The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review
Open accessAbstract
Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can impair wound healing such as oxygenation defects, aging, and stress as well as deleterious health conditions such as infection, diabetes, alcohol overuse, smoking and impaired nutritional status. Growing evidence suggests that reactive oxygen species (ROS) are crucial regulators of several phases of healing processes. ROS are centrally involved in all wound healing processes as low concentrations of ROS generation are required for the fight against invading microorganisms and cell survival signaling. Excessive production of ROS or impaired ROS detoxification causes oxidative damage, which is the main cause of non-healing chronic wounds. In this context, experimental and clinical studies have revealed that antioxidant and anti-inflammatory strategies have proven beneficial in the non-healing state. Among available antioxidant strategies, treatments using mitochondrial-targeted antioxidants are of particular interest. Specifically, mitochondrial-targeted peptides such as elamipretide have the potential to mitigate mitochondrial dysfunction and aberrant inflammatory response through activation of nucleotide-binding oligomerization domain (NOD)-like family receptors, such as the pyrin domain containing 3 (NLRP3) inflammasome, nuclear factor-kappa B (NF-κB) signaling pathway inhibition, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2).
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Cites
Factors affecting wound healing
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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
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Reactive Oxygen Species in Metabolic and Inflammatory Signaling
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Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · cited 2×
“Along with immune competent cell recruitment, mast cell activation and degranulation result in the release of prothombotic factors and antithrombotic/fibrinolytic components, histamine and other active amines, which cause increased endothelial permeability and edema allowing further mononuclear cells recruitment [17,1…”
BackgroundDunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T. (2017) · International Wound Journal · doi:10.1111/iwj.12557 · Cited by 1,380
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
Tracy, L. E., Minasian, R. A., & Caterson, E. J. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0561 · Cited by 1,008
Platelet secretion: From haemostasis to wound healing and beyond
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Oxidative stress in normal and impaired wound repair
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Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
The Role of Antioxidants on Wound Healing: A Review of the Current Evidence
Comino-Sanz, I. M., López-Franco, M. D., Castro, B., & Pancorbo-Hidalgo, P. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163558 · Cited by 412
Chitooligosaccharides for wound healing biomaterials engineering
Jafari, H., Bernaerts, K. V., Dodi, G., & Shavandi, A. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111266 · Cited by 80
The Unexplored Wound Healing Activity of Urtica dioica L. Extract: An In Vitro and In Vivo Study
Kasouni, A. I., Chatzimitakos, T. G., Stalikas, C. D., Trangas, T., Papoudou-Bai, A., & Troganis, A. N. (2021) · Molecules · doi:10.3390/molecules26206248 · Cited by 38
Ebau, F., Scano, A., Manca, M. L., Manconi, M., Cabras, V., Pilloni, M., & Ennas, G. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37462 · Cited by 12
Resveratrol: A Promising Antiaging Agent for Cosmetic Skin Treatments
Fidalgo, J., Novo Barros, A., & Casas, A. (2024) · Resveratrol - Recent Advances, Application, and Therapeutic Potential · doi:10.5772/intechopen.107860 · Cited by 3
Metadata
- Authors
- Cano Sanchez, M., Lancel, S., Boulanger, E., & Neviere, R.
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2018-07-24
- Volume
- 7
- Issue
- 8
- Pages
- 98
- ISSN
- 2076-3921 (ISSN-L)
- OpenAlex
- W2883340199
- Cited by
- 574
- References
- 73
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- gold
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