Cited by 519Edible Oils Quality and AnalysisEssential Oils and Antimicrobial ActivityPhytochemicals and Antioxidant Activities

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Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

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Pereira, Ana Paula, Ferreira, Isabel CFR, Marcelino, Filipa, Valentão, Patricia, Andrade, Paula B, Seabra, Rosa, Estevinho, Leticia, Bento, Albino, Pereira, José Alberto·2007·Molecules

DOI 10.3390/12051153PMC PMC6149345

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Abstract

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.

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Batçıoğlu, K., Küçükbay, F. Z., Alagöz, M. A., Günal, S., & Yılmaztekin, Y. (2023) · Foods and raw materials · doi:10.21603/2308-4057-2023-1-557 · Cited by 16
Biomolecules from olive pruning waste in Sierra Mágina – Engaging the energy transition by multi-actor and multidisciplinary analyses
Cohen, M., Lepesant, G., Lamari, F., Bilodeau, C., Benyei, P., Anglès, S., Bouillon, J., Bourrand, K., Landoulsi, R., Jaboeuf, D., et al. (2017) · Journal of Environmental Management · doi:10.1016/j.jenvman.2017.03.067 · Cited by 16
“HPLC is the preferred technique for such analysis since the polyphenols are mostly non-volatile (Herrero et al., 2011; Pereira et al., 2011; Abaza et al., 2015).”
Combined Antimicrobial Effect of Bio-Waste Olive Leaf Extract and Remote Cold Atmospheric Plasma Effluent
la Ossa, J. G. D., Kadri, H. E., Gutierrez‐Merino, J., Wantock, T., Harle, T., Seggiani, M., Danti, S., Stefano, R. D., & Velliou, E. G. (2021) · Molecules · doi:10.3390/molecules26071890 · Cited by 16
EVALUATION OF ANTIMICROBIAL ACTIVITY IN OLIVE (OLEA EUROPAEA) LEAF EXTRACT
Gökmen, M., Kara, R., Akkaya, L., Torlak, E., & Önen, A. (2014) · Current Research in Microbiology · doi:10.3844/ajmsp.2014.37.40 · Cited by 16
“…that the oleuropein which is included in theese products has a lot of pharmacological properties including antioxidant, antimicrobial, antiinflammatory, antiatherogenic anticarcinogenic and antiviral activities (Owen et al., 2003; Visioli et al., 2002; Micol et al., 2005; Sanchez et al., 2007).”
Background
Structure elucidation of a flavonoid glycoside from the roots of Clerodendrum serratum (L.) Moon, Lamiaceae
Bhujbal, S. S., Nanda, R. K., Deoda, R. S., Kumar, D., Kewatkar, S., S.More, L., & Patil, M. J. (2010) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2010005000041 · Cited by 16
“Previous studies suggests that apigenin-7-glucoside (1) has demonstrated antiinflammatory (Fuchs & Milbradt, 1993), antimicrobial (Pereira et al., 2007), hepatoprotective (Barbenko & Shakhova, 2003) and antidiarrheal properties (Meite et al., 2009).”
Background
The bioprofiling of antibacterials in olive leaf extracts via thin layer chromatography-effect directed analysis (TLC-EDA)
Agatonović-Kuštrin, S., Gegechkori, V., Morton, D. W., Tucci, J., Mohammed, E. U. R., & Ku, H. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.114916 · Cited by 15
Greenly prepared antimicrobial cotton fabrics using bioactive agents from Cupressaceae pods
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Development of Coated PLA Films Containing a Commercial Olive Leaf Extract for the Food Packaging Sector
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“These results were in agreement with several authors who have reported that OL extract exhibits inhibitory activities against E. coli , S. aureus , and L. monocytogenes [30,32].”
A Study of the Protective Properties of Iraqi Olive Leaves against Oxidation and Pathogenic Bacteria in Food Applications
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Extraction of Bioactive Compounds From Olive Leaves Using Emerging Technologies
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Musto, M., Potenza, G., & Cellini, F. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 15
Essential Oil Volatile Fingerprint Differentiates Croatian cv. Oblica from Other Olea europaea L. Cultivars
Popović, M., Špika, M. J., Bratinčević, M. V., Ninčević, T., Matešković, A., Mandušić, M., Rošin, J., Nazlić, M., Dunkić, V., & Vitanović, E. (2021) · Molecules · doi:10.3390/molecules26123533 · Cited by 15
Industrial Biotechnology: Date Palm Fruit Applications
Aleid, S. M. (2011) · Springer eBooks · doi:10.1007/978-94-007-1318-5_32 · Cited by 14
Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles
de Oliveira, N. M., Machado, J. P., Chéu, M. H., Lopes, L. T., Barroso, M. F., Silva, A., Sousa, S., Domingues, V. F., & Grosso, C. (2024) · Pharmaceuticals · doi:10.3390/ph17030274 · Cited by 15
Synergistic antimicrobial activities of aqueous extract derived from olive byproduct and their modes of action
Kim, Y., Zhao, H., Avena‐Bustillos, R. J., Wang, S. C., & Nitin, N. (2024) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-024-00634-5 · Cited by 14
Olive Leaf Extracts as a Medicinal Beverage: Origin, Physico-Chemical Properties, and Bio-Functionality
Panou, A., & Karabagias, I. K. (2025) · Beverages · doi:10.3390/beverages11030066 · Cited by 15
