Cited by 519Edible Oils Quality and AnalysisEssential Oils and Antimicrobial ActivityPhytochemicals and Antioxidant Activities

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Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

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Pereira, Ana Paula, Ferreira, Isabel CFR, Marcelino, Filipa, Valentão, Patricia, Andrade, Paula B, Seabra, Rosa, Estevinho, Leticia, Bento, Albino, Pereira, José Alberto·2007·Molecules

DOI 10.3390/12051153PMC PMC6149345

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Abstract

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.

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“…compound found in olive leaves that exerts antioxidant, anti-inflammatory, anti-atherogenic, anti-carcinogenic, anti-microbial and anti-viral properties (Acar-Tek & A gag€und€uz, 2020; Bakir et al., 2018; Barbaro et al., 2014; Nediani et al., 2019; Pereira et al., 2007; Qabaha et al., 2018).”
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RETRACTED: Polar and apolar extra virgin olive oil and leaf extracts as a promising anti-inflammatory natural treatment for osteoarthritis
Nsir, H., Szychlinska, M. A., Cardile, V., Graziano, A. C. E., Avola, R., Esafi, H., Bendini, A., Zarouk, M., Loreto, C., Rapisarda, V., et al. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.04.005 · Cited by 5
“Oleuropein was the largest fraction present with 701,48 mg/kg of Dar Esalem (name of the sample used), in accordance with various previous studies (Pereira et al., 2007; Mc Donald et al., 2001) however, some variations found in the phenolic compositions of the olive leaf extracts reported might be due to the different…”
Result
Retracted
Wild versus Cultivated Olive Leaves Extracts: Antioxidant Activity, Analysis of Total Phenolics and Oleoropein Content
Rimawi, W. H., & Salim, H. (2016) · Journal of Chemistry and Biochemistry · doi:10.15640/jcb.v4n2a6 · Cited by 5
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Olive tree leaves in dairy sheep diet: effects on rumen metabolism, microbiota composition and milk quality
Valenti, B., Scicutella, F., Viti, C., Daghio, M., Mannelli, F., Gigante, D., Buccioni, A., Bolletta, V., Morbidini, L., Turini, L., et al. (2025) · animal · doi:10.1016/j.animal.2025.101435 · Cited by 6

Authors: Pereira, A. P., Ferreira, I. C., Marcelino, F., Valentão, P., Andrade, P. B., Seabra, R., Estevinho, L., Bento, A., & Pereira, J. A.
Affiliations: Universidade Politécnica de Bragança (PT)
REQUIMTE / Serviço de Farmacognosia, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
Universidade do Porto (PT)
CIMO / Escola Superior Agrária, Instituto Politécnico de Bragança, Campus Sta Apolónia, Apt. 1172, 5301-855 Bragança, Portugal
Corresponding author: Pereira, José Alberto
ORCID: Pereira, Ana Paula
Ferreira, Isabel CFR
Andrade, Paula B
Bento, Albino
Pereira, José Alberto
Venue: Molecules
Publisher: MDPI AG
Published: 2007-05-26
Volume: 12
Issue: 5
Pages: 1153-1162
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/12051153
PMC: PMC6149345
OpenAlex: W2146146382
Cited by: 519
References: 26
Citations by year: 2026: 16 · 2025: 28 · 2024: 38 · 2023: 19 · 2022: 44 · 2021: 34 · 2020: 46 · 2019: 38 · 2018: 34 · 2017: 33 · 2016: 33 · 2015: 36 · 2014: 29 · 2013: 20 · 2012: 19
FWCI: 6.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Interreg
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: olive leaves, Olea europaea, phenolic compounds, antimicrobial activity, antibacterial activity, antifungal activity, caffeic acid, verbascoside, oleuropein, luteolin glycosides, rutin, apigenin glycosides, nutraceuticals, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Candida albicans, Cryptococcus neoformans
MeSH terms: Anti-Infective Agents, Chromatography, High Pressure Liquid, Microbial Sensitivity Tests, Phenols, Molecular Structure, Plant Leaves, Olea

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Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

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