, Y., Wei, Y., Zhu, R., & Wang, F. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.028 · Cited by 147 · see citing works
Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
Potrykus, M., Czaja-Stolc, S., Stankiewicz, M., Kaska, Ł., & Małgorzewicz, S. (2021) · Nutrients · doi:10.3390/nu13113839 · Cited by 146 · see citing works
The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
Bany Bakar, R., Reimann, F., & Gribble, F. M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00830-y · Cited by 144 · see citing works
The Evolving Nexus of Sleep and Depression
Plante, D. T. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21080821 · Cited by 143 · see citing works
Insomnia—A risk factor for mental disorders
Hertenstein, E., Benz, F., Schneider, C. L., & Baglioni, C. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13930 · Cited by 137 · see citing works
Rahmani, M., Rahmani, F., & Rezaei, N. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02914-1 · Cited by 132 · see citing works
Moderators of Cognitive Behavioral Treatment for Insomnia on Depression and Anxiety Outcomes
Mirchandaney, R., Barete, R., & Asarnow, L. D. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01326-3 · Cited by 130 · see citing works
Cognitive Behavioral Therapy for Insomnia in Depression
Asarnow, L. D., & Manber, R. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.01.009 · Cited by 115 · see citing works
Al‐Hasani, R., Gowrishankar, R., Schmitz, G. P., Pedersen, C. E., Marcus, D. J., Shirley, S. E., Hobbs, T. G., Elerding, A. J., Renaud, S. J., Jing, M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00898-2 · Cited by 110 · see citing works
Psychobiotics: the Influence of Gut Microbiota on the Gut-Brain Axis in Neurological Disorders
Oroojzadeh, P., Bostanabad, S. Y., & Lotfi, H. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02053-3 · Cited by 105 · see citing works
Palagini, L., Geoffroy, P. A., Miniati, M., Perugi, G., Biggio, G., Marazziti, D., & Riemann, D. W. (2021) · CNS Spectrums · doi:10.1017/s1092852921000018 · Cited by 98 · see citing works
Insomnia and depression: clinical associations and possible mechanistic links
Vargas, I., & Perlis, M. L. (2020) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.11.004 · Cited by 95 · see citing works
Relationship between sleep disorders and gut dysbiosis: what affects what?
Neroni, B., Evangelisti, M., Radocchia, G., Nardo, G. D., Pantanella, F., Villa, M. P., & Schippa, S. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.08.003 · Cited by 94 · see citing works
Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality
Zhang, Q., Yun, Y., An, H., Zhao, W., Ma, T., Wang, Z., & Yang, F. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.645045 · Cited by 90 · see citing works
Wichers, M., Riese, H., Hodges, T. M., Snippe, E., & Bos, F. M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.719490 · Cited by 90 · see citing works
Neuroimaging insights into the link between depression and Insomnia: A systematic review
Bagherzadeh‐Azbari, S., Khazaie, H., Zarei, M., Spiegelhalder, K., Walter, M., Leerssen, J., Someren, E. J. W. V., Sepehry, A. A., & Tahmasian, M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.089 · Cited by 87 · see citing works
Liu, C., Pan, W., Li, L., Li, B., Ren, Y., & Ma, X. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110516 · Cited by 86 · see citing works
Xia, L., Chen, G.-H., Li, Z.-H., Jiang, S., & Shen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071065 · Cited by 83 · see citing works
Meneo, D., Samea, F., Tahmasian, M., & Baglioni, C. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13983 · Cited by 83 · see citing works
Casement, M. D., Keenan, K. E., Hipwell, A. E., Guyer, A. E., & Forbes, E. E. (2016) · SLEEP · doi:10.5665/sleep.5460 · Cited by 77 · see citing works
Sleep and Depression in Older Adults: A Narrative Review
Nielson, S. A., Kay, D. B., & Dzierzewski, J. M. (2023) · Current Psychiatry Reports · doi:10.1007/s11920-023-01455-3 · Cited by 74 · see citing works
Does insomnia treatment prevent depression?