“In a study, it was found that oleuropein displayed high inhibitory action against Campylobacter jejuni , Helicobacter pylori, and Staphylococcus aureus with minimum inhibitory concentration as low as 0.31% v / v , 0.62% v / v , and 0.78% v / v , respectively [200].”
Influential
Effects of an Extract from Olive Fruits on the Physicochemical Properties, Lipid Oxidation and Volatile Compounds of Beef Patties
Gómez, I., García-Varona, C., Curiel-Fernández, M., & Ortega-Herás, M. (2020) · Foods · doi:10.3390/foods9121728 · Cited by 14
Diversity in Nutrition and Bioactivity of Momordica cochinchinensis
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A novel bioanalytical method based on UHPLC‐HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study
Lemonakis, N., Mougios, V., Halabalaki, M., Skaltsounis, A., & Gikas, E. E. (2016) · Biomedical Chromatography · doi:10.1002/bmc.3779 · Cited by 14
Organic Connection of Holobiont Components and the Essential Roles of Core Microbes in the Holobiont Formation of Feral Brassica napus
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Determination of an optimum extraction region for the recovery of bioactive compounds from olive leaves (Olea europaea L.) using green dynamic pressurized liquid extraction
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Competitive Adsorption of Phenolic Acids, Secoiridoids, and Flavonoids in Quercetin Molecularly Imprinted Polymers and Application for Fractionation of Olive Leaf Extracts
Almeida, A., Martins, C., Dias, R. C. S., & Costa, M. R. P. F. N. (2024) · Journal of Chemical & Engineering Data · doi:10.1021/acs.jced.3c00543 · Cited by 13
Effects of Electron Beam Radiation on the Phenolic Composition and Bioactive Properties of Olive Pomace Extracts
Madureira, J., Gonçalves, I. M., Cardoso, J., Días, M. I., Santos, P. M. P., Margaça, F. M. A., Santos‐Buelga, C., Barros, L., & Verde, S. C. (2024) · Antioxidants · doi:10.3390/antiox13050558 · Cited by 13
“Although no studies described the effect of e-beam radiation on olive pomace, there are some works reporting relevant antimicrobial activities in table olives [48,49], olive leaves [50,51], olive oil [47], and olive mill wastewaters [52].”
Background
Minerals and phytochemical analysis of bitter melon fruits and its components in some indigenous and exotic cultivars
Mahwish, M., Saeed, F., Nisa, M. U., & Nadeem, M. (2018) · Bioscience Journal · doi:10.14393/bj-v34n6a2018-39827 · Cited by 13
Potential aptitude of four olive cultivars as anticancer and antioxidant agents: oleuropein content
Rashed, S. A., Saad, T. I., & El-Darier, S. M. (2022) · RENDICONTI LINCEI · doi:10.1007/s12210-022-01056-x · Cited by 13
Identification of Polyketide Inhibitors Targeting 3-Dehydroquinate Dehydratase in the Shikimate Pathway of Enterococcus faecalis
Cheung, V. W. N., Xue, B., Hernandez-Valladares, M., Go, M. K., Tung, A., Aguda, A. H., Robinson, R. C., & Yew, W. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103598 · Cited by 13
Isolation and characterization of antimicrobial food components
Papetti, A. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.09.001 · Cited by 13
Resin Adsorption of Phenolic Compounds from Olive Leaf and Coffee Residue Extracts: Batch and Packed Column Adsorption Experimental Investigation and Mathematical Modeling
Kodjapashis, M. P., Zentelis, A. D., Zagklis, D. P., Sygouni, V., & Paraskeva, C. Α. (2023) · Separations · doi:10.3390/separations10050313 · Cited by 12
Active Polymer Films with Olive Leaf Extract: Potential for Food Packaging, Biomedical, and Cosmetic Applications
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Hydroxytyrosol downregulates inflammatory responses via Nrf2/HO-1 axis during fungal keratitis and exerts antifungal effects
Gu, L., Chi, M., Wang, Z., Fu, Y., Li, N., Niu, Y., Yu, B., Li, C., Li, C., & Zhao, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114202 · Cited by 12
Development and Validation of a Combined Methodology for Assessing the Total Quality Control of Herbal Medicinal Products – Application to Oleuropein Preparations
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Insecticidal effects of the Olea europaea subsp. laperrinei extracts on the flour Pyralid Ephestia kuehniella
Lahcene, S., Taïbi, F., Mestar, N. G., Ahmed, S. A., Boumendjel, M., Ouafi, S., & Houalı, K. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.11.2 · Cited by 12
Optimization of Bioactive Substances in the Wastes of Some Selective Mediterranean Crops
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Effect of Supplementation with Olive Leaf Extract Enriched with Oleuropein on the Metabolome and Redox Status of Athletes’ Blood and Urine—A Metabolomic Approach
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Natural Sources in Preventive Conservation of Naturally Aged Textiles
Wendt, J. A., Indrie, L., Dejeu, P., Albu, A., Ilieș, D. C., Costea, M., Caciora, T. I., Ilieș, G., Hodor, N., Josan, I., et al. (2021) · Fibres and Textiles in Eastern Europe · doi:10.5604/01.3001.0014.9309 · Cited by 12

