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Cited by 574

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

Open access
Cano Sanchez, Mariola, Lancel, Steve, Boulanger, Eric, Neviere, Remi·2018·Antioxidants
DOI 10.3390/antiox7080098
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Abstract

Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can impair wound healing such as oxygenation defects, aging, and stress as well as deleterious health conditions such as infection, diabetes, alcohol overuse, smoking and impaired nutritional status. Growing evidence suggests that reactive oxygen species (ROS) are crucial regulators of several phases of healing processes. ROS are centrally involved in all wound healing processes as low concentrations of ROS generation are required for the fight against invading microorganisms and cell survival signaling. Excessive production of ROS or impaired ROS detoxification causes oxidative damage, which is the main cause of non-healing chronic wounds. In this context, experimental and clinical studies have revealed that antioxidant and anti-inflammatory strategies have proven beneficial in the non-healing state. Among available antioxidant strategies, treatments using mitochondrial-targeted antioxidants are of particular interest. Specifically, mitochondrial-targeted peptides such as elamipretide have the potential to mitigate mitochondrial dysfunction and aberrant inflammatory response through activation of nucleotide-binding oligomerization domain (NOD)-like family receptors, such as the pyrin domain containing 3 (NLRP3) inflammasome, nuclear factor-kappa B (NF-κB) signaling pathway inhibition, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

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Metadata

Authors
Cano Sanchez, M., Lancel, S., Boulanger, E., & Neviere, R.
Venue
Antioxidants
Publisher
MDPI AG
Published
2018-07-24
Volume
7
Issue
8
Pages
98
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox7080098
OpenAlex
W2883340199
Cited by
574
References
73
FWCI
6.99
Type
journal article
Language
en
Open access
gold

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