Boland, E. M., Goldschmied, J. R., & Gehrman, P. R. (2023) · SLEEP · doi:10.1093/sleep/zsad104 · Cited by 69 · see citing works
Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review
Pferschy‐Wenzig, E., Pausan, M.-R., Ardjomand-Woelkart, K., Röck, S., Ammar, R. M., Kelber, O., Moissl‐Eichinger, C., & Bauer, R. (2022) · Nutrients · doi:10.3390/nu14102111 · Cited by 66 · see citing works
Recent advances in sleep and depression
Mirchandaney, R., Asarnow, L. D., & Kaplan, K. A. (2022) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000837 · Cited by 64 · see citing works
Insomnia symptoms predict both future hypertension and depression
Dong, Y., & Yang, F. M. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.02.001 · Cited by 53 · see citing works
Barnett, R. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31151-1 · Cited by 46 · see citing works
Tang, L., Yu, X., Wu, Y., Zhao, N., Liang, R.-L., Gao, X., Jiang, W., Chen, Y.-F., & Yang, W. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1019635 · Cited by 46 · see citing works
Insomnia in neurological disorders: Prevalence, mechanisms, impact and treatment approaches.
de Bergeyck, R., & Geoffroy, P. (2023) · Revue neurologique (Paris) · doi:10.1016/j.neurol.2023.08.008 · Cited by 44 · see citing works
Blom, K., Forsell, E., Hellberg, M., Svanborg, C., Jernelöv, S., & Kaldo, V. (2024) · Psychotherapy and Psychosomatics · doi:10.1159/000536063 · Cited by 43 · see citing works
Sex differences in insomnia and risk for psychopathology in adolescence
Marver, J. E., & McGlinchey, E. L. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.09.004 · Cited by 41 · see citing works
Circadian aspects in the aetiology and pathophysiology of insomnia
Lack, L. C., Micic, G., & Lovato, N. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13976 · Cited by 41 · see citing works
(2019) · The Lancet · doi:10.1016/s0140-6736(19)31047-5 · Cited by 40 · see citing works
Akram, U., Gardani, M., Akram, A., & Allen, S. F. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01939 · Cited by 38 · see citing works
Wang, L., Wang, K., Liu, J., & Wang, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00917 · Cited by 37 · see citing works
Aukia, L., Paavonen, E. J., Jänkälä, T., Tolvanen, M., Korja, R., Karlsson, L., Karlsson, H., & Polo‐Kantola, P. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.03.031 · Cited by 37 · see citing works
Bajaj, S., Blair, K. S., Schwartz, A., Dobbertin, M. D., & Blair, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243527 · Cited by 37 · see citing works
Li, J., Liu, J., Zhong, Y., Wang, H., Yan, B., Zheng, K., Lei, W., Lu, H., & Baojuan Li, A. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.033 · Cited by 36 · see citing works
Focusing on insomnia symptoms to better understand depression: A STAR*D report
Mason, B. L., Davidov, A., Minhajuddin, A., & Trivedi, M. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.094 · Cited by 35 · see citing works
Hong, M., Zhang, R., Liu, Y., Wu, Z., & Weng, P. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13870 · Cited by 34 · see citing works
Insomnia during the COVID-19 pandemic: the role of depression and COVID-19-related risk factors
Pizzonia, K. L., Koscinski, B., Suhr, J. A., Accorso, C., Allan, D. M., & Allan, N. P. (2021) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2021.1879241 · Cited by 31 · see citing works
Chen, T., & Saito, Y. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.01.003 · Cited by 30 · see citing works
Altered reward network responses to social touch in major depression
Mielacher, C., Scheele, D., Kiebs, M., Schmitt, L., Dellert, T., Philipsen, A., Lamm, C., & Hurlemann, R. (2023) · Psychological Medicine · doi:10.1017/s0033291723001617 · Cited by 30 · see citing works
Matsumura, R., Tsuchiya, Y., Tokuda, I. T., Matsuo, T., Sato, M., Node, K., Nishida, E., & Akashi, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578278 · Cited by 29 · see citing works
Tian, Y., Yang, W., Chen, G., Men, C., Gu, Y., Song, X., Zhang, R., Wang, L., & Zhang, X. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-021-01015-6 · Cited by 29 · see citing works
Morin, C. M., Bertisch, S. M., Pelayo, R., Watson, N. F., Winkelman, J. W., Zee, P. C., & Krystal, A. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051975 · Cited by 28 · see citing works