Authors: Pereira, A. P., Ferreira, I. C., Marcelino, F., Valentão, P., Andrade, P. B., Seabra, R., Estevinho, L., Bento, A., & Pereira, J. A.
Affiliations: Universidade Politécnica de Bragança (PT)
REQUIMTE / Serviço de Farmacognosia, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
Universidade do Porto (PT)
CIMO / Escola Superior Agrária, Instituto Politécnico de Bragança, Campus Sta Apolónia, Apt. 1172, 5301-855 Bragança, Portugal
Corresponding author: Pereira, José Alberto
ORCID: Pereira, Ana Paula
Ferreira, Isabel CFR
Andrade, Paula B
Bento, Albino
Pereira, José Alberto
Venue: Molecules
Publisher: MDPI AG
Published: 2007-05-26
Volume: 12
Issue: 5
Pages: 1153-1162
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/12051153
PMC: PMC6149345
OpenAlex: W2146146382
Cited by: 519
References: 26
Citations by year: 2026: 16 · 2025: 28 · 2024: 38 · 2023: 19 · 2022: 44 · 2021: 34 · 2020: 46 · 2019: 38 · 2018: 34 · 2017: 33 · 2016: 33 · 2015: 36 · 2014: 29 · 2013: 20 · 2012: 19
FWCI: 6.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Interreg
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: olive leaves, Olea europaea, phenolic compounds, antimicrobial activity, antibacterial activity, antifungal activity, caffeic acid, verbascoside, oleuropein, luteolin glycosides, rutin, apigenin glycosides, nutraceuticals, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Candida albicans, Cryptococcus neoformans
MeSH terms: Anti-Infective Agents, Chromatography, High Pressure Liquid, Microbial Sensitivity Tests, Phenols, Molecular Structure, Plant Leaves, Olea

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Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

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