Decreased activity in the reward network of chronic insomnia patients
Motomura, Y., Katsunuma, R., Ayabe, N., Oba, K., Terasawa, Y., Kitamura, S., Moriguchi, Y., Hida, A., Kamei, Y., & Mishima, K. (2021) · Scientific Reports · doi:10.1038/s41598-020-79989-2 · Cited by 26 · see citing works
Alamoudi, D., Breeze, E., Crawley, E. M., & Nabney, I. T. (2023) · JMIR mhealth and uhealth · doi:10.2196/44123 · Cited by 25 · see citing works
Xiao, J., Liu, L., Peng, Y.-M., Wen, Y., Lv, X., Liang, L., Fan, Y., Chen, J., Chen, Y., Hu, H., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1179755 · Cited by 25 · see citing works
Raman, S., Hyland, P., & Coogan, A. N. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114533 · Cited by 24 · see citing works
Lindsay, J. A. B., McGowan, N. M., King, N., Rivera, D., Li, M., Byun, J., Cunningham, S., Saunders, K. E. A., & Duffy, A. C. (2022) · BJPsych Open · doi:10.1192/bjo.2022.48 · Cited by 24 · see citing works
Maternal insomnia during the COVID-19 pandemic: associations with depression and anxiety
Wang, J., Zhou, Y., Qian, W., Zhou, Y., Han, R., & Liu, Z. (2021) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-021-02072-2 · Cited by 22 · see citing works
Huang, X. D., Wu, D., Wu, A., Wei, C.-W., & Jian-dong, G. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s296986 · Cited by 21 · see citing works
Davy, J., Scheuermaier, K. D., Roden, L. C., Christie, C. J.-A., Bentley, A., Gómez-Olivé, F. X., Iacovides, S., Lewis, R., Lipinska, G., Roche, J., et al. (2021) · Journal of Physical Activity and Health · doi:10.1123/jpah.2020-0863 · Cited by 21 · see citing works
Huang, P., Zou, Y., Zhang, X., Ye, X., Wang, Y., Yu, R., & Yang, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.763259 · Cited by 20 · see citing works
Zhang, K., Mi, Z., Parks‐Stamm, E. J., Cao, W., Ji, Y., & Jiang, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.868072 · Cited by 19 · see citing works
Feher, A., Fejes, É., Kapus, K., Jancsák, C., Nagy, G. D., Horváth, L., Tibold, A., & Fehér, G. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1167308 · Cited by 18 · see citing works
Gong, L., Xu, R., Yang, D., Wang, J., Ding, X., Zhang, B., Zhang, X., Hu, Z., & Xi, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.907978 · Cited by 17 · see citing works
Torres-Granados, G. I., Santana-Miranda, R., Barrera-Medina, A., Cruz-Cruz, C., Jiménez‐Correa, U., Rosenthal, L. D., López-Naranjo, F., & Martínez-Núñez, J. M. (2022) · Sleep and Biological Rhythms · doi:10.1007/s41105-022-00412-6 · Cited by 16 · see citing works
Insomnia and depression: How much is the overlap?
Gupta, R. M., Victor, R., & Garg, S. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_461_18 · Cited by 15 · see citing works
Wickwire, E. M., Amari, D. T., Juday, T. R., Frech, F. H., Gor, D., & Malhotra, M. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2047537 · Cited by 12 · see citing works
Tao, H., Zeng, X., Hou, M., Chen, S., Shen, J., Liao, X., & Zou, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1134631 · Cited by 12 · see citing works
Kunicki, Z. J., Frietchen, R. E., McGeary, J. E., Jiang, L., Duprey, M. S., Bayer, T., Singh, M., Primack, J. M., Kelso, C. M., Wu, W., et al. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.01.026 · Cited by 11 · see citing works
Poon, K., Chan, R. S. W., Liang, J., & Li, L. M. W. (2023) · Social Science & Medicine · doi:10.1016/j.socscimed.2023.116384 · Cited by 10 · see citing works
Hu, Q., Wu, X., Wang, Z., Yan, T., Wang, L., Yu, W., Du, Q., Hu, W., Zheng, Y., Wang, K., et al. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.11.004 · Cited by 9 · see citing works
Mojsa‐Kaja, J., Szklarczyk-Smolana, K., Niedzielska, E., Kurpińska, A., Suraj, J., & Walczak, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285797 · Cited by 9 · see citing works
Byrne, J. E. M., & Murray, G. (2017) · Systematic Reviews · doi:10.1186/s13643-017-0631-3 · Cited by 8 · see citing works
Hong, S., Kim, S., Park, D., Ryu, S., Ha, J. H., & Jeon, H. J. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e30 · Cited by 8 · see citing works
Akada, K., Koyama, N., Miura, Y., & Aoshima, K. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2081451 · Cited by 8 · see citing works
Correa‐Muñoz, E., Retana-Ugalde, R., & Mendoza-Núñez, V. M. (2023) · Diagnostics · doi:10.3390/diagnostics13111889 · Cited by 8 · see citing works
Chen, F., Lin, X., Pan, Y., Zeng, X., Zhang, S., Hu, H., Yu, M., & Wu, J. (2021) · PeerJ · doi:10.7717/peerj.11061 · Cited by 7 · see citing works
Muhammad, T., Srivastava, S., Muneera, K., Kumar, M., & Kelekar, U. (2023) · Clinical Gerontologist · doi:10.1080/07317115.2023.2208582 · Cited by 7 · see citing works
Gong, L., Chen, K., Zhang, H., Zhang, S., Xu, R., Liu, D., Zhang, B., Yu, S., & Xi, C. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.09.026 · Cited by 7 · see citing works
Gut microbe composition and metabolic syndrome
Furlow, B. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70128-1 · Cited by 6 · see citing works
α- MSH Plays Anti-inflammatory and Anti-fungal Role in Aspergillus Fumigatus Keratitis
Cui, L., Wu, M., Gu, L., Yin, M., Li, H., Wu, Y., Lin, J., Wang, Q., Xu, Q., Jiang, N., et al. (2021) · Current Eye Research · doi:10.1080/02713683.2021.2006235 · Cited by 6 · see citing works
Lopez-Salinas, A., Arnaud-Gil, C. A., Martínez, D. E. S., Ruiz‐Lozano, R. E., Martínez‐Reséndez, M. F., Cortés, J. J. G., & Torre‐Amione, G. (2023) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2023.72 · Cited by 6 · see citing works
Jung, E., Ryu, H. H., Kim, S., Lee, J. H., Song, K. J., Ro, Y. S., Cha, K., Hwang, S. O., & Phase II Cardiac Arrest Pursuit Trial with Unique Registry and Epidemiologic Surveillance (CAPTURES-II investigators) (2023) · PLoS ONE · doi:10.1371/journal.pone.0287915 · Cited by 6 · see citing works
Sun, S.-Y., Qiu, J. H., Ren, J., Zhao, X., Jiang, Y., Wang, R., Wu, C., Cheng, J., & Su, C. (2020) · Sleep And Breathing · doi:10.1007/s11325-020-02156-4 · Cited by 5 · see citing works
Links between Sleep Apnoea and Insomnia in a British Cohort
Yu, Y. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030036 · Cited by 5 · see citing works
Gammoh, O., & Ennab, W. (2023) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174231190455 · Cited by 4 · see citing works
Geng, J., Cheng, C., Chen, S., Wang, Y., Du, Y., Long, J., Jin, Y., Yang, H., & Duan, G. (2022) · Psychology Health & Medicine · doi:10.1080/13548506.2022.2143542 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [6]Morin CM Drake CL Harvey AG Krystal AD Manber R Riemann D. Insomnia disorder. Nat Rev Dis Primers. (2015) 1: 15026. doi: 10.1038/nrdp.2015.26 27189779 · DOI · Paper page
- [49]Liu M McCurry SM Belza B Dobra A Buchanan DT Vitiello MV. Effects of osteoarthritis pain and concurrent insomnia and depression on health care use in a primary care population of older adults. Arthritis Care Res (Hoboken). (2019) 71: 748–57. doi: 10.1002/acr.2019.71.issue-6 PMC6358516 30067892 · DOI
- [69]Shuqiao Y Yanchun Y. (eds). Medical psychology textbook for the 12th Five-Year Plan, 6th edition: Beijing: People's Medical Publishing House. Beijing, China: People's Health Publishing House (2018).
- [84]Fang H Tu S Sheng J Shao A. Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med. (2019) 23: 2324–32. doi: 10.1111/jcmm.2019.23.issue-4 PMC6433686 30734486 · DOI
- [111]Fernandez-Mendoza J Shea S Vgontzas AN Calhoun SL Liao D Bixler EO. Insomnia and incident depression: role of objective sleep duration and natural history. J Sleep Res. (2015) 24: 390–8. doi: 10.1111/jsr.2015.24.issue-4 PMC7155163 25728794 · DOI
Cited by
Sorted by citations
Pre-Sleep Anxiety: Mechanisms and Therapeutic Approaches in Clinical Practice.
Song, S., Irfan, M., Tahir, Z., Garrison, K. A., & Ziskind, S. (2026) · Current Sleep Medicine Reports · doi:10.1007/s40675-026-00370-2
- Authors
- Gao, T., Xiang, H., Wu, Q. N., Zhu, L. S., Pei, W. J., Fu, W. J., & Chou, T. S.
- Affiliations
- Hunan University of Traditional Chinese Medicine (CN)
- Corresponding author
- Chou, Tian Shu
- ORCID
- Wu, Qian Nan
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2025-03-26
- Volume
- 16
- Pages
- 1468212-1468212
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC11980635
- OpenAlex
- W4408888266
- Cited by
- 17
- References
- 108
- Citations by year
- 2026: 12 · 2025: 5
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National College Students Innovation and Entrepreneurship Training Program
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- insomnia, depression, comorbidities, bidirectional relationship, pathophysiology, hypothalamic-pituitary-adrenal axis, gut microbiota, prevention interventions, precision intervention, psychosocial factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
